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Cancer immunology, immunotherapy, ISSN 1432-0851, 11/2008, Volume 58, Issue 7, pp. 1033 - 1045
Lenalidomide (Revlimid®; CC-5013) and pomalidomide (CC-4047) are IMiDs® proprietary drugs having immunomodulatory properties that have both shown activity in... 
Immunomodulatory drugs | Biomedicine | Immunology | Lenalidomide | T regulatory cells | Cancer Research | Oncology | Pomalidomide | IMiDs | Life Sciences & Biomedicine | Science & Technology | Forkhead Transcription Factors - immunology | Receptors, Nerve Growth Factor - immunology | Receptors, Transforming Growth Factor beta - immunology | Receptors, Nerve Growth Factor - drug effects | Humans | Receptors, Nerve Growth Factor - metabolism | Thalidomide - pharmacology | Colonic Neoplasms - metabolism | Receptors, OX40 - immunology | T-Lymphocytes, Regulatory - immunology | Thalidomide - analogs & derivatives | Receptors, OX40 - metabolism | Transforming Growth Factor beta - drug effects | Colonic Neoplasms - immunology | Forkhead Transcription Factors - metabolism | Interleukin-10 - metabolism | Female | Antineoplastic Agents - pharmacology | Forkhead Transcription Factors - antagonists & inhibitors | Immunosuppressive Agents - pharmacology | Receptors, Tumor Necrosis Factor - metabolism | Transforming Growth Factor beta - immunology | Glucocorticoid-Induced TNFR-Related Protein | T-Lymphocytes, Regulatory - drug effects | Animals | Receptors, Transforming Growth Factor beta - drug effects | Receptors, Transforming Growth Factor beta - metabolism | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Receptors, Tumor Necrosis Factor - immunology | Interleukin-10 - immunology | Transforming Growth Factor beta - metabolism | Receptors, Tumor Necrosis Factor - drug effects | Receptors, OX40 - antagonists & inhibitors | Care and treatment | Dexamethasone | Multiple myeloma | Angiogenesis inhibitors | Transforming growth factors | T cells | Cancer | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 03/2014, Volume 508, Issue 7494, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably. In... 
Antineoplastic Agents/administration & dosage | Transforming Growth Factor beta/metabolism | Humans | Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors | Indoles/administration & dosage | Flow Cytometry | Receptor, Platelet-Derived Growth Factor beta/biosynthesis | Proto-Oncogene Proteins B-raf/antagonists & inhibitors | ErbB Receptors/biosynthesis | Melanoma/drug therapy | Female | Cell Proliferation/drug effects | Sulfonamides/administration & dosage | Gene Library | Cellular Senescence/drug effects | Receptor Protein-Tyrosine Kinases/biosynthesis | Drug Resistance, Neoplasm/drug effects | Gene Expression Regulation, Neoplastic/drug effects | SOXE Transcription Factors/deficiency | Signal Transduction/drug effects | Protein Kinase Inhibitors/administration & dosage | Vemurafenib | Animals | Mice | RNA, Small Interfering | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Receptor, Epidermal Growth Factor - genetics | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Melanoma - genetics | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 10/2012, Volume 109, Issue 41, pp. 16618 - 16623
Although the role of TGF-ß in tumor progression has been studied extensively, its impact on drug delivery in tumors remains far from understood. In this study,... 
Cell growth | Receptors | Perfusion | Collagens | Antineoplastics | Blood vessels | Metastasis | Tumors | Cancer | Apoptosis | Breast cancer | Drug delivery | Vessel normalization | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Antibodies, Neutralizing - administration & dosage | Doxorubicin - therapeutic use | Receptors, Transforming Growth Factor beta - genetics | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Breast Neoplasms - metabolism | Tissue Distribution | Antibodies, Neutralizing - immunology | Lung Neoplasms - secondary | Transforming Growth Factor beta - antagonists & inhibitors | Female | Antibiotics, Antineoplastic - pharmacokinetics | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta - immunology | Collagen Type I - metabolism | Protein-Serine-Threonine Kinases - genetics | Treatment Outcome | Signal Transduction - genetics | Breast Neoplasms - drug therapy | Blotting, Western | Doxorubicin - pharmacokinetics | Antibiotics, Antineoplastic - administration & dosage | Xenograft Model Antitumor Assays | Animals | Lung Neoplasms - prevention & control | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Transforming Growth Factor beta - metabolism | Index Medicus | Biological Sciences | breast cancer | Physical Sciences | drug delivery | vessel normalization
Journal Article
The EMBO journal, ISSN 0261-4189, 03/2011, Volume 30, Issue 5, pp. 823 - 834
Somatic cells can be reprogrammed to an ES‐like state to create induced pluripotent stem cells (iPSCs) by ectopic expression of four transcription factors,... 
gene expression regulation | miRNA | iPS cells | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Receptors, Transforming Growth Factor beta - genetics | Cell Proliferation | Luciferases - metabolism | Oligonucleotide Array Sequence Analysis | Cell Dedifferentiation | Gene Expression Profiling | Embryo, Mammalian - metabolism | Cellular Reprogramming | Teratoma - metabolism | Epithelial-Mesenchymal Transition | Biomarkers, Tumor - metabolism | Transcription, Genetic | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - physiology | RNA Processing, Post-Transcriptional | RNA, Messenger - genetics | Cells, Cultured | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Embryonic Stem Cells - physiology | Teratoma - pathology | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Transforming Growth Factor beta - genetics | Receptors, Transforming Growth Factor beta - metabolism | Embryo, Mammalian - cytology | Mice, Nude | Teratoma - genetics | Biomarkers, Tumor - genetics | Fibroblasts - cytology | Mice | Nuclear Proteins - physiology | RNA, Small Interfering | MicroRNAs - physiology | Transforming Growth Factor beta - metabolism | Proteins | Cell growth | Ribonucleic acid--RNA | Gene expression | Molecular biology | Index Medicus
Journal Article
Nature cell biology, ISSN 1476-4679, 06/2012, Volume 14, Issue 7, pp. 717 - 726
Journal Article