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Aging Cell, ISSN 1474-9718, 12/2012, Volume 11, Issue 6, pp. 1065 - 1073
We explored molecular events associated with aging‐induced matrix changes in the kidney. C 57 BL 6 mice were studied in youth, middle age, and old age.... 
albuminuria | TGF | RNA | micro | collagen | fibrosis | SMAD | beta | SMAD3 | Albuminuria | TGF beta | Collagen | MicroRNAs | Fibrosis | microRNAs | RENAL EPITHELIAL-CELLS | MESSENGER-RNA TRANSLATION | KINASE | DIABETIC-NEPHROPATHY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | HIGH GLUCOSE | EXTRACELLULAR-MATRIX | GLOMERULI | GENE-TRANSFER | EXPRESSION | Humans | Repressor Proteins | ZEB1 protein, mouse | Proteins | Gene Expression Regulation, Developmental | Phosphoproteins | Proteolysis | Cystatin C | Aging | Female | Age | Transforming Growth Factor beta | Smad3 protein, mouse | Promoter Regions, Genetic | Glomerular Filtration Rate | Extracellular Matrix | Kidney Cortex | Mice, Inbred C57BL | Collagen Type I | Glomerular Mesangium | Kruppel-Like Transcription Factors | Membrane Proteins | Adaptor Proteins, Signal Transducing | Serum Albumin | Smad3 Protein | Spry1 protein, mouse | Animals | Homeodomain Proteins | Collagen Type III | Protein Binding | Zfhx1b protein, mouse | Mice | RNA, Messenger | Cystatin C - blood | Kidney Cortex - metabolism | Homeodomain Proteins - metabolism | Collagen Type III - metabolism | Extracellular Matrix - metabolism | Smad3 Protein - metabolism | Phosphoproteins - metabolism | Zinc Finger E-box Binding Homeobox 2 | RNA, Messenger - biosynthesis | Smad3 Protein - genetics | Collagen Type I - genetics | Aging - genetics | Glomerular Mesangium - metabolism | Kruppel-Like Transcription Factors - metabolism | Membrane Proteins - metabolism | Repressor Proteins - metabolism | Collagen Type I - metabolism | Membrane Proteins - genetics | Repressor Proteins - genetics | Kidney Cortex - pathology | Collagen Type III - genetics | Phosphoproteins - genetics | Homeodomain Proteins - genetics | Aging - pathology | Glomerular Mesangium - pathology | Transforming Growth Factor beta - genetics | MicroRNAs - genetics | Extracellular Matrix - pathology | Kruppel-Like Transcription Factors - genetics | Transforming Growth Factor beta - metabolism | Aging - metabolism | Serum Albumin - metabolism | Zinc Finger E-box-Binding Homeobox 1 | Fibronectins | Messenger RNA | MicroRNA | Physiological aspects | Protein biosynthesis | Transforming growth factors | Index Medicus
Journal Article
Science, ISSN 0036-8075, 01/2014, Volume 343, Issue 6173, pp. 885 - 888
Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular... 
CELLS | REPAIR | MICROENVIRONMENT | ANGIOGENESIS | REGENERATION | MULTIDISCIPLINARY SCIENCES | BINDING DOMAIN | Cellular biology | Tissue | Matrix | Pregnancy Proteins - chemistry | Proto-Oncogene Proteins c-sis - chemistry | Humans | Pregnancy Proteins - genetics | Extracellular Matrix - metabolism | Intercellular Signaling Peptides and Proteins - chemistry | Bone Morphogenetic Protein 2 - chemistry | Male | Pregnancy Proteins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Wound Healing | Vascular Endothelial Growth Factor A - genetics | Heparitin Sulfate - metabolism | Vascular Endothelial Growth Factor A - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | Bone Morphogenetic Protein 2 - metabolism | Protein Engineering | Extracellular Matrix Proteins - metabolism | Disease Models, Animal | Protein Structure, Tertiary | Bone Morphogenetic Protein 2 - genetics | Extracellular Matrix Proteins - chemistry | Proto-Oncogene Proteins c-sis - genetics | Proto-Oncogene Proteins c-sis - metabolism | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Animals | Heparitin Sulfate - chemistry | Placenta Growth Factor | Mice | Physiological aspects | Extracellular matrix | Genetic aspects | Regeneration (Biology) | Growth factors | Health aspects | Index Medicus
Journal Article
Journal Article
NATURE, ISSN 0028-0836, 07/2017, Volume 547, Issue 7662, pp. 179 - 179
Journal Article
Science, ISSN 0036-8075, 6/2012, Volume 336, Issue 6085, pp. 1150 - 1153
Protein phosphorylation is a fundamental mechanism regulating nearly every aspect of cellular life. Several secreted proteins are phosphorylated, but the... 
Proteins | T lymphocytes | Phosphorylation | Biomineralogy | Secretion | Phosphoproteins | REPORTS | Immunoblotting | Cellular immunity | Physiological regulation | Siblings | OSTEOPONTIN | INHIBITION | MULTIDISCIPLINARY SCIENCES | PHOSPHOPROTEOME | PURIFICATION | SEQUENCE | GOLGI-APPARATUS | SPECIFICITY DETERMINANTS | MASS-SPECTROMETRY | APPARATUS CASEIN KINASE | LACTATING MAMMARY-GLAND | Mineralogy | Cells | Mutations | Casein | Genes | Biomineralization | Bones | Kinases | Abnormalities, Multiple - metabolism | Golgi Apparatus - enzymology | Microcephaly - genetics | Humans | Secretory Pathway | Caseins - metabolism | Glycoproteins - metabolism | Molecular Sequence Data | Substrate Specificity | Cleft Palate - genetics | Casein Kinase I | Recombinant Fusion Proteins - metabolism | Extracellular Matrix Proteins - secretion | Cattle | Exophthalmos - genetics | HEK293 Cells | Osteosclerosis - metabolism | Osteosclerosis - genetics | Abnormalities, Multiple - genetics | Extracellular Matrix Proteins - metabolism | Amino Acid Sequence | Extracellular Matrix Proteins - chemistry | Milk - enzymology | Extracellular Matrix Proteins - genetics | Microcephaly - metabolism | Osteopontin | Recombinant Fusion Proteins - chemistry | Protein Sorting Signals | Amino Acid Motifs | Animals | Calcification, Physiologic | Casein Kinases - metabolism | Exophthalmos - metabolism | Cell Line, Tumor | Recombinant Fusion Proteins - secretion | Cleft Palate - metabolism | HeLa Cells | Mutation | Physiological aspects | Extracellular matrix | Research | Phosphotransferases | Index Medicus
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2975 - 2984
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 36, pp. 24035 - 24048
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need... 
GENE | LEUCINE-RICH PROTEOGLYCANS | CASPASE-1 | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | HYALURONAN | IL-1-BETA | SECRETION | ATP | NALP3 INFLAMMASOME | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 10/2011, Volume 22, Issue 20, pp. 3791 - 3800
Journal Article
Journal Article
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 01/2018, Volume 78, pp. 132 - 140
Journal Article