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Diabetes, ISSN 0012-1797, 05/2015, Volume 64, Issue 5, pp. 1670 - 1681
Journal Article
Cell Death and Disease, ISSN 2041-4889, 10/2012, Volume 3, Issue 10, pp. e398 - e398
Glioblastoma multiforme (GBM) is a heterogeneous disease despite its seemingly uniform pathology. Deconvolution of The Cancer Genome Atlas's GBM gene... 
microRNA-10b | Angiogenicity | Invasion | Glioblastoma | Apoptosis | GLIOMA-CELLS | SUPPRESSOR | ACTIVATION | ANGIOGENESIS | angiogenicity | THROMBOSPONDIN-1 | apoptosis | P53 | CELL BIOLOGY | CYLD | glioblastoma | invasion | GENE-EXPRESSION | NF-KAPPA-B | ENDOTHELIAL GROWTH-FACTOR | Paired Box Transcription Factors - genetics | MicroRNAs - antagonists & inhibitors | Tumor Suppressor Protein p53 - antagonists & inhibitors | Homeodomain Proteins - metabolism | Humans | Neovascularization, Pathologic | Baculoviridae - genetics | MicroRNAs - metabolism | Transplantation, Heterologous | Repressor Proteins - antagonists & inhibitors | Tumor Suppressor Protein p53 - genetics | Glioblastoma - genetics | RNA Interference | Glioblastoma - metabolism | Eye Proteins - antagonists & inhibitors | Eye Proteins - genetics | Repressor Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Genetic Vectors - metabolism | Repressor Proteins - genetics | Transcription Factors - antagonists & inhibitors | PAX6 Transcription Factor | Paired Box Transcription Factors - antagonists & inhibitors | Receptor, Notch1 - metabolism | Transcription Factors - genetics | Genetic Vectors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Animals | Eye Proteins - metabolism | Glioblastoma - pathology | Homeodomain Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Receptor, Notch1 - antagonists & inhibitors | Receptor, Notch1 - genetics | Paired Box Transcription Factors - metabolism | Cell Movement | RNA, Small Interfering - metabolism | Original
Journal Article
Cancer Science, ISSN 1347-9032, 03/2017, Volume 108, Issue 3, pp. 478 - 487
.... The Yes‐associated protein‐1 (YAP) plays a critical role in cell proliferation, apoptosis and angiogenesis... 
Angiogenesis | apoptosis | pancreatic cancer | vasculogenic mimicry | verteporfin | HUMAN CHOLANGIOCARCINOMA | HIPPO PATHWAY | DOWN-REGULATION | ANGIOPOIETIN-2 | CANCER | MOLECULAR PATHWAYS | HEPATOCELLULAR-CARCINOMA | IN-VITRO | ONCOLOGY | POOR-PROGNOSIS | CHEMORESISTANCE | Human Umbilical Vein Endothelial Cells | Cyclin D1 - metabolism | Apoptosis - drug effects | Humans | Male | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Proto-Oncogene Proteins c-bcl-2 - metabolism | Vesicular Transport Proteins - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Verteporfin | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Matrix Metalloproteinase 2 - metabolism | Pancreatic Neoplasms - pathology | Oncogene Proteins - metabolism | Nuclear Proteins - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Transcription Factors - antagonists & inhibitors | Porphyrins - pharmacology | Carcinoma, Pancreatic Ductal - pathology | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Mice, Nude | Neovascularization, Pathologic - drug therapy | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Cadherins - antagonists & inhibitors | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Cyclin E - metabolism | Adaptor Proteins, Signal Transducing - metabolism | G1 Phase Cell Cycle Checkpoints - drug effects | Antigens, CD | Adenocarcinoma | Proteins | Photochemotherapy | Analysis | Pancreatic cancer | Cancer | Cell proliferation | Metastasis | Cancer therapies | Mimicry | Cell adhesion & migration | Macular degeneration | Cell cycle | Xenografts | G1 phase | Cell survival | Photodynamic therapy | Poly(ADP-ribose) polymerase | Gene expression | Cadherin | Gelatinase A | Yes-associated protein | Microscopy | Medical prognosis | Stem cells | Hypoxia | Apoptosis | Tumors | Original
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2006, Volume 12, Issue 7, pp. 2109 - 2116
Purpose: Aberrant promoter hypermethylation of Wnt-antagonist genes contributes to the pathogenesis of several cancers... 
secreted frizzled-related protein-1, 2, 4 and 5 | Wnt inhibitory factor-1 | Dickkopf family proteins-3 | bladder cancer | methylation | INACTIVATION | HUMAN PROSTATE-CANCER | PROMOTER HYPERMETHYLATION | SFRP GENES | METHYLATION | INHIBITORY FACTOR-I | ONCOLOGY | SIGNALING PATHWAY | COLORECTAL-CANCER | TUMOR-SUPPRESSOR GENES | URINE | Intercellular Signaling Peptides and Proteins - analysis | Multivariate Analysis | Carrier Proteins - urine | Urinary Bladder Neoplasms - diagnosis | Carcinoma, Transitional Cell - urine | Humans | Proto-Oncogene Proteins - urine | Membrane Proteins - urine | Repressor Proteins - analysis | Membrane Proteins - analysis | DNA Methylation | Urinary Bladder Neoplasms - genetics | Biomarkers, Tumor - urine | Proto-Oncogene Proteins - analysis | Sensitivity and Specificity | Eye Proteins - genetics | Carrier Proteins - analysis | Carcinoma, Transitional Cell - genetics | Repressor Proteins - urine | Urinary Bladder Neoplasms - urine | Biomarkers, Tumor - analysis | Membrane Proteins - genetics | Carcinoma, Transitional Cell - diagnosis | RNA, Messenger - genetics | Intercellular Signaling Peptides and Proteins - genetics | Intercellular Signaling Peptides and Proteins - urine | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Eye Proteins - analysis | Reverse Transcriptase Polymerase Chain Reaction | Sequence Analysis, DNA | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Biomarkers, Tumor - genetics | Eye Proteins - urine | Urinary Bladder - physiology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 10, pp. 3913 - 3918
.... Here we chimerized two IL-1 receptor ligands, IL-1β and IL-1Ra, to create an optimized receptor antagonist, EBI-005, for topical ocular administration... 
Molecules | Receptors | Nervous system diseases | Ligands | Agonists | Eye diseases | Chimeras | Mikulicz disease | Thermal stability | Crystal structure | DRY-EYE DISEASE | IL-1 RECEPTOR ANTAGONIST | PROTEIN | OCULAR-SURFACE | CRYSTAL-STRUCTURE | INFLAMMATION | STABILITY | MULTIDISCIPLINARY SCIENCES | I INTERLEUKIN-1 RECEPTOR | IL-1-BETA | BINDING | Humans | Molecular Sequence Data | Crystallography, X-Ray | Interleukin 1 Receptor Antagonist Protein - genetics | Interleukin-1beta - genetics | Cytokines - chemistry | Recombinant Fusion Proteins - antagonists & inhibitors | Receptors, Interleukin-1 Type I - antagonists & inhibitors | Drug Design | Interleukin-1beta - chemistry | Ophthalmic Solutions | Receptors, Interleukin-1 Type I - chemistry | Female | Interleukin-1beta - antagonists & inhibitors | Amino Acid Sequence | Drug Stability | Mice, Inbred C57BL | Models, Molecular | Recombinant Fusion Proteins - chemistry | Static Electricity | Sequence Homology, Amino Acid | Animals | Interleukin 1 Receptor Antagonist Protein - antagonists & inhibitors | Receptors, Interleukin-1 Type I - genetics | Recombinant Fusion Proteins - genetics | Protein Conformation | Mice | Cytokines - antagonists & inhibitors | Kinetics | Interleukin 1 Receptor Antagonist Protein - chemistry | Administration, Topical | Antagonists (Biochemistry) | Research | Cytokines | Biological Sciences
Journal Article
PLoS genetics, ISSN 1553-7390, 2011, Volume 7, Issue 7, p. e1002114
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2007, Volume 104, Issue 39, pp. 15418 - 15423
Journal Article
Developmental Biology, ISSN 0012-1606, 2007, Volume 305, Issue 2, pp. 659 - 673
During neurogenesis, complex networks of genes act sequentially to control neuronal differentiation. In the neural tube, the expression of Pax6, a... 
Spinal cord | Pax6 | Mouse | Neurogenesis | Chick | VENTRAL NEURAL-TUBE | DEVELOPMENTAL BIOLOGY | SPECIFICATION | FATE | chick | mouse | PROGENITOR-CELL IDENTITY | OLFACTORY-BULB | GENE | neurogenesis | CHICK-EMBRYO | spinal cord | TRANSCRIPTION FACTOR | EXPRESSION | Paired Box Transcription Factors - biosynthesis | Neurons - cytology | Stem Cells - cytology | Stem Cells - metabolism | Repressor Proteins - antagonists & inhibitors | Repressor Proteins - physiology | Cell Differentiation - genetics | Time Factors | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Nerve Tissue Proteins - biosynthesis | Eye Proteins - antagonists & inhibitors | Neurons - metabolism | Spinal Cord - cytology | Cell Differentiation - physiology | Gene Expression Regulation, Developmental - physiology | Nerve Tissue Proteins - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - genetics | Homeodomain Proteins - biosynthesis | Paired Box Transcription Factors - physiology | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | PAX6 Transcription Factor | Paired Box Transcription Factors - antagonists & inhibitors | Chick Embryo | Nerve Tissue Proteins - genetics | Spinal Cord - embryology | Animals | Repressor Proteins - biosynthesis | Homeodomain Proteins - antagonists & inhibitors | Spinal Cord - physiology | Cell Cycle - physiology | Eye Proteins - physiology | Mice | Homeodomain Proteins - physiology | Eye Proteins - biosynthesis | Neurons | Paired Box Transcription Factors | Repressor Proteins | Biochemistry, Molecular Biology | Nerve Tissue Proteins | Stem Cells | Life Sciences | Spinal Cord | Cell Cycle | Gene Expression Regulation, Developmental | Homeodomain Proteins | Cell Differentiation | Eye Proteins | Basic Helix-Loop-Helix Transcription Factors
Journal Article
Biochemistry, ISSN 0006-2960, 11/2011, Volume 50, Issue 44, pp. 9511 - 9519
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 09/2011, Volume 164, Issue 1, pp. 170 - 180
BACKGROUND AND PURPOSE Up‐regulation of thioredoxin interacting protein (TXNIP), an endogenous inhibitor of thioredoxin (Trx... 
peroxynitrite | retina | neuroprotection | verapamil | NMDA | neurodegeneration | TXNIP | apoptosis | retinal ganglion cells | Thioredoxin | DIABETIC-RETINOPATHY | OXIDATIVE STRESS | RAT RETINA | FACTOR-KAPPA-B | CALCIUM-CHANNEL BLOCKERS | NERVE GROWTH-FACTOR | OPEN-ANGLE GLAUCOMA | IN-VIVO | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | UP-REGULATED PROTEIN-1 | Retina - drug effects | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Retina - metabolism | Apoptosis - drug effects | Caspase 3 - metabolism | Male | NF-kappa B - metabolism | Retinal Ganglion Cells - metabolism | Tyrosine - analogs & derivatives | Inflammation - metabolism | MAP Kinase Kinase 4 - metabolism | Neuroprotective Agents - pharmacology | Interleukin-1beta - metabolism | MAP Kinase Kinase 4 - antagonists & inhibitors | Thioredoxins - metabolism | Thioredoxins - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | MAP Kinase Kinase Kinase 5 - metabolism | MAP Kinase Kinase Kinase 5 - antagonists & inhibitors | Eye Diseases - pathology | Interleukin-1beta - antagonists & inhibitors | NF-kappa B - antagonists & inhibitors | Carrier Proteins - biosynthesis | Carrier Proteins - antagonists & inhibitors | Rats | Eye Diseases - metabolism | Up-Regulation - genetics | Caspase Inhibitors | Poly(ADP-ribose) Polymerase Inhibitors | Rats, Sprague-Dawley | Verapamil - pharmacology | Carrier Proteins - genetics | Poly(ADP-ribose) Polymerases - metabolism | Tyrosine - metabolism | Animals | Carrier Proteins - metabolism | Eye Diseases - genetics | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Inflammation - genetics | Neuroglia - metabolism | Oxidative Stress - drug effects | Retinal Ganglion Cells - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Index Medicus | Research Papers
Journal Article
Science Signaling, ISSN 1945-0877, 10/2015, Volume 8, Issue 397, pp. ra98 - ra98
Yes-associated protein 1 (YAP1) is a transcriptional coactivator in the Hippo signaling pathway... 
PHOTODYNAMIC THERAPY | PATHWAY | COLORECTAL-CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIPPO | GROWTH | MACULAR DEGENERATION | CELL-PROLIFERATION | CHOROIDAL NEOVASCULARIZATION | TEAD/TEF FAMILY | TUMORIGENESIS | CELL BIOLOGY | Transcription, Genetic - drug effects | Phosphorylation | Adenocarcinoma - pathology | Molecular Weight | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | Humans | Neoplasm Proteins - physiology | Colonic Neoplasms - chemically induced | Neoplasm Proteins - antagonists & inhibitors | Phosphoproteins - antagonists & inhibitors | Adenomatous Polyposis Coli - pathology | Autophagy - drug effects | Genes, APC | Neoplasm Proteins - drug effects | Proteasome Endopeptidase Complex - drug effects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Adenoma - drug therapy | HEK293 Cells | Antineoplastic Agents - pharmacology | Phosphoproteins - physiology | Adenomatous Polyposis Coli - genetics | Mice, Inbred C57BL | Transcription Factors - antagonists & inhibitors | Porphyrins - pharmacology | Adenocarcinoma - drug therapy | Cell Division - drug effects | Mice, Knockout | Xenograft Model Antitumor Assays | Adaptor Proteins, Signal Transducing - physiology | Animals | Adenomatous Polyposis Coli - drug therapy | Colonic Neoplasms - pathology | Adenoma - pathology | Cell Line, Tumor | Mice | Protein Processing, Post-Translational | STAT3 Transcription Factor - antagonists & inhibitors | Protein Multimerization - drug effects
Journal Article