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Cancer Cell, ISSN 1535-6108, 2005, Volume 7, Issue 1, pp. 77 - 85
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e86102
Glioblastoma multiforme (GBM) accounts for about 38% of primary brain tumors in the United States. GBM is characterized by extensive angiogenesis induced by... 
MOLECULAR CHARACTERIZATION | HYPOXIA-INDUCIBLE FACTOR | DE-NOVO | OXYGEN-SENSING PATHWAY | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | PROLINE HYDROXYLATION | TUMOR-SUPPRESSOR PROTEIN | HIF-1-ALPHA | SECONDARY GLIOBLASTOMAS | BRAIN-TUMORS | Neoplasm Transplantation | Humans | Gene Expression Regulation, Neoplastic | Brain Neoplasms - genetics | Glucose Transporter Type 1 - metabolism | E1A-Associated p300 Protein - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Brain Neoplasms - metabolism | Cell Hypoxia | Repressor Proteins - physiology | Animals | Glioblastoma - genetics | Glucose Transporter Type 1 - genetics | Mice, Nude | Cell Line, Tumor | Glioblastoma - metabolism | Transcription, Genetic | Mice | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Mixed Function Oxygenases - physiology | Cytokines | Brain tumors | Genes | Genetic aspects | Genetic transcription | Glioblastoma multiforme | Vascular endothelial growth factor | Brain | Transcription factors | Hypoxia-inducible factor 1 | Transcription | Laboratories | Neuropathology | Brain cancer | Glioblastoma | Biochemistry | Gene deletion | Cancer therapies | Proteins | Angiogenesis | Clonal deletion | Tumorigenesis | Inhibition | Growth factors | Cell survival | Gynecology | Gene expression | Obstetrics | Studies | Hospitals | Hypoxia | Glioblastoma cells | Mutation | Molecular biology | PTEN protein | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 12, pp. 8769 - 8781
Factor Inhibiting HIF (FIH) catalyzes the beta-hydroxylation of asparagine residues in HIF-alpha transcription factors as well as ankyrin repeat domain (ARD)... 
CIRCULAR-DICHROISM SPECTRA | DOMAIN-CONTAINING PROTEINS | TRANSCRIPTIONAL ACTIVITY | STRUCTURAL BASIS | S6 ATPASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ASPARAGINYL HYDROXYLASE FACTOR | DYNAMICS | SECONDARY STRUCTURE | HIF-1-ALPHA | BETA-HYDROXYLATION | Transcription Factors - chemistry | Receptors, Notch - metabolism | Humans | Receptor, Notch1 - chemistry | Molecular Sequence Data | Mixed Function Oxygenases - metabolism | Receptors, Notch - genetics | Proto-Oncogene Proteins - chemistry | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Hydroxylation | Protein Structure, Secondary | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Ankyrin Repeat | Receptor, Notch1 - metabolism | Transcription Factors - genetics | Mice, Knockout | Transcription Factors - metabolism | Sequence Alignment | Animals | Receptors, Notch - chemistry | Protein Binding | Mice | Mixed Function Oxygenases - genetics | Receptor, Notch1 - genetics | Receptor, Notch4 | Gene Regulation | Hydroxylase | Protein Chemical Modification | Ankyrin Repeats | Hypoxia | Hypoxia-inducible Factor (HIF) | Enzymology | Factor Inhibiting HIF (FIH)
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, p. e25799
Our previous studies have shown that benzyl isothiocyanate (BITC) suppresses pancreatic tumor growth by inhibiting STAT-3; however, the exact mechanism of... 
MIGRATION | ORGANIZATION | APOPTOSIS | CANCER CELLS | CARCINOMA CELLS | BIOLOGY | VEGF EXPRESSION | CELL-CYCLE ARREST | RHO-GTPASES | HYPOXIA | ENDOTHELIAL GROWTH-FACTOR | Pancreatic Neoplasms - metabolism | rho GTP-Binding Proteins - antagonists & inhibitors | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Pancreatic Neoplasms - blood supply | Transcriptional Activation - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Vascular Endothelial Growth Factor A - genetics | Vascular Endothelial Growth Factor A - secretion | Vascular Endothelial Growth Factor Receptor-2 - genetics | Dose-Response Relationship, Drug | Isothiocyanates - therapeutic use | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Female | Isothiocyanates - pharmacology | STAT3 Transcription Factor - metabolism | Cell Hypoxia - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Matrix Metalloproteinase 2 - metabolism | Neoplasm Invasiveness | rho GTP-Binding Proteins - genetics | Pancreatic Neoplasms - pathology | Rats | Pancreatic Neoplasms - genetics | Down-Regulation - drug effects | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Animals | Signal Transduction - drug effects | Neovascularization, Pathologic - drug therapy | rho GTP-Binding Proteins - metabolism | Cell Line, Tumor | Matrix Metalloproteinase 2 - secretion | Mice | In Vitro Techniques | STAT3 Transcription Factor - antagonists & inhibitors | Health sciences | Phosphorylation | Leukocyte migration | Immunoblotting | Biology | Biochemistry | Metastasis | Kinases | Guanine nucleotide-binding protein | Cancer therapies | Eggs | Cell adhesion & migration | Metastases | Interleukin 6 | Angiogenesis | Signal transduction | Rodents | Hemoglobin | Aorta | Inhibition | Vascular endothelial growth factor | Plugs | Cytokines | Stat3 protein | Isothiocyanate | Permeability | Vascular endothelial growth factor receptors | Gelatinase A | Studies | Overexpression | Chorioallantoic membrane | Medical prognosis | Pancreatic cancer | Pharmacy | Hypoxia | Tumor suppressor genes | Photographs | Cell migration | Tumors | Cancer
Journal Article
Cell Metabolism, ISSN 1550-4131, 04/2018, Volume 27, Issue 4, pp. 898 - 913.e7
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are... 
HIF | hypoxia | metabolism | SKELETAL-MUSCLE | OXYGEN-CONSUMPTION | COMPLEX | FIH | ENDOCRINOLOGY & METABOLISM | TUMOR-SUPPRESSOR PROTEIN | ALPHA | HIF-1-ALPHA | VHL | EXPRESSION | INDUCIBLE-FACTOR | CELL BIOLOGY | Muscles | Physiological aspects | Neurosciences | Molecular biology | Analysis
Journal Article