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NATURE REVIEWS MOLECULAR CELL BIOLOGY, ISSN 1471-0072, 06/2016, Volume 17, Issue 6, pp. 337 - 349
The Fanconi anaemia pathway repairs DNA interstrand crosslinks (ICLs) in the genome. Our understanding of this complex pathway is still evolving, as new... 
COMPLEMENTATION GROUP-M | DNA-POLYMERASE-ZETA | FANCD2 MONOUBIQUITINATION | XERODERMA-PIGMENTOSUM | CROSS-LINK REPAIR | REPLICATION FORK RECOVERY | HOMOLOGOUS-RECOMBINATION | GENOME STABILITY | DOUBLE-STRAND BREAK | BONE-MARROW FAILURE | CELL BIOLOGY
Journal Article
Genes and Development, ISSN 0890-9369, 08/2004, Volume 18, Issue 16, pp. 1958 - 1963
Journal Article
Nature Genetics, ISSN 1061-4036, 08/2018, Volume 50, Issue 8, pp. 1132 - 1139
Journal Article
11/2010
Fanconi anaemia (FA) is an inherited disorder characterized by bone marrow failure, cancer predisposition and congenital abnormalities. The 12 known FA genes... 
0369 | Fanconi anaemia | recombination | FANCD2 | telomere | ALT | genomic instability | 0307
Dissertation
Cell Reports, ISSN 2211-1247, 06/2019, Volume 27, Issue 10, pp. 2990 - 3005.e5
Interstrand crosslinks (ICLs) of the DNA helix are a deleterious form of DNA damage. ICLs can be repaired by the Fanconi anemia pathway. At the center of the... 
genome stability | kinase | Fanconi anemia | FANCD2/FANCI | CK2 | ICL repair | DNA repair | casein kinase 2 | phosphorylation | interstrand crosslink repair
Journal Article
Cell Reports, ISSN 2211-1247, 01/2019, Volume 26, Issue 3, pp. 564 - 572.e5
Fanconi anemia (FA) is characterized by developmental abnormalities, bone marrow failure, and cancer predisposition. FA cells are hypersensitive to DNA... 
RNA | transcription perturbation | Fanconi anemia | FANCD2 | R-loop | DNA damage | FANCI-FANCD2 | monoubiquitination | RECRUITMENT | REPAIR | REPLICATION | RAD51 | SLX4 | GENE | FANCONI-ANEMIA PROTEINS | DNA-DAMAGE | SITES | BRCA1 | CELL BIOLOGY
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 04/2015, Volume 15, Issue 5, pp. 276 - 280
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2017, Volume 65, Issue 2, pp. 247 - 259
Monoubiquitination and deubiquitination of FANCD2:FANCI heterodimer is central to DNA repair in a pathway that is defective in the cancer predisposition... 
core complex | RING E3 | Fanconi anemia | FANCD2 | deubiquitination | FANCB | enzyme mechanism | monoubiquitination | DNA repair | NUCLEAR ACCUMULATION | MONOUBIQUITINATED FANCD2 | TARGETED DISRUPTION | COMPLEX | DNA-REPAIR PATHWAY | CROSS-LINK REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEINS | DAMAGE | COMPLEMENTATION GROUP-B | LIGASE | CELL BIOLOGY | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | Multiprotein Complexes | Protein Multimerization | Substrate Specificity | Fanconi Anemia Complementation Group A Protein - metabolism | DNA-Binding Proteins - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Transfection | Time Factors | Fanconi Anemia - genetics | Ubiquitin-Specific Proteases - metabolism | Recombinant Proteins - metabolism | Cell Line | Fanconi Anemia Complementation Group Proteins - genetics | Nuclear Proteins - metabolism | Fanconi Anemia Complementation Group G Protein - metabolism | DNA - metabolism | Inhibitor of Differentiation Protein 2 - metabolism | DNA - genetics | Fanconi Anemia Complementation Group C Protein - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Protein Binding | Fanconi Anemia Complementation Group L Protein - metabolism | Fanconi Anemia Complementation Group E Protein - metabolism | Ubiquitin | Chemotherapy | Ligases | Genomics | Research institutes | Cancer | Fanconi's anemia | Proteins | Medical research | Molecular genetics | Medicine, Experimental
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 514, Issue 3, pp. 713 - 719
Fanconi anemia (FA) is a genetic disorder characterized by congenital malfunction, bone marrow failure and hypersensitivity to DNA damage. FANCD2 protein play... 
Crispr-Cas9 | Mouse model | Fanconi anemia | FANCD2 | Phenotype | Genetic aspects | Mice | Cell death | Analysis | Fanconi's anemia
Journal Article
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 660 - 660
Carcinogens often generate mutable DNA lesions that contribute to cancer and aging. However, the chemical structure of tumorigenic DNA lesions formed by... 
CELLS | REPAIR | ACTIVATION | CROTONALDEHYDE | ALCOHOL | PATHWAY | FANCD2 | MULTIDISCIPLINARY SCIENCES | ADDUCTS | ALDEHYDES
Journal Article
Journal Article