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Molecular cancer therapeutics, ISSN 1535-7163, 01/2019, Volume 18, Issue 1, pp. 17 - 27
Small cell lung cancer (SCLC) has a poor prognosis. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase regulating cell proliferation, survival,... 
UNITED-STATES | SURVIVAL | ACTIVATION | TYROSINE PHOSPHORYLATION | ONCOLOGY | SAFETY | GROWTH | FAK INHIBITOR | PROLIFERATION | V-SRC | TRENDS | PF-573,228 | FRNK | Rac1 | small cell lung cancer | FAK inhibition | FAK shRNA
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2019, Volume 168, pp. 366 - 383
Phytohormones have shown great potential as natural anticancer compounds, being interesting in cancer prevention and therapy. Strigolactones are a class of... 
VEGFR2 | Angiogenesis | FAK | Cytoskeleton | GR-24 | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 03/2011, Volume 30, Issue 13, pp. 1566 - 1576
Journal Article
Cell Adhesion & Migration, ISSN 1933-6918, 01/2019, Volume 13, Issue 1, pp. 1 - 12
The natural flavonoid quercetin has antioxidant, anti-inflammatory, and anticancer effects. We investigated the effect of quercetin on lipopolysaccharide... 
migration | macrophage | iNOS/FAK-paxillin pathway | Quercetin | PAXILLIN | TYROSINE PHOSPHORYLATION | ACTIN | P38 MAPK | CELL BIOLOGY | MAPK ACTIVATION | FAK | CELL-MIGRATION | NITRIC-OXIDE | FOCAL ADHESION KINASE | ERK
Journal Article
Biomedical Research (India), ISSN 0970-938X, 2018, Volume 29, Issue 12, pp. 2490 - 2494
Journal Article
Oncotarget, 2015, Volume 6, Issue 30, pp. 29585 - 29598
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2014, Volume 450, Issue 4, pp. 1696 - 1701
Tumor-infiltrating macrophages are potential candidates for cancer immunotherapy. However, the detailed molecular mechanism underlying macrophage infiltration... 
FAK | PAI-1 | LRP1 | Invasion | Melanoma | Macrophage
Journal Article
Biochemical and biophysical research communications, 08/2019
Journal Article
CANCERS, ISSN 2072-6694, 06/2019, Volume 11, Issue 6, p. 758
Exosomes are one of the most important mediators of the cross talk occurring between glioma stem cells (GSCs) and the surrounding microenvironment. We have... 
glioblastoma microenvironment | Semaphorin 7A | PLEXIN C1 | TRANSMEMBRANE | CANCER | GLIOBLASTOMA STEM-CELLS | EXTRACELLULAR VESICLES | ONCOLOGY | exosomes | integrin beta 1/FAK signalling | GROWTH | motility | FOCAL ADHESION KINASE | RECEPTORS | BRAIN | integrin β1/FAK signalling
Journal Article
Cancers, ISSN 2072-6694, 06/2019, Volume 11, Issue 6, p. 813
Metabolic reprogramming is a common phenomenon in cancers. Thus, glycolytic enzymes could be exploited to selectively target cancer cells in cancer therapy.... 
metastasis | FAK/ERK signaling | ovarian cancer | HK2 | stemness
Journal Article
Neuroscience Letters, ISSN 0304-3940, 04/2018, Volume 672, pp. 96 - 102
Neurogenesis in the cerebral infarction after an ischemic event is important to the rehabilitation of patients. However, the mechanism of angiogenesis around... 
Angiogenesis | Cerebral ischemia | NGF | Neurogenesis | P-FAK | CELLS | ENDOGENOUS NEUROGENESIS | ARTERY OCCLUSION | PROLIFERATION | MODEL | NEUROSCIENCES | NERVE GROWTH-FACTOR | FAK | Nerve growth factor | Index Medicus
Journal Article
12/2017, Volume 7, Issue 89, pp. 5628 - 56288
We aim to explore the role of semaphorin 7A (SEMA7A) and its receptor plexin C1 in the migration of NSCLC cells. In the present study, expression of SEMA7A and... 
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2019, Volume 509, Issue 4, pp. 1034 - 1040
Malignant melanoma typically metastasizes to lymph nodes (LNs) as a primary or in-transit lesion before secondary metastasis occurs, and LN biopsy is a common... 
α4 integrin | FAK | VCAM-1 | Metastasis | Lymph node | Melanoma
Journal Article
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 09/2018, Volume 503, Issue 2, pp. 843 - 848
Acid ceramidase (ASAH1) has been implicated in the progression and chemoresistance in different cancers. Its role in colon cancer biology and response to... 
APOPTOSIS | beta 1 integrin/FAK | BIOCHEMISTRY & MOLECULAR BIOLOGY | Chemoresistance | AKT | Acid ceramidase | CHEMOTHERAPY | p53 | OVEREXPRESSION | FAK | Colon cancer | Oxaliplatin | BIOPHYSICS | PHARMACOLOGICAL-INHIBITION | COLORECTAL-CANCER | RESISTANCE | NF-KAPPA-B | TUMOR-GROWTH
Journal Article
Molecular Medicine Reports, ISSN 1791-2997, 08/2013, Volume 8, Issue 2, pp. 703 - 707
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2010, Volume 399, Issue 3, pp. 434 - 439
► Integrin α8β1 is expressed at significant levels in normal intestinal crypt cells. ► Integrin α8β1 deficiency confers anoikis resistance to human intestinal... 
FAK | Anoikis | Integrin | Crypt | Intestine
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 03/2003, Volume 160, Issue 5, pp. 769 - 780
Collagen plays a critical role in hemostasis by promoting adhesion and activation of platelets at sites of vessel injury. In the present model of... 
FAK | Blood platelets | PLCγ2 | Inregrin α | Cell spreading | integrin α2β1; blood platelets; cell spreading; PLCγ2; FAK
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2019, Volume 854, pp. 9 - 21
Colitis-associated cancer (CAC) has a close relationship with ulcerative colitis (UC). Therapeutic effect of Schisandrin B (SchB) on UC and CAC remains largely... 
Gut microbiota | Ulcerative colitis (UC) | Schisandrin B (SchB) | Focal adhesion kinase (FAK) | Colitis-associated cancer (CAC) | CELLS | BARRIER | RECEPTOR | P-GLYCOPROTEIN | SIGNAL-TRANSDUCTION | FAK | IMPACT | INHIBITION | INFLAMMATION | GROWTH | PHARMACOLOGY & PHARMACY
Journal Article
RSC Advances, ISSN 2046-2069, 2017, Volume 7, Issue 89, pp. 56280 - 56288
We aim to explore the role of semaphorin 7A (SEMA7A) and its receptor plexin C1 in the migration of NSCLC cells. In the present study, expression of SEMA7A and... 
FAK | COLLAPSIN | CHEMISTRY, MULTIDISCIPLINARY | FAMILY
Journal Article
Cellular Signalling, ISSN 0898-6568, 08/2019, Volume 60, pp. 91 - 99
Despite advances in therapies to treat breast cancer, over 100,000 patients die in the UK of this disease per year, highlighting the need to develop effect... 
Phosphorylation | Molecular subtypes | Breast cancer | Focal adhesion kinase | Survival | Tumour microenvironment | PATHWAYS | ACTIVATION | MAP-KINASE | NUCLEAR FAK | CLASSIFICATION | CELL BIOLOGY | SIGNAL-TRANSDUCTION | OVEREXPRESSION | FAK CONTROLS | CARCINOMAS | EXPRESSION | Care and treatment | Chemotherapy | Patient outcomes | Analysis | T cells | Cancer
Journal Article
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