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Cancer Cell, ISSN 1535-6108, 2007, Volume 11, Issue 2, pp. 103 - 105
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 10/2010, Volume 17, Issue 10, pp. 1247 - 1254
Inherited mutations in human PALB2 are associated with a predisposition to breast and pancreatic cancers. PALB2's tumor-suppressing effect is thought to be... 
POLY(ADP-RIBOSE) POLYMERASE | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | HISTONE H2AX | FANCONI-ANEMIA | CELL BIOLOGY | RAD51 | BIOPHYSICS | IN-VIVO | SUSCEPTIBILITY GENE | D-LOOP FORMATION | DNA-REPAIR | Recombination, Genetic - physiology | DNA, Neoplasm - metabolism | Humans | Neoplasm Proteins - physiology | DNA Repair - physiology | Molecular Sequence Data | Structure-Activity Relationship | DNA Breaks, Double-Stranded | BRCA2 Protein - physiology | Breast Neoplasms - metabolism | Base Sequence | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Female | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Nucleic Acid Conformation | Fanconi Anemia Complementation Group N Protein | Peptide Fragments - metabolism | Neoplasm Proteins - chemistry | Nuclear Proteins - chemistry | Poly(ADP-ribose) Polymerase Inhibitors | Protein Interaction Mapping | Tumor Suppressor Proteins - physiology | Peptide Fragments - chemistry | Apoptosis Regulatory Proteins | Models, Biological | Rad51 Recombinase - chemistry | Rad51 Recombinase - physiology | BRCA2 Protein - chemistry | Nuclear Proteins - physiology | Poly (ADP-Ribose) Polymerase-1 | Breast cancer | Genetic aspects | Research | BRCA mutations | Ovarian cancer | Proteins | Mutation | Molecular biology | Prostate cancer | homologous recombination | BRCA2 | PALB2
Journal Article
Nature, ISSN 0028-0836, 12/2015, Volume 528, Issue 7582, pp. 422 - 426
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2280 - 14
Defects in DNA repair can cause various genetic diseases with severe pathological phenotypes. Fanconi anemia ( FA) is a rare disease characterized by bone... 
UBIQUITINATION | DAMAGE RESPONSE | CHROMATIN | CROSS-LINK REPAIR | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | HOMOLOGOUS RECOMBINATION | BRCA1 | ENRICHMENT ANALYSIS | ASSOCIATION | Genetic Therapy | Ubiquitin-Specific Proteases - genetics | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | DNA Repair - physiology | DNA Repair - genetics | Fanconi Anemia Complementation Group C Protein - genetics | Fanconi Anemia Complementation Group A Protein - genetics | Fanconi Anemia Complementation Group D2 Protein - deficiency | Fanconi Anemia Complementation Group A Protein - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Fanconi Anemia Complementation Group G Protein - genetics | Ubiquitin-Specific Proteases - deficiency | Fanconi Anemia Complementation Group G Protein - deficiency | BRCA1 Protein - metabolism | Fanconi Anemia - genetics | Ubiquitin-Specific Proteases - metabolism | Chromosomal Instability | Rad51 Recombinase - metabolism | Cell Line | Fanconi Anemia Complementation Group Proteins - deficiency | Fanconi Anemia Complementation Group Proteins - genetics | Fanconi Anemia Complementation Group G Protein - metabolism | Gene Knockout Techniques | Fanconi Anemia Complementation Group C Protein - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Fanconi Anemia Complementation Group A Protein - deficiency | CRISPR-Cas Systems | Fanconi Anemia Complementation Group C Protein - deficiency | Fanconi Anemia - therapy | DNA Damage | Histones - metabolism | Mutation
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7676, pp. 360 - 365
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 08/2004, Volume 24, Issue 16, pp. 7130 - 7139
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 42, pp. 17041 - 17046
Breast Cancer Type 1 Susceptibility Protein (BRCA1)-deficient cells have compromised DNA repair and are sensitive to poly(ADP-ribose) polymerase (PARP)... 
Proteins | BRCA proteins | Platinum | DNA | Cell lines | Small interfering RNA | Cellular immunity | Breast cancer | Genetic mutation | Tumors | Cancer therapy | Homologous recombination | cancer therapy | POLY(ADP-RIBOSE) POLYMERASE | CELLS | REPAIR | homologous recombination | TUMOR SUPPRESSION | 53BP1 | MULTIDISCIPLINARY SCIENCES | BREAST CANCERS | OVARIAN CARCINOMAS | MUTATIONS | CHEMOTHERAPY | Humans | Ovarian Neoplasms - pathology | Ovarian Neoplasms - genetics | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - genetics | Female | Antineoplastic Agents - pharmacology | HSP90 Heat-Shock Proteins - genetics | Ovarian Neoplasms - metabolism | Nuclear Proteins - genetics | Fanconi Anemia Complementation Group N Protein | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Protein Structure, Tertiary | Rad51 Recombinase - metabolism | Tumor Suppressor Proteins - metabolism | Rad51 Recombinase - genetics | Nuclear Proteins - metabolism | Cisplatin - pharmacology | Lactams, Macrocyclic - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Benzoquinones - pharmacology | BRCA1 Protein - genetics | Drug Resistance, Neoplasm - genetics | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Poly(ADP-ribose) Polymerases - genetics | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Mutation | BRCA2 Protein - genetics | Drug Resistance, Neoplasm - drug effects | Gene mutations | Physiological aspects | Genetic aspects | Research | Binding proteins | Health aspects | Biological Sciences
Journal Article
Cancer Research, ISSN 0008-5472, 08/2007, Volume 67, Issue 15, pp. 7395 - 7405
Proteasome inhibitors sensitize tumor cells to DNA-damaging agents, including ionizing radiation (IR), and DNA crosslinking agents (melphalan and cisplatin)... 
MULTIPLE-MYELOMA | CELLS | REPAIR | GENOMIC STABILITY | PROTEIN | ONCOLOGY | 53BP1 | IN-VIVO | DOUBLE-STRAND BREAKS | ATM | S-PHASE CHECKPOINT | Gamma Rays | Humans | Ovarian Neoplasms - pathology | Ubiquitin - metabolism | Ovarian Neoplasms - metabolism | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Rad51 Recombinase - metabolism | Tumor Suppressor Proteins - metabolism | Bortezomib | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Cell Cycle Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | Blotting, Western | Proteasome Endopeptidase Complex - genetics | Leupeptins - pharmacology | Phosphorylation - radiation effects | BRCA1 Protein - antagonists & inhibitors | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Pyrazines - pharmacology | Proteasome Endopeptidase Complex - radiation effects | Fanconi Anemia Complementation Group D2 Protein - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Fanconi Anemia | Rad51 Recombinase - antagonists & inhibitors | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Flow Cytometry | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Nuclear Proteins - genetics | Rad51 Recombinase - genetics | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Fanconi Anemia Complementation Group D2 Protein - antagonists & inhibitors | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | BRCA1 Protein - genetics | Fanconi Anemia Complementation Group D2 Protein - metabolism | DNA Repair | Nuclear Proteins - antagonists & inhibitors | Proteasome Inhibitors | DNA Damage - radiation effects | Microscopy, Fluorescence | Boronic Acids - pharmacology
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2017, Volume 65, Issue 2, pp. 247 - 259
Monoubiquitination and deubiquitination of FANCD2:FANCI heterodimer is central to DNA repair in a pathway that is defective in the cancer predisposition... 
core complex | RING E3 | Fanconi anemia | FANCD2 | deubiquitination | FANCB | enzyme mechanism | monoubiquitination | DNA repair | NUCLEAR ACCUMULATION | MONOUBIQUITINATED FANCD2 | TARGETED DISRUPTION | COMPLEX | DNA-REPAIR PATHWAY | CROSS-LINK REPAIR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEINS | DAMAGE | COMPLEMENTATION GROUP-B | LIGASE | CELL BIOLOGY | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Humans | Multiprotein Complexes | Protein Multimerization | Substrate Specificity | Fanconi Anemia Complementation Group A Protein - metabolism | DNA-Binding Proteins - metabolism | Fanconi Anemia Complementation Group Proteins - metabolism | Ubiquitination | Transfection | Time Factors | Fanconi Anemia - genetics | Ubiquitin-Specific Proteases - metabolism | Recombinant Proteins - metabolism | Cell Line | Fanconi Anemia Complementation Group Proteins - genetics | Nuclear Proteins - metabolism | Fanconi Anemia Complementation Group G Protein - metabolism | DNA - metabolism | Inhibitor of Differentiation Protein 2 - metabolism | DNA - genetics | Fanconi Anemia Complementation Group C Protein - metabolism | Fanconi Anemia Complementation Group D2 Protein - metabolism | Protein Binding | Fanconi Anemia Complementation Group L Protein - metabolism | Fanconi Anemia Complementation Group E Protein - metabolism | Ubiquitin | Chemotherapy | Ligases | Genomics | Research institutes | Cancer | Fanconi's anemia | Proteins | Medical research | Molecular genetics | Medicine, Experimental
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 4, pp. 688 - 703
Covalent DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription.... 
DVC1 | progeria | protease | formaldehyde | Spartan | Wss1 | Ruijs-Aalfs syndrome | SPRTN | topoisomerase | DNA-protein crosslinks | DNA repair | hepatocellular carcinoma | GENOMIC INSTABILITY | CELLS | DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SPARTAN/C1ORF124 | DVC1 C1ORF124 | FANCONI-ANEMIA | HELICASE | NUCLEOTIDE EXCISION-REPAIR | CELL BIOLOGY | Schizosaccharomyces pombe Proteins - chemistry | Fibroblasts - enzymology | Formaldehyde - chemistry | Caenorhabditis elegans Proteins - chemistry | Humans | Caenorhabditis elegans Proteins - metabolism | Substrate Specificity | Crystallography, X-Ray | DNA-Binding Proteins - metabolism | Schizosaccharomyces - genetics | Cisplatin - chemistry | Ultraviolet Rays | Schizosaccharomyces pombe Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Amino Acid Sequence | Cell Line | Xeroderma Pigmentosum Group A Protein - metabolism | Cross-Linking Reagents - chemistry | Schizosaccharomyces pombe Proteins - genetics | Protein Structure, Secondary | Caenorhabditis elegans - genetics | Xeroderma Pigmentosum Group A Protein - genetics | Models, Molecular | DNA - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Caenorhabditis elegans - radiation effects | Xeroderma Pigmentosum Group A Protein - chemistry | DNA - genetics | Sequence Homology, Amino Acid | DNA - chemistry | Sequence Alignment | Animals | Caenorhabditis elegans - drug effects | Fibroblasts - radiation effects | DNA Repair | Fibroblasts - drug effects | Protein Binding | Schizosaccharomyces - enzymology | Fibroblasts - cytology | Mice | HeLa Cells | Kinetics | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Ubiquitin | Chromatin | Proteases | DNA | Genetic research | Genetic transcription | Molecular biology | Formaldehyde | BASIC BIOLOGICAL SCIENCES | protease Ruijs-Aalfs syndrome
Journal Article