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Journal of Clinical Oncology, ISSN 0732-183X, 12/2013, Volume 31, Issue 34, pp. 4333 - 4342
Purpose The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic... 
REGRESSION | ACTIVATION | THERAPY | NOTCH1 | PRETHYMIC PHENOTYPE | ONCOLOGY | PATHWAY | GENES | PTEN | MUTATIONS | EXPRESSION | F-Box-WD Repeat-Containing Protein 7 | Multivariate Analysis | Predictive Value of Tests | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Humans | Male | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Young Adult | Time Factors | DNA Mutational Analysis | Gene Deletion | Cell Cycle Proteins - genetics | Adult | Female | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy | PTEN Phosphohydrolase - genetics | Genetic Predisposition to Disease | Membrane Proteins - genetics | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Disease-Free Survival | Phenotype | GTP Phosphohydrolases - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - classification | Mutation | Receptor, Notch1 - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Index Medicus | GTP Phosphohydrolases | ras Proteins | Innate immunity | Life Sciences | F-Box Proteins | Immunology | PTEN Phosphohydrolase | Proto-Oncogene Proteins | Membrane Proteins | Ubiquitin-Protein Ligases | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Receptor, Notch1 | Cell Cycle Proteins
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 371 - 375
Cervical cancer is responsible for 10-15% of cancer-related deaths in women worldwide(1,2). The aetiological role of infection with high-risk human papilloma... 
FUSION | MULTIDISCIPLINARY SCIENCES | SQUAMOUS-CELL CARCINOMA | HUMAN-PAPILLOMAVIRUS | SENSITIVE DETECTION | SAMPLES | DNA-SEQUENCING DATA | EXPRESSION | SOMATIC MUTATIONS | HUMAN CANCER | DISCOVERY | F-Box-WD Repeat-Containing Protein 7 | Receptor, ErbB-2 - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Genomics | Humans | E1A-Associated p300 Protein - genetics | Core Binding Factor beta Subunit - genetics | Case-Control Studies | Papillomaviridae - genetics | Tumor Suppressor Protein p53 - genetics | DNA Mutational Analysis | Mitogen-Activated Protein Kinase 1 - genetics | Cell Cycle Proteins - genetics | Female | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Papillomaviridae - physiology | HLA-B Antigens - genetics | Gene Expression Regulation, Neoplastic - genetics | Proto-Oncogene Proteins c-ets | Virus Integration - genetics | Proto-Oncogene Proteins - genetics | DNA Copy Number Variations - genetics | Transcriptome - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Uterine Cervical Neoplasms - genetics | Adenocarcinoma - virology | Genome, Human - genetics | Papillomavirus Infections - genetics | Exome - genetics | Uterine Cervical Neoplasms - virology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Prevention | Gene mutations | Oncology, Experimental | Exome sequencing | Genetic aspects | Research | Cervical cancer | Cancer | Human papillomavirus | Mutation | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 05/2012, Volume 109, Issue 19, pp. E1192 - E1200
Plants must effectively defend against biotic and abiotic stresses to survive in nature. However, this defense is costly and is often accompanied by... 
Light response | Disease resistance | Plant growth | Plant defense | Plant immunity | plant growth | TRANSCRIPTION FACTORS | ARABIDOPSIS-THALIANA | CYTOCHROME-P450 MONOOXYGENASE | PROTEIN | MULTIDISCIPLINARY SCIENCES | RECEPTOR | RESPONSES | plant defense | disease resistance | GENE | light response | REPRESSOR | plant immunity | ALPHA-AMYLASE | RICE | Arabidopsis - growth & development | Oryza - metabolism | Seedlings - genetics | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Proteolysis - drug effects | Oryza - growth & development | Basic Helix-Loop-Helix Transcription Factors - metabolism | Oryza - genetics | Plants - genetics | RNA Interference | Gibberellins - metabolism | Plant Proteins - metabolism | Repressor Proteins - metabolism | Arabidopsis Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Plant Development | F-Box Proteins - metabolism | Repressor Proteins - genetics | Signal Transduction - genetics | Cyclopentanes - pharmacology | Seedlings - drug effects | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Arabidopsis - metabolism | Arabidopsis - genetics | Transcription Factors - metabolism | Oxylipins - metabolism | Plant Proteins - genetics | Two-Hybrid System Techniques | Gene Expression Regulation, Plant - drug effects | Plants - metabolism | Signal Transduction - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Oxylipins - pharmacology | Gibberellins - pharmacology | Protein Binding | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Cyclopentanes - metabolism | Signal Transduction - physiology | Mutation | Plant Growth Regulators - metabolism | F-Box Proteins - genetics | Plant Growth Regulators - pharmacology | Seedlings - metabolism | Proteins | Signal transduction | Flowers & plants | Hormones | Binding sites | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2012, Volume 44, Issue 12, pp. 1310 - 1315
Journal Article
Nature Communications, ISSN 2041-1723, 07/2015, Volume 6, Issue 1, pp. 7557 - 7557
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number... 
WIDE DNA METHYLATION | AMPLIFICATION | PIK3CA GENE | EMBRYONAL RHABDOMYOSARCOMA | PATHWAY MUTATIONS | ADOLESCENTS | MULTIDISCIPLINARY SCIENCES | PTEN | ALVEOLAR RHABDOMYOSARCOMA | HUMAN CANCER | BREAST | Paired Box Transcription Factors - genetics | F-Box-WD Repeat-Containing Protein 7 | ras Proteins - genetics | Prognosis | Rhabdomyosarcoma, Embryonal - classification | Humans | Transcriptome | Child, Preschool | PAX7 Transcription Factor - genetics | Infant | Male | Rhabdomyosarcoma, Alveolar - classification | RNA, Messenger - metabolism | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Exome | Rhabdomyosarcoma, Embryonal - genetics | Young Adult | Cell Cycle Proteins - genetics | Female | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Child | Gene Expression Regulation, Neoplastic - genetics | PTEN Phosphohydrolase - genetics | PAX3 Transcription Factor | Rhabdomyosarcoma, Alveolar - genetics | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | DNA Methylation - genetics | Forkhead Transcription Factors - genetics | beta Catenin - genetics | Epigenesis, Genetic - genetics | Adolescent | Rhabdomyosarcoma - classification | Forkhead Box Protein O1 | Rhabdomyosarcoma - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2009, Volume 36, Issue 1, pp. 39 - 50
In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination.... 
PROTEINS | E3 LIGASE | OXIDATIVE STRESS | PROTEIN SPOP | NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCF | ADAPTER | DEGRADATION | BTB DOMAIN | F-BOX | TRANSCRIPTION FACTOR | CELL BIOLOGY | Transcription Factors - chemistry | Humans | Crystallography, X-Ray | Drosophila Proteins - metabolism | Mutation - physiology | Protein Multimerization - physiology | Protein Structure, Quaternary - physiology | Ubiquitination - physiology | Peptide Fragments - genetics | Repressor Proteins - metabolism | Amino Acid Sequence | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Repressor Proteins - genetics | Recombinant Fusion Proteins - chemistry | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Cullin Proteins - chemistry | Peptide Fragments - chemistry | Phosphoprotein Phosphatases - genetics | Consensus Sequence - physiology | Recombinant Fusion Proteins - genetics | Histones - metabolism | Ubiquitin-Protein Ligases - genetics | Drosophila melanogaster | Phosphoprotein Phosphatases - chemistry | Protein Binding - physiology | Adaptor Proteins, Signal Transducing - chemistry | Histones - chemistry | Protein Interaction Domains and Motifs - physiology | Phosphoprotein Phosphatases - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Cullin Proteins - metabolism | Nuclear Proteins - genetics | Peptide Fragments - metabolism | Repressor Proteins - chemistry | Nuclear Proteins - metabolism | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cullin Proteins - genetics | Transcription Factors - metabolism | Animals | Histones - genetics | Adaptor Proteins, Signal Transducing - genetics | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Chromatin | Phosphatases | Ligases | Index Medicus | CHROMATIN | BASIC BIOLOGICAL SCIENCES | SUBSTRATES | FLEXIBILITY | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | LIGASES | DIMERIZATION | DIMERS | PHOSPHATASES
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2009, Volume 106, Issue 52, pp. 22540 - 22545
Auxin regulates most aspects of plant growth and development. The hormone is perceived by the TIR1/AFB family of F-box proteins acting in concert with the... 
Receptors | Phenotypes | RNA | Genes | Alleles | Auxins | Gene expression regulation | Plants | Seedlings | Plant cells | Plant hormone | Plant development | plant hormone | plant development | ARABIDOPSIS-THALIANA | DOMAIN | MEMBERS | ARF | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL GENOMIC ANALYSIS | BOX PROTEIN TIR1 | TRANSCRIPTIONAL REPRESSION | DEGRADATION | AUX/IAA PROTEINS | Arabidopsis Proteins - genetics | Plant Roots - metabolism | Indoleacetic Acids - metabolism | Arabidopsis - growth & development | F-Box Proteins - metabolism | Receptors, Cell Surface - metabolism | RNA, Plant - genetics | Recombinant Fusion Proteins - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Plant Proteins - genetics | Indoleacetic Acids - pharmacology | Plants, Genetically Modified | Gene Expression Regulation, Plant | Recombinant Fusion Proteins - genetics | MicroRNAs - genetics | Plant Proteins - metabolism | Mutation | F-Box Proteins - genetics | Genes, Plant - drug effects | Plant Roots - growth & development | Receptors, Cell Surface - genetics | Plant proteins | Auxin | Research | Arabidopsis | Growth | Proteins | Genotype & phenotype | Genetics | Plant growth | Index Medicus | RNA, Plant | Genes, Plant | Receptors, Cell Surface | Recombinant Fusion Proteins | Life Sciences | F-Box Proteins | Arabidopsis Proteins | Plant Roots | MicroRNAs | Plant Proteins | Vegetal Biology | Indoleacetic Acids | Biological Sciences
Journal Article
Nature, ISSN 0028-0836, 05/2005, Volume 435, Issue 7041, pp. 441 - 445
The plant hormone auxin regulates diverse aspects of plant growth and development. Recent studies indicate that auxin acts by promoting the degradation of the... 
SCFTIR1 | COMPLEX | MULTIDISCIPLINARY SCIENCES | GROWTH | DEGRADATION | AUX/IAA PROTEINS | MECHANISMS | ARABIDOPSIS | SCF UBIQUITIN-LIGASE | EXPRESSION | BINDING | Transcription, Genetic - drug effects | Temperature | Molecular Sequence Data | Spodoptera | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Protein Binding - drug effects | Carrier Proteins - chemistry | Receptors, Cell Surface - chemistry | Receptors, Cell Surface - isolation & purification | Repressor Proteins - metabolism | Amino Acid Sequence | Cell Line | Arabidopsis Proteins - genetics | Indoleacetic Acids - metabolism | Signal Transduction | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - chemistry | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - isolation & purification | Carrier Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Animals | Carrier Proteins - metabolism | Arabidopsis Proteins - chemistry | Indoleacetic Acids - pharmacology | Carrier Proteins - isolation & purification | F-Box Proteins - isolation & purification | F-Box Proteins - genetics | Receptors, Cell Surface - genetics | Proteins | Hormones | Physical growth | Botany | Index Medicus | Space life sciences
Journal Article