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American Journal of Surgical Pathology, ISSN 0147-5185, 2016, Volume 40, Issue 7, pp. 876 - 885
Journal Article
International Journal of Oncology, ISSN 1019-6439, 07/2015, Volume 47, Issue 1, pp. 231 - 243
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 01/2014, Volume 6, Issue 1, pp. 99 - 119
Mammary epithelial stem cells are fundamental to maintain tissue integrity. Cancer stem cells (CSCs) are implicated in both treatment resistance and disease... 
stem cells | breast cancer | Fbxw7 E3 ubiquitin‐ligase | prolyl‐isomerase Pin1 | Notch | Breast cancer | Prolyl-isomerase Pin1 | Fbxw7 E3 ubiquitin-ligase | Stem cells | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | ACTIVATION | prolyl-isomerase Pin1 | PHOSPHORYLATION | MOLECULAR HETEROGENEITY | P53 | EPITHELIAL-MESENCHYMAL TRANSITION | THERAPEUTIC TARGET | TUMOR-SUPPRESSOR | GROWTH-FACTOR | F-Box-WD Repeat-Containing Protein 7 | Neoplastic Stem Cells - cytology | Receptors, Notch - metabolism | Humans | Peptidylprolyl Isomerase - antagonists & inhibitors | Receptors, Notch - genetics | Transplantation, Heterologous | Antineoplastic Agents - therapeutic use | Stem Cells - cytology | Stem Cells - metabolism | Breast Neoplasms - metabolism | Neoplastic Stem Cells - metabolism | Triple Negative Breast Neoplasms - pathology | Cell Cycle Proteins - genetics | Female | Peptidylprolyl Isomerase - metabolism | Peptidylprolyl Isomerase - genetics | Proto-Oncogene Proteins - metabolism | Mammary Glands, Human - cytology | Signal Transduction | F-Box Proteins - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins - genetics | NIMA-Interacting Peptidylprolyl Isomerase | Receptor, Notch1 - metabolism | Mice, SCID | Breast Neoplasms - drug therapy | Mice, Knockout | Animals | Breast Neoplasms - pathology | Triple Negative Breast Neoplasms - metabolism | Cell Line, Tumor | Mice | Receptor, Notch1 - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Receptor, Notch4 | Ubiquitin | Ligases | Phenotypes | Phosphorylation | Metastasis | Gene expression | Kinases | Pin1 protein | Experiments | Metastases | Signal transduction | Disease resistance | Cell fate | Proteasomes | Breast | Mutation | Ubiquitin-protein ligase | Tumors
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 12/2019, Volume 498, p. 110541
MicroRNAs (miRNAs) are small RNAs without protein-coding functions that negatively regulate target genes and play important roles in physiological and... 
Diabetic retinopathy neovascularization | STAT4 | miR-223-3p | FBXW7 | Transthyretin
Journal Article
by Petit, Arnaud and Trinquand, Amélie and Chevret, Sylvie and Ballerini, Paola and Cayuela, Jean-Michel and Grardel, Nathalie and Touzart, Aurore and Brethon, Benoit and Lapillonne, Hélène and Schmitt, Claudine and Thouvenin, Sandrine and Michel, Gerard and Preudhomme, Claude and Soulier, Jean and Landman-Parker, Judith and Leverger, Guy and Macintyre, Elizabeth and Baruchel, André and Asnafi, Vahid and Aladjidi, Nathalie and Auvrignon, Anne and Baruchel, André and Berger, Claire and Blouin, Pascale and Brethon, Benoit and Chambost, Hervé and Couillault, Gérard and Dalle, Jean-Hugues and Debre, Marianne and Devoldere, Catherine and Dollfus, Catherine and Donadieu, Jean and De Maricourt, Cécile Dumesnil and Edan, Christine and Fasola, Sylvie and Fouyssac, Fanny and Galambrun, Claire and Gandemer, Virginie and Haouy, Stéphanie and Jehanne, Mathilde and Jubert, Charlotte and Kanold, Justyna and Landman-Parker, Judith and Leblanc, Thierry and Lejars, Odile and Le Moine, Philippe and Leverger, Guy and Marie-Cardine, Aude and Margueritte, Geneviève and Mechinaud, Françoise and Michel, Gérard and Oudin, Claire and Oudot, Caroline and Paillard, Catherine and Pautard, Brigitte and Perel, Yves and Petit, Arnaud and Piguet, Christophe and Ray-Lunven, Anne-France and Rialland, Fanny and Schmitt, Claudine and Schneider, Pascale and Stephan, Jean-Louis and Tabone, Marie-Dominique and Thomas, Caroline and Vannier, Jean-Pierre and French Acute Lymphoblastic Leukemi and French Acute Lymphoblastic Leukemia Study Group (FRALLE)
Blood, ISSN 0006-4971, 01/2018, Volume 131, Issue 3, pp. 289 - 300
Journal Article
Autophagy, ISSN 1554-8627, 08/2019, Volume 15, Issue 8, pp. 1470 - 1472
MTORC1 is a well-known key regulator of macroautophagy/autophagy. However, the underlying regulatory mechanisms of MTORC1 activity remains elusive. We showed... 
RPTOR | SHOC2 | FBXW7 | Autophagy | MTOR | proliferation and survival | CELL BIOLOGY
Journal Article
Cancer Cell International, ISSN 1475-2867, 01/2017, Volume 17, Issue 1, p. 14
Background: MicroRNAs are a class of small non-coding RNAs that are involved in many important physiological and pathological processes by regulating gene... 
Breast cancer | Proliferation | MiR-32 | FBXW7 | Apoptosis | FBXW7/HCDC4 | METASTASIS | UBIQUITIN LIGASE | STATISTICS | INVASION | ONCOLOGY | GASTRIC-CANCER | COLORECTAL-CANCER | TUMOR-SUPPRESSOR | FBW7 | EXPRESSION
Journal Article
Molecular Cancer, ISSN 1476-4598, 07/2017, Volume 16, Issue 1, pp. 123 - 15
Background: Recently, it has been reported that long non-coding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2), a novel tumor suppressor, participates... 
MiR-367 | Epithelial-mesenchymal transition | Hepatocellular carcinoma | CASC2 | FBXW7 | Long non-coding RNA | TRANSFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | miR-367 | LUNG-CANCER | INVASION | ONCOLOGY | SIGNALING PATHWAY | GASTRIC-CANCER | GROWTH ARREST | COLORECTAL-CANCER | TARGETING FBXW7 | MIR-367 PROMOTES | Prognosis | Liver Neoplasms - genetics | Neoplasm Invasiveness | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | MicroRNAs - metabolism | RNA, Long Noncoding - genetics | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Down-Regulation - genetics | Base Sequence | Carcinoma, Hepatocellular - genetics | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Female | Liver Neoplasms - pathology | MicroRNAs - genetics | F-Box-WD Repeat-Containing Protein 7 - metabolism | RNA, Long Noncoding - metabolism | Immunohistochemistry | MicroRNA | Analysis | Stem cells | Development and progression | Disease susceptibility | Hepatoma | Metastasis | Health aspects | Biotechnology | Leukocyte migration | Mesenchyme | Lung cancer | Colorectal cancer | Kinases | Tissues | Assaying | Carcinogenesis | Stomach cancer | Cdc4 protein | Western blotting | Metastases | Cell adhesion & migration | Liver cancer | Carcinogens | Cell growth | MiRNA | Biotin | RNA polymerase | Ribonucleic acid--RNA | Polymerase chain reaction | MicroRNAs | Cell lines | Tumor suppressor genes | Non-coding RNA | In vitro methods and tests | Cell migration | Cancer | Apoptosis
Journal Article
Journal Article
Cancers, ISSN 2072-6694, 09/2019, Volume 11, Issue 10, p. 1456
N6-isopentenyladenosine has been shown to exert potent in vitro antitumor activity on different human cancers, including colorectal cancer. Although some... 
5-fluorouracil | N6-isopentenyladenosine | chemoresistance | mevalonate pathway | FBXW7 | colon cancer
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 39, pp. 66360 - 66370
The NOTCH1 signaling pathway is crucial for T-cell development, and NOTCH1 and/or FBXW7 mutations are frequently detected in T-cell acute lymphoblastic... 
NOTCH1 | Prognosis | FBXW7 | T-ALL | Meta-analysis | PATHOGENESIS | meta-analysis | prognosis | CELL BIOLOGY
Journal Article
by Kuai, XL and Li, L and Chen, R and Wang, KJJ and Chen, M and Cui, BH and Zhang, YX and Li, JQ and Zhu, HW and Zhou, H and Huang, JF and Qin, J and Wang, ZW and Wei, WY and Gao, DM
CANCER RESEARCH, ISSN 0008-5472, 09/2019, Volume 79, Issue 17, pp. 4387 - 4398
Gastric cancer is the third leading cause of cancer-related death worldwide. The regulatory mechanisms underlying gastric cancer cell proliferation are largely... 
APOPTOSIS | ONCOLOGY | FBXW7 | STATISTICS | PROGNOSIS | GROWTH | GENES | C-MYC | TUMOR-SUPPRESSOR | EXPRESSION | FBW7 UBIQUITIN LIGASE
Journal Article
Tumor Biology, ISSN 1010-4283, 10/2016, Volume 37, Issue 10, pp. 13893 - 13902
Journal Article
Journal Article
by Zhu, JL and Li, Y and Chen, CY and Ma, JG and Sun, WR and Tian, ZX and Li, JX and Xu, JH and Liu, CS and Zhang, DY and Huang, CS and Huang, HS
NEOPLASIA, ISSN 1476-5586, 09/2017, Volume 19, Issue 9, pp. 672 - 683
BACKGROUND: Since invasive bladder cancer (BC) is one of the most lethal urological malignant tumors worldwide, understanding the molecular mechanisms that... 
BREAST-CANCER | ACTIVATION | INVASION | METASTASIS | ONCOLOGY | FBXW7 | PHOSPHORYLATION | TUMOR-SUPPRESSOR | RHO-GTPASES | FBW7 UBIQUITIN LIGASE | PTEN EXPRESSION
Journal Article