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Science, ISSN 0036-8075, 03/2012, Volume 335, Issue 6075, pp. 1503 - 1506
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 5/2016, Volume 131, Issue 5, pp. 725 - 736
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2012, Volume 21, Issue 3, pp. 418 - 429
Pancreatic ductal adenocarcinomas (PDAs) are characterized by a robust fibroinflammatory response. We show here that this desmoplastic reaction generates... 
INTERSTITIAL FLUID PRESSURE | SOLID TUMORS | ONCOLOGY | COMPARING STANDARD PANCREATICODUODENECTOMY | HUMAN OSTEOSARCOMA XENOGRAFTS | RANDOMIZED-TRIAL | HEAD ADENOCARCINOMA | TUMOR VASCULATURE | EXTENDED LYMPHADENECTOMY | CANCER | BLOOD-PRESSURE | CELL BIOLOGY | Adenocarcinoma - pathology | Cell Adhesion Molecules - administration & dosage | Stromal Cells - pathology | Pancreatic Neoplasms - blood supply | Deoxycytidine - pharmacology | Hyaluronic Acid - physiology | Polyethylene Glycols - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Stromal Cells - drug effects | Hyaluronoglucosaminidase - administration & dosage | Drug Evaluation, Preclinical | Hyaluronoglucosaminidase - therapeutic use | Tumor Microenvironment - drug effects | Animals, Genetically Modified | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Microvessels - drug effects | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Extracellular Fluid - drug effects | Polyethylene Glycols - administration & dosage | Adenocarcinoma - blood supply | Hyaluronoglucosaminidase - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Hyaluronic Acid - metabolism | Mice | Carcinoma, Pancreatic Ductal - blood supply | Cell Adhesion Molecules - therapeutic use | Deoxycytidine - analogs & derivatives | Enzymes | Medical colleges | Care and treatment | Glycosaminoglycans | Oncology, Experimental | Research | Chemotherapy | Universities and colleges | Drug therapy | Hyaluronic acid | Public health | Tumors | Cancer | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2009, Volume 15, Issue 11, pp. 1318 - 1321
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, pp. e29318 - e29318
Background: Gout is a prevalent inflammatory arthritis affecting 1-2% of adults characterized by activation of innate immune cells by monosodium urate (MSU)... 
MONOSODIUM URATE CRYSTALS | ACTIVATION | MECHANISM | INDUCE | PHOSPHATIDYLINOSITOL 3-KINASE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | ANAKINRA | RELEASE | ARTHRITIS | EXPRESSION | Acute Disease | Humans | Neutrophils - drug effects | Crystallization | Extracellular Space - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Protein Transport - drug effects | DNA - metabolism | Synovial Fluid - drug effects | Autophagy - drug effects | Endosomes - metabolism | Extracellular Space - metabolism | Gout - metabolism | Signal Transduction - drug effects | Gout - pathology | Interleukin-1beta - metabolism | Uric Acid - pharmacology | HMGB1 Protein - metabolism | Endosomes - drug effects | Synovial Fluid - cytology | Neutrophils - metabolism | Interleukin-1beta - antagonists & inhibitors | Neutrophils - pathology | Pathogenesis | Gout | Interleukin | Activation | Arthritis | Kinases | Autophagy | Machinery | HMGB1 protein | Blood | Proteins | Synovial fluid | Cell activation | Rodents | Peripheral blood | Rheumatism | Lupus | Cytokines | Internal medicine | Secretion | Interleukin 1 receptor antagonist | Neutrophils | Crystals | Leukocytes (neutrophilic) | Inflammation | Uric acid | Patients | 1-Phosphatidylinositol 3-kinase | Immune systems | Medicine | Signaling | Hospitals | Respiratory distress syndrome | Microscopy | Rheumatoid arthritis | Adults | Immunofluorescence | Phagocytosis | Apoptosis | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2012, Volume 34, Issue 9, pp. 2277 - 2288
Abstract Interstitial fluid pressure (IFP) in tumor is much higher than that in normal tissue and it constitutes a great obstacle for the delivery of... 
Advanced Basic Science | Dentistry | Tumor interstitial fluid pressure | Intratumoral delivery | Imatinib | Combination therapy | Doxorubicin | Sterically stabilized liposome | VASCULAR NORMALIZATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | PHASE-II | CANCER | ANTICANCER THERAPEUTICS | MESYLATE | PDGFR-BETA | MELANOMA | INHIBITION | GENE-EXPRESSION | DRUG-COMBINATION | Immunohistochemistry | NIH 3T3 Cells | Apoptosis - drug effects | Melanoma, Experimental - drug therapy | Drug Delivery Systems | Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors | Doxorubicin - analogs & derivatives | Female | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Drug Therapy, Combination | Fibroblasts - metabolism | Polyethylene Glycols - pharmacology | Receptor, Platelet-Derived Growth Factor beta - metabolism | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Extracellular Fluid - drug effects | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | Liposomes - pharmacology | Doxorubicin - pharmacology | Anthracyclines | Chemotherapy | Biological products | Platelet-derived growth factor | Biomimetics | Oncology, Experimental | Melanoma | Physiological aspects | Research | Cancer | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2009, Volume 31, Issue 6, pp. 1133 - 1139
Journal Article
Journal Article