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Trends in molecular medicine, ISSN 1471-4914, 9/2018, Volume 24, Issue 9, pp. 781 - 793
Studies have proven that per- and polyfluoroalkyl substances are harmful to humans, most notably PFOS (perfluorooctanesulfonate). PFOS induces rapid... 
microtubule | Sertoli cell injury | environmental toxicant | FAK | actin | human Sertoli cell | rpS6 | cytoskeleton | mTORC1 | PFOS
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 33, pp. 54735 - 54746
Argonaute 2 (AGO2) protein is usually overexpressed in various head and neck squamous cell carcinoma. However, the precise molecular mechanisms of AGO2 in... 
Cell proliferation | Hypopharyngeal cancer | FAK/PI3K/AKT signaling pathway | AGO2 | HEAD | cell proliferation | CARDIOMYOCYTE PROLIFERATION | CANCER | CELL BIOLOGY | TRANSLATIONAL REPRESSION | INHIBITION | ARGONAUTE 2 | PROTEINS | EXPRESSION | CARCINOMA | ASSOCIATION | hypopharyngeal cancer
Journal Article
Cancer Research, ISSN 0008-5472, 2019, Volume 79, Issue 10, pp. 2619 - 2633
The PDLIM2 protein regulates stability of transcription factors including NF-kappa B and STATs in epithelial and hemopoietic cells. PDLIM2 is strongly... 
MIGRATION | LIM DOMAIN PROTEIN | PROFILES | ONCOLOGY | INSULIN-LIKE-GROWTH | SUBTYPES | FAK ACTIVATION | DEFICIENT | E-CADHERIN | CELL-LINES | EXPRESSION
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 09/2005, Volume 24, Issue 42, pp. 6406 - 6417
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 514, Issue 2, pp. 524 - 529
The biophysical microenvironment of the tumor site has significant impact on breast cancer progression and metastasis. The importance of altered... 
FAK | AMPK | Mechanotransduction | Src | Metabolic signaling | Physiological aspects | Development and progression | Breast cancer | Metastasis | Biomedical engineering
Journal Article
Lung Cancer, ISSN 0169-5002, 2008, Volume 64, Issue 3, pp. 263 - 270
Abstract Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Osteopontin (OPN), which is abundantly... 
Hematology, Oncology and Palliative Medicine | Pulmonary/Respiratory | FAK | Integrin | OPN | Lung cancer | Migration
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2019, Volume 512, Issue 2, pp. 182 - 188
Background Ventilator-induced lung injury (VILI) is the most common complication in the mechanical ventilation in clinic. The pathogenesis of VILI has not been... 
FAK | Sox11 | Mouse | Ventilator induced lung injury | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITOR | EXPRESSION | Lung diseases | Analysis
Journal Article
Genes and Cancer, ISSN 1947-6019, 2012, Volume 3, Issue 5-6, pp. 371 - 381
The Cas family proteins, p130(Cas) (Cas) and NEDD9, are adaptor molecules that regulate cytoskeletal dynamics to promote multiple cellular processes, including... 
FAK | NEDD9 | Rac1 | Cas | mechanosensor | Src | Monographs
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2019, Volume 62, Issue 5, pp. 2508 - 2520
Focal adhesion tyrosine kinase (PTK2) is often overexpressed in human hepatocellular carcinoma (HCC), and several reports have linked PTK2 depletion and/or... 
FAK | OVEREXPRESSION | HEPATOCELLULAR-CARCINOMA | COMPLEX | CHEMISTRY, MEDICINAL | STRUCTURE-GUIDED DESIGN | PROTEIN-DEGRADATION | INHIBITOR | PROTAC DESIGN | CANCER | E3 UBIQUITIN LIGASE
Journal Article
Nature Medicine, ISSN 1078-8956, 08/2016, Volume 22, Issue 8, pp. 851 - 860
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKIN WOUND REPAIR | DUCTAL ADENOCARCINOMA | DECREASES GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-INFILTRATING MACROPHAGES | 2 KNOCKOUT MICE | ACTIN CYTOSKELETAL REARRANGEMENT | TISSUE STIFFNESS | CELL BIOLOGY | FAK | ANTIGEN RECEPTOR | T-CELLS | Immunohistochemistry | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Tumor Microenvironment | Deoxycytidine - pharmacology | Immunoblotting | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Immunotherapy | Antimetabolites, Antineoplastic - pharmacology | Carcinoma, Pancreatic Ductal - immunology | Disease Models, Animal | Tumor Escape - immunology | Immunotherapy, Adoptive - methods | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Pancreatic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Disease Progression | Animals | Aminopyridines - pharmacology | Pancreatic Neoplasms - immunology | Fibrosis | Cell Proliferation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Deoxycytidine - analogs & derivatives | Molecular targeted therapy | Care and treatment | Pancreatic cancer | Patient outcomes | Innovations | Genetic aspects | Properties | Phosphotransferases | Methods | Kinases | Cell adhesion & migration | Index Medicus | pancreatic cancer | PDAC | CXCL12 | VS-4718 | immunotherapy | fibrosis | tumor microenvironment | PD-1
Journal Article
Journal Article
by Lu, JX and Li, X and Tu, K and Guan, YL and Fung, KP and Liu, FY
ONCOTARGETS AND THERAPY, ISSN 1178-6930, 2019, Volume 12, pp. 5823 - 5833
Background and purpose: Verticillin A is a fungal epipolythiodioxopiperazine (ETP) metabolite that was isolated from Amanita flavorubescens Alk infected by... 
SRC | RECEPTOR | MET/HGF SIGNALING PATHWAY | PROGNOSTIC VALUE | FAK | OVEREXPRESSION | INHIBITION | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | verticillin A | cell migration | c-Met | MET | EXPRESSION | gastric and cervical cancers | Verticillin A | c-Met;FAK | Gastric and Cervical cancer
Journal Article