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ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 05/2019, Volume 17, Issue 18, pp. 4512 - 4522
Drug induced liver injury (DILI) and tissue discoloration led to the recent discontinuation of the therapeutic use of the closely related drugs flupirtine and... 
EZOGABINE | CHEMISTRY, ORGANIC | DERIVATIVES
Journal Article
Bipolar Disorders, ISSN 1398-5647, 05/2019, Volume 21, Issue 3, pp. 283 - 284
Journal Article
Expert Opinion on Pharmacotherapy, ISSN 1465-6566, 08/2012, Volume 13, Issue 12, pp. 1807 - 1816
Introduction: Epilepsy is a serious and common chronic neurological disease with an urgent need for novel treatment options, because 30% of all epilepsy... 
epilepsy | potassium channel | antiepileptic drug | retigabine/ezogabine | pharmacotherapy | Antiepileptic drug | Pharmacotherapy | Potassium channel | Epilepsy | Retigabine/ezogabine
Journal Article
Future Medicinal Chemistry, ISSN 1756-8919, 02/2019, Volume 11, Issue 4, pp. 337 - 355
The highly structurally similar drugs flupirtine and retigabine have been regarded as safe and effective for many years but lately they turned out to exert... 
drug-induced liver injury | flupirtine | ezogabine | DILI | retigabine | voltage-gated potassium channel
Journal Article
PLOS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2
The hetero-tetrameric voltage-gated potassium channel K(v)7.2/K(v)7.3, which is encoded by KCNQ2 and KCNQ3, plays an important role in limiting network... 
EZOGABINE | ANTICONVULSANT RETIGABINE | POTASSIUM CHANNELS | MULTIDISCIPLINARY SCIENCES | RAT HIPPOCAMPUS | CURRENTS | KCNQ2/KCNQ3 K+ CHANNELS | NEURONAL EXCITABILITY | EPILEPTIC ENCEPHALOPATHY | MOUSE MODELS | FAMILIAL NEONATAL CONVULSIONS
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 10/2014, Volume 171, Issue 19, pp. 4413 - 4424
Background and PurposeThe KCNQ-encoded voltage-gated potassium channel family (K(v)7.1-K(v)7.5) are established regulators of smooth muscle contractility,... 
KCNQ POTASSIUM CHANNELS | ACTIVATION | ANTICONVULSANT RETIGABINE | PHARMACOLOGY | TARGETS | RELAXATION | PHARMACOLOGY & PHARMACY | FUNCTIONAL-CHARACTERIZATION | KV7 CHANNELS | K+ CHANNEL | EZOGABINE RETIGABINE
Journal Article
Journal of Pharmaceutical Sciences and Research, 01/2016, Volume 8, Issue 1, pp. 19 - 23
Journal Article
Annals of Pharmacotherapy, ISSN 1060-0280, 10/2012, Volume 46, Issue 10, pp. 1358 - 1367
Journal Article
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 10/2016, Volume 6
Enhancement of neuronal M-currents, generated through K(V)7.2-K(V)7.5 channels, has gained much interest for its potential in developing treatments for... 
LOCALIZATION | KV2.1 | ACTIVATION | POTASSIUM CHANNELS | MULTIDISCIPLINARY SCIENCES | MUTATION | VOLTAGE SENSOR | GENE-THERAPY | EPILEPSY | K+ CHANNEL | EZOGABINE RETIGABINE
Journal Article
Microchemical Journal, ISSN 0026-265X, 01/2019, Volume 144, pp. 130 - 138
The electrochemical oxidation of Ezogabine (EZG) based on Graphene Oxide Nanosheets (GO) and Ionic Liquids (IL)-modified carbon paste electrodes (CPE) has been... 
Response surface | Graphene oxide | Factorial design | Ezogabine | Ionic liquid | Modified sensors | GOLD NANOPARTICLES | CHEMISTRY, ANALYTICAL | VOLTAMMETRIC DETERMINATION | GLASSY-CARBON ELECTRODE | IDENTIFICATION | SENSORS | PROCESS-RELATED IMPURITIES | OXIDE NANOSHEETS | DOPAMINE | LIQUID-FUNCTIONALIZED GRAPHENE | RETIGABINE | Anticonvulsants | Sensors | Graphene | Nanotechnology | Graphite
Journal Article
PEDIATRIC NEUROLOGY, ISSN 0887-8994, 11/2013, Volume 49, Issue 5, pp. 368 - 369
BACKGROUND: Ring chromosome 20 is a genetic disorder characterized by intractable epilepsy, behavioral problems, and cognitive deficit. The potassium channel... 
epilepsy | OPENER | FRONTAL-LOBE EPILEPSY | SEIZURES | ring chromosome 20 | potassium channel openers | ezogabine | PEDIATRICS | CLINICAL NEUROLOGY
Journal Article
American Journal of Health-System Pharmacy, ISSN 1079-2082, 07/2011, Volume 68, Issue 14, p. 1277
Journal Article
JAMA Dermatology, ISSN 2168-6068, 09/2014, Volume 150, Issue 9, pp. 984 - 989
Journal Article
Epilepsia, ISSN 0013-9580, 04/2015, Volume 56, Issue 4, pp. 647 - 657
ObjectiveWithin its range of therapeutic plasma concentrations, the anticonvulsant retigabine (ezogabine) is believed to selectively act on Kv7 channels. Here,... 
Kv7 channels | Seizure-like activity | Extrasynaptic GABA A receptors | Retigabine | POTASSIUM CHANNELS | CLINICAL NEUROLOGY | EZOGABINE | A RECEPTORS | TRANSMISSION | INHIBITION | CALCIUM-CHANNELS | EPILEPTIFORM ACTIVITY | NEURONS | KCNQ | Extrasynaptic GABA(A) receptors | Full‐Length Original Research | Seizure‐like activity | Extrasynaptic GABAA receptors
Journal Article
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