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Nature, ISSN 0028-0836, 05/2005, Volume 435, Issue 7041, pp. 441 - 445
The plant hormone auxin regulates diverse aspects of plant growth and development. Recent studies indicate that auxin acts by promoting the degradation of the... 
SCFTIR1 | COMPLEX | MULTIDISCIPLINARY SCIENCES | GROWTH | DEGRADATION | AUX/IAA PROTEINS | MECHANISMS | ARABIDOPSIS | SCF UBIQUITIN-LIGASE | EXPRESSION | BINDING | Transcription, Genetic - drug effects | Temperature | Molecular Sequence Data | Spodoptera | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Protein Binding - drug effects | Carrier Proteins - chemistry | Receptors, Cell Surface - chemistry | Receptors, Cell Surface - isolation & purification | Repressor Proteins - metabolism | Amino Acid Sequence | Cell Line | Arabidopsis Proteins - genetics | Indoleacetic Acids - metabolism | Signal Transduction | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - chemistry | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - isolation & purification | Carrier Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Animals | Carrier Proteins - metabolism | Arabidopsis Proteins - chemistry | Indoleacetic Acids - pharmacology | Carrier Proteins - isolation & purification | F-Box Proteins - isolation & purification | F-Box Proteins - genetics | Receptors, Cell Surface - genetics | Proteins | Hormones | Physical growth | Botany
Journal Article
Journal of Molecular Recognition, ISSN 0952-3499, 03/2010, Volume 23, Issue 2, pp. 105 - 116
Recognition requires protein flexibility because it facilitates conformational rearrangements and induced-fit mechanisms upon target binding. Intrinsic... 
NMR | Dynamic complex | Sic1 | Disordered complex | Polyelectrostatic effect | Protein dynamics | Conformational disorder | Disorder-to-order transition | SIDE-CHAIN DYNAMICS | DEUTERIUM SPIN PROBES | dynamic complex | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein dynamics | disorder-to-order transition | INTRINSICALLY UNSTRUCTURED PROTEINS | UBIQUITIN LIGASES | SUBSTRATE RECOGNITION | BIOPHYSICS | polyelectrostatic effect | HUB PROTEINS | RECEPTOR ZETA-CHAIN | STRUCTURAL DISORDER | ORDER PARAMETERS | INTERACTION NETWORKS | disordered complex | conformational disorder | Adaptor Proteins, Signal Transducing - chemistry | Receptors, Antigen, T-Cell - chemistry | Phosphorylation | Receptors, Antigen, T-Cell - metabolism | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Cyclin-Dependent Kinase Inhibitor Proteins - metabolism | Ubiquitin-Protein Ligases - chemistry | Protein Folding | Cell Cycle Proteins - chemistry | Thermodynamics | Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor Proteins - chemistry | Protein Binding | Protein Conformation | Proteins - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Evolution, Molecular | Saccharomyces cerevisiae Proteins - chemistry | Binding | Proteins | Dynamics | Evolutionary | Disorders | Charge | Order disorder | Recognition
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2009, Volume 106, Issue 52, pp. 22540 - 22545
Auxin regulates most aspects of plant growth and development. The hormone is perceived by the TIR1/AFB family of F-box proteins acting in concert with the... 
Receptors | Phenotypes | RNA | Genes | Alleles | Auxins | Gene expression regulation | Plants | Seedlings | Plant cells | Plant hormone | Plant development | plant hormone | plant development | ARABIDOPSIS-THALIANA | DOMAIN | MEMBERS | ARF | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL GENOMIC ANALYSIS | BOX PROTEIN TIR1 | TRANSCRIPTIONAL REPRESSION | DEGRADATION | AUX/IAA PROTEINS | Arabidopsis Proteins - genetics | Plant Roots - metabolism | Indoleacetic Acids - metabolism | Arabidopsis - growth & development | F-Box Proteins - metabolism | Receptors, Cell Surface - metabolism | RNA, Plant - genetics | Recombinant Fusion Proteins - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Plant Proteins - genetics | Indoleacetic Acids - pharmacology | Plants, Genetically Modified | Gene Expression Regulation, Plant | Recombinant Fusion Proteins - genetics | MicroRNAs - genetics | Plant Proteins - metabolism | Mutation | F-Box Proteins - genetics | Genes, Plant - drug effects | Plant Roots - growth & development | Receptors, Cell Surface - genetics | Plant proteins | Auxin | Research | Arabidopsis | Growth | Proteins | Genotype & phenotype | Genetics | Plant growth | RNA, Plant | Genes, Plant | Receptors, Cell Surface | Recombinant Fusion Proteins | Life Sciences | F-Box Proteins | Arabidopsis Proteins | Plant Roots | MicroRNAs | Plant Proteins | Vegetal Biology | Indoleacetic Acids | Biological Sciences
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2009, Volume 36, Issue 1, pp. 39 - 50
In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination.... 
PROTEINS | E3 LIGASE | OXIDATIVE STRESS | PROTEIN SPOP | NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCF | ADAPTER | DEGRADATION | BTB DOMAIN | F-BOX | TRANSCRIPTION FACTOR | CELL BIOLOGY | Transcription Factors - chemistry | Humans | Crystallography, X-Ray | Drosophila Proteins - metabolism | Mutation - physiology | Protein Multimerization - physiology | Protein Structure, Quaternary - physiology | Ubiquitination - physiology | Peptide Fragments - genetics | Repressor Proteins - metabolism | Amino Acid Sequence | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Repressor Proteins - genetics | Recombinant Fusion Proteins - chemistry | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Cullin Proteins - chemistry | Peptide Fragments - chemistry | Phosphoprotein Phosphatases - genetics | Consensus Sequence - physiology | Recombinant Fusion Proteins - genetics | Histones - metabolism | Ubiquitin-Protein Ligases - genetics | Drosophila melanogaster | Phosphoprotein Phosphatases - chemistry | Protein Binding - physiology | Adaptor Proteins, Signal Transducing - chemistry | Histones - chemistry | Protein Interaction Domains and Motifs - physiology | Phosphoprotein Phosphatases - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Cullin Proteins - metabolism | Nuclear Proteins - genetics | Peptide Fragments - metabolism | Repressor Proteins - chemistry | Nuclear Proteins - metabolism | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cullin Proteins - genetics | Transcription Factors - metabolism | Animals | Histones - genetics | Adaptor Proteins, Signal Transducing - genetics | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Chromatin | Phosphatases | Ligases | CHROMATIN | BASIC BIOLOGICAL SCIENCES | SUBSTRATES | FLEXIBILITY | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | LIGASES | DIMERIZATION | DIMERS | PHOSPHATASES
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2013, Volume 31, Issue 34, pp. 4333 - 4342
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2009, Volume 296, Issue 6, pp. 1258 - 1270
Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle cell differentiation. Myostatin requires both Smad2 and Smad3... 
MAFbx | Mammalian target of rapamycin complex signaling | MuRF1 | S6 kinase | Smad signaling | Human skeletal muscle cells | Transducer of regulated Ca | responsive element-binding protein activity | MuRF-1 | Atrogin | Transforming growth factor-β-like molecules | IGF-I | PHYSIOLOGY | ATROPHY | RAPID DISUSE | human skeletal muscle cells | transforming growth factor-beta-like molecules | SKELETAL-MUSCLE HYPERTROPHY | FOXO TRANSCRIPTION FACTORS | UBIQUITIN LIGASES | transducer of regulated Ca2+-responsive element-binding protein activity | CELL BIOLOGY | atrogin | PATHWAY | GROWTH | GENE-EXPRESSION | mammalian target of rapamycin complex signaling | CONDITIONAL ACTIVATION | Activin Receptors, Type I - antagonists & inhibitors | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Humans | Smad3 Protein - metabolism | Muscle Fibers, Skeletal - drug effects | Tripartite Motif Proteins | Smad3 Protein - genetics | Transfection | RNA Interference | Myoblasts, Skeletal - pathology | Smad2 Protein - genetics | Muscle Proteins - metabolism | Dioxoles - pharmacology | Regulatory-Associated Protein of mTOR | Benzamides - pharmacology | Myostatin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Cell Size - drug effects | Cells, Cultured | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Organ Size | Activin Receptors, Type I - metabolism | Myoblasts, Skeletal - enzymology | SKP Cullin F-Box Protein Ligases - metabolism | Mice, SCID | Myostatin - antagonists & inhibitors | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Cell Differentiation - drug effects | Follistatin - pharmacology | Muscle Fibers, Skeletal - pathology | Creatine Kinase - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Myoblasts, Skeletal - drug effects | Insulin-Like Growth Factor I - metabolism | Muscle Fibers, Skeletal - enzymology | RNA, Small Interfering - metabolism | Abdominal surgery | Musculoskeletal system | Signal transduction | Cell growth | Kinases | Gene expression | Cells
Journal Article
Science, ISSN 0036-8075, 11/2008, Volume 322, Issue 5903, pp. 923 - 929
Ubiquitin-mediated proteolysis regulates all aspects of cellular function, and defects in this process are associated with human diseases. The limited number... 
Proteins | Polymerase chain reaction | DNA | Cell cycle | Cell lines | Viruses | Protein stability | Libraries | Research Articles | Open reading frames | F box proteins | COMPLEX | CYCLIN-E | PATHWAY | MULTIDISCIPLINARY SCIENCES | F-BOX PROTEINS | S-PHASE | DEGRADATION | KAPPA-B-ALPHA | BETA-CATENIN | HISTONE MESSENGER-RNA | REVEALS | Oligonucleotide Array Sequence Analysis | SKP Cullin F-Box Protein Ligases - genetics | Humans | Open Reading Frames | Half-Life | Substrate Specificity | Proteins - isolation & purification | Recombinant Fusion Proteins - metabolism | Luminescent Proteins - analysis | Cullin Proteins - metabolism | Protein Stability | cdc25 Phosphatases - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Cell Cycle Proteins - isolation & purification | cdc25 Phosphatases - isolation & purification | Green Fluorescent Proteins - analysis | Signal Transduction | Cell Cycle Proteins - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - antagonists & inhibitors | Cullin Proteins - genetics | Proteins - genetics | Proteins - metabolism | Cell Cycle | Apoptosis | Luminescent Proteins - metabolism | Evaluation | Protein research | Substrates (Biochemistry) | Proteolysis | Research | Ubiquitin-proteasome system | Properties | Genetics | Cellular biology | Research methodology | Substrates
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 3, pp. 493 - 506
amplification in human cancers predicts poor prognosis and resistance to therapy. However, pharmacological strategies that directly target N-Myc, the protein... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer
Journal Article
Biogerontology, ISSN 1389-5729, 2013, Volume 14, Issue 3, pp. 303 - 323
During ageing skeletal muscles undergo a process of structural and functional remodelling that leads to sarcopenia, a syndrome characterized by loss of muscle... 
Life Sciences | Sarcopenia | FoxO | Geriatrics/Gerontology | Ageing | mTOR | IGF1 | Akt | Developmental Biology | Cell Biology | LIFE-SPAN | IGF-I | ALPHA-V-BETA-3 INTEGRIN | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | GERIATRICS & GERONTOLOGY | GROWTH-HORMONE | MESSENGER-RNA | GENETIC-DETERMINANTS | FAST-TWITCH | CELL-CYCLE | S6 KINASE | Microtubule-Associated Proteins - genetics | SKP Cullin F-Box Protein Ligases - genetics | Humans | SKP Cullin F-Box Protein Ligases - physiology | Male | Forkhead Transcription Factors - physiology | Ubiquitin-Protein Ligases - physiology | Tripartite Motif Proteins | Young Adult | Aged, 80 and over | Adult | Female | Mice, Inbred DBA | Models, Animal | TOR Serine-Threonine Kinases - physiology | Muscle Proteins - physiology | Serpin E2 - physiology | Mice, Inbred C57BL | Mice, Transgenic | Proto-Oncogene Proteins c-akt - physiology | Muscle, Skeletal - physiology | Mice, Knockout | Microtubule-Associated Proteins - physiology | Muscle Proteins - genetics | Autophagy-Related Protein 7 | Sarcopenia - physiopathology | Serpin E2 - genetics | Animals | Aging - physiology | Insulin-Like Growth Factor I - physiology | Adolescent | Signal Transduction - physiology | Aged | Forkhead Box Protein O1 | Mice | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Muscles | Ligases | Proteolysis | Analysis | SKP Cullin F-Box Protein Ligases | Muscle Proteins | Aging | Serpin E2 | Signal Transduction | Biochemistry, Molecular Biology | Microtubule-Associated Proteins | Insulin-Like Growth Factor I | Proto-Oncogene Proteins c-akt | Ubiquitin-Protein Ligases | TOR Serine-Threonine Kinases | Muscle, Skeletal | Forkhead Transcription Factors | Clinical Medicine | Neurology | Neurologi | Medical and Health Sciences | Medicin och hälsovetenskap | Clinical Neurophysiology | Klinisk neurofysiologi | Klinisk medicin
Journal Article