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Free Radical Biology and Medicine, ISSN 0891-5849, 01/2015, Volume 78, pp. 202 - 212
The transcription factor Nrf2 regulates the basal and inducible expression of a battery of cytoprotective genes. Whereas numerous Nrf2-inducing small molecules... 
Brusatol | Free radicals | Hepatocyte | Nrf2 | Toxicity | Keap1 | Chemical stress | Cell defense | OXIDATIVE STRESS | ACTIVATION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-SYNTHESIS INHIBITION | CANCER | TRANSCRIPTION FACTOR NRF2 | DEFENSE PATHWAY | ACETAMINOPHEN | ENDOCRINOLOGY & METABOLISM | DEGRADATION | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Oxidative Stress | Apoptosis - drug effects | Humans | Hepatocytes - metabolism | Autophagy | Quassins - pharmacology | Hepatocytes - cytology | Carcinoma, Hepatocellular - drug therapy | Liver Neoplasms - pathology | NF-E2-Related Factor 2 - genetics | Real-Time Polymerase Chain Reaction | Hepatocytes - drug effects | Oxidation-Reduction | RNA, Messenger - genetics | Cells, Cultured | Liver Neoplasms - drug therapy | Reverse Transcriptase Polymerase Chain Reaction | Brucea - chemistry | Blotting, Western | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Proliferation - drug effects | Mice | Carcinoma, Hepatocellular - metabolism | Chemical inhibitors | Metabolites | Proteolysis | Health aspects | Quinone | Cells | Index Medicus | Gclm, glutamate–cysteine ligase regulatory subunit | NEM, N-ethylmaleimide | NAPQI, N-acetyl-p-benzoquinone imine | IAA, iodoacetamide | Nrf2, nuclear factor erythroid 2-related factor 2 | Original Contribution | Keap1, Kelch-like ECH-associated protein 1 | DNCB, 2,4-dinitrochlorobenzene | Nqo1, NAD(P)H dehydrogenase quinone 1 | CDDO-Me, methyl-2-cyano-3,12-dioxooleana-1, 9dien-28-oate | HIF-1α, hypoxia-inducible factor 1α | RT-qPCR, real-time quantitative PCR | AMC, 7-amino-4-methylcoumarin
Journal Article
by Ma, Q and Kinneer, K and Bi, Y and Chan, JY and Kan, YW
Biochemical Journal, ISSN 0264-6021, 01/2004, Volume 377, Issue 1, pp. 205 - 213
TCDD (2,3,7,8-tetrachlorodibenzo-p-dixoin) induces phase II drug-metabolizing enzyme NQO1 [NAD(P)H:quinone oxidoreductase; EC 1.6.99.2; DT-diaphorase] in a... 
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2004, Volume 377, Issue 1, pp. 205 - 213
TCDD (2,3,7,8-tetrachlorodibenzo-p-dixoin) induces phase II drug-metabolizing enzyme NQO1 [NAD(P)H:quinone oxidoreductase; EC 1.6.99.2; DT-diaphorase] in a... 
AhR (aryl hydrocarbon receptor) | DRE (dioxin response element) | TCDD (2,3,7,8-tetrachlorodibenzo-p- dioxin) | ARE (antioxidant response element) | NQO1 [NAD(P)H:quinone oxidoreductase 1] | Nrf2 (nuclear factor erythroid 2-related factor 2) | NQO1 [NAD(P)H : quinone oxidoreductase 1] | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | POLYMORPHISM | IDENTIFICATION | ANTIOXIDANT RESPONSE ELEMENT | CARCINOGENESIS | DT-DIAPHORASE | NQO1 GENE | GENE-EXPRESSION | TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) | UBIQUITIN-PROTEASOME PATHWAY | INDUCIBLE EXPRESSION | Leucine Zippers | Multienzyme Complexes - metabolism | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroquinones - pharmacology | Proteasome Endopeptidase Complex | Trans-Activators - chemistry | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Cysteine Endopeptidases - metabolism | Polychlorinated Dibenzodioxins - pharmacology | Receptors, Aryl Hydrocarbon - metabolism | Transcription, Genetic | Protein Synthesis Inhibitors - pharmacology | Ubiquitins - metabolism | DNA-Binding Proteins - physiology | Signal Transduction | Cells, Cultured | Enzyme Induction | Antioxidants - pharmacology | DNA-Binding Proteins - chemistry | Cycloheximide - pharmacology | NAD(P)H Dehydrogenase (Quinone) - biosynthesis | Animals | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Ligands | NF-E2-Related Factor 2 | Trans-Activators - metabolism | Mice
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2015, Volume 88, Issue Pt B, pp. 417 - 426
In light of the emerging interplay between redox and metabolic signaling pathways we investigated the potential cross talk between nuclear factor E2-related... 
Xanthohumol | Nrf2 | ER stress | AMPK | HO-1 | PERK | LKB1 | MEF | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | MECHANISMS | ENERGY SENSOR | CELL DEFENSE PATHWAY | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | NRF2-MEDIATED INDUCTION | HEME OXYGENASE-1 | STRESS | AMP-Activated Protein Kinases - metabolism | Heme Oxygenase-1 - metabolism | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Oxidative Stress - physiology | Propiophenones - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Cross-Talk - physiology | Blotting, Western | Animals | Flow Cytometry | Fibroblasts - drug effects | NF-E2-Related Factor 2 - metabolism | Signal Transduction - physiology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Mice | Real-Time Polymerase Chain Reaction | Unfolded Protein Response - physiology | Fibroblasts - metabolism | RNA | Glycogen | Synthesis | ACC, acetyl-CoA carboxylase | CHO, Chinese hamster ovary | GSH, glutathione (reduced) | OCR, oxygen consumption rate | HO-1, heme oxygenase 1 | CaMKK, calcium calmodulin-dependent kinase kinase | Maf, small musculoaponeurotic fibrosarcoma | PERK, protein kinase RNA-like endoplasmic reticulum kinase | Xn, xanthohumol | Hrd1, synoviolin | TAK, transforming growth factor β-activated kinase | UPR, unfolded protein response | Hrd1 (HMG-CoA reductase degradation)-ubiquitin ligase | MEF, mouse embryonic fibroblasts | βTrcP1, β-transducin-repeat containing protein 1 | mTOR, mammalian target of rapamycin | ROS, reactive oxygen species | LKB1, liver kinase B1 | Keap1, Kelch-like ECH-associated protein | GSSG, oxidized glutathione | ARE, antioxidant response element | WT, wild type | GSK3β, glycogen synthase kinase 3β | Nrf2, nuclear factor E2-related factor 2 | AMPK, AMP-activated kinase | DCF, dichlorofluorescein | NADPH, nicotinamide adenine dinucleotide phosphate | DMSO, dimethyl sulfoxide | ER, endoplasmic reticulum | FCS, fetal calf serum
Journal Article
Journal Article