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Publication DateJournal of clinical oncology, ISSN 0732-183X, 12/2013, Volume 31, Issue 34, pp. 4333 - 4342
Life Sciences & Biomedicine | Oncology | Science & Technology | Hematologic and hematopoietic diseases | Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis | Biological and medical sciences | Medical sciences | Tumors | F-Box-WD Repeat-Containing Protein 7 | Multivariate Analysis | Predictive Value of Tests | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Humans | Male | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Young Adult | Time Factors | DNA Mutational Analysis | Gene Deletion | Cell Cycle Proteins - genetics | Adult | Female | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy | PTEN Phosphohydrolase - genetics | Genetic Predisposition to Disease | Membrane Proteins - genetics | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Disease-Free Survival | Phenotype | GTP Phosphohydrolases - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - classification | Mutation | Receptor, Notch1 - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Index Medicus | GTP Phosphohydrolases | ras Proteins | Innate immunity | Life Sciences | F-Box Proteins | Immunology | PTEN Phosphohydrolase | Proto-Oncogene Proteins | Membrane Proteins | Ubiquitin-Protein Ligases | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Receptor, Notch1 | Cell Cycle Proteins
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Loading RightsBiochemical journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | Index Medicus | MEL26, maternal effect lethal 26 | small molecule | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | structure-based design | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | assembly | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | structure | ubiquitin | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | ubiquitination | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
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Loading RightsThe Journal of neuroscience, ISSN 0270-6474, 02/2012, Volume 32, Issue 8, pp. 2628 - 2636
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Protein Binding - genetics | Immunoprecipitation | Humans | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | rab GTP-Binding Proteins - genetics | Axons - physiology | Synapses - genetics | Amino Acid Sequence - genetics | Guanine Nucleotide Exchange Factors - metabolism | Mass Spectrometry | Mechanoreceptors - cytology | rab GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Animals, Genetically Modified | F-Box Proteins - metabolism | Gene Expression Regulation - genetics | Synapses - physiology | Ubiquitin-Protein Ligases - metabolism | Nuclear Matrix-Associated Proteins - metabolism | Signal Transduction - genetics | Mutation - genetics | Nucleocytoplasmic Transport Proteins - genetics | Caenorhabditis elegans | Microscopy, Confocal | Nuclear Matrix-Associated Proteins - deficiency | Animals | Nucleocytoplasmic Transport Proteins - metabolism | Nuclear Matrix-Associated Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Luminescent Proteins - genetics | Nucleocytoplasmic Transport Proteins - deficiency | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Motifs - genetics | Ubiquitin-Protein Ligases - genetics | Caenorhabditis elegans Proteins - genetics | F-Box Proteins - genetics | Index Medicus
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Loading RightsNature, ISSN 0028-0836, 05/2005, Volume 435, Issue 7041, pp. 441 - 445
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Metabolism | Plant physiology and development | Growth regulators | Transcription, Genetic - drug effects | Temperature | Molecular Sequence Data | Spodoptera | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Protein Binding - drug effects | Carrier Proteins - chemistry | Receptors, Cell Surface - chemistry | Receptors, Cell Surface - isolation & purification | Repressor Proteins - metabolism | Amino Acid Sequence | Cell Line | Arabidopsis Proteins - genetics | Indoleacetic Acids - metabolism | Signal Transduction | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - chemistry | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - isolation & purification | Carrier Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Animals | Carrier Proteins - metabolism | Arabidopsis Proteins - chemistry | Indoleacetic Acids - pharmacology | Carrier Proteins - isolation & purification | F-Box Proteins - isolation & purification | F-Box Proteins - genetics | Receptors, Cell Surface - genetics | Proteins | Hormones | Physical growth | Botany | Index Medicus | Space life sciences
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Distinct interactions of EBP1 isoforms with FBXW7 elicits different functions in cancer
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2017, Volume 77, Issue 8, pp. 1983 - 1996
Life Sciences & Biomedicine | Oncology | Science & Technology | Immunohistochemistry | Neoplasms - metabolism | F-Box-WD Repeat-Containing Protein 7 | RNA-Binding Proteins - genetics | Humans | Cytoplasm - metabolism | Protein Interaction Maps | Heterografts | Neoplasms - genetics | HEK293 Cells | Cell Cycle Proteins - genetics | Binding Sites | F-Box Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Cell Cycle Proteins - deficiency | Glycogen Synthase Kinase 3 beta - metabolism | Phenotype | Animals | Mice, Nude | Protein Isoforms | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Ubiquitin-Protein Ligases - deficiency | Mice | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA-Binding Proteins - metabolism | Binding | Ubiquitin | Alternative splicing | Adapters | ErbB-3 protein | Cytosol | Substrates | Cdc4 protein | Degradation | Proteins | Isoforms | Tumor suppressor genes | Tumorigenesis | Ubiquitin-protein ligase | Cancer | EBP1 protein | Index Medicus | EBP1 P48 | colorectal cancer | BASIC BIOLOGICAL SCIENCES | FBXW7 | protein isoform | 60 APPLIED LIFE SCIENCES | EBP1 P42 | Protein isoform | Colorectal cancer
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Loading RightsBiogerontology (Dordrecht), ISSN 1389-5729, 06/2013, Volume 14, Issue 3, pp. 303 - 23
Forkhead Transcription Factors/physiology | Serpin E2/genetics | Humans | Male | Microtubule-Associated Proteins/genetics | Signal Transduction/physiology | Tripartite Motif Proteins | Young Adult | Aging/physiology | TOR Serine-Threonine Kinases/physiology | Aged, 80 and over | Adult | Female | Mice, Inbred DBA | Models, Animal | Insulin-Like Growth Factor I/physiology | Muscle Proteins/genetics | Mice, Inbred C57BL | Proto-Oncogene Proteins c-akt/physiology | Mice, Transgenic | SKP Cullin F-Box Protein Ligases/genetics | Mice, Knockout | Autophagy-Related Protein 7 | Animals | Sarcopenia/physiopathology | Adolescent | Aged | Forkhead Box Protein O1 | Mice | Muscle, Skeletal/physiology | Ubiquitin-Protein Ligases/genetics | Life Sciences | Sarcopenia | FoxO | Geriatrics/Gerontology | Ageing | mTOR | IGF1 | Akt | Developmental Biology | Cell Biology | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Microtubule-Associated Proteins - genetics | SKP Cullin F-Box Protein Ligases - genetics | SKP Cullin F-Box Protein Ligases - physiology | Forkhead Transcription Factors - physiology | Ubiquitin-Protein Ligases - physiology | TOR Serine-Threonine Kinases - physiology | Muscle Proteins - physiology | Serpin E2 - physiology | Proto-Oncogene Proteins c-akt - physiology | Muscle, Skeletal - physiology | Microtubule-Associated Proteins - physiology | Muscle Proteins - genetics | Sarcopenia - physiopathology | Serpin E2 - genetics | Aging - physiology | Insulin-Like Growth Factor I - physiology | Signal Transduction - physiology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Muscles | Ligases | Proteolysis | Analysis | Index Medicus | SKP Cullin F-Box Protein Ligases | Muscle Proteins | Aging | Serpin E2 | Signal Transduction | Biochemistry, Molecular Biology | Microtubule-Associated Proteins | Insulin-Like Growth Factor I | Proto-Oncogene Proteins c-akt | Ubiquitin-Protein Ligases | TOR Serine-Threonine Kinases | Muscle, Skeletal | Forkhead Transcription Factors
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Loading RightsMolecular cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 493 - 506
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer | Index Medicus
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