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Nature communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 2280 - 14
Defects in DNA repair can cause various genetic diseases with severe pathological phenotypes. Fanconi anemia ( FA) is a rare disease characterized by bone... 
UBIQUITINATION | DAMAGE RESPONSE | CHROMATIN | CROSS-LINK REPAIR | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | BRCA1 | ENRICHMENT ANALYSIS | ASSOCIATION | NUCLEASE | Genetic Therapy | Ubiquitin-Specific Proteases - genetics | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | DNA Repair - physiology | DNA Repair - genetics | Fanconi Anemia Complementation Group C Protein - genetics | Fanconi Anemia Complementation Group A Protein - genetics | Fanconi Anemia Complementation Group D2 Protein - deficiency | Fanconi Anemia Complementation Group A Protein - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Fanconi Anemia Complementation Group G Protein - genetics | Ubiquitin-Specific Proteases - deficiency | Fanconi Anemia Complementation Group G Protein - deficiency | BRCA1 Protein - metabolism | Fanconi Anemia - genetics | Ubiquitin-Specific Proteases - metabolism | Chromosomal Instability | Rad51 Recombinase - metabolism | Cell Line | Fanconi Anemia Complementation Group Proteins - deficiency | Fanconi Anemia Complementation Group Proteins - genetics | Fanconi Anemia Complementation Group G Protein - metabolism | Gene Knockout Techniques | Fanconi Anemia Complementation Group C Protein - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Fanconi Anemia Complementation Group A Protein - deficiency | CRISPR-Cas Systems | Fanconi Anemia Complementation Group C Protein - deficiency | Fanconi Anemia - therapy | DNA Damage | Histones - metabolism | Mutation | Phenotypes | Stability | Deactivation | BRCA1 protein | Anemia | Abnormalities | DNA damage | Genotoxicity | Health risks | Crosslinking | Breast cancer | Genomes | Inactivation | Fanconi syndrome | DNA repair | Screens | Genomic instability | FANCC protein | Bone cancer | Bone marrow | Repair | Deoxyribonucleic acid--DNA | Cancer
Journal Article
Molecular cell, ISSN 1097-2765, 2017, Volume 65, Issue 2, pp. 247 - 259
Monoubiquitination and deubiquitination of FANCD2:FANCI heterodimer is central to DNA repair in a pathway that is defective in the cancer predisposition... 
core complex | RING E3 | Fanconi anemia | FANCD2 | deubiquitination | FANCB | enzyme mechanism | monoubiquitination | DNA repair | NUCLEAR ACCUMULATION | MONOUBIQUITINATED FANCD2 | TARGETED DISRUPTION | COMPLEX | DNA-REPAIR PATHWAY | CROSS-LINK REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEINS | DAMAGE | COMPLEMENTATION GROUP-B | LIGASE | CELL BIOLOGY | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | Multiprotein Complexes | Protein Multimerization | Substrate Specificity | Fanconi Anemia Complementation Group A Protein - metabolism | DNA-Binding Proteins - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Transfection | Time Factors | Fanconi Anemia - genetics | Ubiquitin-Specific Proteases - metabolism | Recombinant Proteins - metabolism | Cell Line | Fanconi Anemia Complementation Group Proteins - genetics | Nuclear Proteins - metabolism | Fanconi Anemia Complementation Group G Protein - metabolism | DNA - metabolism | Inhibitor of Differentiation Protein 2 - metabolism | DNA - genetics | Fanconi Anemia Complementation Group C Protein - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Protein Binding | Fanconi Anemia Complementation Group L Protein - metabolism | Fanconi Anemia Complementation Group E Protein - metabolism | Ubiquitin | Chemotherapy | Ligases | Genomics | Research institutes | Cancer | Fanconi's anemia | Proteins | Medical research | Molecular genetics | Medicine, Experimental
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 2, pp. 388 - 404
Journal Article
Journal of biomedical science, ISSN 1021-7770, 09/2015, Volume 22, Issue 1, p. 77
Background: Cisplatin is one of the most commonly used chemotherapy agent for lung cancer. The therapeutic efficacy of cisplatin is limited by the development... 
RNA interference | Fanconi anemia/BRCA pathway | Lung cancer | Cisplatin | Chemoresistance | Core complex | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | PROTEIN | CHEMOTHERAPY | CELL BIOLOGY | CROSS-LINK REPAIR | MUTATIONS | EXPRESSION | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Fanconi Anemia Complementation Group D2 Protein - genetics | Humans | Lung Neoplasms - metabolism | Fanconi Anemia Complementation Group F Protein - metabolism | Fanconi Anemia Complementation Group L Protein - genetics | Fanconi Anemia Complementation Group D2 Protein - antagonists & inhibitors | Lung Neoplasms - pathology | Signal Transduction - genetics | Cisplatin - pharmacology | Fanconi Anemia Complementation Group F Protein - genetics | Fanconi Anemia Complementation Group L Protein - antagonists & inhibitors | BRCA1 Protein - genetics | Drug Resistance, Neoplasm - genetics | BRCA1 Protein - antagonists & inhibitors | Fanconi Anemia Complementation Group D2 Protein - metabolism | RNA Interference | Signal Transduction - drug effects | BRCA1 Protein - metabolism | Fanconi Anemia Complementation Group F Protein - antagonists & inhibitors | Cell Line, Tumor | Fanconi Anemia Complementation Group L Protein - metabolism | Drug Resistance, Neoplasm - drug effects | RNA | DNA damage | Genes | Respiratory agents | Drug resistance | Antineoplastic agents | Fanconi's anemia | Antimitotic agents | Prevention | Chemotherapy | Cancer cells | Genetic research | Genetic aspects | Drug therapy | Health aspects | Cancer | Ribonucleic acid--RNA | Anemia
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 553, Issue 7687, pp. 171 - 177
Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damage initiates malignancies.... 
REPLICATION | FANCONI-ANEMIA PATHWAY | MULTIDISCIPLINARY SCIENCES | MICE | HOMOLOGOUS RECOMBINATION | DNA-REPAIR | IDENTIFICATION | EXPRESSION | BONE-MARROW FAILURE | GENOME | PROGRESSION | Acetaldehyde - metabolism | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Ethanol - administration & dosage | Hematopoietic Stem Cells - pathology | Male | Fanconi Anemia Complementation Group D2 Protein - deficiency | Tumor Suppressor Protein p53 - genetics | DNA Breaks, Double-Stranded - drug effects | DNA End-Joining Repair | Gene Deletion | Genomic Instability - drug effects | Fanconi Anemia - pathology | Female | Alcohol Dehydrogenase - deficiency | Fanconi Anemia - genetics | Recombinational DNA Repair - drug effects | Alcohol Dehydrogenase - metabolism | Hematopoietic Stem Cells - drug effects | Cell Survival - drug effects | Ethanol - metabolism | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Hematopoietic Stem Cell Transplantation | Hematopoietic Stem Cells - metabolism | Ku Autoantigen - metabolism | Genes, p53 - genetics | Tumor Suppressor Protein p53 - deficiency | Whole Genome Sequencing | Ethanol - pharmacology | Animals | Fanconi Anemia Complementation Group D2 Protein - metabolism | Alcohol Dehydrogenase - genetics | Mice | Mutation | Aldehydes | Health aspects | Chromosomes | Hematopoietic stem cells | Alcohols | Recombination | Dehydrogenases | Cell survival | Ethanol | p53 Protein | DNA damage | Alcohol | Transplantation | Genomes | Chromosome rearrangements | DNA repair | Gene sequencing | Acetaldehyde | Genomic instability | Mutagenesis | Clonal deletion | Stem cells | Cell cycle | Alcoholic beverages | Damage accumulation | Deoxyribonucleic acid--DNA
Journal Article
Molecular cell, ISSN 1097-2765, 2018, Volume 71, Issue 4, pp. 621 - 628.e4
FANCA is a component of the Fanconi anemia (FA) core complex that activates DNA interstrand crosslink repair by monoubiquitination of FANCD2. Here, we report... 
FANCA | strand exchange | DNA double-strand break repair | Fanconi anemia | single-strand annealing | UBIQUITINATION | COMPLEX | RESECTION | REPLICATION PROTEIN-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT | HUMAN RAD52 PROTEIN | ANEMIA PATHWAY | LIGASE RFWD3 | HOMOLOGOUS RECOMBINATION | ACCUMULATION | CELL BIOLOGY | Epithelial Cells - metabolism | Baculoviridae - metabolism | Humans | Baculoviridae - genetics | Moths | DNA Breaks, Double-Stranded | Fanconi Anemia Complementation Group A Protein - genetics | Fanconi Anemia Complementation Group A Protein - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Fanconi Anemia Complementation Group G Protein - genetics | Rad52 DNA Repair and Recombination Protein - metabolism | DNA End-Joining Repair | DNA Mismatch Repair | Cloning, Molecular | Osteoblasts - cytology | Epithelial Cells - cytology | Recombinant Proteins - metabolism | Gene Expression | Recombinational DNA Repair | Genetic Vectors - chemistry | Fanconi Anemia Complementation Group Proteins - genetics | Genetic Vectors - metabolism | Fanconi Anemia Complementation Group G Protein - metabolism | Recombinant Proteins - genetics | DNA - metabolism | Rad52 DNA Repair and Recombination Protein - genetics | DNA - genetics | Animals | Cell Line, Tumor | Osteoblasts - metabolism | Yuan (China) | Medical colleges | Annealing | DNA | Genetic research | Molecular biology | Fanconi's anemia | DNA double strand break repair
Journal Article
Molecular cell, ISSN 1097-2765, 07/2012, Volume 47, Issue 1, pp. 61 - 75
The Fanconi anemia (FA) protein network is necessary for repair of DNA interstrand crosslinks (ICLs), but its control mechanism remains unclear. Here we show... 
CELLS | DAMAGE RESPONSE | COMPLEX | KIAA1018/FAN1 | REPLICATION | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RNF8 | STRESS | FAN1 | NUCLEASE | CELL BIOLOGY | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Immunoblotting | Green Fluorescent Proteins - genetics | Fanconi Anemia Complementation Group Proteins - chemistry | DNA-Binding Proteins - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | RNA Interference | HEK293 Cells | Fanconi Anemia - genetics | Lysine - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Signal Transduction | Fanconi Anemia Complementation Group Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | DNA-Binding Proteins - genetics | Sequence Homology, Amino Acid | Lysine - genetics | Animals | Fanconi Anemia Complementation Group D2 Protein - metabolism | DNA Repair | Cell Line, Tumor | Protein Binding | HeLa Cells | Mutation | Lysine - chemistry | Ubiquitin-Protein Ligases - genetics | Microscopy, Fluorescence | Ubiquitin | Care and treatment | Molecular genetics | Anemia | DNA damage | Radiation | DNA repair | Fanconi's anemia | Gerontology | Nuclear radiation | DNA | Genetic research | Cancer | RNF168 | Fanconi Anemia | UBC13 | FAAP20 | ubiquitin
Journal Article
Journal of Virology, ISSN 0022-538X, 08/2012, Volume 86, Issue 15, pp. 8131 - 8138
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
IMMUNE | ONCOPROTEIN | PROTEIN | VIROLOGY | GENE | DNA | TYPE-16 | DIFFERENTIATION | SQUAMOUS-CELL CARCINOMAS | EXPRESSION | HPV | Head and Neck Neoplasms - virology | Human papillomavirus 16 - physiology | Fanconi Anemia Complementation Group D2 Protein - genetics | Keratinocytes - virology | Fanconi Anemia - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Carcinoma, Squamous Cell - virology | Humans | Male | Fanconi Anemia Complementation Group A Protein - genetics | Head and Neck Neoplasms - metabolism | Fanconi Anemia Complementation Group A Protein - metabolism | Papillomavirus E7 Proteins - genetics | Papillomavirus Infections - pathology | Head and Neck Neoplasms - epidemiology | Fanconi Anemia - pathology | Female | Fanconi Anemia - genetics | Brazil - epidemiology | Fanconi Anemia - virology | Carcinoma, Squamous Cell - epidemiology | Papillomavirus Infections - epidemiology | Fanconi Anemia - epidemiology | Head and Neck Neoplasms - pathology | Papillomavirus Infections - genetics | Keratinocytes - pathology | Papillomavirus E7 Proteins - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Genome, Viral - physiology | Keratinocytes - metabolism | Papillomavirus Infections - metabolism | Head and Neck Neoplasms - genetics | Virus Replication - physiology | Cell Line, Transformed | Transformation and Oncogenesis
Journal Article