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Nature, ISSN 0028-0836, 09/2008, Volume 455, Issue 7211, pp. 416 - 420
Translation initiation, the rate- limiting step of the universal process of protein synthesis, proceeds through sequential, tightly regulated steps. In... 
MESSENGER-RNA TRANSLATION | BACTERIA | BOOTSTRAP | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | MOVEMENT | FMET-TRNA(FMET) | TERMINATION | BINDING | RIBOSOMAL-SUBUNIT | Ribosome Subunits - chemistry | RNA, Transfer, Met - ultrastructure | Ribosomes - metabolism | Crystallography, X-Ray | Multiprotein Complexes - genetics | Thermus thermophilus - ultrastructure | Guanosine Triphosphate - metabolism | Peptide Chain Initiation, Translational | RNA, Messenger - metabolism | RNA, Transfer, Met - genetics | Multiprotein Complexes - metabolism | Thermus thermophilus - genetics | Prokaryotic Initiation Factor-1 - chemistry | Guanosine Triphosphate - chemistry | Prokaryotic Initiation Factor-1 - ultrastructure | Prokaryotic Initiation Factor-2 - chemistry | Prokaryotic Initiation Factor-2 - ultrastructure | Thermus thermophilus - enzymology | RNA, Messenger - genetics | RNA, Transfer, Met - metabolism | Ribosomes - chemistry | Models, Molecular | Prokaryotic Initiation Factor-1 - genetics | Cryoelectron Microscopy | Multiprotein Complexes - ultrastructure | Multiprotein Complexes - chemistry | Ribosomes - ultrastructure | RNA, Transfer, Met - chemistry | Ribosome Subunits - ultrastructure | Prokaryotic Initiation Factor-1 - metabolism | Prokaryotic Initiation Factor-2 - metabolism | Protein Conformation | RNA, Messenger - chemistry | Ribosome Subunits - metabolism | Prokaryotic Initiation Factor-2 - genetics | Physiological aspects | Protein biosynthesis | Research | RNA | Ribosomal proteins | Genetic translation | Proteins | Bacteria | Statistical analysis | Methods | Crystal structure | Prokaryotic Initiation Factor-1 | Prokaryotic Initiation Factor-2 | Multiprotein Complexes | Biochemistry, Molecular Biology | Ribosomes | Cellular Biology | RNA, Transfer, Met | Thermus thermophilus | Life Sciences | Ribosome Subunits | RNA, Messenger | Guanosine Triphosphate
Journal Article
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 507 - 511
The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer's, Parkinson's and... 
UNFOLDED PROTEIN RESPONSE | TOXICITY IN-VIVO | ALZHEIMERS-DISEASE | ER STRESS | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | MICE | ENDOPLASMIC-RETICULUM STRESS | DYSFUNCTION | PRP | PROTEOSTASIS | Neurons - pathology | Neuroprotective Agents | Phosphorylation | Prions - genetics | Eukaryotic Initiation Factor-2 - chemistry | Neurodegenerative Diseases - etiology | PrPSc Proteins - analysis | Synapses - pathology | Thiourea - pharmacology | Phosphoproteins - metabolism | Repressor Proteins - analysis | PrPSc Proteins - metabolism | Synapses - metabolism | Phosphoproteins - analysis | Protein Folding - drug effects | Protein Phosphatase 1 - genetics | Eukaryotic Initiation Factor-2 - metabolism | Synaptic Transmission - drug effects | Cell Death - drug effects | PrPSc Proteins - toxicity | Neurons - drug effects | Repressor Proteins - metabolism | Prions - metabolism | Synapses - drug effects | Repressor Proteins - chemistry | Neurodegenerative Diseases - pathology | Mice, Inbred C57BL | Kaplan-Meier Estimate | Hippocampus - pathology | Prion Diseases - pathology | Neurodegenerative Diseases - metabolism | Hippocampus - cytology | Cinnamates - pharmacology | Eukaryotic Initiation Factor-2 - analysis | Hippocampus - metabolism | Protein Phosphatase 1 - metabolism | Animals | Prions - biosynthesis | Protein Biosynthesis - drug effects | Mice | Unfolded Protein Response - physiology | Thiourea - analogs & derivatives
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 34, pp. 15163 - 15168
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2012, Volume 48, Issue 5, pp. 667 - 680
Journal Article