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f-box-wd repeat-containing protein 7 (474) 474
ubiquitin-protein ligases - genetics (318) 318
f-box proteins - genetics (316) 316
cell cycle proteins - genetics (294) 294
f-box proteins - metabolism (270) 270
ubiquitin-protein ligases - metabolism (270) 270
cell cycle proteins - metabolism (252) 252
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phosphorylation (137) 137
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adult (67) 67
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proto-oncogene proteins c-myc - metabolism (64) 64
tumors (62) 62
gene (59) 59
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receptor, notch1 - genetics (56) 56
differentiation (55) 55
gene expression (55) 55
f-box-wd repeat-containing protein 7 - genetics (54) 54
f-box proteins (52) 52
cyclin e - metabolism (50) 50
fbw7 ubiquitin ligase (46) 46
health aspects (46) 46
ligases (46) 46
multidisciplinary sciences (46) 46
micrornas - genetics (44) 44
mutations (44) 44
protein binding (44) 44
protein stability (44) 44
glycogen synthase kinase 3 - metabolism (43) 43
hek293 cells (43) 43
genetics & heredity (42) 42
mice, knockout (42) 42
activation (41) 41
f-box proteins - physiology (41) 41
hematology (41) 41
ubiquitin-protein ligases - physiology (41) 41
genes (40) 40
molecular sequence data (40) 40
rna interference (40) 40
chromosomal instability (39) 39
analysis (38) 38
cdc4 protein (38) 38
f-box-wd repeat-containing protein 7 - metabolism (38) 38
proteasome endopeptidase complex - metabolism (38) 38
acute lymphoblastic-leukemia (37) 37
amino acid sequence (36) 36
cells (36) 36
colorectal cancer (36) 36
kinases (36) 36
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ubiquitin-protein ligases (36) 36
development and progression (35) 35
metastasis (34) 34
mice, nude (34) 34
proto-oncogene proteins c-myc - genetics (34) 34
tumor suppressor protein p53 - genetics (34) 34
breast-cancer (33) 33
cell cycle proteins - physiology (33) 33
precursor t-cell lymphoblastic leukemia-lymphoma - genetics (33) 33
transcription factors (33) 33
breast cancer (32) 32
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Cancer, ISSN 0008-543X, 09/2016, Volume 122, Issue 18, pp. 2828 - 2835
Journal Article
STEM CELLS, ISSN 1066-5099, 09/2017, Volume 35, Issue 9, pp. 2027 - 2036
The cancer stem cell (CSC) paradigm suggests that tumors are organized hierarchically. Chugai previously established an LGR5 + human colorectal cancer (CRC)... 
Cancer stem cells | F‐box/WD repeat‐containing protein 7 | c‐Myc | Colorectal cancer | Chemoresistance | F-box/WD repeat-containing protein 7 | c-Myc | INITIATING CELLS | HEMATOPOIETIC-CELL | COLON | IDENTIFICATION | CHROMOSOMAL INSTABILITY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | GENE | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DIFFERENTIATION | LEUKEMIA | HEMATOLOGY | TUMOR-GROWTH | EXPRESSION | Receptors, G-Protein-Coupled - metabolism | Neoplastic Stem Cells - drug effects | Colorectal Neoplasms - genetics | Humans | Antineoplastic Agents - therapeutic use | F-Box-WD Repeat-Containing Protein 7 - genetics | Proteolysis - drug effects | Neoplastic Stem Cells - metabolism | Colorectal Neoplasms - drug therapy | Neoplastic Stem Cells - pathology | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Liver Neoplasms - secondary | Proto-Oncogene Proteins c-myc - metabolism | Down-Regulation - genetics | Up-Regulation - drug effects | Drug Resistance, Neoplasm - genetics | Animals | Cell Line, Tumor | Mice | Receptors, G-Protein-Coupled - genetics | Colorectal Neoplasms - pathology | F-Box-WD Repeat-Containing Protein 7 - metabolism | Drug Resistance, Neoplasm - drug effects | Cell death | Liver | Colorectal carcinoma | c-Myc protein | Myc protein | Drug resistance | Cdc4 protein | Metastases | Anticancer properties | Antitumor agents | Cell cycle | siRNA | Tumor cell lines | Irinotecan | Chemotherapy | Molecular modelling | Overexpression | Ribonucleic acids | Stem cells | Regulatory mechanisms (biology) | Sensitivity enhancement | Differentiation | Tumors | Cancer | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 342 - 354
Journal Article
Oncology Letters, ISSN 1792-1074, 04/2018, Volume 15, Issue 4, pp. 4439 - 4444
Breast cancer is the most common type of malignant cancer in females. An increasing number of studies have revealed that microRNAs (miR), which belong to a... 
Breast cancer | MicroRNA | Proliferation | F-box/WD repeat-containing protein 7 | FBXW7 EXPRESSION | CYCLIN-E | SEL-10 | proliferation | C-MYC | breast cancer | GENE | ONCOLOGY | GASTRIC-CANCER | PATHWAY | MIRNA | microRNA | MIR-194
Journal Article
Oncology Reports, ISSN 1021-335X, 01/2017, Volume 37, Issue 2, pp. 1052 - 1058
The involvement of miR-367 in lung cancer development remains unclear. In the present study, we analyzed the expression of miR-367 in tumor and adjacent tissue... 
miR-367 | NSCLC | proliferation | invasion | FBXW7 | Proliferation | Invasion | CYCLIN-E | TUMOR-SUPPRESSOR GENE | DOWN-REGULATION | C-MYC | CERVICAL-CANCER | MCL-1 DEGRADATION | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | GASTRIC-CANCER | COLORECTAL-CANCER | ACUTE LYMPHOBLASTIC-LEUKEMIA | F-Box-WD Repeat-Containing Protein 7 | Lung Neoplasms - mortality | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Lung Neoplasms - pathology | Male | MicroRNAs - metabolism | Biomarkers, Tumor - metabolism | Cell Cycle Proteins - genetics | Female | 3' Untranslated Regions | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Cell Proliferation - genetics | Carcinoma, Non-Small-Cell Lung - genetics | F-Box Proteins - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Carcinoma, Non-Small-Cell Lung - mortality | Cell Line, Tumor | Aged | Biomarkers, Tumor - genetics | MicroRNAs - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Cellular proteins | Care and treatment | MicroRNA | Development and progression | Genetic aspects | Lung cancer, Non-small cell | Gene expression | Health aspects | Biotechnology | Thoracic surgery | Immunoglobulins | Lung cancer | Metastasis | Experiments | Cancer therapies | Proteins | Chemotherapy | Plasmids | Medical prognosis | Surgery | MicroRNAs | Binding sites | Apoptosis | Index Medicus
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 1/2015, Volume 11, Issue 1, pp. 105 - 112
Ampelopsin (AMP), a plant flavonoid, has been reported to inhibit cell growth and/or induce apoptosis in various types of tumor. The aim of the present study... 
lung cancer | ampelopsin | F-box/WD repeat-containing protein 7 | c-Myc | S-phase kinase-associated protein 2 | C-Myc | Ampelopsin | Lung cancer | MEDICINE, RESEARCH & EXPERIMENTAL | PHOSPHORYLATION | MITOGENS | MECHANISMS | PROTEOLYSIS | CANCER | WD repeat-containing protein 7 | F-box | ONCOLOGY | UBIQUITYLATION | DEGRADATION | INHIBITORS | FBW7 | TRANSCRIPTION FACTOR | F-Box-WD Repeat-Containing Protein 7 | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Membrane Potential, Mitochondrial - drug effects | RNA, Messenger - metabolism | Adenocarcinoma - metabolism | Adenocarcinoma - genetics | Adenosine Monophosphate - pharmacology | Flavonoids - pharmacology | Lung Neoplasms - genetics | Histone Deacetylase 2 - genetics | Adenosine Monophosphate - metabolism | F-Box Proteins - metabolism | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | S-Phase Kinase-Associated Proteins - genetics | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-myc - genetics | Histone Deacetylase 2 - metabolism | Flavonoids | Care and treatment | Flavones | Bioflavonoids | Genetic aspects | Research | Health aspects | Risk factors | Apoptosis | Cell proliferation | Adenocarcinoma | Cell culture | Flow cytometry | Histone deacetylase | Phosphorylation | Transcription factors | Bcl-2 protein | Epithelial cells | Leukemia | c-Myc protein | Reverse transcription | Propidium iodide | Myc protein | Drug resistance | Kinases | Western blotting | Plant cells | Cell adhesion & migration | Proteins | Cell growth | Enzymes | AMP | Glycogen | Glycogen synthase kinase 3 | Cell division | Breast cancer | Gene expression | Lymphoma | Polymerase chain reaction | Lymphocytes B | Annexin V | B-cell lymphoma
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 110 - 114
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 371 - 375
Cervical cancer is responsible for 10-15% of cancer-related deaths in women worldwide(1,2). The aetiological role of infection with high-risk human papilloma... 
DOMAIN | CATALOG | FUSION | MULTIDISCIPLINARY SCIENCES | FRAMEWORK | HUMAN-PAPILLOMAVIRUS | SENSITIVE DETECTION | CANCER | EXPRESSION | SOMATIC MUTATIONS | DISCOVERY | F-Box-WD Repeat-Containing Protein 7 | Receptor, ErbB-2 - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Genomics | Humans | E1A-Associated p300 Protein - genetics | Core Binding Factor beta Subunit - genetics | Case-Control Studies | Papillomaviridae - genetics | Tumor Suppressor Protein p53 - genetics | DNA Mutational Analysis | Mitogen-Activated Protein Kinase 1 - genetics | Cell Cycle Proteins - genetics | Female | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Papillomaviridae - physiology | HLA-B Antigens - genetics | Gene Expression Regulation, Neoplastic - genetics | Proto-Oncogene Proteins c-ets | Virus Integration - genetics | Proto-Oncogene Proteins - genetics | DNA Copy Number Variations - genetics | Transcriptome - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Uterine Cervical Neoplasms - genetics | Adenocarcinoma - virology | Genome, Human - genetics | Papillomavirus Infections - genetics | Exome - genetics | Uterine Cervical Neoplasms - virology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Prevention | Gene mutations | Oncology, Experimental | Exome sequencing | Genetic aspects | Research | Cervical cancer | Cancer | Human papillomavirus | Mutation | Index Medicus
Journal Article
Science, ISSN 0036-8075, 8/2011, Volume 333, Issue 6046, pp. 1154 - 1157