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Journal of Biological Chemistry, ISSN 0021-9258, 01/2004, Volume 279, Issue 4, pp. 2544 - 2549
Fas-associated factor-1 (FAF1) is a Fas-binding proapoptotic protein that is a component of the death-inducing signaling complex in Fas-mediated apoptosis.... 
SIGNAL-TRANSDUCTION | DOMAIN-CONTAINING RECEPTOR | APOPTOSIS | ACTIVATION | PROTEIN | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | BCL-2 EXPRESSION | DEATH-DOMAIN | CELL-DEATH | interleukin 1b | 293 cells | lipopolysaccharides | Fas-associated factor 1 | interleukin 1^b | Fas-associated factor-1 | NF-^KB protein
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 01/2013, Volume 83, Issue 1, pp. 245 - 255
Journal Article
Journal of Immunology, ISSN 0022-1767, 11/2010, Volume 185, Issue 10, pp. 6306 - 6316
Journal Article
The Journal of Immunology, ISSN 0022-1767, 07/2001, Volume 167, Issue 1, pp. 514 - 523
Con A administration results in dose-dependent immune-mediated liver injury. Cytokines are important to determine the outcome of liver failure in this model,... 
INDUCED HEPATITIS | CONCANAVALIN-A | TUMOR-NECROSIS-FACTOR | INTERFERON-GAMMA | N-TERMINAL KINASE | T-CELL ACTIVATION | TNF-ALPHA | KAPPA-B | IMMUNOLOGY | C-JUN | FACTOR-ALPHA | Injections, Intravenous | Intracellular Fluid - immunology | Concanavalin A - pharmacology | Humans | Leukocyte Common Antigens - biosynthesis | Liver Failure - pathology | Hepatocytes - pathology | Male | NF-kappa B - metabolism | Phosphoproteins - antagonists & inhibitors | Hepatocytes - metabolism | CD4-Positive T-Lymphocytes - pathology | Liver Failure - immunology | Phosphoproteins - metabolism | fas Receptor - metabolism | Cell Movement - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Interferon Regulatory Factor-1 | Interferon-gamma - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases | Phosphoproteins - physiology | Tumor Cells, Cultured | DNA-Binding Proteins - physiology | DNA-Binding Proteins - antagonists & inhibitors | Concanavalin A - administration & dosage | Immune Sera - administration & dosage | Interferon-gamma - physiology | Fas-Associated Death Domain Protein | Hepatocytes - immunology | Tumor Necrosis Factor-alpha - pharmacology | Adaptor Proteins, Signal Transducing | Intracellular Fluid - enzymology | Animals | Carrier Proteins - metabolism | Mitogen-Activated Protein Kinases - physiology | Interferon-gamma - immunology | STAT1 Transcription Factor | Liver Failure - enzymology | Trans-Activators - metabolism | Liver Failure - prevention & control | Mice | Mice, Inbred BALB C | Trans-Activators - antagonists & inhibitors | Hepatocytes - enzymology | interferon regulatory factor 1 | concanavalin A | JNK protein | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 01/2018, Volume 592, Issue 1, pp. 78 - 88
Parkin encodes an E3 ubiquitin ligase, and mutations affecting its catalytic potential are implicated in autosomal recessive Parkinson's disease (PD). The... 
ubiquitination | Parkinson's disease | Parkin mutation | OXIDATIVE STRESS | UBIQUITIN-PROTEIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALPHA-SYNUCLEIN | CELL-DEATH | CELL BIOLOGY | BIOPHYSICS | PROTECTIVE FUNCTION | SUBSTRATE | DEGRADATION | FAS-ASSOCIATED FACTOR-1 | DISEASE GENE-PRODUCT | EARLY-ONSET PARKINSONISM | Index Medicus
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 12/2018, Volume 24, Issue 6, pp. 776 - 790.e5
Mitochondrial antiviral signaling protein (MAVS) is an adaptor of the innate immune receptor retinoic acid-inducible gene 1 (RIG-I) that links recognition of... 
IKKɛ | MAVS | RLR signaling pathway | aggregation | innate immunity | FAF1 | UBIQUITINATION | VIROLOGY | ADAPTER | RIG-I | MICROBIOLOGY | FAS-ASSOCIATED FACTOR-1 | PATTERN-RECOGNITION RECEPTORS | NF-KAPPA-B | CONTAINING PROTEIN | PARASITOLOGY | INNATE IMMUNITY | INSIGHTS | Ubiquitin | Medical colleges | RNA | Lysine | Ligases | Research institutes | Health aspects | Cells | Tretinoin | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2007, Volume 282, Issue 38, pp. 27572 - 27577
This study presents a molecular inhibitory mechanism by Fas-associated factor 1 (FAF1) on I kappa B kinase (IKK) activation, where divergent NF-kappa... 
GAMMA | PROTEIN | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | NECROSIS-FACTOR-ALPHA | FAS-ASSOCIATED FACTOR-1 | MEDIATED APOPTOSIS | IDENTIFICATION | ASSOCIATION | BETA
Journal Article
Molecular Oncology, ISSN 1574-7891, 10/2018, Volume 12, Issue 10, pp. 1753 - 1777
Overexpression of oncoproteins is a major cause of treatment failure using current chemotherapeutic drugs. Drug‐induced degradation of oncoproteins is feasible... 
mortalin‐2 | mouse | CHIP | E3 ligase | colorectal cancer | UBXN | veratridine | mortalin-2 | CHIP E3 ligase | UBXN2A | MOLECULAR-INTERACTIONS | VALOSIN-CONTAINING PROTEIN | TUMOR-SUPPRESSOR P53 | COLON-CANCER | UBIQUITYLATED PROTEINS | ONCOLOGY | ORTHOGONAL UBIQUITIN TRANSFER | MITOCHONDRIAL CHAPERONES | FAS-ASSOCIATED FACTOR-1 | NF-KAPPA-B | E3 LIGASE ACTIVITY | s
Journal Article