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Journal Article
American Heart Journal, ISSN 0002-8703, 2010, Volume 160, Issue 4, pp. 635 - 641.e2
Journal Article
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 2008, Volume 47, Issue 3, pp. 203 - 216
Journal Article
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 04/2010, Volume 103, Issue 4, pp. 815 - 825
Journal Article
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 05/2017, Volume 15, Issue 5, pp. 931 - 937
Essentials FXaI16L is a recombinant zymogen‐like variant of activated coagulation factor X (FXa). A phase 1 dose escalation clinical trial of FXaI16L was... 
clinical trial | hematologic agents | hemorrhagic disorders | blood coagulation factor | activated partial thromboplastin time | PF‐05230907 | PF-05230907 | HUMAN-PLASMA | ACTIVATION | PROTEIN | BYPASS | FACTOR-VIII | SPONTANEOUS INTRACEREBRAL HEMORRHAGE | THROMBIN GENERATION | INHIBITION | HEMOPHILIA-A | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Factor Xa - administration & dosage | Injections, Intravenous | Area Under Curve | Fibrin Fibrinogen Degradation Products - metabolism | Humans | Prothrombin Time | Half-Life | Male | Metabolic Clearance Rate | Recombinant Proteins | Healthy Volunteers | Young Adult | Peptide Hydrolases - blood | Antithrombin III | Coagulants - administration & dosage | Peptide Fragments - blood | Adult | Coagulants - pharmacokinetics | Factor Xa - adverse effects | Factor Xa - immunology | Double-Blind Method | Factor Xa - pharmacokinetics | Biomarkers - blood | Blood Coagulation - drug effects | Partial Thromboplastin Time | Adolescent | Prothrombin | Antibodies - blood | Coagulants - adverse effects | Coagulants - immunology | Coagulation factor X | Pharmacodynamics | Intravenous administration | Toxicity | Coagulation | Clinical trials | Thrombin | Antithrombin | Hemorrhage | Bleeding | Antibody response | Proenzymes | Thromboplastin | Coagulation factors | Immunogenicity | Plasma levels | Pharmacokinetics
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 12/2015, Volume 373, Issue 25, pp. 2413 - 2424
Journal Article
American Heart Journal, ISSN 0002-8703, 2010, Volume 159, Issue 3, pp. 340 - 347.e1
Background Atrial fibrillation (AF), the most common significant cardiac arrhythmia, increases the risk of stroke, particularly in the elderly. Warfarin is... 
Cardiovascular | ENOXAPARIN | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | BAY 59-7939 | WARFARIN | ANTITHROMBOTIC THERAPY | PLACEBO-CONTROLLED TRIALS | DEEP-VEIN THROMBOSIS | ACTIVE-CONTROL TRIALS | THROMBOPROPHYLAXIS | ANTICOAGULATION | Factor Xa Inhibitors | Follow-Up Studies | Thiophenes - adverse effects | Humans | Warfarin - adverse effects | Secondary Prevention | Thiophenes - administration & dosage | Warfarin - therapeutic use | Fibrinolytic Agents - adverse effects | Rivaroxaban | Vitamin K - antagonists & inhibitors | Embolism - etiology | Morpholines - adverse effects | Stroke - prevention & control | Embolism - prevention & control | Double-Blind Method | Drug Administration Schedule | Administration, Oral | Atrial Fibrillation - drug therapy | Morpholines - administration & dosage | Risk Factors | Medical Records | Anticoagulants - therapeutic use | Anticoagulants - adverse effects | Stroke - etiology | Fibrinolytic Agents - administration & dosage | Hemorrhage - chemically induced | Research Design | Prevention | Stroke (Disease) | Warfarin | Diet therapy | Atrial fibrillation | Clinical trials | Comparative analysis | Vitamins | Cardiac arrhythmia | Anticoagulants | Stroke | Aspirin | Embolisms | Patients | Studies | Hepatitis | Human immunodeficiency virus--HIV | Blood pressure | Clinical medicine | Drug therapy | Drug dosages | Age
Journal Article