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Current pharmaceutical design, ISSN 1381-6128, 01/2007, Volume 13, Issue 3, pp. 333 - 346
The matrix metalloproteinase family of enzymes has been a pharmaceutical target for over 20 years... 
Cardiovascular disease | Inflammation | Topical | Acute therapy | Remodeling | SMOKE-INDUCED EMPHYSEMA | cardiovascular disease | remodeling | topical | ABDOMINAL AORTIC-ANEURYSMS | HEART-FAILURE | BLOOD-BRAIN-BARRIER | RESPIRATORY-DISTRESS-SYNDROME | MUSCLE-CELL-MIGRATION | OBSTRUCTIVE PULMONARY-DISEASE | TISSUE-PLASMINOGEN-ACTIVATOR | inflammation | acute therapy | MACROPHAGE ELASTASE MMP-12 | PHARMACOLOGY & PHARMACY | PREVENTS CARDIAC RUPTURE | Hypertrophy, Left Ventricular - enzymology | Humans | Eye Diseases - enzymology | Protease Inhibitors - pharmacology | Atherosclerosis - enzymology | Drug Design | Hypertrophy, Left Ventricular - drug therapy | Protease Inhibitors - therapeutic use | Vascular Diseases - drug therapy | Extracellular Matrix Proteins - metabolism | Myocardial Infarction - enzymology | Atherosclerosis - drug therapy | Heart Rupture, Post-Infarction - enzymology | Neoplasms - enzymology | Skin Diseases - drug therapy | Stroke - drug therapy | Respiratory Distress Syndrome, Adult - drug therapy | Vascular Diseases - enzymology | Arthritis - enzymology | Neoplasms - drug therapy | Pulmonary Disease, Chronic Obstructive - enzymology | Stroke - enzymology | Animals | Myocardial Infarction - drug therapy | Eye Diseases - drug therapy | Arthritis - drug therapy | Matrix Metalloproteinase Inhibitors | Matrix Metalloproteinases - metabolism | Heart Rupture, Post-Infarction - drug therapy | Respiratory Distress Syndrome, Adult - enzymology | Skin Diseases - enzymology | Pulmonary Disease, Chronic Obstructive - drug therapy
Journal Article
Journal of leukocyte biology, ISSN 0741-5400, 2013, Volume 94, Issue 2, pp. 237 - 246
... myelin basic protein MC mast cell mDC mature DC MMP matrix metalloproteinase MS multiple sclerosis MT‐MMP membrane‐type matrix metalloproteinase PMN... 
migration | immune system cells | inflammation | extracellular matrix | proteases | Extracellular matrix | Inflammation | Proteases | Immune system cells | Migration | CYTOPLASMIC TAIL | 1-MATRIX METALLOPROTEINASE | PROTEOLYTIC ACTIVATION | CELL-SURFACE | CATALYTIC-ACTIVITIES | IMMUNOLOGY | CELL BIOLOGY | NK CELLS | TISSUE INHIBITOR | EXTRACELLULAR-MATRIX | MT1-MMP TRAFFICKING | HEMATOLOGY | EXPRESSION | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Extracellular Matrix - metabolism | Structure-Activity Relationship | Leukocytes - enzymology | Leukocytes - immunology | Atherosclerosis - enzymology | Tissue Inhibitor of Metalloproteinases - physiology | Diabetes Mellitus, Type 1 - immunology | Autoimmune Diseases - pathology | Extracellular Matrix Proteins - metabolism | Diabetes Mellitus, Type 1 - enzymology | Protein Structure, Tertiary | Matrix Metalloproteinases, Membrane-Associated - chemistry | Multiple Sclerosis - enzymology | Encephalomyelitis, Autoimmune, Experimental - pathology | Autoimmune Diseases - enzymology | Islets of Langerhans - pathology | Neutrophils - enzymology | Islets of Langerhans - enzymology | Autoimmune Diseases - immunology | Diabetes Mellitus, Type 1 - pathology | Islets of Langerhans - immunology | Arthritis, Rheumatoid - enzymology | Inflammation - immunology | Matrix Metalloproteinases, Membrane-Associated - physiology | Arthritis, Rheumatoid - pathology | Atherosclerosis - blood | Animals | Encephalomyelitis, Autoimmune, Experimental - enzymology | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Leukocytes, Mononuclear - enzymology | Lymphocyte Subsets - enzymology | Mice | Arthritis, Rheumatoid - immunology | Inflammation - enzymology
Journal Article
Journal Article
Circulation research, ISSN 1524-4571, 2013, Volume 112, Issue 4, pp. 675 - 688
RATIONALE:Matrix metalloproteinase (MMP)-28 regulates the inflammatory and extracellular matrix responses in cardiac aging, but the roles of MMP-28 after myocardial infarction (MI... 
fibroblast | MMP-28 | inflammation | macrophage phenotype | myocardial infarction | LYSYL OXIDASE | CARDIAC & CARDIOVASCULAR SYSTEMS | TGF-BETA | VENTRICULAR-FUNCTION | HEART-FAILURE | CORONARY MICROEMBOLIZATION | REPAIR | MATRIX-METALLOPROTEINASE-9 | PERIPHERAL VASCULAR DISEASE | EPILYSIN MMP-28 | TNF-ALPHA | TARGETED DELETION | HEMATOLOGY | Myocardial Infarction - blood | Cell Adhesion Molecules - genetics | Cicatrix - etiology | Extracellular Matrix Proteins - biosynthesis | Male | Matrix Metalloproteinases, Secreted - deficiency | Pulmonary Edema - etiology | Myocytes, Cardiac - enzymology | Myofibroblasts - metabolism | Ventricular Dysfunction, Left - enzymology | Ventricular Remodeling - genetics | Female | Myocardial Infarction - physiopathology | Transcription, Genetic | Cytokines - genetics | Heart Rupture - enzymology | Receptors, Cytokine - genetics | Matrix Metalloproteinase 9 - blood | Myocardial Infarction - enzymology | Macrophage Activation - physiology | Macrophages - classification | Cell Adhesion Molecules - biosynthesis | Receptors, Cytokine - biosynthesis | Extracellular Matrix Proteins - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Ventricular Dysfunction, Left - etiology | Inflammation | Ventricular Remodeling - physiology | Macrophages - enzymology | Mice, Knockout | Collagen - metabolism | Myocardial Infarction - complications | Heart Rupture - etiology | Animals | Pulmonary Edema - enzymology | Matrix Metalloproteinases, Secreted - genetics | Matrix Metalloproteinases, Secreted - physiology | Protein-Lysine 6-Oxidase - metabolism | Cicatrix - enzymology | Mice | Cytokines - biosynthesis
Journal Article
Neuroscience, ISSN 0306-4522, 2009, Volume 158, Issue 3, pp. 983 - 994
Journal Article
Journal of neurochemistry, ISSN 1471-4159, 2007, Volume 101, Issue 2, pp. 566 - 576
... with them. Using human BMVEC grown on porous membranes covered with basement membrane (BM) matrix (BBB models), we demonstrated that reactive oxygen species... 
blood–brain barrier | protein tyrosine kinase | matrix metalloproteinases | protein tyrosine phosphatase | brain endothelial cell | oxidative stress | Protein tyrosine kinase | Oxidative stress | Matrix metalloproteinases | Blood-brain barrier | Brain endothelial cell | Protein tyrosine phosphatase | blood-brain barrier | HUMAN STROKE | FACTOR RECEPTOR TRANSACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL CEREBRAL-ISCHEMIA | VASCULAR-PERMEABILITY | TIGHT JUNCTION | NEUROSCIENCES | SIGNAL-TRANSDUCTION | MULTIPLE-SCLEROSIS | ENDOTHELIAL-CELLS | RHO GTPASES | EXTRACELLULAR-MATRIX | Reactive Oxygen Species - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Oxidative Stress - physiology | Reactive Oxygen Species - pharmacology | Blood-Brain Barrier - physiopathology | Basement Membrane - pathology | Chemotaxis, Leukocyte - physiology | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Encephalitis - physiopathology | Chemotaxis, Leukocyte - drug effects | Up-Regulation - physiology | Basement Membrane - enzymology | Tight Junctions - metabolism | Encephalitis - enzymology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Cerebral Arteries - physiopathology | Basement Membrane - metabolism | Blood-Brain Barrier - enzymology | Neurodegenerative Diseases - physiopathology | Cerebral Arteries - enzymology | Endothelial Cells - cytology | Matrix Metalloproteinases - metabolism | Endothelial Cells - enzymology | Enzyme Activation - physiology | Neurodegenerative Diseases - enzymology | Neurosciences | Biochemistry | Oxidation | Brain research | Kinases | Neurological disorders
Journal Article