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Journal of clinical oncology, ISSN 1527-7755, 2013, Volume 31, Issue 34, pp. 4333 - 4342
Journal Article
Nature (London), ISSN 1476-4687, 2013, Volume 506, Issue 7488, pp. 371 - 375
Cervical cancer is responsible for 10-15% of cancer-related deaths in women worldwide(1,2). The aetiological role of infection with high-risk human papilloma... 
DOMAIN | CATALOG | FUSION | MULTIDISCIPLINARY SCIENCES | FRAMEWORK | HUMAN-PAPILLOMAVIRUS | SENSITIVE DETECTION | CANCER | EXPRESSION | SOMATIC MUTATIONS | DISCOVERY | F-Box-WD Repeat-Containing Protein 7 | Receptor, ErbB-2 - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Genomics | Humans | E1A-Associated p300 Protein - genetics | Core Binding Factor beta Subunit - genetics | Case-Control Studies | Papillomaviridae - genetics | Tumor Suppressor Protein p53 - genetics | DNA Mutational Analysis | Mitogen-Activated Protein Kinase 1 - genetics | Cell Cycle Proteins - genetics | Female | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Papillomaviridae - physiology | HLA-B Antigens - genetics | Gene Expression Regulation, Neoplastic - genetics | Proto-Oncogene Proteins c-ets | Virus Integration - genetics | Proto-Oncogene Proteins - genetics | DNA Copy Number Variations - genetics | Transcriptome - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Uterine Cervical Neoplasms - genetics | Adenocarcinoma - virology | Genome, Human - genetics | Papillomavirus Infections - genetics | Exome - genetics | Uterine Cervical Neoplasms - virology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Prevention | Gene mutations | Oncology, Experimental | Exome sequencing | Genetic aspects | Research | Cervical cancer | Cancer | Human papillomavirus | Mutation
Journal Article
Structure (London), ISSN 0969-2126, 2018, Volume 26, Issue 1, pp. 85 - 95.e3
The CXXC domain, first identified as the reader of unmodified CpG dinucleotide, plays important roles in epigenetic regulation by targeting various activities... 
histone methylation | DNMT1 | KDM2A | DNA methylation | TET1 | CFP1 | CpG island | MLL | CXXC domain | epigenetics | HOMEODOMAIN | METHYLATION | METHYLTRANSFERASE | CHROMATIN-STRUCTURE | 5-METHYLCYTOSINE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | BINDING DOMAIN | CELL BIOLOGY | BIOPHYSICS | GENES | DIOXYGENASE | CPG ISLANDS | Epigenesis, Genetic | Humans | Crystallography, X-Ray | Mixed Function Oxygenases - metabolism | Mixed Function Oxygenases - chemistry | Proto-Oncogene Proteins - chemistry | Neoplasm Proteins - metabolism | DNA-Binding Proteins - metabolism | Protein Isoforms - metabolism | Protein Isoforms - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Jumonji Domain-Containing Histone Demethylases - chemistry | Protein Interaction Domains and Motifs | Neoplasm Proteins - genetics | Binding Sites | Proto-Oncogene Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Genetic Vectors - chemistry | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Neoplasm Proteins - chemistry | Proto-Oncogene Proteins - genetics | Recombinant Proteins - genetics | DNA - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Jumonji Domain-Containing Histone Demethylases - genetics | DNA - genetics | Sequence Homology, Amino Acid | DNA - chemistry | Sequence Alignment | Protein Conformation, beta-Strand | Escherichia coli - genetics | CpG Islands | Protein Binding | Mixed Function Oxygenases - genetics | F-Box Proteins - genetics | Jumonji Domain-Containing Histone Demethylases - metabolism | Protein Isoforms - genetics | Epigenetic inheritance | Chromatin | Methyltransferases | DNA | Crystals | Physiological aspects | Genetic research | Nucleotide sequencing | Methylation | Structure | Protein binding | DNA sequencing
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2012, Volume 109, Issue 19, pp. E1192 - E1200
... (the JAZ or DELLA family of proteins), which, at the resting state, represses cognate transcription factors involved in defense (e.g., MYCs) or growth [e.g... 
Light response | Disease resistance | Plant growth | Plant defense | Plant immunity | plant growth | TRANSCRIPTION FACTORS | ARABIDOPSIS-THALIANA | CYTOCHROME-P450 MONOOXYGENASE | PROTEIN | MULTIDISCIPLINARY SCIENCES | RECEPTOR | RESPONSES | plant defense | disease resistance | GENE | light response | REPRESSOR | plant immunity | ALPHA-AMYLASE | RICE | Arabidopsis - growth & development | Oryza - metabolism | Seedlings - genetics | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Proteolysis - drug effects | Oryza - growth & development | Basic Helix-Loop-Helix Transcription Factors - metabolism | Oryza - genetics | Plants - genetics | RNA Interference | Gibberellins - metabolism | Plant Proteins - metabolism | Repressor Proteins - metabolism | Arabidopsis Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Plant Development | F-Box Proteins - metabolism | Repressor Proteins - genetics | Signal Transduction - genetics | Cyclopentanes - pharmacology | Seedlings - drug effects | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Arabidopsis - metabolism | Arabidopsis - genetics | Transcription Factors - metabolism | Oxylipins - metabolism | Plant Proteins - genetics | Two-Hybrid System Techniques | Gene Expression Regulation, Plant - drug effects | Plants - metabolism | Signal Transduction - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Oxylipins - pharmacology | Gibberellins - pharmacology | Protein Binding | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Cyclopentanes - metabolism | Signal Transduction - physiology | Mutation | Plant Growth Regulators - metabolism | F-Box Proteins - genetics | Plant Growth Regulators - pharmacology | Seedlings - metabolism | Biological Sciences | PNAS Plus
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 3, pp. 493 - 506
.... However, pharmacological strategies that directly target N-Myc, the protein encoded by MYCN, remain elusive... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer
Journal Article
Cancer, ISSN 0008-543X, 01/2018, Volume 124, Issue 1, pp. 84 - 94
BACKGROUND Human immunodeficiency virus–infected individuals (HIVIIs) have a higher incidence of head and neck squamous cell carcinoma (HNSCC), and clinical... 
human papillomavirus (HPV) | mutation | head and neck cancer | human immunodeficiency virus (HIV) | TP53 gene | UNITED-STATES | HIV/AIDS | POPULATION | HUMAN-PAPILLOMAVIRUS | HIV PATIENTS | P53 | P53-MEDIATED APOPTOSIS | BREAST-CANCER | CIGARETTE-SMOKING | ONCOLOGY | INFECTION | Receptors, Transforming Growth Factor beta - genetics | Class I Phosphatidylinositol 3-Kinases - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | ErbB Receptors - genetics | Male | Receptor, Notch2 - genetics | Case-Control Studies | Papillomaviridae - genetics | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p16 | Caspase 8 - genetics | Kelch-Like ECH-Associated Protein 1 - genetics | F-Box-WD Repeat-Containing Protein 7 - genetics | Squamous Cell Carcinoma of Head and Neck | In Situ Hybridization | Receptor, Transforming Growth Factor-beta Type II | Tumor Suppressor Proteins - genetics | Adult | Female | NF-E2-Related Factor 2 - genetics | Cadherins - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Papillomavirus Infections - complications | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | Cyclin-Dependent Kinase Inhibitor p18 - genetics | Histone Methyltransferases | Cyclin D1 - genetics | Carcinoma, Squamous Cell - complications | HIV Infections - complications | HLA-A Antigens - genetics | Head and Neck Neoplasms - complications | Head and Neck Neoplasms - genetics | LIM Domain Proteins - genetics | Aged | Receptor, Notch1 - genetics | Multiplexing | Pathogenesis | Exons | p53 Protein | Genes | Viruses | Genomes | Infections | Cdc4 protein | Gene sequencing | Biological effects | Human papillomavirus | Human immunodeficiency virus--HIV | Deoxyribonucleic acid--DNA | Head | Squamous cell carcinoma | Nucleotide sequence | Epidermal growth factor receptors | Data processing | Patients | Polymerase chain reaction | Head and neck cancer | Histocompatibility antigen HLA | Mutation | Tumors | DNA sequencing | Cancer
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2013, Volume 123, Issue 12, pp. 5231 - 5246
Epigenetic dysregulation has emerged as a major contributor to tumorigenesis. Histone methylation is a well-established mechanism of epigenetic regulation that... 
MEDICINE, RESEARCH & EXPERIMENTAL | HISTONE LYSINE METHYLATION | REGULATES CELL-PROLIFERATION | EMBRYONIC FIBROBLASTS | PATHWAY | TYROSINE-PHOSPHATASE VHR | ADENOCARCINOMA | DIMETHYLATION | CANCER | DEMETHYLASES | GENOME | Prognosis | Humans | Neoplasm Proteins - physiology | Protein Processing, Post-Translational - genetics | Jumonji Domain-Containing Histone Demethylases - physiology | Lung Neoplasms - pathology | Male | Neoplasm Proteins - antagonists & inhibitors | Dual Specificity Phosphatase 3 - genetics | F-Box Proteins - antagonists & inhibitors | MAP Kinase Signaling System | Epigenesis, Genetic - physiology | RNA, Messenger - biosynthesis | Heterografts | RNA Interference | Cell Division | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Female | Neoplasm Proteins - genetics | Gene Expression Regulation, Neoplastic - physiology | Gene Expression Regulation, Neoplastic - genetics | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Promoter Regions, Genetic | Dual Specificity Phosphatase 3 - physiology | Carcinoma, Non-Small-Cell Lung - genetics | Neoplasm Invasiveness | Neoplasm Proteins - biosynthesis | RNA, Messenger - genetics | F-Box Proteins - biosynthesis | Jumonji Domain-Containing Histone Demethylases - genetics | Protein Processing, Post-Translational - physiology | Dual Specificity Phosphatase 3 - biosynthesis | Animals | F-Box Proteins - physiology | RNA, Neoplasm - biosynthesis | Jumonji Domain-Containing Histone Demethylases - biosynthesis | Epigenesis, Genetic - genetics | Mice, Nude | Cell Line, Tumor | RNA, Neoplasm - genetics | Mice | Histones - metabolism | Methylation | F-Box Proteins - genetics | Genetic aspects | Research | Lung cancer, Non-small cell | Genetic regulation | Tumors | Cancer | Proteins | Survival analysis | Gene amplification | Lung cancer | Epigenetics | Kinases | Gene expression
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2009, Volume 106, Issue 52, pp. 22540 - 22545
Auxin regulates most aspects of plant growth and development. The hormone is perceived by the TIR1/AFB family of F-box proteins acting in concert with the Aux/IAA transcriptional repressors... 
Receptors | Phenotypes | RNA | Genes | Alleles | Auxins | Gene expression regulation | Plants | Seedlings | Plant cells | Plant hormone | Plant development | plant hormone | plant development | ARABIDOPSIS-THALIANA | DOMAIN | MEMBERS | ARF | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL GENOMIC ANALYSIS | BOX PROTEIN TIR1 | TRANSCRIPTIONAL REPRESSION | DEGRADATION | AUX/IAA PROTEINS | Arabidopsis Proteins - genetics | Plant Roots - metabolism | Indoleacetic Acids - metabolism | Arabidopsis - growth & development | F-Box Proteins - metabolism | Receptors, Cell Surface - metabolism | RNA, Plant - genetics | Recombinant Fusion Proteins - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Plant Proteins - genetics | Indoleacetic Acids - pharmacology | Plants, Genetically Modified | Gene Expression Regulation, Plant | Recombinant Fusion Proteins - genetics | MicroRNAs - genetics | Plant Proteins - metabolism | Mutation | F-Box Proteins - genetics | Genes, Plant - drug effects | Plant Roots - growth & development | Receptors, Cell Surface - genetics | Plant proteins | Auxin | Research | Arabidopsis | Growth | RNA, Plant | Genes, Plant | Receptors, Cell Surface | Recombinant Fusion Proteins | Life Sciences | F-Box Proteins | Arabidopsis Proteins | Plant Roots | MicroRNAs | Plant Proteins | Vegetal Biology | Indoleacetic Acids | Biological Sciences
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2012, Volume 32, Issue 8, pp. 2628 - 2636
...) regulates axon termination and synapse formation. To understand the mechanism of how rpm-1 functions, we have used mass spectrometry to identify RPM-1 binding proteins, and have identified RAE-1... 
REGULATOR | GENE | MAP KINASE PATHWAY | SYNAPTOGENESIS | NUCLEAR-PORE COMPLEX | NEURONS | RNA EXPORT FACTOR | C-ELEGANS | RPM-1 | NUP98 | NEUROSCIENCES | Protein Binding - genetics | Immunoprecipitation | Humans | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | rab GTP-Binding Proteins - genetics | Axons - physiology | Synapses - genetics | Amino Acid Sequence - genetics | Guanine Nucleotide Exchange Factors - metabolism | Mass Spectrometry | Mechanoreceptors - cytology | rab GTP-Binding Proteins - metabolism | Guanine Nucleotide Exchange Factors - genetics | Animals, Genetically Modified | F-Box Proteins - metabolism | Gene Expression Regulation - genetics | Synapses - physiology | Ubiquitin-Protein Ligases - metabolism | Nuclear Matrix-Associated Proteins - metabolism | Signal Transduction - genetics | Mutation - genetics | Nucleocytoplasmic Transport Proteins - genetics | Caenorhabditis elegans | Microscopy, Confocal | Nuclear Matrix-Associated Proteins - deficiency | Animals | Nucleocytoplasmic Transport Proteins - metabolism | Nuclear Matrix-Associated Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Luminescent Proteins - genetics | Nucleocytoplasmic Transport Proteins - deficiency | Adaptor Proteins, Signal Transducing - metabolism | Amino Acid Motifs - genetics | Ubiquitin-Protein Ligases - genetics | Caenorhabditis elegans Proteins - genetics | F-Box Proteins - genetics
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 9, pp. 3443 - 3448
Journal Article
Journal of dental research, ISSN 1544-0591, 2012, Volume 91, Issue 7_suppl, pp. S21 - S28
.... To date, there is limited evidence on host genetic risk loci associated with periodontal pathogen colonization... 
infection | genetics | bacteria | dentistry | genome-wide association studies | chronic periodontitis | VISUALIZATION | ADULTS | RISK | MICROBIOTA | HEALTHY | GENE POLYMORPHISMS | DENTISTRY, ORAL SURGERY & MEDICINE | DISEASE | AGGREGATIBACTER-ACTINOMYCETEMCOMITANS | THICKNESS | Humans | Middle Aged | Periodontium - microbiology | Campylobacter rectus - classification | Male | Prevotella nigrescens - classification | Fusobacterium nucleatum - genetics | Prevotella intermedia - genetics | Interleukins - genetics | Metagenome - genetics | Chronic Periodontitis - microbiology | Trans-Activators - genetics | Treponema denticola - classification | Female | Bacteroides - classification | Porphyromonas gingivalis - genetics | Vesicle-Associated Membrane Protein 3 - genetics | Aggregatibacter actinomycetemcomitans - classification | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Nucleic Acid Hybridization | Interleukin-33 | Fusobacterium nucleatum - classification | Prevotella intermedia - classification | Potassium Channels, Tandem Pore Domain - genetics | Bacterial Load | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Prevotella nigrescens - genetics | Bacteroides - genetics | Campylobacter rectus - genetics | DNA, Bacterial - genetics | Treponema denticola - genetics | Aggregatibacter actinomycetemcomitans - genetics | Zinc Fingers - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Core Binding Factor Alpha 1 Subunit - genetics | Calcium-Binding Proteins - genetics | Porphyromonas gingivalis - classification | Clinical Trials and Human Investigations
Journal Article