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science & technology (534) 534
humans (520) 520
life sciences & biomedicine (483) 483
f-box-wd repeat-containing protein 7 (473) 473
ubiquitin-protein ligases - genetics (313) 313
f-box proteins - genetics (311) 311
cell cycle proteins - genetics (291) 291
f-box proteins - metabolism (266) 266
ubiquitin-protein ligases - metabolism (266) 266
animals (264) 264
cell cycle proteins - metabolism (251) 251
oncology (234) 234
mice (195) 195
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cell biology (183) 183
cell line, tumor (176) 176
mutation (172) 172
biochemistry & molecular biology (141) 141
male (132) 132
proteins (119) 119
cancer (117) 117
fbxw7 (114) 114
tumors (105) 105
signal transduction (103) 103
ubiquitin (99) 99
cell cycle (96) 96
phosphorylation (96) 96
gene expression regulation, neoplastic (93) 93
ubiquitination (93) 93
middle aged (92) 92
genetic aspects (91) 91
f-box-wd repeat-containing protein 7 - genetics (89) 89
research (88) 88
cell proliferation (86) 86
prognosis (79) 79
apoptosis (77) 77
biological and medical sciences (75) 75
adult (71) 71
gene expression (70) 70
f-box-wd repeat-containing protein 7 - metabolism (69) 69
proto-oncogene proteins c-myc - metabolism (69) 69
aged (67) 67
fbw7 (67) 67
proteolysis (66) 66
cell line (63) 63
cdc4 protein (61) 61
medical sciences (59) 59
receptor, notch1 - genetics (57) 57
ligases (52) 52
micrornas - genetics (51) 51
multidisciplinary sciences (51) 51
protein binding (51) 51
science & technology - other topics (51) 51
cyclin e - metabolism (50) 50
hek293 cells (50) 50
health aspects (49) 49
f-box proteins (48) 48
kinases (48) 48
genes (46) 46
analysis (45) 45
genetics & heredity (45) 45
mice, knockout (45) 45
ubiquitin-protein ligases (44) 44
glycogen synthase kinase 3 - metabolism (43) 43
proteasome endopeptidase complex - metabolism (42) 42
protein stability (42) 42
research article (42) 42
colorectal cancer (41) 41
hematology (41) 41
rna interference (41) 41
f-box proteins - physiology (40) 40
molecular sequence data (40) 40
ubiquitin-protein ligases - physiology (40) 40
gene expression regulation (39) 39
breast cancer (38) 38
transfection (38) 38
amino acid sequence (37) 37
development and progression (37) 37
hct116 cells (37) 37
mice, nude (37) 37
precursor t-cell lymphoblastic leukemia-lymphoma - genetics (36) 36
proto-oncogene proteins c-myc - genetics (36) 36
tumor suppressor protein p53 - genetics (36) 36
tumor suppressor genes (35) 35
ubiquitin - metabolism (35) 35
colorectal neoplasms - genetics (34) 34
metastasis (34) 34
aged, 80 and over (33) 33
biology (33) 33
microrna (33) 33
cell cycle proteins - physiology (32) 32
child (32) 32
receptor, notch1 - metabolism (32) 32
rna, messenger - genetics (32) 32
care and treatment (31) 31
cells, cultured (31) 31
dna mutational analysis (31) 31
hela cells (31) 31
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1. Full Text Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver
by Onoyama, Ichiro and Suzuki, Atsushi and Matsumoto, Akinobu and Tomita, Kengo and Katagiri, Hideki and Oike, Yuichi and Nakayama, Keiko and Nakayama, Keiichi I
The Journal of clinical investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 342 - 354
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | F-Box-WD Repeat-Containing Protein 7 | Liver - pathology | Fatty Liver - pathology | Humans | Hepatocytes - pathology | DNA Primers - genetics | Hepatocytes - metabolism | Stem Cells - metabolism | Cell Differentiation - genetics | Lipogenesis - genetics | Mice, Mutant Strains | Base Sequence | Female | Lipid Metabolism - genetics | Adipogenesis - genetics | Cell Differentiation - physiology | Disease Models, Animal | Fatty Liver - genetics | Gene Expression | Fatty Liver - metabolism | F-Box Proteins - metabolism | Liver - metabolism | Ubiquitin-Protein Ligases - metabolism | Mice, Transgenic | Mice, Knockout | Pregnancy | Animals | Models, Biological | Stem Cells - pathology | Ubiquitin-Protein Ligases - deficiency | Liver - cytology | Mice | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Lipid Metabolism - physiology | Cell proliferation | Genes | Liver | Physiological aspects | Genetic aspects | Research | Lipid metabolism | Index Medicus | Abridged Index Medicus
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2. Full Text Overexpression of miR-92a promotes the tumor growth of osteosarcoma by suppressing F-box and WD repeat-containing protein 7
by Jiang, Xuesheng and Li, Xiongfeng and Wu, Fengfeng and Gao, Hongliang and Wang, Guorong and Zheng, Hua and Wang, Huajun and Li, Jianyou and Chen, Chao
Gene, ISSN 0378-1119, 03/2017, Volume 606, pp. 10 - 16
Cell cycle progression | Proliferation | Osteosarcoma | FBXW7 | miR-92a | Apoptosis | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | F-Box-WD Repeat-Containing Protein 7 | F-Box Proteins - metabolism | Humans | Cell Cycle Proteins - metabolism | Gene Expression Regulation, Neoplastic | Ubiquitin-Protein Ligases - metabolism | MicroRNAs - metabolism | Animals | Mice, Nude | Bone and Bones - metabolism | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Osteosarcoma - pathology | Development and progression | Tumors | Index Medicus
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3. Full Text Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers
by Kothari, Nishi and Teer, Jamie K and Abbott, Andrea M and Srikumar, Thejal and Zhang, Yonghong and Yoder, Sean J and Brohl, Andrew S and Kim, Richard D and Reed, Damon R and Shibata, David
Cancer, ISSN 0008-543X, 09/2016, Volume 122, Issue 18, pp. 2828 - 2835
adolescent and young adults | colorectal cancer | biomarkers | F‐box and WD repeat‐containing protein 7 (FBXW7) | Adolescent and young adults | Biomarkers | F-box and WD repeat-containing protein 7 (FBXW7) | Colorectal cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | F-Box-WD Repeat-Containing Protein 7 | Colorectal Neoplasms - enzymology | Age Factors | F-Box Proteins - metabolism | Colorectal Neoplasms - genetics | Humans | Middle Aged | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Male | DNA Polymerase II - metabolism | Incidence | Poly-ADP-Ribose Binding Proteins | Aged, 80 and over | Cell Cycle Proteins - genetics | Female | Aged | Retrospective Studies | Mutation | Colorectal Neoplasms - pathology | Ubiquitin-Protein Ligases - genetics | DNA Polymerase II - genetics | F-Box Proteins - genetics | Cohort Studies | Diagnosis | Demographic aspects | Patient outcomes | Index Medicus | Abridged Index Medicus | AYA | iomarkers
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4. Full Text Stringent control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) protein degradation by FBW7 (F-box/WD Repeatcontaining Protein 7) and glycogen synthase kinase 3 (GSK3)
by Kannan, Meenakshi B and Dodard-Friedman, Isadore and Blank, Volker
The Journal of biological chemistry, ISSN 0021-9258, 10/2015, Volume 290, Issue 43, pp. 26292 - 26302
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | F-Box-WD Repeat-Containing Protein 7 | Phosphorylation | Basic-Leucine Zipper Transcription Factors - metabolism | F-Box Proteins - metabolism | Humans | Cell Cycle Proteins - metabolism | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Glycogen Synthase Kinase 3 - metabolism | Ubiquitination | Proteolysis | Proteasome Endopeptidase Complex - metabolism | Dimerization | Index Medicus | ubiquitin ligase | GSK3 | ubiquitination | Protein Synthesis and Degradation | NFE2L3 | E3 ubiquitin ligase | FBW7 | oxidative stress | protein degradation | ubiquitin
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5. Promotional effect of microRNA-194 on breast cancer cells via targeting F-box/WD repeat-containing protein 7
by Chen, Yaomin and Wei, Haiyan and Liu, Yu and Zheng, Shusen
Oncology letters, ISSN 1792-1074, 04/2018, Volume 15, Issue 4, pp. 4439 - 4444
Breast cancer | MicroRNA | Proliferation | F-box/WD repeat-containing protein 7 | Life Sciences & Biomedicine | Oncology | Science & Technology
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6. MiR-367 promotes the proliferation and invasion of non-small cell lung cancer via targeting FBXW7
by Xu, Jing and Wu, Weibing and Jun, Wang and Chenjun, Huang and Wen, Wei and Fei, Zhao and Xu, Xinfeng and Pan, Xianglong and Wei, Wang and Zhu, Quan and Chen, Liang
Oncology reports, ISSN 1021-335X, 02/2017, Volume 37, Issue 2, pp. 1052 - 1058
miR-367 | Proliferation | NSCLC | FBXW7 | Invasion | Life Sciences & Biomedicine | Oncology | Science & Technology | F-Box-WD Repeat-Containing Protein 7 | Lung Neoplasms - mortality | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Lung Neoplasms - pathology | Male | MicroRNAs - metabolism | Biomarkers, Tumor - metabolism | Cell Cycle Proteins - genetics | Female | 3' Untranslated Regions | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Cell Proliferation - genetics | Carcinoma, Non-Small-Cell Lung - genetics | F-Box Proteins - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Carcinoma, Non-Small-Cell Lung - mortality | Cell Line, Tumor | Aged | Biomarkers, Tumor - genetics | MicroRNAs - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics
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7. Full Text FBW7 (F-box and WD Repeat Domain-Containing 7) negatively regulates glucose metabolism by targeting the c-Myc/TXNIP (Thioredoxin-binding protein) axis in pancreatic cancer
by Ji, Shunrong and Qin, Yi and Liang, Chen and Huang, Run and Shi, Si and Liu, Jiang and Jin, Kaizhou and Liang, Dingkong and Xu, Wenyan and Zhang, Bo and Liu, Liang and Liu, Chen and Xu, Jin and Ni, Quanxing and Chiao, Paul J and Li, Min and Yu, Xianjun
Clinical cancer research, ISSN 1078-0432, 08/2016, Volume 22, Issue 15, pp. 3950 - 3960
Life Sciences & Biomedicine | Oncology | Science & Technology | Gene Expression | Pancreatic Neoplasms - metabolism | Pancreatic Neoplasms - diagnosis | Humans | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins c-myc - metabolism | Positron Emission Tomography Computed Tomography | Proteins | F-Box-WD Repeat-Containing Protein 7 - genetics | Animals | Carrier Proteins - metabolism | Heterografts | Cell Line, Tumor | Glucose - metabolism | Female | Fluorodeoxyglucose F18 | Mice | F-Box-WD Repeat-Containing Protein 7 - metabolism | Disease Models, Animal | Index Medicus
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8. Full Text FBXW7: A critical tumor suppressor of human cancers
by Yeh, Chien-Hung and Bellon, Marcia and Nicot, Christophe
Molecular cancer, ISSN 1476-4598, 08/2018, Volume 17, Issue 1, pp. 115 - 115
Mcl-1 | Jun | FBXW7 | HTLV | Notch | Cyclin E | C-myc | CDC4 | MTOR | Cancer | Biochemistry & Molecular Biology | Oncology | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | F-Box-WD Repeat-Containing Protein 7 - genetics | Prognosis | Neoplasms - genetics | Signal Transduction | Humans | Gene Expression Regulation, Neoplastic | MicroRNAs - genetics | RNA, Long Noncoding - genetics | Mutation | Proteasome Endopeptidase Complex - metabolism | F-Box-WD Repeat-Containing Protein 7 - metabolism | Cell proliferation | Phosphorylation | Usage | Research | Gene expression | Index Medicus | mcl-1
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9. Full Text The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response
by Zhang, Qiang and Mady, Ahmed S A and Ma, Yuanyuan and Ryan, Caila and Lawrence, Theodore S and Nikolovska-Coleska, Zaneta and Sun, Yi and Morgan, Meredith A
Nucleic acids research, ISSN 0305-1048, 05/2019, Volume 47, Issue 8, pp. 4039 - 4053
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Gamma Rays | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | Stem Cell Factor - genetics | Fibroblasts - ultrastructure | DNA-Binding Proteins - metabolism | F-Box-WD Repeat-Containing Protein 7 - genetics | Insulin-Secreting Cells - metabolism | DNA End-Joining Repair | Protein Domains | Protein Interaction Domains and Motifs | Binding Sites | Fibroblasts - metabolism | Cell Line | F-Box-WD Repeat-Containing Protein 7 - chemistry | Stem Cell Factor - metabolism | Protein Structure, Secondary | HCT116 Cells | Models, Molecular | Poly (ADP-Ribose) Polymerase-1 - metabolism | DNA-Binding Proteins - genetics | Cell Survival - radiation effects | Poly Adenosine Diphosphate Ribose - chemistry | Insulin-Secreting Cells - ultrastructure | Poly Adenosine Diphosphate Ribose - metabolism | Fibroblasts - radiation effects | Cell Line, Tumor | Protein Binding | Ubiquitination - radiation effects | DNA Damage | Mutation | Ataxia Telangiectasia Mutated Proteins - genetics | F-Box-WD Repeat-Containing Protein 7 - metabolism | Poly (ADP-Ribose) Polymerase-1 - genetics | Insulin-Secreting Cells - radiation effects | Index Medicus | Genome Integrity, Repair and
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10. Full Text The ubiquitin ligase FBXW7 targets the centriolar assembly protein HsSAS-6 for degradation and thereby regulates centriole duplication
by Badarudeen, Binshad and Gupta, Ria and Nair, Sreeja V and Chandrasekharan, Aneesh and Manna, Tapas K and Sung, Patrick
The Journal of biological chemistry, ISSN 0021-9258, 04/2020, Volume 295, Issue 14, pp. 4428 - 4437
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Gene Duplication | Humans | Cell Cycle Proteins - metabolism | Ubiquitin - metabolism | Substrate Specificity | Amino Acid Motifs | Centrosome - metabolism | Cell Cycle Proteins - chemistry | F-Box-WD Repeat-Containing Protein 7 - genetics | G1 Phase | Ubiquitination | RNA Interference | S Phase | Cell Cycle Proteins - genetics | Cell Line, Tumor | Protein Binding | Centrioles - metabolism | F-Box-WD Repeat-Containing Protein 7 - antagonists & inhibitors | Binding Sites | Centrioles - ultrastructure | F-Box-WD Repeat-Containing Protein 7 - metabolism | RNA, Small Interfering - metabolism | Index Medicus
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