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1. Full Text Novel Conformation-Specific Antibodies Against Matrix γ-Carboxyglutamic Acid (Gla) Protein: Undercarboxylated Matrix Gla Protein as Marker for Vascular Calcification
by Schurgers, Leon J and Teunissen, Kirsten J.F and Knapen, Marjo H.J and Kwaijtaal, Martijn and van Diest, Rob and Appels, Ad and Reutelingsperger, Chris P and Cleutjens, Jack P.M and Vermeer, Cees
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 08/2005, Volume 25, Issue 8, pp. 1629 - 1633
OBJECTIVE—Matrix γ-carboxyglutamic acid (Gla) protein (MGP), a vitamin K–dependent protein, is a potent in vivo inhibitor of arterial calcification. We... 
atherosclerosis | ATHEROSCLEROTIC PLAQUES | MYOCARDIAL-INFARCTION | BONE MORPHOGENETIC PROTEIN-2 | SERUM | BEAM COMPUTED-TOMOGRAPHY | vitamin K | CORONARY-ARTERY CALCIFICATION | MINERALIZATION | matrix Gla protein (MGP) | VITAMIN-K | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | calcification | HEMATOLOGY | EXPRESSION | Antibody Specificity | Tunica Media - pathology | Epitopes - metabolism | Humans | Vitamin K - metabolism | Epitopes - immunology | Monckeberg Medial Calcific Sclerosis - pathology | Calcium-Binding Proteins - immunology | Tunica Media - metabolism | Calcinosis - metabolism | Calcium-Binding Proteins - blood | Biomarkers - metabolism | Calcium-Binding Proteins - chemistry | Atherosclerosis - pathology | Extracellular Matrix Proteins - chemistry | Extracellular Matrix Proteins - blood | Atherosclerosis - metabolism | Immunohistochemistry - methods | Tunica Intima - metabolism | Tunica Intima - pathology | Extracellular Matrix Proteins - immunology | Protein Conformation | Epitopes - chemistry | Calcinosis - pathology | Biomarkers - chemistry | Monckeberg Medial Calcific Sclerosis - metabolism | Index Medicus
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2. Full Text The Associations of Fibroblast Growth Factor 23 and Uncarboxylated Matrix Gla Protein With Mortality in Coronary Artery Disease: The Heart and Soul Study
by Parker, Benjamin D and Schurgers, Leon J and Brandenburg, Vincent M and Christenson, Robert H and Vermeer, Cees and Ketteler, Markus and Shlipak, Michael G and Whooley, Mary A and Ix, Joachim H
Annals of Internal Medicine, ISSN 0003-4819, 05/2010, Volume 152, Issue 10, pp. 640 - +
Background: Fibroblast growth factor 23 (FGF23), uncarboxylated matrix Gla protein (ucMGP), and fetuin-A are regulators of mineral metabolism and inhibitors of... 
FETUIN-A LEVELS | MEDICINE, GENERAL & INTERNAL | MYOCARDIAL-INFARCTION | DIALYSIS PATIENTS | PHOSPHATE LEVELS | VASCULAR CALCIFICATION | CARDIOVASCULAR MORTALITY | RISK | CHRONIC KIDNEY-DISEASE | SERUM PHOSPHORUS | GLYCOPROTEIN/FETUIN-A | Coronary Disease - blood | Follow-Up Studies | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Extracellular Matrix Proteins - blood | Male | Biomarkers - blood | alpha-2-HS-Glycoprotein | Blood Proteins - metabolism | Coronary Disease - mortality | Fibroblast Growth Factors - blood | Aged, 80 and over | Female | Aged | Calcium-Binding Proteins - blood | Cellular proteins | Prognosis | Mortality | Physiological aspects | Fibroblast growth factors | Research | Health aspects | Coronary heart disease | Risk factors | Proteins | Cardiovascular disease | Kidney diseases
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3. Full Text Circulating Nonphosphorylated Carboxylated Matrix Gla Protein Predicts Survival in ESRD
by Schlieper, Georg and Westenfeld, Ralf and Krueger, Thilo and Cranenburg, Ellen C and Magdeleyns, Elke J. P and Brandenburg, Vincent M and Djuric, Zivka and Damjanovic, Tatjana and Ketteler, Markus and Vermeer, Cees and Dimkovic, Nada and Floege, Juergen and Schurgers, Leon J
Journal of the American Society of Nephrology, ISSN 1046-6673, 02/2011, Volume 22, Issue 2, pp. 387 - 395
The mechanisms for vascular calcification and its associated cardiovascular mortality in patients with ESRD are not completely understood. Dialysis patients... 
ALL-CAUSE | HEART-DISEASE | CORONARY-ARTERY CALCIUM | DIALYSIS PATIENTS | VASCULAR CALCIFICATION | HEMODIALYSIS-PATIENTS | CARDIOVASCULAR MORTALITY | UROLOGY & NEPHROLOGY | RISK | SERUM | COMPUTED-TOMOGRAPHY | Kidney Failure, Chronic - mortality | Vitamin K 2 - administration & dosage | Phosphorylation | Prospective Studies | Protein Precursors - blood | Humans | Middle Aged | Proportional Hazards Models | Extracellular Matrix Proteins - blood | Male | Biomarkers - blood | Calcinosis - blood | Kidney Failure, Chronic - blood | Renal Dialysis - mortality | Prothrombin | Adult | Female | Aged | Calcium-Binding Proteins - blood | Index Medicus | Clinical Research
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4. Full Text Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species
by Cranenburg, Ellen C. M and Koos, Ralf and Schurgers, Leon J and Magdeleyns, Elke J and Schoonbrood, Thea H. M and Landewé, Robert B and Brandenburg, Vincent M and Bekers, Otto and Vermeer, Cees
Thrombosis and Haemostasis, ISSN 0340-6245, 2010, Volume 104, Issue 4, pp. 811 - 822
Matrix γ-carboxyglutamate (Gla) protein (MGP) is an important local inhibitor of vascular calcification, which can undergo two post-translational... 
Cardiovascular Disease | matrix Gla protein | calcification | vitamin K | Gla-domain proteins | Cardiovascular Biology and Cell Signalling | Calcification | Cardiovascular disease | Matrix gla protein | Vitamin K | RHEUMATOID-ARTHRITIS | cardiovascular disease | BONE MORPHOGENETIC PROTEIN-2 | VASCULAR CALCIFICATION | MENAQUINONE INTAKE | GAMMA-CARBOXYGLUTAMIC ACID | CORONARY-ARTERY ATHEROSCLEROSIS | VITAMIN-K | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | STAGE RENAL-DISEASE | CARDIOVASCULAR RISK | Enzyme-Linked Immunosorbent Assay - methods | Prognosis | Extracellular Matrix Proteins - biosynthesis | Arthritis, Rheumatoid - blood | Humans | Middle Aged | Chondrocalcinosis - diagnosis | Feasibility Studies | Aortic Valve Insufficiency - blood | Adult | Vitamin K - administration & dosage | Chondrocalcinosis - physiopathology | Calcium-Binding Proteins - blood | Arthritis, Rheumatoid - diagnosis | Arthritis, Rheumatoid - physiopathology | Kidney Failure, Chronic - physiopathology | Calcium-Binding Proteins - biosynthesis | Kidney Failure, Chronic - diagnosis | Extracellular Matrix Proteins - genetics | Aortic Valve Insufficiency - physiopathology | Extracellular Matrix Proteins - blood | Biomarkers - blood | Disease Progression | Kidney Failure, Chronic - blood | Calcinosis | Vitamin K - blood | Aged | Protein Processing, Post-Translational | Antibodies, Monoclonal - metabolism | Chondrocalcinosis - blood | Aortic Valve Insufficiency - diagnosis | Calcium-Binding Proteins - genetics
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5. Full Text Inactive Matrix Gla Protein Is Causally Related to Adverse Health Outcomes A Mendelian Randomization Study in a Flemish Population
by Liu, Yan-Ping and Gu, Yu-Mei and Thijs, Lutgarde and Knapen, Marjo H. J and Salvi, Erika and Citterio, Lorena and Petit, Thibault and Carpini, Simona Delli and Zhang, Zhenyu and Jacobs, Lotte and Jin, Yu and Barlassina, Cristina and Manunta, Paolo and Kuznetsova, Tatiana and Verhamme, Peter and Struijker-Boudier, Harry A and Cusi, Daniele and Vermeer, Cees and Staessen, Jan A
Hypertension, ISSN 0194-911X, 02/2015, Volume 65, Issue 2, pp. 463 - U497
Matrix Gla-protein is a vitamin K–dependent protein that strongly inhibits arterial calcification. Vitamin K deficiency leads to production of inactive... 
mortality | matrix Gla protein | Mendelian randomization | INSTRUMENTAL VARIABLES | RISK | COMPUTED-TOMOGRAPHY | SUPPLEMENTATION | MESSENGER-RNA | VITAMIN-K | CARDIOVASCULAR-DISEASE | CALCIFICATION | PERIPHERAL VASCULAR DISEASE | CORONARY-ARTERY-DISEASE | RECEPTOR TYROSINE KINASE | Follow-Up Studies | Humans | Middle Aged | Vitamin K Deficiency - blood | Male | Cardiovascular Diseases - genetics | Gene-Environment Interaction | Incidence | Neoplasms - genetics | Mendelian Randomization Analysis | Aged, 80 and over | Cardiovascular Diseases - mortality | Adult | Female | Calcium-Binding Proteins - blood | Chromosomes, Human, Pair 12 - genetics | Genetic Predisposition to Disease | Belgium - epidemiology | Vitamin K Deficiency - epidemiology | Extracellular Matrix Proteins - genetics | Kaplan-Meier Estimate | Proportional Hazards Models | Extracellular Matrix Proteins - physiology | Neoplasms - mortality | Extracellular Matrix Proteins - blood | Genotype | Environmental Exposure | Linkage Disequilibrium | Calcium-Binding Proteins - physiology | Aged | Polymorphism, Single Nucleotide | Protein Processing, Post-Translational | Calcium-Binding Proteins - genetics | Index Medicus
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6. Full Text Inactive Matrix Gla-Protein Is Associated With Arterial Stiffness in an Adult Population-Based Study
by Pivin, Edward and Ponte, Belen and Pruijm, Menno and Ackermann, Daniel and Guessous, Iis and Ehret, Georg and Liu, Yan-ping and mmen, Nadja E. A and Knapen, Marjo H. J and Pechere-Bertschi, Antoinette and Paccaud, Fred and Mohaupt, Markus and Vermeer, Cees and Staessen, Jan A and Vogt, Bruno and Martin, Pierre-Yves and Burnier, Michel and Bochud, Murielle
Hypertension, ISSN 0194-911X, 07/2015, Volume 66, Issue 1, pp. 85 - 92
Increased pulse wave velocity (PWV) is a marker of aortic stiffness and an independent predictor of mortality. Matrix Gla-protein (MGP) is a vascular... 
calcium-binding protein | matrix Gla-protein | vascular stiffness | pulse wave velocity | vitamin K | KEUTEL-SYNDROME | VASCULAR CALCIFICATION | FOLLOW-UP | VESSEL WALL | REFERENCE VALUES | GAMMA-CARBOXYGLUTAMIC ACID | MENAQUINONE-7 SUPPLEMENTATION | VITAMIN-K | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | POSTMENOPAUSAL WOMEN | Kidney - physiology | Phosphorylation | Age Factors | Pulse Wave Analysis | Humans | Middle Aged | Male | Sampling Studies | Lipids - blood | Cardiovascular Diseases - epidemiology | Adult | Female | Calcium-Binding Proteins - blood | Body Mass Index | Calcium-Binding Proteins - chemistry | Extracellular Matrix Proteins - chemistry | Blood Glucose - analysis | Cross-Sectional Studies | Comorbidity | Extracellular Matrix Proteins - blood | Smoking - epidemiology | Diabetes Mellitus - epidemiology | Switzerland - epidemiology | Vascular Stiffness - physiology | Aged | Protein Processing, Post-Translational | Hemodynamics | Index Medicus
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7. Full Text Serum cartilage oligomeric matrix protein (COMP) in knee osteoarthritis: A novel diagnostic and prognostic biomarker
by Verma, Priyanka and Dalal, Krishna
Journal of Orthopaedic Research, ISSN 0736-0266, 07/2013, Volume 31, Issue 7, pp. 999 - 1006
A casecontrol study was conducted to estimate the association of cartilage oligomeric matrix protein (COMP) with knee osteoarthritis (OA) and to examine the... 
COMP | diagnosis | biomarker | prognosis | knee osteoarthritis | RHEUMATOID-ARTHRITIS | INTERLEUKIN-1 | COLLAGEN | SYNOVIAL-FLUID | BONE METABOLISM | MARKERS | TUMOR-NECROSIS-FACTOR | ARTICULAR CHONDROCYTES | ORTHOPEDICS | JOINT | PROGRESSION | Prognosis | Cartilage Oligomeric Matrix Protein | Humans | Middle Aged | Osteoarthritis, Knee - diagnosis | Tumor Necrosis Factor-alpha - blood | Knee Joint - diagnostic imaging | Extracellular Matrix Proteins - blood | Male | Glycoproteins - blood | Biomarkers - blood | Osteoarthritis, Knee - diagnostic imaging | Case-Control Studies | Disease Progression | Interleukin-1beta - blood | Matrilin Proteins | Radiography | Osteoarthritis, Knee - blood | Sex Factors | Aged, 80 and over | Adult | Female | Aged | Periodical publishing | Biological products | Analysis | Hemoglobin | Diagnosis | Osteoarthritis | Enzyme-linked immunosorbent assay | Index Medicus
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8. Full Text Novel serological neo‐epitope markers of extracellular matrix proteins for the detection of portal hypertension
by Leeming, D. J and Karsdal, M. A and Byrjalsen, I and Bendtsen, F and Trebicka, J and Nielsen, M. J and Christiansen, C and Møller, S and Krag, A
Alimentary Pharmacology & Therapeutics, ISSN 0269-2813, 11/2013, Volume 38, Issue 9, pp. 1086 - 1096
BackgroundThe hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension... 
PRESSURE | AMINOTERMINAL PROPEPTIDE | COLLAGEN | SERUM LAMININ | BIOCHEMICAL MARKERS | III PROCOLLAGEN | DEGRADATION | PHARMACOLOGY & PHARMACY | PREDICTIVE VALUE | STAGE LIVER-DISEASE | MODEL | GASTROENTEROLOGY & HEPATOLOGY | Severity of Illness Index | Hypertension, Portal - physiopathology | Humans | Middle Aged | Extracellular Matrix Proteins - blood | Male | Biomarkers - blood | Epitopes | Case-Control Studies | Hypertension, Portal - diagnosis | Regression Analysis | Venous Pressure | Adult | Female | Liver Diseases - diagnosis | Aged | Liver Cirrhosis - physiopathology | Liver Diseases - physiopathology | Liver Cirrhosis, Alcoholic - physiopathology | Medical examination | Collagen | Elastin | Portal hypertension | Liver cirrhosis | Blood | Venous pressure | Antigenic determinants | Index Medicus | Alcoholics | Portal Hypertension
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9. Full Text Serum Osteocalcin Level Is Associated with Glucose Metabolism and Atherosclerosis Parameters in Type 2 Diabetes Mellitus
by Kanazawa, Ippei and Yamaguchi, Toru and Yamamoto, Masahiro and Yamauchi, Mika and Kurioka, Soichi and Yano, Shozo and Sugimoto, Toshitsugu
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 01/2009, Volume 94, Issue 1, pp. 45 - 49
Context: Recent animal studies showed that osteocalcin action is related to not only bone metabolism but also glucose metabolism and fat mass. We investigated... 
TURNOVER | BONE-MINERAL DENSITY | MATRIX GLA PROTEIN | ADIPONECTIN | ENDOCRINOLOGY & METABOLISM | OSTEOPOROTIC FRACTURES | CARDIOVASCULAR-DISEASE | GENE-EXPRESSION | IMPROVEMENT | ELDERLY-WOMEN | CALCIFICATION | Humans | Middle Aged | Extracellular Matrix Proteins - blood | Male | Atherosclerosis - blood | Osteocalcin - blood | Diabetes Mellitus, Type 2 - blood | Aged, 80 and over | Glucose - metabolism | Female | Aged | Calcium-Binding Proteins - blood | Alkaline Phosphatase - blood | Index Medicus | Abridged Index Medicus
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10. Full Text HMGB1 and its hyperacetylated isoform are sensitive and specific serum biomarkers to detect asbestos exposure and to identify mesothelioma patients
by Napolitano, Andrea and Antoine, Daniel J and Pellegrini, Laura and Baumann, Francine and Pagano, Ian and Pastorino, Sandra and Goparaju, Chandra M and Prokrym, Kirill and Canino, Claudia and Pass, Harvey I and Carbone, Michele and Yang, Haining
Clinical Cancer Research, ISSN 1078-0432, 06/2016, Volume 22, Issue 12, pp. 3087 - 3096
Purpose: To determine whether serum levels of high mobility group box protein 1 (HMGB1) could differentiate malignant mesothelioma patients, asbestos-exposed... 
RHEUMATOID-ARTHRITIS | CELLS | ONCOLOGY | CHROMATIN PROTEIN HMGB1 | FIBULIN-3 | DISEASE | MALIGNANT PLEURAL MESOTHELIOMA | RELEASE | PROGNOSTIC VALUE | CANCER | SOLUBLE MESOTHELIN | Osteopontin - blood | Asbestos - toxicity | Asbestos - blood | Humans | Middle Aged | Pleural Neoplasms - diagnosis | Male | Young Adult | HMGB1 Protein - metabolism | Sensitivity and Specificity | Adult | Female | Acetylation | Pleural Effusion - diagnosis | Extracellular Matrix Proteins - blood | Mesothelioma - diagnosis | Biomarkers - blood | Environmental Exposure | Mesothelioma - blood | GPI-Linked Proteins - blood | Pleural Neoplasms - blood | Aged | Lung Neoplasms - blood | Lung Neoplasms - diagnosis | HMGB1 Protein - blood | Pleural Effusion - blood | Index Medicus
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11. Full Text Spondin-2, a Secreted Extracellular Matrix Protein, is a Novel Diagnostic Biomarker for Prostate Cancer
by Lucarelli, Giuseppe|Rutigliano, Monica|Bettocchi, Carlo|Palazzo, Silvano|Vavallo, Antonio|Galleggiante, Vanessa|Trabucco, Senia|Di Clemente, Daniela|Selvaggi, Francesco Paolo|Battaglia, Michele|Ditonno, Pasquale
Journal of Urology, The, ISSN 0022-5347, 2013, Volume 190, Issue 6, pp. 2271 - 2277
Purpose SPON2 belongs to the F-spondin family of secreted extracellular matrix proteins. It is deregulated in some tumors, including prostate cancer. In this... 
Urology | biological markers | prostate | SPON2 protein | human | prostatic neoplasms | prostate-specific antigen | SPON2 protein, human | Prostatic neoplasms | Biological markers | Prostate-specific antigen | Prostate | MARKER | VALIDATION | IDENTIFICATION | SERUM SARCOSINE | URINE | UROLOGY & NEPHROLOGY | MINDIN | LESS | EXAMINATION FAILS | SPON2 protein human | DIGITAL RECTAL EXAMINATION | ANTIGEN | Prospective Studies | Humans | Middle Aged | Extracellular Matrix Proteins - blood | Male | Biomarkers - blood | Prostatic Neoplasms - diagnosis | Case-Control Studies | Prostate-Specific Antigen - blood | Aged, 80 and over | Prostatic Neoplasms - blood | Sarcosine - blood | Neoplasm Proteins - blood | Aged | Proteins | Deregulation | Diagnosis | Prostate cancer | Cancer | Index Medicus | Abridged Index Medicus
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12. Full Text Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways
by Koskinen, Anna and Juslin, Sami and Nieminen, Riina and Moilanen, Teemu and Vuolteenaho, Katriina and Moilanen, Eeva
Arthritis Research and Therapy, ISSN 1478-6354, 11/2011, Volume 13, Issue 6, pp. R184 - R184
Introduction: Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in... 
RHEUMATOID-ARTHRITIS | LEPTIN | SYNOVIAL-FLUID | NITRIC-OXIDE SYNTHASE | HUMAN CHONDROCYTES | SERUM | RHEUMATOLOGY | NF-KAPPA-B | KNEE OSTEOARTHRITIS | EXPRESSION | TERMINAL KINASE | Chondrocytes - cytology | Humans | Glycoproteins - metabolism | Male | Cartilage - drug effects | Dose-Response Relationship, Drug | Matrilin Proteins | Chondrocytes - drug effects | HEK293 Cells | Adiponectin - metabolism | Flavonoids - pharmacology | Osteoarthritis - pathology | Interleukin-6 - metabolism | Chondrocytes - metabolism | Extracellular Matrix Proteins - metabolism | Severity of Illness Index | Adiponectin - pharmacology | Cartilage Oligomeric Matrix Protein | Tissue Culture Techniques | Cells, Cultured | Osteoarthritis - metabolism | Extracellular Matrix Proteins - blood | Matrix Metalloproteinase 3 - metabolism | Osteoarthritis - blood | Glycoproteins - blood | Biomarkers - blood | Cartilage - metabolism | Blotting, Western | Adiponectin - blood | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Aged | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - blood | Nitric Oxide - metabolism | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Protein hormones | Research | Osteoarthritis | Protein kinases | Risk factors | Index Medicus
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13. Full Text Matrix Gla Protein Species and Risk of Cardiovascular Events in Type 2 Diabetic Patients
by Dalmeijer, Geertje W and van der Schouw, Yvonne T and Magdeleyns, Elke J and Vermeer, Cees and Verschuren, W. M. Monique and Boer, Jolanda M. A and Beulens, Joline W. J
Diabetes Care, ISSN 0149-5992, 11/2013, Volume 36, Issue 11, pp. 3766 - 3771
OBJECTIVETo investigate the relationship of circulating matrix Gla protein (MGP) species with incident cardiovascular disease (CVD) or coronary heart disease... 
CORONARY-ARTERY CALCIUM | MENAQUINONE-7 SUPPLEMENTATION | EPIC-NL | VASCULAR CALCIFICATION | HEART-FAILURE | DISEASE | ENDOCRINOLOGY & METABOLISM | VITAMIN-K STATUS | HEMODIALYSIS-PATIENTS | DIFFERENTIALLY EXPRESSED GENES | UP-REGULATION | Coronary Disease - blood | Prospective Studies | Humans | Middle Aged | Netherlands - epidemiology | Proportional Hazards Models | Coronary Disease - epidemiology | Extracellular Matrix Proteins - blood | Male | Risk | Diabetes Mellitus, Type 2 - epidemiology | Incidence | Vitamin K - metabolism | Diabetes Mellitus, Type 2 - blood | Cardiovascular Diseases - blood | Cardiovascular Diseases - epidemiology | Female | Calcium-Binding Proteins - blood | Waist-Hip Ratio | Heart failure | Diabetics | Diabetes | Coronary heart disease | Risk factors | Enzyme-linked immunosorbent assay | Cholesterol | Proteins | Cardiovascular disease | Correlation analysis | Risk assessment | Index Medicus | Original Research
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