X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (3760) 3760
humans (1906) 1906
animals (1785) 1785
f-box proteins - metabolism (1276) 1276
cell biology (1209) 1209
biochemistry & molecular biology (1178) 1178
f-box proteins - genetics (958) 958
proteins (945) 945
mice (882) 882
ubiquitin-protein ligases - metabolism (876) 876
skp cullin f-box protein ligases - metabolism (866) 866
f-box protein (795) 795
ubiquitin (736) 736
phosphorylation (717) 717
signal transduction (711) 711
cell cycle proteins - metabolism (691) 691
f-box proteins (666) 666
proteolysis (618) 618
ubiquitin-protein ligases - genetics (580) 580
molecular sequence data (575) 575
protein binding (565) 565
degradation (564) 564
mutation (564) 564
male (552) 552
amino acid sequence (544) 544
ubiquitination (540) 540
research (538) 538
plant sciences (532) 532
gene expression (514) 514
skp cullin f-box protein ligases - genetics (505) 505
cell cycle proteins - genetics (438) 438
expression (432) 432
female (430) 430
cancer (425) 425
gene-expression (419) 419
ubiquitin - metabolism (419) 419
cell cycle (418) 418
cell line (418) 418
ligases (413) 413
physiological aspects (412) 412
cell line, tumor (399) 399
article (397) 397
f-box (397) 397
muscle proteins - metabolism (393) 393
genetic aspects (379) 379
genes (375) 375
f-box-wd repeat-containing protein 7 (372) 372
arabidopsis proteins - metabolism (364) 364
proteasome endopeptidase complex - metabolism (360) 360
oncology (348) 348
multidisciplinary sciences (341) 341
ubiquitin ligase (340) 340
analysis (333) 333
arabidopsis proteins - genetics (323) 323
arabidopsis - genetics (317) 317
gene expression regulation (316) 316
complex (315) 315
transcription factors - metabolism (295) 295
genetics & heredity (292) 292
muscle proteins - genetics (287) 287
research article (285) 285
gene expression regulation, plant (280) 280
protein (279) 279
plant proteins - metabolism (278) 278
apoptosis (270) 270
plants (268) 268
arabidopsis - metabolism (264) 264
cell-cycle (263) 263
cell proliferation (260) 260
rna, messenger - metabolism (259) 259
biology (255) 255
tripartite motif proteins (255) 255
muscle, skeletal - metabolism (248) 248
rats (245) 245
models, biological (242) 242
saccharomyces-cerevisiae (242) 242
arabidopsis-thaliana (240) 240
gene (239) 239
plant proteins - genetics (239) 239
arabidopsis (231) 231
hela cells (231) 231
protein structure, tertiary (226) 226
hek293 cells (222) 222
transcription factors (222) 222
identification (220) 220
phenotype (216) 216
activation (211) 211
ubiquitin-protein ligases (211) 211
cells, cultured (210) 210
cells (209) 209
dna-binding proteins - metabolism (209) 209
rna interference (207) 207
life sciences (204) 204
molecular biology (204) 204
transcription factors - genetics (204) 204
base sequence (201) 201
developmental biology (197) 197
growth (196) 196
kinases (196) 196
pathway (196) 196
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nutrition, ISSN 0899-9007, 2016, Volume 36, pp. 8 - 16
Abstract Objectives Branched-chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), are key regulators of protein synthesis in... 
Gastroenterology and Hepatology | Branched-chain amino acid ratio | Protein metabolism | Proliferation and differentiation | mTORC1 | Myocyte | ADIPOCYTES | TRANSPORTER EXPRESSION | ATROPHY | UBIQUITIN LIGASES | TOR SIGNALING NETWORK | SUPPLEMENTATION | NUTRITION & DIETETICS | SKELETAL-MUSCLE CELLS | MTORC1 ACTIVATION | GROWTH | L-LEUCINE AVAILABILITY | Up-Regulation | Protein Biosynthesis | TOR Serine-Threonine Kinases - metabolism | SKP Cullin F-Box Protein Ligases - genetics | Uncoupling Protein 3 - genetics | Muscle Cells - drug effects | Multiprotein Complexes - genetics | Muscle Fibers, Skeletal - drug effects | Muscle Fibers, Skeletal - metabolism | RNA, Messenger - metabolism | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Muscle Proteins - metabolism | Cell Survival - drug effects | Uncoupling Protein 3 - metabolism | Down-Regulation | RNA, Messenger - genetics | Muscle Cells - metabolism | Ubiquitin-Protein Ligases - metabolism | Tripartite Motif Proteins - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Muscle Proteins - genetics | Animals | Cell Differentiation - drug effects | Amino Acids, Branched-Chain - pharmacology | Cell Line, Tumor | Muscle Fibers, Skeletal - cytology | Cell Proliferation - drug effects | Mice | Tripartite Motif Proteins - metabolism | Ubiquitin-Protein Ligases - genetics | Physiological aspects | Protein biosynthesis | Livestock | Branched chain amino acids | Sensors | Ubiquitin | Energy metabolism | Regulators | Interleukin | Chain branching | Amino acids | Chains | Myocytes | Leucine | Kinases | Protein turnover | Proteins | Atrophy | Ratios | Cell growth | Medical laboratories | Cell cycle | Ubiquitin-protein ligase | Food | G1 phase | Isoleucine | Animal nutrition | Myotubes | Myogenin | Nutrition | Ribosomal protein S6 | Gene expression | Metabolism | Interleukin 15 | Ribosomal protein S6 kinase | Musculoskeletal system | Protein synthesis | Valine | S phase | Differentiation | Viability | Transporter | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 05/2012, Volume 109, Issue 19, pp. E1192 - E1200
Plants must effectively defend against biotic and abiotic stresses to survive in nature. However, this defense is costly and is often accompanied by... 
Light response | Disease resistance | Plant growth | Plant defense | Plant immunity | plant growth | TRANSCRIPTION FACTORS | ARABIDOPSIS-THALIANA | CYTOCHROME-P450 MONOOXYGENASE | PROTEIN | MULTIDISCIPLINARY SCIENCES | RECEPTOR | RESPONSES | plant defense | disease resistance | GENE | light response | REPRESSOR | plant immunity | ALPHA-AMYLASE | RICE | Arabidopsis - growth & development | Oryza - metabolism | Seedlings - genetics | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Proteolysis - drug effects | Oryza - growth & development | Basic Helix-Loop-Helix Transcription Factors - metabolism | Oryza - genetics | Plants - genetics | RNA Interference | Gibberellins - metabolism | Plant Proteins - metabolism | Repressor Proteins - metabolism | Arabidopsis Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Plant Development | F-Box Proteins - metabolism | Repressor Proteins - genetics | Signal Transduction - genetics | Cyclopentanes - pharmacology | Seedlings - drug effects | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Arabidopsis - metabolism | Arabidopsis - genetics | Transcription Factors - metabolism | Oxylipins - metabolism | Plant Proteins - genetics | Two-Hybrid System Techniques | Gene Expression Regulation, Plant - drug effects | Plants - metabolism | Signal Transduction - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Oxylipins - pharmacology | Gibberellins - pharmacology | Protein Binding | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Cyclopentanes - metabolism | Signal Transduction - physiology | Mutation | Plant Growth Regulators - metabolism | F-Box Proteins - genetics | Plant Growth Regulators - pharmacology | Seedlings - metabolism | Proteins | Signal transduction | Flowers & plants | Hormones | Binding sites | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Acta Physiologica, ISSN 1748-1708, 07/2013, Volume 208, Issue 3, pp. 251 - 264
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 06/2009, Volume 296, Issue 6, pp. 1258 - 1270
Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle cell differentiation. Myostatin requires both Smad2 and Smad3... 
MAFbx | Mammalian target of rapamycin complex signaling | MuRF1 | S6 kinase | Smad signaling | Human skeletal muscle cells | Transducer of regulated Ca | responsive element-binding protein activity | MuRF-1 | Atrogin | Transforming growth factor-β-like molecules | IGF-I | PHYSIOLOGY | ATROPHY | RAPID DISUSE | human skeletal muscle cells | transforming growth factor-beta-like molecules | SKELETAL-MUSCLE HYPERTROPHY | FOXO TRANSCRIPTION FACTORS | UBIQUITIN LIGASES | transducer of regulated Ca2+-responsive element-binding protein activity | CELL BIOLOGY | atrogin | PATHWAY | GROWTH | GENE-EXPRESSION | mammalian target of rapamycin complex signaling | CONDITIONAL ACTIVATION | Activin Receptors, Type I - antagonists & inhibitors | Protein Kinases - metabolism | Phosphorylation | Protein Kinases - genetics | Humans | Smad3 Protein - metabolism | Muscle Fibers, Skeletal - drug effects | Tripartite Motif Proteins | Smad3 Protein - genetics | Transfection | RNA Interference | Myoblasts, Skeletal - pathology | Smad2 Protein - genetics | Muscle Proteins - metabolism | Dioxoles - pharmacology | Regulatory-Associated Protein of mTOR | Benzamides - pharmacology | Myostatin - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Rapamycin-Insensitive Companion of mTOR Protein | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Cell Size - drug effects | Cells, Cultured | Smad2 Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Organ Size | Activin Receptors, Type I - metabolism | Myoblasts, Skeletal - enzymology | SKP Cullin F-Box Protein Ligases - metabolism | Mice, SCID | Myostatin - antagonists & inhibitors | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Cell Differentiation - drug effects | Follistatin - pharmacology | Muscle Fibers, Skeletal - pathology | Creatine Kinase - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Myoblasts, Skeletal - drug effects | Insulin-Like Growth Factor I - metabolism | Muscle Fibers, Skeletal - enzymology | RNA, Small Interfering - metabolism | Abdominal surgery | Musculoskeletal system | Signal transduction | Cell growth | Kinases | Gene expression | Cells | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2005, Volume 435, Issue 7041, pp. 441 - 445
The plant hormone auxin regulates diverse aspects of plant growth and development. Recent studies indicate that auxin acts by promoting the degradation of the... 
SCFTIR1 | COMPLEX | MULTIDISCIPLINARY SCIENCES | GROWTH | DEGRADATION | AUX/IAA PROTEINS | MECHANISMS | ARABIDOPSIS | SCF UBIQUITIN-LIGASE | EXPRESSION | BINDING | Transcription, Genetic - drug effects | Temperature | Molecular Sequence Data | Spodoptera | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Protein Binding - drug effects | Carrier Proteins - chemistry | Receptors, Cell Surface - chemistry | Receptors, Cell Surface - isolation & purification | Repressor Proteins - metabolism | Amino Acid Sequence | Cell Line | Arabidopsis Proteins - genetics | Indoleacetic Acids - metabolism | Signal Transduction | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - chemistry | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - isolation & purification | Carrier Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Animals | Carrier Proteins - metabolism | Arabidopsis Proteins - chemistry | Indoleacetic Acids - pharmacology | Carrier Proteins - isolation & purification | F-Box Proteins - isolation & purification | F-Box Proteins - genetics | Receptors, Cell Surface - genetics | Proteins | Hormones | Physical growth | Botany | Index Medicus | Space life sciences
Journal Article
Nature, ISSN 0028-0836, 11/2010, Volume 468, Issue 7322, pp. 400 - 405
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 05/2012, Volume 112, Issue 9, pp. 1529 - 1537
In this study, the coordinated activation of ubiquitin-proteasome pathway (UPP), autophagy-lysosomal pathway (ALP), and mitochondrial remodeling including... 
Muscle protein degradation | Mitochondrial remodelling | Mitophagy | LC3b | MuRF1 | MAMMALIAN TARGET | mitochondrial remodelling | SPORT SCIENCES | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | muscle protein degradation | EXERCISE-INDUCED MUSCLE | COORDINATE ACTIVATION | FOXO TRANSCRIPTION FACTORS | HUMAN SKELETAL-MUSCLE | MITOCHONDRIAL FISSION | mitophagy | RESISTANCE EXERCISE | GENE-EXPRESSION | C2C12 MYOTUBES | Protein Kinases - metabolism | AMP-Activated Protein Kinases - metabolism | Phosphorylation | TOR Serine-Threonine Kinases - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Serine | Ubiquitin - metabolism | Male | Physical Endurance | Insulin - blood | Phosphoproteins - metabolism | Autophagy | Tripartite Motif Proteins | Quadriceps Muscle - enzymology | Time Factors | Forkhead Transcription Factors - metabolism | Mitochondrial Proteins - metabolism | Muscle Proteins - metabolism | Adult | Proto-Oncogene Proteins c-akt - metabolism | Quadriceps Muscle - pathology | Autophagy-Related Protein 12 | Mitochondrial Membrane Transport Proteins - metabolism | Mitochondria, Muscle - enzymology | Signal Transduction | Mitochondria, Muscle - pathology | Small Ubiquitin-Related Modifier Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | SKP Cullin F-Box Protein Ligases - metabolism | Energy Intake | GTP Phosphohydrolases - metabolism | Autophagy-Related Protein 5 | Energy Metabolism | Biopsy | Running | Proteasome Endopeptidase Complex - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Blood Glucose - metabolism | Forkhead Box Protein O3 | Proteins | Musculoskeletal system | Signal transduction | Physiology | Athletes | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 06/2011, Volume 300, Issue 6, pp. E993 - E1001
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2009, Volume 36, Issue 1, pp. 39 - 50
In the largest E3 ligase subfamily, Cul3 binds a BTB domain, and an associated protein-interaction domain such as MATH recruits substrates for ubiquitination.... 
PROTEINS | E3 LIGASE | OXIDATIVE STRESS | PROTEIN SPOP | NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCF | ADAPTER | DEGRADATION | BTB DOMAIN | F-BOX | TRANSCRIPTION FACTOR | CELL BIOLOGY | Transcription Factors - chemistry | Humans | Crystallography, X-Ray | Drosophila Proteins - metabolism | Mutation - physiology | Protein Multimerization - physiology | Protein Structure, Quaternary - physiology | Ubiquitination - physiology | Peptide Fragments - genetics | Repressor Proteins - metabolism | Amino Acid Sequence | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Repressor Proteins - genetics | Recombinant Fusion Proteins - chemistry | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Cullin Proteins - chemistry | Peptide Fragments - chemistry | Phosphoprotein Phosphatases - genetics | Consensus Sequence - physiology | Recombinant Fusion Proteins - genetics | Histones - metabolism | Ubiquitin-Protein Ligases - genetics | Drosophila melanogaster | Phosphoprotein Phosphatases - chemistry | Protein Binding - physiology | Adaptor Proteins, Signal Transducing - chemistry | Histones - chemistry | Protein Interaction Domains and Motifs - physiology | Phosphoprotein Phosphatases - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | Cullin Proteins - metabolism | Nuclear Proteins - genetics | Peptide Fragments - metabolism | Repressor Proteins - chemistry | Nuclear Proteins - metabolism | Drosophila Proteins - chemistry | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cullin Proteins - genetics | Transcription Factors - metabolism | Animals | Histones - genetics | Adaptor Proteins, Signal Transducing - genetics | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Chromatin | Phosphatases | Ligases | Index Medicus | CHROMATIN | BASIC BIOLOGICAL SCIENCES | SUBSTRATES | FLEXIBILITY | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | LIGASES | DIMERIZATION | DIMERS | PHOSPHATASES
Journal Article