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Chinese Journal of New Drugs, ISSN 1003-3734, 04/2018, Volume 27, Issue 7, pp. 827 - 829
Journal Article
12/2011
Background and Objective : Cerebral vasospasm is a serious complication of subarachnoid hemorrhage (SAH) and is associated with clinical deterioration and... 
continuous intravertebral artery injection | subarachnoid hemorrhage | Cerebral vasospasm | fasudil hydrochloride
Web Resource
International Journal of Nanomedicine, ISSN 1176-9114, 08/2016, Volume 11, pp. 3891 - 3905
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 11/2019, Volume 373, p. 112083
Twenty-nine protein kinase inhibitors have been used to treat human diseases. Out of these, two are Rho-associated protein kinase (ROCK) 1 and 2 inhibitors.... 
Anxiety | Rho kinase | ROCK1 | ROCK2 | Fasudil
Journal Article
11/2013
Chronic neonatal pulmonary hypertension (PHT) frequently presents with rightventricular (RV) dysfunction. In neonatal rats exposed to chronic hypoxia, RV... 
Vascular Remodeling | Rat | Rho-kinase | Hypoxia | Right-ventricular Dysfunction | 0719 | Pulmonary Hypertension | Y27632 | Fasudil
Dissertation
Behavioural Brain Research, ISSN 0166-4328, 10/2018, Volume 351, pp. 4 - 16
Restoration of PI3-kinase signaling portrays therapeutic potential in Alzheimer’s disease (AD). Hyperactive Rho-kinase in AD negatively modulates PI3-kinase... 
NFκB | Wortmannin | Endothelial NOS | Memory | PI3-kinase | Acetylcholinesterase | Fasudil
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 09/2019, Volume 20, Issue 18, p. 4408
In various models of chronic kidney disease, the amount and localization of Cx43 in the nephron is known to increase, but the intracellular pathways that... 
fibrosis | Hypertensive nephropathy | Cx43 | inflammation | oxidative stress | Fasudil
Journal Article
Drug and Chemical Toxicology, ISSN 0148-0545, 2018, pp. 1 - 7
Acrylamide (ACR), a vinyl monomer that has multiple chemical and industrial applications, is a neurotoxic agent in human and animal. Fasudil is a potent... 
Acrylamide | apoptosis | neurotoxicity | rho-kinase inhibitor | Fasudil
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 03/2018, Volume 14, Issue 3, pp. 306 - 317
Synapse loss is the structural correlate of the cognitive decline indicative of dementia. In the brains of Alzheimer's disease sufferers, amyloid β (Aβ)... 
Dickkopf-1 | Synapse | ROCK | Synaptotoxicity | DAAM1 | Planar cell polarity | Amyloid | Wnt | Alzheimer's disease | Fasudil | ALZHEIMERS-DISEASE | MECHANISMS | INDUCTION | CLINICAL NEUROLOGY | DEGENERATION | VANGL2 | SYNAPSES | PATHWAY
Journal Article
CURRENT OPINION IN CELL BIOLOGY, ISSN 0955-0674, 04/2008, Volume 20, Issue 2, pp. 242 - 248
ROCK kinases, which play central roles in the organization of the actin cytoskeleton, are tantalizing targets for the treatment of human diseases. Deletion of... 
FASUDIL HYDROCHLORIDE | STABLE ANGINA | APOPTOSIS | STEM-CELLS | ANEURYSMAL SUBARACHNOID HEMORRHAGE | PROTEIN-KINASE | RHO-KINASE | DOUBLE-BLIND | CEREBRAL VASOSPASM | VENTRAL BODY-WALL | CELL BIOLOGY
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2018, Volume 61, Issue 14, pp. 5922 - 5933
Biophysical parameters can accelerate drug development; e.g., rigid ligands may reduce entropic penalty and improve binding affinity. We studied systematically... 
CATALYTIC SUBUNIT | COMPLEX | FASUDIL | CHEMISTRY, MEDICINAL | THERMODYNAMICS | CALORIMETRY | ASSIGNMENT | DYNAMICS | DEPENDENT PROTEIN-KINASE | INHIBITOR | HYDRATION
Journal Article
Circulation Journal, ISSN 1346-9843, 2013, Volume 77, Issue 10, pp. 2619 - 2625
Background: We have previously demonstrated that long-term inhibition of Rho-kinase ameliorates pulmonary arterial hypertension (PAH) in animal models. In the... 
Signal transduction | Rho-kinase inhibitor | Pulmonary arterial hypertension | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN-KINASE | PROSTACYCLIN | RATS | CARDIOVASCULAR MEDICINE | FASUDIL | THERAPEUTIC TARGET | BINDING | GTPASE
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 05/2017, Volume 15, Issue 20, pp. 4336 - 4343
Fasudil (FSD), a selective rho kinase (ROCK) inhibitor, was found to form 1 : 1 host-guest inclusion complexes with a synthetic macrocyclic receptor,... 
DRUG | VITRO | MIGRATION | FASUDIL | AFFINITY | STABILITY | IN-VIVO | ENCAPSULATION | CHEMISTRY, ORGANIC | ZEBRAFISH MODELS | COMPLEXATION
Journal Article
CARDIOVASCULAR RESEARCH, ISSN 0008-6363, 09/2017, Volume 113, Issue 11, pp. 1273 - 1275
Journal Article
Journal of Interventional Radiology (China), ISSN 1008-794X, 10/2015, Volume 24, Issue 10, pp. 846 - 848
Journal Article
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