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Diabetes, ISSN 0012-1797, 02/2014, Volume 63, Issue 2, pp. 514 - 525
The number and activity of brown adipocytes are linked to the ability of mammals to resist body fat accumulation. In some conditions, certain white adipose... 
OBESITY | GENE | ENDOCRINOLOGY & METABOLISM | MUSCLE | RECEPTOR | PROLIFERATION | DIFFERENTIATION | EXPRESSION | FAT-CELL | EXERCISE | ADIPOSE-TISSUE | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Adipose Tissue, White - metabolism | Caenorhabditis elegans Proteins - metabolism | Adipocytes - cytology | Male | Adipocytes - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Recombinant Proteins | Extracellular Signal-Regulated MAP Kinases - genetics | Pichia - metabolism | Membrane Transport Proteins - genetics | Dietary Fats | Membrane Transport Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Butadienes - pharmacology | Fibronectins - pharmacology | Fibronectins - administration & dosage | Mice, Inbred C57BL | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | 3T3-L1 Cells | Rats, Sprague-Dawley | Animals | Adipocytes - metabolism | Pichia - genetics | Protein Binding | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Fibronectins - genetics | Mice | Pyridines - pharmacology | Mutation | Mitochondrial Uncoupling Proteins | Caenorhabditis elegans Proteins - genetics | Adipose Tissue, White - drug effects | Physiological research | Cellular signal transduction | Research | Identification and classification | Membrane proteins | Proteins | Homeostasis | Diabetes | Kinases | Genes | Cells | Index Medicus | Abridged Index Medicus
Journal Article
Cancer Discovery, ISSN 2159-8274, 07/2013, Volume 3, Issue 7, pp. 742 - 750
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2012, Volume 18, Issue 8, pp. 2316 - 2325
Purpose: This study evaluated the clinical relevance of the dual-targeting strategy involving PI3K/AKT/mTOR and RAF/MEK/ERK pathways. Experimental Design: We... 
COLON-CANCER | METASTATIC MELANOMA | PIK3CA MUTATIONS | PI3K | ONCOLOGY | COLORECTAL-CANCER | RESISTANCE | BRAF | ANTITUMOR-ACTIVITY | MEK INHIBITORS | TUMORS | Neoplasms - metabolism | Extracellular Signal-Regulated MAP Kinases - drug effects | TOR Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Middle Aged | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Young Adult | MAP Kinase Signaling System - genetics | TOR Serine-Threonine Kinases - genetics | Neoplasms - genetics | Aged, 80 and over | Adult | Female | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins p21(ras) - metabolism | Neoplasms - drug therapy | Phosphatidylinositol 3-Kinases - genetics | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins B-raf - genetics | Proto-Oncogene Proteins p21(ras) - antagonists & inhibitors | Adolescent | Aged | Mutation | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 42, pp. 35576 - 35588
Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the broadly used Chinese medicinal herb Stephaniae tetrandrae, exhibits potent antitumor effects... 
CYTOCHROME-C | APOPTOSIS | COLON-CANCER CELLS | ACTIVATION | THERAPY | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | GROWTH | DEATH | PERMEABILIZATION | Transcription, Genetic - drug effects | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - genetics | Humans | Ubiquitin-Activating Enzymes - biosynthesis | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Neoplasm Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Autophagy - drug effects | Benzylisoquinolines - chemistry | Dose-Response Relationship, Drug | Carcinoma, Hepatocellular - drug therapy | MAP Kinase Signaling System - genetics | Mitochondria - genetics | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Autophagy - genetics | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Stephania tetrandra - chemistry | Antineoplastic Agents, Phytogenic - pharmacokinetics | Benzylisoquinolines - pharmacology | Gene Expression Regulation, Neoplastic - genetics | Ubiquitin-Activating Enzymes - genetics | Liver Neoplasms - genetics | Liver Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - chemistry | Mitochondria - metabolism | Mitochondria - pathology | Microtubule-Associated Proteins - biosynthesis | Hep G2 Cells | Xenograft Model Antitumor Assays | Autophagy-Related Protein 7 | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Mice | Mice, Inbred BALB C | Transcription, Genetic - genetics | Carcinoma, Hepatocellular - metabolism | Index Medicus | Gene Regulation | Cancer Therapy | Autophagy-related Gene 7 (ATG7) | Tetrandrine | Reactive Oxygen Species (ROS) | Signal Transduction | Autophagy | Anticancer Drug | ERK | Hepatocellular Carcinoma
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 50, pp. 42981 - 42991
Background: Listeria monocytogenes is an intracellular pathogen that invades the host cytoplasm. Results: Cells deficient in TLR2 and NOD2 show defective... 
ADAPTIVE IMMUNITY | CROHN-DISEASE | EARLY PHASE | CRYOPYRIN INFLAMMASOME | EPITHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HOST-DEFENSE | INTRACELLULAR PATHOGENS | INFECTION | GENOME-WIDE ASSOCIATION | INNATE IMMUNITY | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Cell Line | Microscopy, Electron, Transmission | Toll-Like Receptor 2 - genetics | Cells, Cultured | Nod2 Signaling Adaptor Protein - genetics | Signal Transduction - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Listeria monocytogenes - immunology | Macrophages - cytology | Toll-Like Receptor 2 - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Blotting, Western | Autophagy - immunology | Listeria monocytogenes - pathogenicity | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Nod2 Signaling Adaptor Protein - metabolism | Mice, Mutant Strains | Listeriosis - immunology | Mice | Macrophages - immunology | Index Medicus | Toll-Like Receptor 2 | Signal Transduction | Receptor-Interacting Protein Serine-Threonine Kinases | Listeria monocytogenes | Listeriosis | Nod2 Signaling Adaptor Protein | Extracellular Signal-Regulated MAP Kinases | Macrophages | Autophagy | Life Sciences | Development Biology | Toll-like receptors (TLR) | Immunology | Nod-like receptors (NLR) | ERK
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 01/2016, Volume 29, Issue 1, pp. 75 - 89
Journal Article
Neuron, ISSN 0896-6273, 10/2012, Volume 76, Issue 2, pp. 325 - 337
Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the... 
MAMMALIAN TARGET | RAPAMYCIN SIGNALING PATHWAY | FMR1 KNOCKOUT MOUSE | MESSENGER-RNA | MEMORY | LONG-TERM DEPRESSION | PHOSPHOINOSITIDE 3-KINASE-AKT-MAMMALIAN TARGET | TRANSLATION | MENTAL-RETARDATION PROTEIN | NEUROSCIENCES | MTOR | Electric Stimulation | Fragile X Syndrome - pathology | Male | Fragile X Mental Retardation Protein - metabolism | Synapses - genetics | Recognition (Psychology) - physiology | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | Ribosomal Protein S6 Kinases, 70-kDa - deficiency | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Membrane Potentials - drug effects | Synapses - drug effects | Maze Learning - physiology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Dendritic Spines - physiology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Behavior, Animal - physiology | Mice, Transgenic | Hippocampus - pathology | Mutation - genetics | Patch-Clamp Techniques | Phenotype | Analysis of Variance | Mice | Long-Term Synaptic Depression - genetics | Neurons - pathology | Membrane Potentials - genetics | Fragile X Syndrome - physiopathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Extracellular Signal-Regulated MAP Kinases - genetics | Exploratory Behavior - physiology | Neurons - classification | Female | Interpersonal Relations | Fragile X Syndrome - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Biophysics | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Motor Activity - genetics | Rotarod Performance Test | Animals | Fragile X Syndrome - prevention & control | Dendritic Spines - classification | Fragile X Mental Retardation Protein - genetics | In Vitro Techniques | Depression, Mental | Analysis | Genetic research | Protein biosynthesis | Genetic aspects | Fragile X syndrome | Genetic translation | Proteins | Phosphorylation | Brain research | Kinases | Protein synthesis | Rodents | Index Medicus | Animal models | Translation | Translation initiation | Pattern recognition | Mental retardation | Ribosomal protein S6 kinase | Autism | Dendritic spines | Molecular modelling | Social interactions | Etiology | p70 S6 kinase | Long-term depression | Elongation
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 21, pp. 17065 - 17076
The role and the mechanisms by which β1 integrins regulate the survival and chemoresistance of T cell acute lymphoblastic leukemia (T-ALL) still are poorly... 
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology | Caspase 9 - genetics | Caspase 9 - metabolism | Antibiotics, Antineoplastic - pharmacology | Humans | Caspase 3 - metabolism | Drug Resistance, Neoplasm | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Cytochromes c - genetics | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Gene Knockdown Techniques | Proto-Oncogene Proteins c-bcl-2 - metabolism | Collagen Type I - genetics | MAP Kinase Signaling System - genetics | Caspase 3 - genetics | Female | JNK Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - metabolism | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Collagen Type I - metabolism | Jurkat Cells | Cytochromes c - metabolism | Fibronectins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Myeloid Cell Leukemia Sequence 1 Protein | Fibronectins - genetics | Integrin alpha2beta1 - metabolism | Integrin alpha2beta1 - genetics | Enzyme Activation - genetics | Proto-Oncogene Proteins c-bcl-2 - genetics | Doxorubicin - pharmacology | Index Medicus | Signal Transduction | JNK | T Cell Leukemia | Alpha2beta1 Integrin | Cell Signaling | Collagen 1 | MAPK | Anticancer Drug | Apoptosis | Bcl-2 Family Proteins | Integrins | ERK
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 01/2014, Volume 34, Issue 1, pp. 84 - 95
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
RAS ACTIVATION | HUMAN BREAST | PROTEIN | CYTOSKELETAL REORGANIZATION | SPECIFICITY | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIATED ENDOCYTOSIS | D ISOFORM | PLASMA-MEMBRANE | CELL BIOLOGY | Neoplasms - metabolism | Cricetulus | Humans | Qb-SNARE Proteins - metabolism | Qb-SNARE Proteins - genetics | Green Fluorescent Proteins - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Cell Nucleus - metabolism | Neoplasms - genetics | Qc-SNARE Proteins - metabolism | RNA Interference | Time Factors | HEK293 Cells | Cell Membrane - metabolism | Phospholipase D - genetics | Cell Membrane - drug effects | CHO Cells | Green Fluorescent Proteins - metabolism | Cricetinae | Signal Transduction | Diacylglycerol Kinase - metabolism | Binding Sites - genetics | Saccharomyces cerevisiae Proteins - genetics | Phospholipase D - metabolism | Blotting, Western | Diacylglycerol Kinase - genetics | Microscopy, Confocal | Animals | Saccharomyces cerevisiae Proteins - metabolism | Cell Line, Tumor | Qc-SNARE Proteins - genetics | Luminescent Proteins - genetics | Cell Proliferation - drug effects | Phosphatidic Acids - metabolism | Epidermal Growth Factor - pharmacology | Cell Nucleus - drug effects | Neoplasms - pathology | Luminescent Proteins - metabolism | Index Medicus
Journal Article
Journal Article
13.