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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 513, Issue 4, pp. 1055 - 1062
The main purpose of this study is to explore the role of integrin αvβ5 in hepatic sinusoidal capillarization under high glucose/ox-LDL conditions. Establish... 
FAK | Vitronectin | Liver sinusoidal endothelial cells | Integrin αvβ5 | ERK
Journal Article
Experimental Cell Research, ISSN 0014-4827, 12/2018, Volume 373, Issue 1-2, pp. 99 - 111
Neuroinflammation is often associated with pathological changes in the function of the blood-brain barrier (BBB) caused by disassembly of tight and adherens... 
FAK | Blood-brain barrier | α5β1 integrin | Actin | Src | Transendothelial migration | Fibronectin | integrin
Journal Article
Oncogene, ISSN 0950-9232, 02/2008, Volume 27, Issue 10, pp. 1439 - 1448
Signals from fibronectin-binding integrins promote neural crest cell motility during development in part through protein-tyrosine kinase (PTK) activation.... 
α4 integrin | FAK | Motility | Neuroblastoma | Src | α5 integrin | signaling | neuroblastoma | motility
Journal Article
Genes and Cancer, ISSN 1947-6019, 03/2016, Volume 7, Issue 3-4, pp. 110 - 124
MUC16, a heavily glycosylated type-I transmembrane mucin is overexpressed in several cancers including pancreatic ductal adenocarcinoma (PDAC). Previously, we... 
Metastasis | MUC16 | Pancreatic cancer | FAK and CRISPR/Cas9 | FAK | CRISPR | pancreatic cancer | metastasis | Research Paper | Cas9
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 01/2012, Volume 196, Issue 2, pp. 223 - 232
Cell migration is a dynamic process that involves the continuous formation, maturation, and turnover of matrix-cell adhesion sites. New (nascent) adhesions... 
CYTOSKELETAL | FERM DOMAIN | PAXILLIN | INTEGRIN ACTIVATION | PROTEIN | CALPAIN-MEDIATED PROTEOLYSIS | KINASE FAK | DYNAMICS | BINDING | REVEALS | CELL BIOLOGY | Adhesions | Motility | Cell adhesion | Physiological aspects | Research | Cells | Integrins | Index Medicus | s
Journal Article
BBA - General Subjects, ISSN 0304-4165, 05/2019, Volume 1863, Issue 5, pp. 813 - 829
The matricellular protein periostin (PN) promotes postnatal valve remodeling and maturation. Incomplete remodeling of the valve can trigger degenerative... 
Fak | Pak1 | Actin-remodeling | Valve-interstitial-fibroblast cell | Periostin | α5β1-integrin
Journal Article
CANCERS, ISSN 2072-6694, 06/2019, Volume 11, Issue 6
Metabolic reprogramming is a common phenomenon in cancers. Thus, glycolytic enzymes could be exploited to selectively target cancer cells in cancer therapy.... 
STEM-CELLS | FAK/ERK signaling | ovarian cancer | stemness | 2-DEOXY-D-GLUCOSE | PROLIFERATION | HK2 | BETA | GLYCOLYSIS | FAK | ONCOLOGY | metastasis | FOCAL ADHESION KINASE | CARCINOMA | CONTRIBUTES | EXPRESSION
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 02/2018, Volume 110, Issue 2, pp. 195 - 204
Background: Overexpression of focal adhesion kinase (FAK) has been reported in lung cancer, but the somatic mutations and alternative splicing variants of this... 
FAK | OVEREXPRESSION | EVENTS | MESSENGER-RNA | GENE | ONCOLOGY | LANDSCAPE | RESISTANCE | IDENTIFICATION | INHIBITOR | AUTOPHOSPHORYLATION | Index Medicus
Journal Article
Atherosclerosis, ISSN 0021-9150, 2009, Volume 208, Issue 2, pp. 358 - 365
Abstract Smooth muscle cell (SMC) migration involves interactions of integrin receptors with extracellular matrix (ECM) and is an important process of... 
Cardiovascular | FRNK | SMC | FAK | Integrin receptors | Migration | Periostin
Journal Article
BMC Pharmacology and Toxicology, ISSN 2050-6511, 10/2018, Volume 19, Issue 1, pp. 64 - 64
BackgroundAn increasing number of studies are investigating the effects of Chinese medicine on hepatic fibrosis, but only few studies have examined the... 
Hepatic stellate cells | Activation | FAK/Akt/β-catenin | Liver fibrosis | Artesunate | APOPTOSIS | FAK/Akt/beta-catenin | RATS | PROLIFERATION | MECHANISMS | BETA-CATENIN | IN-VITRO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | FOCAL ADHESION KINASE | GROWTH-FACTOR | EXPRESSION | Studies | Collagen | Liver | Rodents | Gene expression | Kinases | Cell adhesion & migration | Apoptosis
Journal Article
by Chen, B and Hu, ZM and Li, BF and Lin, X and Luo, ZJ and Hu, ZQ
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, ISSN 1936-2625, 2019, Volume 12, Issue 6, pp. 2381 - 2388
Objective: To investigate the expression and clinical significance of Shh, Gli1, FAK, p-FAK and p-AKT in HCC. Methods: Immunohistochemistry was used to measure... 
PROTEIN | SONIC HEDGEHOG | GLI | KINASE | Hepatocellular carcinoma | PATHOLOGY | Gli1 | p-FAK | CANCER | FAK | Shh | p-AKT | ONCOLOGY | SIGNALING PATHWAY | MEDIATED ACTIVATION
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 12, pp. 10228 - 10246
Membrane trafficking via the Golgi-localised KDEL receptor activates signalling cascades that coordinate both trafficking and other cellular functions,... 
Cell signalling | FAK | Membrane trafficking | Src | KDEL receptor
Journal Article
Molecular cancer research : MCR, ISSN 1541-7786, 4/2014, Volume 12, Issue 4, pp. 514 - 526
Despite the tremendous advances in the treatment of childhood kidney tumors, there remain subsets of pediatric renal tumors that continue to pose a therapeutic... 
PF-573,228 | FAK | SK-NEP-1 G401 | Y15
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 01/2019, Volume 18, Issue 1, pp. 139 - 146
TRAF2, a RING finger adaptor protein, plays an important function in tumor necrosis factor (TNF)-and TNF-like weak inducer of apoptosis (TWEAK)-dependent... 
PATHWAYS | BCL-2 | FAK | ACTIVATION | ONCOLOGY | PHOSPHORYLATION | N-TERMINAL KINASE | RESISTANCE | FACTOR-KAPPA-B | TNF | EXPRESSION
Journal Article
Methods in Enzymology, ISSN 0076-6879, 01/2019, Volume 621, pp. 131 - 152
Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Although the efficient recombinant production of active PTKs is... 
Kinase activity | Kinase recombinant expression | Lyn | Protein tyrosine kinase | FAK | Src
Conference Proceeding