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Journal of Medical Genetics, ISSN 0022-2593, 11/2011, Volume 48, Issue 11, pp. 752 - 760
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2001, Volume 107, Issue 4, pp. 513 - 523
In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth... 
MINERAL DENSITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | OSTEOBLAST LINEAGE | MOLECULAR-CLONING | MICE | DIFFERENTIATION | BETA-CATENIN | OSTEOPOROSIS | CELL-DEATH | FAMILY | CELL BIOLOGY | Wnt2 Protein | Humans | Child, Preschool | Male | Bone Density - genetics | Wnt Proteins | Mesoderm - cytology | Wnt-5a Protein | Eye - embryology | Osteoporosis - genetics | Animals, Outbred Strains | Dishevelled Proteins | Bone Morphogenetic Proteins - pharmacology | Child | Organ Culture Techniques | Transforming Growth Factor beta | Signal Transduction | Chromosomes, Human, Pair 11 - genetics | Adaptor Proteins, Signal Transducing | Skull - cytology | Wnt3 Protein | Mice | Receptors, LDL - physiology | COS Cells | Species Specificity | LDL-Receptor Related Proteins | DNA, Complementary - genetics | Recombinant Fusion Proteins - physiology | Cercopithecus aethiops | Culture Media, Conditioned - pharmacology | Recombinant Proteins | Transfection | Receptors, LDL - deficiency | Stromal Cells - drug effects | Adult | Female | Phosphoproteins - physiology | Proteins - physiology | Receptors, LDL - genetics | Bone Morphogenetic Protein 2 | Low Density Lipoprotein Receptor-Related Protein-5 | Mice, Inbred C57BL | Zebrafish Proteins | Proto-Oncogene Proteins - genetics | Phosphoproteins - genetics | Eye Abnormalities - genetics | Genes, Recessive | Syndrome | Proteins - genetics | Animals | Proto-Oncogene Proteins - physiology | Heterozygote | Osteoblasts - metabolism | Stromal Cells - cytology | Wnt4 Protein | Osteoporosis | Bones | Density | Low density lipoproteins | Proteins | Cell research | Lipoproteins | Growth | Analysis | Physiological aspects | Receptors, LDL | Mesoderm | Osteoblasts | Recombinant Fusion Proteins | Eye | Life Sciences | Stromal Cells | Eye Abnormalities | Phosphoproteins | Proto-Oncogene Proteins | Bone Density | Biochemistry, Molecular Biology | Culture Media, Conditioned | Skull | Chromosomes, Human, Pair 11 | Bone Morphogenetic Proteins | DNA, Complementary
Journal Article
Genes & development, ISSN 1549-5477, 2018, Volume 32, Issue 5-6, pp. 389 - 401
Cis-regulatory modules (CRMs) are defined by unique combinations of transcription factor-binding sites. Emerging evidence suggests that the number, affinity,... 
TRANSCRIPTION FACTORS | STRUCTURAL INSIGHTS | SITE | heart development | DNA-BINDING | DEVELOPMENTAL BIOLOGY | Drosophila embryogenesis | even-skipped | DROSOPHILA EMBRYONIC MESODERM | cis-regulatory syntax | CHROMATIN OCCUPANCY | CELL BIOLOGY | SWISS-MODEL | SELF-ASSOCIATION | ETS transcription factor | PATHWAY | GENETICS & HEREDITY | receptor tyrosine kinase | EYE DEVELOPMENT | Drosophila melanogaster - embryology | Transcription Factors - chemistry | Homeodomain Proteins - metabolism | Eye Proteins - chemistry | Gene Expression Regulation, Developmental - genetics | Proto-Oncogene Proteins - chemistry | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Nerve Tissue Proteins - chemistry | Protein Structure, Quaternary | Eye Proteins - genetics | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Repressor Proteins - chemistry | Drosophila melanogaster - cytology | Models, Molecular | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - chemistry | DNA-Binding Proteins - chemistry | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Myocardium - cytology | Protein Transport | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Eye Proteins - metabolism | Organogenesis - genetics | Embryo, Nonmammalian | Protein Binding | Enhancer Elements, Genetic - genetics | Drosophila Proteins - genetics | Research Paper
Journal Article
Nature neuroscience, ISSN 1546-1726, 2010, Volume 13, Issue 5, pp. 551 - 558
... by both alterations in the NSC mitotic division plane and asymmetric inheritance of proteins that regulate cell fate (4-6). The exact mechanisms that define NSC divisions remain, how... 
HUMAN-CHROMOSOMES | PROTEIN | LIS1 EXPRESSION | LISSENCEPHALY GENE | SECKEL-SYNDROME | NASHI | SPINDLE ORIENTATION | NEUROGENESIS | NEUROSCIENCES | MESSENGER-RNA LOCALIZATION | CEREBRAL CORTICAL SIZE | Brain - embryology | Microcephaly - genetics | Embryo, Mammalian | Homeodomain Proteins - metabolism | Humans | Apoptosis - genetics | Green Fluorescent Proteins - genetics | RNA, Messenger - metabolism | Neurogenesis - genetics | DNA Mutational Analysis | Organ Size - genetics | Repressor Proteins - metabolism | Animals, Newborn | Oligonucleotide Array Sequence Analysis - methods | Repressor Proteins - genetics | Genotype | Mice, Transgenic | In Situ Nick-End Labeling - methods | Mutation - genetics | T-Box Domain Proteins - metabolism | Eye Proteins - metabolism | Brain - pathology | Mice | HeLa Cells | Paired Box Transcription Factors - genetics | Neurons - pathology | Age Factors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Gene Expression Regulation, Developmental - genetics | Brain - growth & development | Cell Differentiation - genetics | 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics | Transfection | Microcephaly - pathology | Microcephaly - physiopathology | Bromodeoxyuridine - metabolism | Eye Proteins - genetics | Nuclear Proteins - genetics | RNA Interference - physiology | Cell Division - genetics | Mice, Inbred C57BL | Gene Expression Profiling - methods | Nuclear Proteins - metabolism | PAX6 Transcription Factor | Nerve Tissue Proteins - genetics | T-Box Domain Proteins - genetics | Homeodomain Proteins - genetics | Nerve Tissue Proteins - metabolism | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism | Animals | Stem Cells - physiology | Paired Box Transcription Factors - metabolism | Animal experimentation | Axons | Usage | Brain research | Cell division | Physiological aspects | Causes of | Research | Microcephaly | Mental retardation | Risk factors
Journal Article
Gastroenterology, ISSN 0016-5085, 2012, Volume 143, Issue 5, pp. 1244 - 1252.e12
...) infection in genome-wide association (GWA) studies. Only a fraction of patients with chronic HCV infection develop liver fibrosis, a process that might also be affected by genetic factors... 
Gastroenterology and Hepatology | Cirrhosis | Genetic Analysis | Liver Disease | Risk Factors | CLEARANCE | PROTEIN | CHRONIC HEPATITIS-C | SUSCEPTIBILITY | IL28B | INTERFERON-ALPHA | REACTIVE OXYGEN | POLYMORPHISMS | 2 GENE VARIANTS | APOPTOTIC CELLS | GASTROENTEROLOGY & HEPATOLOGY | Humans | Hepatitis C, Chronic - virology | Apoptosis - genetics | Male | Hepatitis C, Chronic - complications | Young Adult | c-Mer Tyrosine Kinase | Adult | Female | Eye Proteins - genetics | Liver Cirrhosis - genetics | Genome-Wide Association Study | Membrane Proteins - genetics | Proportional Hazards Models | Genotype | Logistic Models | Proto-Oncogene Proteins - genetics | Disease Progression | Phenotype | Liver Cirrhosis - virology | Receptor Protein-Tyrosine Kinases - genetics | Polymorphism, Single Nucleotide | Ubiquitin-Protein Ligases - genetics | Hepacivirus | Lipase - genetics | Antiviral agents | Medical research | Medical colleges | Liver | Genomics | Immunodeficiency | Development and progression | Genomes | HIV (Viruses) | Risk factors | Analysis | Fibrosis | Medical genetics | Medicine, Experimental | Hepatitis C virus | Hepatitis C | Health aspects | Liver diseases | Genetic research | Life Sciences | Human health and pathology | Genetics | Hépatology and Gastroenterology | Infectious diseases | Human genetics | risk factors | genetic analysis | liver disease | cirrhosis
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 545, Issue 7653, pp. 175 - 180
Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites)... 
TERT PROMOTER MUTATIONS | SIGNATURES | MULTIDISCIPLINARY SCIENCES | RECURRENT MUTATIONS | FREQUENT SOMATIC MUTATIONS | MALIGNANT-MELANOMA | INFERENCE | GENERAL FRAMEWORK | CANCER | ACTIVATING MUTATIONS | REVEALS | Membrane Proteins - genetics | Humans | X-linked Nuclear Protein | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Mutation - genetics | Genes, p16 | Genome, Human - genetics | Tumor Suppressor Protein p53 - genetics | Ultraviolet Rays - adverse effects | Telomerase - genetics | Signal Transduction - drug effects | GTP Phosphohydrolases - genetics | Melanoma - genetics | Proto-Oncogene Proteins B-raf - genetics | Mitogen-Activated Protein Kinases - genetics | Neurofibromatosis 1 - genetics | Melanoma - classification | Nuclear Proteins - genetics | DNA Helicases - genetics | Telomere - genetics | Genetic research | Genetic aspects | Genomes | Research | Melanoma | Pathogenesis | Copy number | Mucosa | p53 Protein | Radiation | Security | Epidemiology | Metastases | Scholarships & fellowships | Reproduction (copying) | Coding | Mismatch repair | Clusters | Eye (anatomy) | Deoxyribonucleic acid--DNA | Medical research | Breakpoints | Radiation effects | MAP kinase | Exposure | Sun | Amplification | Bridges | Pathology | Ultraviolet radiation | Mutagenesis | Computation | Skin | Mutation | Internet | Aberration | Biotechnology | Genes | DNA damage | Carcinogens | Infrastructure | Signatures | Health | U.V. radiation | Inversions | Foldback | Data processing | Energy policy | Readers | Deamination | Protein kinase | Cell lines | Gene mapping | Tumors | Cancer | Index Medicus | Biological Science | 60 APPLIED LIFE SCIENCES
Journal Article
Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 188 - 8
.... The overwhelming majority of these TADs are demarcated by the insulator complexes, BEAF-32/CP190, or BEAF-32/Chromator, indicating that these proteins may play an analogous role in flies as that of... 
ORGANIZATION | DROSOPHILA GENOME | 3D GENOME | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | ARCHITECTURE | LONG-RANGE INTERACTIONS | TOPOLOGICALLY ASSOCIATING DOMAINS | CHROMOSOME CONFORMATION CAPTURE | CHROMATIN INTERACTIONS | INSULATOR PROTEINS | Mammals - genetics | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Molecular Conformation | CCCTC-Binding Factor - genetics | CCCTC-Binding Factor - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Chromosome Mapping - instrumentation | DNA-Binding Proteins - metabolism | Chromosome Mapping - methods | Cell Cycle Proteins - genetics | Eye Proteins - genetics | Genome, Insect | Nuclear Proteins - genetics | Chromatin - chemistry | Chromatin - ultrastructure | Chromosomes, Insect - chemistry | Gene Expression | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Chromatin Assembly and Disassembly | Nuclear Matrix-Associated Proteins - metabolism | Nuclear Proteins - metabolism | Drosophila melanogaster - ultrastructure | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Biological Evolution | Animals | Eye Proteins - metabolism | Nuclear Matrix-Associated Proteins - genetics | Chromosomes, Insect - ultrastructure | Drosophila Proteins - genetics | Proteins | Insects | Drosophila | Genomes | Cohesin | Mammals | Mammalian cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 30, pp. 11181 - 11186
Acute glaucoma is a sight-threatening condition characterized by a sudden and substantial rise in intraocular pressure (IOP) and consequent retinal ganglion... 
Glaucoma | Reperfusion | Messenger RNA | Ischemia | Toll like receptors | Central nervous system | Retina | Brain damage | Intraocular pressure | Microglia | Retinal ischemia/reperfusion injury | Cell apoptosis | BRAIN-INJURY | MICROGLIA ACTIVATION | INTERLEUKIN-1-BETA | MULTIDISCIPLINARY SCIENCES | REPERFUSION INJURY | POPULATIONS | retinal ischemia/reperfusion injury | ANGLE-CLOSURE GLAUCOMA | cell apoptosis | TOLL-LIKE RECEPTORS | CENTRAL-NERVOUS-SYSTEM | MICE | CEREBRAL-ISCHEMIA | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 8 - metabolism | Caspase 1 - metabolism | Interleukin-1beta - genetics | Caspase 8 - genetics | Interleukin-1beta - metabolism | Apoptosis Regulatory Proteins - genetics | Eye Proteins - genetics | Glaucoma - metabolism | Disease Models, Animal | Acute Disease | Rats | Toll-Like Receptor 4 - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Inflammasomes - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Eye Proteins - metabolism | Caspase 1 - genetics | Adaptor Proteins, Signal Transducing - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | Enzyme Activation - genetics | Glaucoma - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Biological Sciences | reperfusion injury | retinal ischemia
Journal Article
Oncogene, ISSN 1476-5594, 2009, Volume 28, Issue 17, pp. 1916 - 1927
.... Thus, investigations of the role of Yki and its mammalian homolog Yes-associated protein (YAP... 
CELL CONTACT INHIBITION | YES-ASSOCIATED PROTEIN | APOPTOSIS | GROWTH-CONTROL | hippo | MECHANISM | ORGAN SIZE CONTROL | Drosophila | BIOCHEMISTRY & MOLECULAR BIOLOGY | yorkie | HIPPO PATHWAY | YAP | TEAD/TEF FAMILY | CELL BIOLOGY | Warts | ONCOLOGY | tumor | GENETICS & HEREDITY | phosphorylation | Protein Kinases - metabolism | Wings, Animal - cytology | Phosphorylation | Protein Kinases - genetics | Immunoprecipitation | Luciferases - metabolism | Male | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Recombinant Fusion Proteins - metabolism | Luciferases - genetics | Drosophila melanogaster - metabolism | Cell Nucleus - metabolism | Trans-Activators - genetics | Female | Nuclear Proteins - genetics | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Eye - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Drosophila melanogaster - cytology | Protein-Serine-Threonine Kinases - genetics | Eye - cytology | Serine - genetics | Nuclear Proteins - metabolism | Serine - metabolism | Blotting, Western | Wings, Animal - metabolism | Animals | Protein Binding | Recombinant Fusion Proteins - genetics | Trans-Activators - metabolism | Drosophila Proteins - genetics | Amino Acid Substitution | Genetic aspects | Research | Health aspects | Cancer | Proteins | Oncology | Genetics | Kinases | Binding sites
Journal Article
Journal Article