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by Li, YW and Zhao, CY and Luo, F and Liu, ZY and Gui, XR and Luo, ZP and Zhang, X and Li, D and Liu, C and Li, XM
CELL RESEARCH, ISSN 1001-0602, 09/2018, Volume 28, Issue 9, pp. 897 - 903
alpha-Synuclein (alpha-syn) amyloid fibrils are the major component of Lewy bodies, which are the pathological hallmark of Parkinson's disease (PD) and other... 
SYSTEM | CELLS | FILAMENTS | ALZHEIMERS-DISEASE | MUTATION | STATE | FAMILIAL PARKINSONS-DISEASE | SECRETION | BINDING | AGGREGATION | CELL BIOLOGY
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 12/2012, Volume 4, Issue 164
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson's disease (PD). Although biochemical studies have... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | MUTANT | LOCALIZATION | NEURONAL TOXICITY | FAMILIAL PARKINSONS-DISEASE | AUTOPHAGY | INHIBITORS | PROTEIN-PHOSPHORYLATION | GTP-BINDING | ASSOCIATION | CELL BIOLOGY
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 2014, Volume 34, Issue 1, pp. 249 - 259
Familial Parkinson disease is associated with mutations in alpha-synuclein (alpha-syn), a presynaptic protein that has been localized not only to the cytosol,... 
ALZHEIMER-DISEASE | OXIDATIVE STRESS | FUSION | PROTEIN | INHIBITION | VESICLES | ENDOPLASMIC-RETICULUM | TOXICITY | FAMILIAL PARKINSONS-DISEASE | FISSION | NEUROSCIENCES | Endoplasmic Reticulum - chemistry | Animals | alpha-Synuclein - analysis | Humans | Cells, Cultured | Female | Male | Mice, Transgenic | Mice | HeLa Cells | Mitochondria - chemistry | Mice, Knockout | Index Medicus
Journal Article
SCIENCE, ISSN 0036-8075, 06/2002, Volume 296, Issue 5575, pp. 1991 - 1995
A broad range of neurodegenerative disorders is characterized by neuronal damage that may be caused by toxic, aggregation-prone proteins. As genes are... 
NUCLEAR-LOCALIZATION | EXPANDED POLYGLUTAMINE | MULTIDISCIPLINARY SCIENCES | FAMILIAL ALZHEIMERS-DISEASE | AMYLOID PRECURSOR PROTEIN | AMYOTROPHIC-LATERAL-SCLEROSIS | ALPHA-SYNUCLEIN | SUSCEPTIBILITY LOCUS | TRANSGENIC MOUSE MODEL | HUNTINGTONS-DISEASE | PARKINSONS-DISEASE
Journal Article
Nature Neuroscience, ISSN 1097-6256, 03/2008, Volume 11, Issue 3, pp. 301 - 308
Pathogenic aggregates of alpha-synuclein are thought to contribute to the development of Parkinson's disease. Inclusion bodies containing alpha-synuclein are... 
PROTEIN | GENE | ALZHEIMERS-DISEASE | MOUSE MODEL | PLAQUE-FORMATION | FAMILIAL PARKINSONS-DISEASE | NEUROSCIENCES | LEWY BODIES | APOLIPOPROTEIN-E | TRANSGENIC MICE | DEGENERATION
Journal Article
Journal of Neurology, ISSN 0340-5354, 11/2013, Volume 260, Issue 11, pp. 2802 - 2814
Journal Article
BRAIN, ISSN 0006-8950, 04/2009, Volume 132, Issue 4, pp. 1093 - 1101
A number of neurodegenerative diseases including Parkinsons disease, dementia with Lewy bodies (DLB) and multiple system atrophy are characterized by the... 
dementia with Lewy bodies | amyloid oligomers | BRITISH DEMENTIA | THERAPEUTIC STRATEGY | APOPTOTIC CELL-DEATH | ALZHEIMERS-DISEASE | neurodegeneration | COMMON MECHANISM | ALPHA-SYNUCLEIN | NEUROSCIENCES | NEURODEGENERATIVE DISEASES | CLINICAL NEUROLOGY | synuclein | HYDROGEN-PEROXIDE | FAMILIAL PARKINSONS-DISEASE | LONG-TERM POTENTIATION
Journal Article
HUMAN MOLECULAR GENETICS, ISSN 0964-6906, 10/2008, Volume 17, Issue 19, pp. 2997 - 3009
Mutations or multiplications in alpha-synuclein gene cause familial forms of Parkinson disease or dementia with Lewy bodies (LB), and the deposition of... 
CAENORHABDITIS-ELEGANS | PROTEIN | PHOSPHOLIPASE-D | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATION | GENETICS & HEREDITY | NEURODEGENERATION | MICE | FAMILIAL PARKINSONS-DISEASE | MODEL | LEWY BODIES | AGGREGATION
Journal Article
Biochemistry, ISSN 0006-2960, 08/2018, Volume 57, Issue 34, pp. 5145 - 5158
The intrinsically disordered protein a-synuclein (aSN) forms insoluble aggregates in the brains of Parkinson's disease (PD) patients. Cytotoxicity is... 
IN-VITRO | VESICLES | BEHAVIOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTATION | X-RAY-SCATTERING | HELIX | FAMILIAL PARKINSONS-DISEASE | PROTEINS | BINDING | AGGREGATION | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2010, Volume 30, Issue 20, pp. 6838 - 6851
alpha-Synuclein is central in Parkinson's disease pathogenesis. Although initially alpha-synuclein was considered a purely intracellular protein, recent data... 
FIBRIL FORMATION | PROTEIN | MULTIVESICULAR BODIES | HUMAN PLASMA | ACTIVATES MICROGLIA | CONGO RED | ENDOPLASMIC-RETICULUM | FAMILIAL PARKINSONS-DISEASE | RELEASE | BODY FORMATION | NEUROSCIENCES | Molecular Weight | Serum - metabolism | Calcium - metabolism | Microscopy, Electron, Transmission - methods | Humans | Culture Media, Conditioned - chemistry | Cell Survival - genetics | Brefeldin A - pharmacology | Neurons - ultrastructure | Piperidines - pharmacology | Neurons - metabolism | alpha-Synuclein - genetics | Protein Synthesis Inhibitors - pharmacology | Exosomes - ultrastructure | Cell Survival - drug effects | Calcium - pharmacology | Immunoprecipitation - methods | Multivesicular Bodies - pathology | Endocytosis - drug effects | Rats | Microscopy, Confocal - methods | Analysis of Variance | Cell Line, Tumor | beta-Galactosidase - genetics | Multivesicular Bodies - drug effects | Temperature | Chromatography, High Pressure Liquid - methods | Culture Media, Conditioned - pharmacology | Cerebral Cortex - cytology | Dose-Response Relationship, Drug | Subcellular Fractions - ultrastructure | Transfection | Exosomes - physiology | beta-Galactosidase - metabolism | Presenilin-1 - pharmacology | Cell Death - drug effects | Cytotoxicity Tests, Immunologic - methods | Gene Expression Regulation, Neoplastic - drug effects | Neurons - drug effects | Neuroblastoma - pathology | Pyrazoles - pharmacology | Subcellular Fractions - drug effects | Multivesicular Bodies - ultrastructure | Cells, Cultured | Hydrogen Peroxide - pharmacology | Receptors, Transferrin - metabolism | Subcellular Fractions - metabolism | Peptides - pharmacology | Nerve Tissue Proteins - metabolism | Animals | Neuroblastoma - ultrastructure | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mass Spectrometry - methods | alpha-Synuclein - metabolism | Index Medicus
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2013, Volume 368, Issue 21, pp. 1992 - 2003
Journal Article
CURRENT TOPICS IN MEDICINAL CHEMISTRY, ISSN 1568-0266, 2016, Volume 16, Issue 17, pp. 1951 - 1960
Resveratrol (3,4',5-trihydroxystilbene) is a naturally occurring phytochemical present in red wine, grapes, berries, chocolate and peanuts. Clinically,... 
NEURONAL APOPTOSIS | Oxidative stress | CHEMISTRY, MEDICINAL | FAMILIAL ALZHEIMERS | MILD COGNITIVE IMPAIRMENT | A beta pathology | A-BETA OLIGOMERS | Antioxidants | AMYLOID-BETA | Resveratrol | MOUSE MODEL | TRANS-RESVERATROL | INDUCED NEUROTOXICITY | Alzheimer's disease | PARKINSONS-DISEASE
Journal Article