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Molecular Imaging and Biology, ISSN 1536-1632, 8/2016, Volume 18, Issue 4, pp. 479 - 482
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 03/2017, Volume 58, Issue 3, pp. 484 - 491
18 F-T807 is a PET radiotracer developed for imaging tau protein aggregates, which are implicated in neurological disorders including Alzheimer's disease (AD)... 
Tau | Kinetic modeling | Pharmacokinetics | F-T807 | PET | pharmacokinetics | 18F-T807 | kinetic modeling
Journal Article
Frontiers in Aging Neuroscience, ISSN 1663-4365, 06/2018, Volume 10
Positron-emission-tomography (PET) imaging of tau pathology has facilitated development of anti-tau therapies. While members of the arylquinoline and... 
Small animal PET | Tau | F-T807 | Transgenic mice | F-THK5117 | Immunohistochemistry | Nuclear medicine | Disease | Brain stem | Radioisotopes | Pathology | Neurofibrillary tangles | Brain research | Tau protein | Transgenic animals | Rodents | Ligands | Positron emission tomography | Age | Dementia | Tracers | tau | 18F-T807 | transgenic mice | small animal PET | 18F-THK5117
Journal Article
Journal Article
JAMA Neurology, ISSN 2168-6149, 05/2018, Volume 75, Issue 5, pp. 548 - 556
IMPORTANCE It is critically important to improve our ability to diagnose and track Alzheimer disease (AD) as early as possible. Individuals with autosomal... 
BIOMARKERS | INDIVIDUALS | RADIOLIGAND | DEPOSITION | NEURODEGENERATION | MILD COGNITIVE IMPAIRMENT | FLORBETAPIR F 18 | PET | CLINICAL NEUROLOGY | BETA | Online First | Original Investigation | Research
Journal Article
Alzheimer's Research and Therapy, ISSN 1758-9193, 03/2017, Volume 9, Issue 1, pp. 1 - 9
Background 18F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired helical filaments (PHF). However, high levels of 18F-THK5351... 
Selegiline | Alzheimer's disease | Positron emission tomography | Monoamine oxidase-B | F-THK5351 tau tracer | Hypotheses | Medical imaging | Nuclear magnetic resonance--NMR | Brain research | Disease | Binding sites | 18F-THK5351 tau tracer | Alzheimer’s disease
Journal Article
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, ISSN 2352-8729, 2017, Volume 9, Issue C, pp. 57 - 66
We investigated the association between olfactory identification and Alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. Thirty-four... 
Tau | [18F]Flortaucipir (AV-1451) | Neurodegeneration | Alzheimer's disease | Olfaction | [18F]Flortaucipir (AV‐1451) | F]Flortaucipir (AV-1451)
Journal Article
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 6/2015, Volume 42, Issue 7, pp. 1052 - 1061
Visualization of the spatial distribution of neurofibrillary tangles would help in the diagnosis, prevention and treatment of dementia. The purpose of the... 
[ 18 F]THK-5117 | Neurofibrillary tangles | Medicine & Public Health | Alzheimer’s disease | Orthopedics | Imaging | Oncology | Tau | Nuclear Medicine | Imaging / Radiology | Cardiology | PET | F]THK-5117
Journal Article
Journal of Radioanalytical and Nuclear Chemistry, ISSN 0236-5731, 12/2017, Volume 314, Issue 3, pp. 1587 - 1593
[18F]THK-5351, a new candidate for tau protein imaging, is based on an aryl quinoline structure. We report the full automatic synthesis using disposable... 
THK-5351 | Chemistry | [ 18 F]fluorination | Automatic synthesis | Nuclear Physics, Heavy Ions, Hadrons | Diagnostic Radiology | PET imaging | Physical Chemistry | Inorganic Chemistry | Tau protein positron emission tomography | Nuclear Chemistry | F]fluorination
Journal Article
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 2019, Volume 46, Issue 5, pp. 1152 - 1163
Purpose Studies comparing CSF and PET tau biomarkers have included only commercial CSF assays examining specific phosphorylation sites (e.g. threonine 181,... 
F]THK5317 | Tau | Alzheimer’s disease | PET imaging | CSF | F]FDG | Phosphorylation | Threonine | Positron emission | Fluorine isotopes | Cerebrospinal fluid | Glucose | Metabolism | Assaying | Glucose metabolism | Tau protein | Neurodegeneration | N-Terminus | Tomography | Dementia disorders | Biomarkers | Positron emission tomography | Hypometabolism | Alzheimer's disease | Dementia
Journal Article