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Journal Article
Journal Article
Science, ISSN 0036-8075, 1/2002, Volume 295, Issue 5552, pp. 140 - 143
Tumstatin is a 28-kilodalton fragment of type IV collagen that displays both anti-angiogenic and proapoptotic activity. Here we show that tumstatin functions... 
Phosphorylation | Messenger RNA | Protein synthesis | Long term potentiation | Reports | Angiogenesis inhibitors | Endothelial cells | Medical schools | Integrins | Apoptosis | Tumors | RAPAMYCIN | TARGET | ANGIOGENESIS | CAP-DEPENDENT INITIATION | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | DISTINCT ANTITUMOR PROPERTIES | TRANSLATION | ENDOSTATIN | Endothelium, Vascular - cytology | Protein Kinases - metabolism | Autoantigens - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Protein-Serine-Threonine Kinases | Molecular Sequence Data | Endothelium, Vascular - drug effects | Peptide Fragments - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Phosphoproteins - metabolism | RNA Caps - metabolism | RNA, Messenger - metabolism | Eukaryotic Initiation Factor-4E | Focal Adhesion Kinase 1 | Collagen Type IV - chemistry | Collagen Type IV - pharmacology | Cattle | Protein Synthesis Inhibitors - pharmacology | Receptors, Vitronectin - metabolism | Tumor Cells, Cultured | Autoantigens - pharmacology | Collagen Type IV - metabolism | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Signal Transduction | RNA, Messenger - genetics | Cells, Cultured | Focal Adhesion Protein-Tyrosine Kinases | Autoantigens - chemistry | Enzyme Activation - drug effects | Peptide Initiation Factors - metabolism | Proto-Oncogene Proteins c-akt | Adaptor Proteins, Signal Transducing | Protein Kinase Inhibitors | Animals | Carrier Proteins - metabolism | Endothelium, Vascular - metabolism | Protein Biosynthesis - drug effects | Mice | TOR Serine-Threonine Kinases | Proteins | Synthesis | Organic compounds | Cellular biology | Cells | TOR protein | tumstatin | FAK protein | initiation factor eIF-4E | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 03/2008, Volume 68, Issue 6, pp. 1935 - 1944
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2018, Volume 20, Issue 12, pp. 1634 - 1642
Abstract Background GSK2256098 is a novel oral focal adhesion kinase (FAK) inhibitor. Preclinical studies demonstrate growth inhibition in glioblastoma cell... 
glioblastoma | GSK2256098 | focal adhesion kinase | PET | MIGRATION | MULTICENTER | LOMUSTINE | PHASE-III | COMBINATION | CLINICAL NEUROLOGY | FAK | ONCOLOGY | TEMSIROLIMUS | EXPRESSION | BRAIN
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 11/2018, Volume 138, Issue 11, pp. 2452 - 2460
Formation of scars after wounding or trauma represents a significant health care burden costing the economy billions of dollars every year. Activation of focal... 
FAK | focal adhesion kinase | HTS | hypertrophic scar | focal adhesion kinase inhibitor | FAKI | phosphorylated | p | HYDROGELS | ADVANCED SOLID TUMORS | REGENERATION | CHITOSAN | SKIN | PHASE-I | CANCER | PULMONARY-FIBROSIS | PULLULAN | DERMATOLOGY
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2012, Volume 30, Issue 13, pp. 1527 - 1533
Purpose PF-00562271 is a novel inhibitor of focal adhesion kinase (FAK). The objectives of this study were to identify the recommended phase II dose (RP2D) and... 
FAK OVEREXPRESSION | INVASIVENESS | MIGRATION | CELLS | HEPATOCELLULAR-CARCINOMA | METASTASIS | ONCOLOGY | PYK2 | PHOSPHORYLATION | CANCER | PROGRESSION | United States | Humans | Middle Aged | Male | Positron-Emission Tomography | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Focal Adhesion Kinase 2 - antagonists & inhibitors | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Enzyme Inhibitors - pharmacokinetics | Focal Adhesion Kinase 2 - metabolism | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Radiopharmaceuticals | Focal Adhesion Kinase 1 - metabolism | Protein Kinase Inhibitors - pharmacokinetics | Drug Administration Schedule | Pyrimidines - administration & dosage | Neoplasms - enzymology | Treatment Outcome | Neoplasms - diagnostic imaging | Sulfonamides - pharmacokinetics | Neoplasms - drug therapy | Canada | Protein Kinase Inhibitors - administration & dosage | Maximum Tolerated Dose | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Pyrimidines - adverse effects | Midazolam - metabolism | Pyrimidines - pharmacokinetics | Sulfonamides - adverse effects | Fluorodeoxyglucose F18 | Aged | Australia | Neoplasm Staging | Neoplasms - pathology | Nonlinear Dynamics | Focal Adhesion Kinase 1 - antagonists & inhibitors | Sulfonamides - administration & dosage | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 10/2013, Volume 49, Issue 4, pp. 536 - 543
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase involved in various biological functions, including cell survival, proliferation, migration, and... 
Fibroblast | Pulmonary fibrosis | Focal adhesion kinase | T-CELL MIGRATION | LUNG FIBROSIS | TGF-BETA | COLLAGEN | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYOFIBROBLAST | CELL BIOLOGY | FAK | IN-VITRO | fibroblast | focal adhesion kinase | RESPIRATORY SYSTEM | pulmonary fibrosis | IMATINIB | GROWTH-FACTOR | Focal Adhesion Kinase 1 - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Actins - metabolism | Insulin-Like Growth Factor I - genetics | Pulmonary Fibrosis - genetics | Platelet-Derived Growth Factor - genetics | Actins - genetics | Myofibroblasts - metabolism | Cell Differentiation - genetics | Phosphorylation - genetics | Bleomycin | Collagen Type I - genetics | Female | Pulmonary Fibrosis - metabolism | Phosphorylation - drug effects | Focal Adhesion Kinase 1 - metabolism | Fibroblasts - metabolism | Collagen Type I - metabolism | Mice, Inbred C57BL | Mesenchymal Stromal Cells - metabolism | Morpholines - pharmacology | DNA - metabolism | Myofibroblasts - drug effects | Platelet-Derived Growth Factor - metabolism | Tyrosine - metabolism | Animals | Transforming Growth Factor beta - genetics | Cell Differentiation - drug effects | Fibroblasts - drug effects | Pulmonary Fibrosis - chemically induced | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Pulmonary Fibrosis - drug therapy | Focal Adhesion Kinase 1 - antagonists & inhibitors | Transforming Growth Factor beta - metabolism | Insulin-Like Growth Factor I - metabolism | Tyrosine - genetics | Index Medicus
Journal Article
Annals of oncology : official journal of the European Society for Medical Oncology, ISSN 0923-7534, 12/2016, Volume 27, Issue 12, pp. 2268 - 2274
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 11/2009, Volume 101, Issue 10, pp. 1699 - 1708
BACKGROUND: Here, we explore the therapeutic potential of dasatinib, a small-molecule inhibitor that targets multiple cytosolic and membrane-bound tyrosine... 
Dasatinib | FAK | Eph2A | Src | UPA | Ovarian cancer | ovarian cancer | TYROSINE KINASE | uPA | PATIENT SELECTION | BREAST-CANCER | dasatinib | MOLECULAR MARKERS | ONCOLOGY | PROSTATE-CANCER | ANCHORAGE-INDEPENDENT GROWTH | FOCAL ADHESION KINASE | FACTOR-BINDING PROTEIN-2 | SRC FAMILY KINASES | C-SRC | Apoptosis - drug effects | Humans | Ovarian Neoplasms - pathology | Receptor, EphA2 - metabolism | Thiazoles - administration & dosage | Gene Expression Profiling | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Ovarian Neoplasms - genetics | Flow Cytometry | src-Family Kinases - metabolism | Inhibitory Concentration 50 | Female | Phosphorylation - drug effects | Focal Adhesion Kinase 1 - metabolism | Ovarian Neoplasms - drug therapy | Proto-Oncogene Proteins c-yes - metabolism | Cell Growth Processes - drug effects | Pyrimidines - administration & dosage | src-Family Kinases - antagonists & inhibitors | Pyrimidines - pharmacology | Ovarian Neoplasms - enzymology | Cell Movement - drug effects | Protein Kinase Inhibitors - administration & dosage | Proto-Oncogene Proteins c-yes - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Receptor, EphA2 - antagonists & inhibitors | Cell Cycle - drug effects | Focal Adhesion Kinase 1 - antagonists & inhibitors | Index Medicus | Translational Therapeutics
Journal Article