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Nature, ISSN 0028-0836, 09/2008, Volume 455, Issue 7211, pp. 416 - 420
Translation initiation, the rate- limiting step of the universal process of protein synthesis, proceeds through sequential, tightly regulated steps. In... 
MESSENGER-RNA TRANSLATION | BACTERIA | BOOTSTRAP | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | MOVEMENT | FMET-TRNA(FMET) | TERMINATION | BINDING | RIBOSOMAL-SUBUNIT | Ribosome Subunits - chemistry | RNA, Transfer, Met - ultrastructure | Ribosomes - metabolism | Crystallography, X-Ray | Multiprotein Complexes - genetics | Thermus thermophilus - ultrastructure | Guanosine Triphosphate - metabolism | Peptide Chain Initiation, Translational | RNA, Messenger - metabolism | RNA, Transfer, Met - genetics | Multiprotein Complexes - metabolism | Thermus thermophilus - genetics | Prokaryotic Initiation Factor-1 - chemistry | Guanosine Triphosphate - chemistry | Prokaryotic Initiation Factor-1 - ultrastructure | Prokaryotic Initiation Factor-2 - chemistry | Prokaryotic Initiation Factor-2 - ultrastructure | Thermus thermophilus - enzymology | RNA, Messenger - genetics | RNA, Transfer, Met - metabolism | Ribosomes - chemistry | Models, Molecular | Prokaryotic Initiation Factor-1 - genetics | Cryoelectron Microscopy | Multiprotein Complexes - ultrastructure | Multiprotein Complexes - chemistry | Ribosomes - ultrastructure | RNA, Transfer, Met - chemistry | Ribosome Subunits - ultrastructure | Prokaryotic Initiation Factor-1 - metabolism | Prokaryotic Initiation Factor-2 - metabolism | Protein Conformation | RNA, Messenger - chemistry | Ribosome Subunits - metabolism | Prokaryotic Initiation Factor-2 - genetics | Physiological aspects | Protein biosynthesis | Research | RNA | Ribosomal proteins | Genetic translation | Proteins | Bacteria | Statistical analysis | Methods | Crystal structure | Prokaryotic Initiation Factor-1 | Prokaryotic Initiation Factor-2 | Multiprotein Complexes | Biochemistry, Molecular Biology | Ribosomes | Cellular Biology | RNA, Transfer, Met | Thermus thermophilus | Life Sciences | Ribosome Subunits | RNA, Messenger | Guanosine Triphosphate
Journal Article
Blood, ISSN 0006-4971, 2011, Volume 118, Issue 9, pp. 2578 - 2588
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 27, pp. 9983 - 9988
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 08/2012, Volume 72, Issue 16, pp. 3906 - 3911
Hypoxia within a tumor acts as a strong selective pressure that promotes angiogenesis, invasion, and metastatic spread. In this study, we used immune competent... 
LUNG | METASTATIC NICHE | ONCOLOGY | INDUCIBLE FACTOR-1
Journal Article
Nature, ISSN 0028-0836, 12/2015, Volume 528, Issue 7581, pp. 218 - 224
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2006, Volume 103, Issue 41, pp. 15136 - 15141
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 11/2016, Volume 99, Issue 5, pp. 1190 - 1198
Uveal melanoma (UM) is a rare intraocular tumor that, similar to cutaneous melanoma, originates from melanocytes. To gain insights into its genetics, we... 
OCULAR MELANOMA | CELLS | COLORECTAL-CANCER | PROTEINS DLK1 | METASTASES | GENETICS & HEREDITY | RISK | EXPRESSION | RADIATION | SF3B1 | SOMATIC MUTATIONS | Melanoma - diagnosis | Exons | Humans | Middle Aged | Male | Phosphoproteins - metabolism | Case-Control Studies | RNA Splicing Factors - metabolism | DNA Copy Number Variations | Melanoma - genetics | Melanocytes - pathology | Tumor Suppressor Proteins - genetics | Aged, 80 and over | Ubiquitin Thiolesterase - metabolism | Adult | Female | Membrane Proteins - metabolism | Eukaryotic Initiation Factor-1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Uveal Neoplasms - genetics | Genome-Wide Association Study | Tumor Suppressor Proteins - metabolism | GTP-Binding Protein alpha Subunits - metabolism | Tumor Suppressor p53-Binding Protein 1 - genetics | Membrane Proteins - genetics | Eukaryotic Initiation Factor-1 - genetics | Ubiquitin-Protein Ligases - metabolism | GTP-Binding Protein alpha Subunits - genetics | Phosphoproteins - genetics | RNA Splicing Factors - genetics | Ubiquitin Thiolesterase - genetics | Skin Neoplasms | Uveal Neoplasms - diagnosis | Aged | Mutation | Ubiquitin-Protein Ligases - genetics | Genetic aspects | Nucleotide sequencing | Methods | Melanoma | DNA sequencing | Report
Journal Article
Circulation, ISSN 0009-7322, 06/2010, Volume 121, Issue 24, pp. 2661 - 2671
Background-Excessive proliferation and impaired apoptosis of pulmonary artery (PA) smooth muscle cells (PASMCs) contribute to vascular obstruction in patients... 
genetic | mitochondrial diseases | epigenesis | hypoxia-inducible factor-1 | gene silencing | pulmonary | oxidation-reduction | subunit | hypertension | superoxide dismutase 2 | MULTIPLE-MYELOMA | APOPTOSIS | METHYLATION | CARDIAC & CARDIOVASCULAR SYSTEMS | hypertension, pulmonary | epigenesis, genetic | HYPOXIA | CANCER | OVEREXPRESSION | GENE | hypoxia-inducible factor-1, alpha-subunit | PATHWAY | DNA METHYLTRANSFERASE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | SOD2 EXPRESSION | Superoxide Dismutase - genetics | Cell Proliferation | Mitochondria, Muscle - enzymology | Humans | Myocytes, Smooth Muscle - pathology | Rats | Hypertension, Pulmonary - metabolism | Rats, Sprague-Dawley | Hydrogen Peroxide - metabolism | Epigenesis, Genetic - physiology | Phenotype | Animals | Biomimetics | Epigenesis, Genetic - genetics | Rats, Mutant Strains | Adenoviridae - genetics | Hypertension, Pulmonary - drug therapy | Hypertension, Pulmonary - pathology | Myocytes, Smooth Muscle - metabolism | Superoxide Dismutase - metabolism | Apoptosis | Disease Models, Animal | Cell proliferation | Physiological aspects | Development and progression | Superoxide dismutase | Research | Vascular smooth muscle | Pulmonary hypertension | Epigenetic gene methylation | DNA methyltransferase | Pulmonary arterial hypertension | Hypoxia-inducible factor-1α (HIF-1α) | Voltage-gated potassium channels (Kv1.5)
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2007, Volume 293, Issue 2, pp. 621 - 631
The nucleus pulposus is an aggrecan-rich, avascular tissue that permits the intervertebral disk to resist compressive loads. In the disk, nucleus pulposus... 
Hypoxia-inducible factor-1α | Hypoxia | LACTATE-DEHYDROGENASE | hypoxia | ACTIVATION | PHYSIOLOGY | TRANSCRIPTION | FACTOR-I | CELL BIOLOGY | HIF-1 | ARTICULAR-CARTILAGE | RESPONSE ELEMENTS | ADAPTATION | BINDING-SITES | hypoxia-inducible factor-1 alpha | HYPOXIA-INDUCIBLE FACTOR-1
Journal Article
FEBS Letters, ISSN 0014-5793, 02/2006, Volume 580, Issue 3, pp. 755 - 762
Majority of cancer cells upregulate co-inhibitory molecule B7-H1 which confers resistance to anti-tumor immunity, allowing cancers to escape from host immune... 
IFN-γ | B7-H1 | IRF-1 | JAK/STAT pathway | interferon-γ | STAT | JAK | Janus activated kinase | interferon regulatory factor-1 | signal transducer and activator of transcription | TRANSCRIPTIONAL ACTIVATION | T-CELL IMMUNITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | FAMILY | MOLECULES | CELL BIOLOGY | BIOPHYSICS | IFN-gamma | EPITHELIAL-CELLS | LIGANDS | NUCLEAR FACTOR | PROMOTER | NF-KAPPA-B | Tumor Escape - drug effects | RNA, Small Interfering - genetics | Transcription, Genetic - drug effects | B7-1 Antigen - genetics | Tumor Escape - genetics | Humans | Membrane Glycoproteins - biosynthesis | Peptides - genetics | Promoter Regions, Genetic - genetics | Protein-Tyrosine Kinases - immunology | Antineoplastic Agents - metabolism | Signal Transduction - immunology | RNA, Small Interfering - immunology | Antineoplastic Agents - pharmacology | Electrophoretic Mobility Shift Assay | B7-1 Antigen - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Membrane Glycoproteins - immunology | Gene Expression Regulation, Neoplastic - genetics | Interferon Regulatory Factor-1 - biosynthesis | Tumor Escape - immunology | Mutagenesis, Site-Directed | B7-1 Antigen - immunology | B7-H1 Antigen | Interferon Regulatory Factor-1 - immunology | Peptides - immunology | RNA, Small Interfering - pharmacology | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic - immunology | Up-Regulation - genetics | Tyrphostins - pharmacology | Interferon Regulatory Factor-1 - genetics | Membrane Glycoproteins - genetics | Up-Regulation - drug effects | Signal Transduction - drug effects | Up-Regulation - immunology | Interferon-gamma - immunology | Transcription, Genetic - immunology | HeLa Cells | Promoter Regions, Genetic - immunology | Transcription, Genetic - genetics | Interferon-gamma - pharmacology | Antigens, CD | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Journal Article