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Journal of Cellular Physiology, ISSN 0021-9541, 04/2008, Volume 215, Issue 1, pp. 1 - 7
Fibroblast growth factor‐21 (FGF‐21) is a metabolic regulator that can influence glucose and lipid control in diabetic rodents and primates. We demonstrate... 
SIGNAL | PPAR-ALPHA | REGULATOR | HOMEOSTASIS | PHYSIOLOGY | FIBROBLAST-GROWTH-FACTOR-21 | FACTOR-21 | FIBROBLAST-GROWTH-FACTOR | FGF-21 | METABOLIC-RATE | EXPRESSION | CELL BIOLOGY
Journal Article
Cell Metabolism, ISSN 1550-4131, 2010, Volume 11, Issue 3, pp. 206 - 212
Plasma FGF21 levels and hepatic gene expression increase dramatically after birth in mice. This induction is initiated by suckling, requires lipid intake, is... 
HUMDISEASE | DEVBIO | OBESITY | LIPID-METABOLISM | METABOLIC REGULATOR | FIBROBLAST-GROWTH-FACTOR-21 | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | FIBROBLAST GROWTH FACTOR-21 | LINK | MICE | INDUCTION | INSULIN SENSITIVITY | CELL BIOLOGY
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 10/2018, Volume 239, Issue 1, pp. 73 - 80
Fibroblast growth factor 21 (FGF21) is a metabolic regulator of energy and lipid metabolism. FGF21 is highly expressed in liver while FGF21 receptors... 
adipose tissue | fasting | FGF21 receptors | obesity | FGF21 | PPAR-ALPHA | FIBROBLAST-GROWTH-FACTOR-21 | BETA-KLOTHO EXPRESSION | FIBROBLAST | FACTOR-21 | METABOLISM | ENDOCRINOLOGY & METABOLISM | FGF-21 | HEPATIC STEATOSIS | GROWTH-FACTOR 21
Journal Article
NEUROSCIENCE LETTERS, ISSN 0304-3940, 01/2017, Volume 638, pp. 35 - 38
Fibroblast growth factor 21 (FGF21) is primarily secreted by the liver as an endocrine hormone and is suggested as a promising target for the treatment of... 
PPAR-ALPHA | FIBROBLAST-GROWTH-FACTOR-21 | MEDIATOR | FACTOR-21 | NEUROSCIENCES | Glucose tolerance | Prazosin | OBESITY | METABOLIC REGULATOR | INSULIN-RESISTANCE | Phentolamine | Adrenergic receptor | GROWTH-FACTOR 21 | FGF21
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2018, Volume 497, Issue 4, pp. 1097 - 1103
Brown adipose tissue (BAT) has been found as an endocrine organ that maintains metabolic homeostasis; however, the effects on atherosclerosis remain undefined.... 
Fibroblast growth factor-21 | Brown adipose tissue | Sympathetic nervous system | Atherosclerosis | Adiponectin | GAMMA | FIBROBLAST-GROWTH-FACTOR-21 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN SENSITIVITY | GLUCOSE-HOMEOSTASIS | ENERGY-EXPENDITURE | BIOPHYSICS | METABOLISM | GROWTH | FAT | Index Medicus
Journal Article
LANCET NEUROLOGY, ISSN 1474-4422, 09/2011, Volume 10, Issue 9, pp. 806 - 818
Background Muscle biopsy is the gold standard for diagnosis of mitochondrial disorders because of the lack of sensitive biomarkers in serum. Fibroblast growth... 
PPAR-ALPHA | VALOSIN-CONTAINING PROTEIN | OBESITY | METABOLIC REGULATOR | FIBROBLAST-GROWTH-FACTOR-21 | FATTY LIVER-DISEASE | DISORDERS | SERUM FGF21 LEVELS | PREVALENCE | GROWTH-FACTOR 21 | CLINICAL NEUROLOGY
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 11/2009, Volume 297, Issue 5, pp. 1105 - 1114
Recombinant fibroblast growth factor (FGF)21 has antihyperglycemic, antihyperlipidemic, and antiobesity effects in diabetic rodent and monkey models. Previous... 
Blood glucose | Signal transduction | Fibroblast growth factor 21 | Hepatic glucose production | Insulin | fibroblast growth factor 21 | BETA-KLOTHO | blood glucose | ACTIVATION | PHYSIOLOGY | insulin | RAT PANCREAS | FIBROBLAST-GROWTH-FACTOR-21 | signal transduction | SENSITIVITY | MECHANISMS | hepatic glucose production | METABOLIC REGULATOR | ENDOCRINOLOGY & METABOLISM | FIBROBLAST GROWTH FACTOR-21 | FGF-21 | Islets of Langerhans - drug effects | Area Under Curve | Humans | Male | Adipocytes - drug effects | Dose-Response Relationship, Drug | Adipose Tissue - metabolism | Hypoglycemic Agents | Liver Neoplasms, Experimental - metabolism | Liver - drug effects | Insulin Resistance - physiology | Islets of Langerhans - metabolism | Enzyme-Linked Immunosorbent Assay | Liver - metabolism | Mice, Inbred C57BL | Islet Amyloid Polypeptide - metabolism | Fibroblast Growth Factors - pharmacology | Recombinant Proteins - pharmacology | 3T3-L1 Cells | Blotting, Western | Obesity - metabolism | Animals | Fibroblast Growth Factors - pharmacokinetics | Diet | Cell Differentiation - drug effects | Cell Line, Tumor | Mice, Obese | Mice | Glucose Clamp Technique | Adipose Tissue - drug effects | Adipose tissues | Blood sugar | Liver | Insulin resistance | Development and progression | Fibroblast growth factors | Cellular signal transduction | Research | Properties | Tissue | Obesity | Rodents | Glucose | Diabetes | Effects | Index Medicus
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 04/2008, Volume 22, Issue 4, pp. 1006 - 1014
Fibroblast growth factor (FGF) 21, a structural relative of FGF23 that regulates phosphate homeostasis, is a regulator of insulin-independent glucose transport... 
FACTOR FAMILY | PPAR-ALPHA | FIBROBLAST-GROWTH-FACTOR-21 | GENE | SPECIFICITY | METABOLIC-ACTIVITY | ENDOCRINOLOGY & METABOLISM | HEPARAN-SULFATE | MICE | SUPPRESSION | EXPRESSION
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e63517 - e63517
Fibroblast growth factor 21 (FGF21) plays an important role in the regulation of energy homeostasis during starvation and has an excellent therapeutic... 
PPAR-ALPHA | ACTIVATION | OBESITY | METABOLIC REGULATOR | FIBROBLAST-GROWTH-FACTOR-21 | MULTIDISCIPLINARY SCIENCES | FIBROBLAST GROWTH FACTOR-21 | INDUCTION | FGF-21 | HEPATIC STEATOSIS | HUMAN SKELETAL-MUSCLE | Health | Humans | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Fibroblast Growth Factors - genetics | Male | Young Adult | Animals | Exercise | Activating Transcription Factor 4 - metabolism | Fibroblast Growth Factors - blood | Mice | PPAR alpha - metabolism | Physical Conditioning, Animal | Type 2 diabetes | Genes | Muscles | Glycerol | Glucose | Gene expression | Fatty acids | Dextrose | Glycerin | Glucose metabolism | Physiological aspects | Fibroblast growth factors | Health aspects | Diabetes therapy | Health sciences | Fibroblast growth factor | Adipose tissue | Liver | Homeostasis | Monkeys | Kinases | Autophagy | Rodents | Fibroblasts | Physiology | Oxidation | Lipid metabolism | Growth factors | Obesity | Maximum oxygen consumption | Starvation | Fitness equipment | Diabetes mellitus | Activating transcription factor 4 | Oxygen consumption | Catecholamines | Metabolism | Insulin | Lipolysis | Skeletal muscle | Medicine | Serum levels | Human subjects | Energy balance | Musculoskeletal system | Physical fitness | Brain-derived neurotrophic factor | Running | Insulin resistance | Diabetes | Laboratory animals | Metabolic disorders | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 08/2008, Volume 8, Issue 2, pp. 169 - 174
FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARα in rodents. However, the physiological role of FGF21 in... 
HUMDISEASE | BETA-KLOTHO | FGF19 | SUBFAMILY MEMBERS | FACTOR-21 | ENDOCRINOLOGY & METABOLISM | RECEPTOR | FIBROBLAST-GROWTH-FACTOR | BILE-ACID SYNTHESIS | DIURNAL-VARIATION | FIBROBLAST-GROWTH-FACTOR-19 | EXPRESSION | CELL BIOLOGY
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 06/2012, Volume 153, Issue 6, pp. 2689 - 2700
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2007, Volume 282, Issue 37, pp. 26687 - 26695
The fibroblast growth factor (FGF) 19 subfamily of ligands, FGF19, FGF21, and FGF23, function as hormones that regulate bile acid, fatty acid, glucose, and... 
FACTOR FAMILY | PPAR-ALPHA | FIBROBLAST-GROWTH-FACTOR-21 | PHOSPHATE HOMEOSTASIS | STRUCTURAL BASIS | NEGATIVE FEEDBACK-REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BILE-ACID SYNTHESIS | DOMINANT HYPOPHOSPHATEMIC RICKETS | MICE | SUPPRESSION
Journal Article
FEBS Letters, ISSN 0014-5793, 2008, Volume 582, Issue 12, pp. 1725 - 1730
Journal Article