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1. Full Text Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
by Sahay, Amar and Scobie, Kimberly N and Hill, Alexis S and O'Carroll, Colin M and Kheirbek, Mazen A and Burghardt, Nesha S and Fenton, André A and Dranovsky, Alex and Hen, René
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7344, pp. 466 - 470
Adult hippocampal neurogenesis is a unique form of neural circuit plasticity that results in the generation of new neurons in the dentate gyrus throughout... 
DEPRESSION | MODELS | MEMORY | MULTIDISCIPLINARY SCIENCES | NEURONS | DISORDER | DENTATE GYRUS | MATURATION | SYNAPTIC PLASTICITY | FLUOXETINE | BRAIN | Apoptosis - drug effects | Learning - drug effects | Neuronal Plasticity - drug effects | Male | Neural Stem Cells - cytology | Anxiety - therapy | Neuronal Plasticity - physiology | Long-Term Potentiation - drug effects | Exploratory Behavior - drug effects | Cognition - physiology | Long-Term Potentiation - physiology | Antidepressive Agents - pharmacology | bcl-2-Associated X Protein - deficiency | Extinction, Psychological - physiology | Cell Survival - drug effects | Synapses - drug effects | Conditioning, Classical - drug effects | Affect - physiology | bcl-2-Associated X Protein - metabolism | Anxiety - physiopathology | Mice, Transgenic | Hippocampus - pathology | Cognition - drug effects | Mice, Knockout | Dentate Gyrus - cytology | Aging - physiology | Dentate Gyrus - physiology | Mice | Dentate Gyrus - pathology | Hippocampus - physiopathology | Memory - physiology | Memory - drug effects | Aging - drug effects | Extinction, Psychological - drug effects | Fear - physiology | Dentate Gyrus - physiopathology | Exploratory Behavior - physiology | Synapses - metabolism | Fear - psychology | Female | Neurogenesis - drug effects | bcl-2-Associated X Protein - genetics | Neural Stem Cells - drug effects | Hippocampus - cytology | Physical Conditioning, Animal - physiology | Conditioning, Classical - physiology | Aging - pathology | Learning - physiology | Animals | Neurogenesis - physiology | Models, Neurological | Hippocampus - physiology | Neural Stem Cells - metabolism | Physiological aspects | Hippocampus (Brain) | Neurogenesis | Health aspects | Proteins | Studies | Young adults | Cognition & reasoning | Neurons | Anxieties | Rodents | Behavior
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2. Full Text Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus, and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear
by Sierra-Mercado, Demetrio and Padilla-Coreano, Nancy and Quirk, Gregory J
Neuropsychopharmacology, ISSN 0893-133X, 01/2011, Volume 36, Issue 2, pp. 529 - 538
Current models of conditioned fear expression and extinction involve the basolateral amygdala (BLA), ventral medial prefrontal cortex (vmPFC), and the... 
GABA | muscimol | rat | conditioning | prefrontal cortex | inactivation | POSTTRAUMATIC-STRESS-DISORDER | NMDA RECEPTORS | PSYCHIATRY | POTENTIATED STARTLE | RELEARNING EXTINCTION | SYNAPTIC PLASTICITY | NEUROSCIENCES | GABA(A) | CONSOLIDATION | MEMORY | MEDIAL PREFRONTAL CORTEX | NEURONS | PHARMACOLOGY & PHARMACY | Amygdala - drug effects | CA1 Region, Hippocampal - physiology | Conditioning, Operant - physiology | Extinction, Psychological - drug effects | Fear - drug effects | Rats | Male | Fear - physiology | Rats, Sprague-Dawley | CA1 Region, Hippocampal - drug effects | Animals | Prefrontal Cortex - drug effects | Conditioning, Operant - drug effects | Amygdala - physiology | Prefrontal Cortex - physiology | Extinction, Psychological - physiology | Animal models | Plasticity | Learning & Memory | Original | GABAA
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3. Full Text Beyond extinction: erasing human fear responses and preventing the return of fear
by Kindt, M and Soeter, M and Vervliet, B
Nature Neuroscience, ISSN 1097-6256, 2009, Volume 12, Issue 3, pp. 256 - 258
Animal studies have shown that fear memories can change when recalled, a process referred to as reconsolidation. We found that oral administration of the... 
CONSOLIDATION | MEMORIES | RECONSOLIDATION | POTENTIATED STARTLE | NEUROSCIENCES | RETRIEVAL | AMYGDALA | Memory - drug effects | Humans | Extinction, Psychological - drug effects | Fear - drug effects | Male | Reaction Time - physiology | Fear - physiology | Acoustic Stimulation - methods | Young Adult | Propranolol - pharmacology | Reaction Time - drug effects | Adolescent | Reflex, Startle - drug effects | Fear - psychology | Adult | Female | Reflex, Startle - physiology | Extinction, Psychological - physiology | Memory - physiology | Physiological aspects | Brain research | Research | Emotional intelligence | Memory
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4. Full Text Stress, glucocorticoids and memory: Implications for treating fear-related disorders
by Quervain, D. de and Schwabe, L and Roozendaal, B
Nature Reviews Neuroscience, ISSN 1471-003X, 2017, Volume 18, Issue 1, pp. 7 - 19
Glucocorticoid stress hormones are crucially involved in modulating mnemonic processing of emotionally arousing experiences. They enhance the consolidation of... 
TERM DECLARATIVE MEMORY | GOAL-DIRECTED ACTION | BASOLATERAL AMYGDALA | NORADRENERGIC ACTIVITY | HIPPOCAMPAL ENDOCANNABINOID SYSTEM | POSTTRAUMATIC-STRESS | ANXIETY DISORDERS | NEUROSCIENCES | STIMULUS-RESPONSE MEMORY | HEALTHY-YOUNG MEN | OBSESSIVE-COMPULSIVE DISORDER | Memory - drug effects | Glucocorticoids - therapeutic use | Animals | Stress Disorders, Post-Traumatic - drug therapy | Humans | Extinction, Psychological - drug effects | Fear - drug effects | Stress, Psychological | Clinical Trials as Topic | Stress Disorders, Post-Traumatic - psychology | Memory - physiology | Psychological aspects | Memory consolidation | Care and treatment | Corticosteroids | Brain research | Phobias | Research
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5. Full Text Mechanisms of exposure therapy: How neuroscience can improve psychological treatments for anxiety disorders
by McNally, Richard J
Clinical Psychology Review, ISSN 0272-7358, 2007, Volume 27, Issue 6, pp. 750 - 759
Exposure therapy for anxiety disorders has been one of success stories of clinical psychology and psychiatry. Nevertheless, a significant minority of patients... 
POSTTRAUMATIC-STRESS-DISORDER | PANIC DISORDER | FEAR EXTINCTION | EMOTIONAL DISORDERS | MEMORY | CLINICAL IMPLICATIONS | MEDIAL PREFRONTAL CORTEX | PREPAREDNESS THEORY | D-CYCLOSERINE | PSYCHOLOGY, CLINICAL | AMYGDALA | Amygdala - physiopathology | Amygdala - drug effects | Humans | Prefrontal Cortex - physiopathology | Extinction, Psychological - drug effects | Fear - drug effects | Nerve Net - drug effects | Fear - physiology | Arousal - drug effects | Prefrontal Cortex - drug effects | Anxiety Disorders - therapy | Dominance, Cerebral - physiology | Anti-Anxiety Agents - therapeutic use | Dominance, Cerebral - drug effects | Nerve Net - physiopathology | Extinction, Psychological - physiology | Cognitive Therapy - methods | Brain - physiopathology | Rats | Desensitization, Psychologic - methods | Mental Recall - drug effects | Cycloserine - therapeutic use | Brain - drug effects | Arousal - physiology | Animals | Receptors, N-Methyl-D-Aspartate - agonists | Mental Recall - physiology | Anxiety Disorders - physiopathology | Psychotherapy | Neurosciences | Anxiety | Drug therapy | Analysis | Cognitive Processes | Literature Review | Anxiety Disorders | Exposure Therapy | Neurobiology | Cognitive Behavioral Therapy | Conditioned Emotional Responses | Psychophysiology
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6. Full Text Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in Amygdala
by Sawamura, Takehito and Klengel, Torsten and Armario, Antonio and Jovanovic, Tanja and Norrholm, Seth D and Ressler, Kerry J and Andero, Raül
Neuropsychopharmacology, ISSN 0893-133X, 02/2016, Volume 41, Issue 3, pp. 832 - 846
Posttraumatic stress disorder (PTSD) is both a prevalent and debilitating trauma-related disorder associated with dysregulated fear learning at the core of... 
POSTTRAUMATIC-STRESS-DISORDER | DNA METHYLATION | PSYCHIATRY | COMBAT VETERANS | RECEPTOR | CONDITIONED FEAR | NEUROSCIENCES | CHILDHOOD ADVERSITY | EPIGENETIC REGULATION | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | PITUITARY-ADRENAL AXIS | EXPOSURE | Amygdala - drug effects | Learning - drug effects | Epigenesis, Genetic | Extinction, Psychological - drug effects | Fear - drug effects | Male | Receptors, Glucocorticoid - metabolism | Tacrolimus Binding Proteins - metabolism | Time | Auditory Perception - physiology | Fear - physiology | RNA, Messenger - metabolism | Freezing Reaction, Cataleptic - drug effects | Dose-Response Relationship, Drug | Dexamethasone - pharmacology | Psychotropic Drugs - pharmacology | Stress, Psychological - metabolism | Corticosterone - blood | Extinction, Psychological - physiology | Disease Models, Animal | Stress, Psychological - drug therapy | Auditory Perception - drug effects | Mice, Inbred C57BL | Amygdala - metabolism | Learning - physiology | Animals | Freezing Reaction, Cataleptic - physiology | Original
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7. Full Text Effect of 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, on Emotional Learning
by Andero, Raul and Heldt, Scott A and Ye, Keqiang and Liu, Xia and Armario, Antonio and Ressler, Kerry J
American Journal of Psychiatry, ISSN 0002-953X, 2/2011, Volume 168, Issue 2, pp. 163 - 172
Objective:Despite increasing awareness of the many important roles played by brain-derived neurotrophic factor (BDNF) activation of TrkB, a fuller... 
FEAR EXTINCTION | MEMORY | ADULT HIPPOCAMPUS | PSYCHIATRY | NEUROTROPHIC FACTOR | D-CYCLOSERINE | BDNF VAL66MET POLYMORPHISM | LONG-TERM POTENTIATION | STRESS | UP-REGULATION | EXPRESSION | Amygdala - physiopathology | Amygdala - drug effects | Humans | Extinction, Psychological - drug effects | Fear - drug effects | Immunoblotting | Male | Receptor, trkB - agonists | Fear - physiology | Immobilization - psychology | Brain-Derived Neurotrophic Factor - physiology | Immobilization - physiology | Extinction, Psychological - physiology | Conditioning, Classical - drug effects | Flavanones - pharmacology | Mice, Inbred C57BL | Injections, Intraperitoneal | Mental Recall - drug effects | Conditioning, Classical - physiology | Amygdala - pathology | Association Learning - physiology | Association Learning - drug effects | Animals | Mental Recall - physiology | Mice | Stress, Psychological - complications | Stress, Psychological - physiopathology | Learning | Proteins | Physiological aspects | Research | Properties | Amygdala (Brain) | Emotions | Agonists (Biochemistry)
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8. Full Text Disrupting reconsolidation: pharmacological and behavioral manipulations
by Soeter, M and Kindt, M
Learning & Memory, ISSN 1072-0502, 2011, Volume 18, Issue 6, pp. 357 - 366
We previously demonstrated that disrupting reconsolidation by pharmacological manipulations "deleted" the emotional expression of a fear memory in humans. If... 
RESPONSES | REINSTATEMENT | ACQUISITION | FEAR-POTENTIATED STARTLE | CONDITIONED FEAR | MEMORY RECONSOLIDATION | EXTINCTION | CONTEXT | NEUROSCIENCES | AMYGDALA | Fear | Anxiety Disorders | Memory | Behavior Modification | Drug Therapy | Anxiety | Emotional Response | Conditioning | Generalization | Patients | Memory Disorders - physiopathology | Stress, Psychological - chemically induced | Electric Stimulation - adverse effects | Conditioning, Classical - drug effects | Humans | Extinction, Psychological - drug effects | Fear - drug effects | Male | alpha-Amylases - metabolism | Saliva - chemistry | Young Adult | Galvanic Skin Response - drug effects | Psychiatric Status Rating Scales | Analysis of Variance | Generalization (Psychology) - drug effects | Propranolol - adverse effects | Adolescent | Reflex, Startle - drug effects | Adrenergic beta-Antagonists - adverse effects | Adult | Female | Blood Pressure - drug effects | Memory Disorders - chemically induced
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9. Full Text Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders
by Singewald, N and Schmuckermair, C and Whittle, N and Holmes, A and Ressler, K.J
Pharmacology and Therapeutics, ISSN 0163-7258, 05/2015, Volume 149, pp. 150 - 190
Pathological fear and anxiety are highly debilitating and, despite considerable advances in psychotherapy and pharmacotherapy they remain insufficiently... 
Fear extinction | Reconsolidation | Cognitive enhancer | Drug development | Augmented relearning | Exposure therapy | POSTTRAUMATIC-STRESS-DISORDER | ACTIVATED PROTEIN-KINASE | RECEPTOR MESSENGER-RNA | FIBROBLAST-GROWTH-FACTOR | RANDOMIZED CONTROLLED-TRIAL | GATED CALCIUM-CHANNELS | D-CYCLOSERINE AUGMENTATION | OBSESSIVE-COMPULSIVE DISORDER | MEDIAL PREFRONTAL CORTEX | PHARMACOLOGY & PHARMACY | PLACEBO-CONTROLLED TRIAL | Humans | Extinction, Psychological - drug effects | Nootropic Agents - therapeutic use | Anxiety - drug therapy | Combined Modality Therapy | Implosive Therapy | Anxiety - therapy | Animals | Phobic Disorders - drug therapy | Signal Transduction - drug effects | Stress Disorders, Post-Traumatic - drug therapy | Synaptic Transmission - drug effects | Models, Neurological | Nootropic Agents - pharmacology | Psychic trauma | Anxiety | Smart drugs and nutrients | Index Medicus | In-Process
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