X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (27) 27
index medicus (27) 27
cats (15) 15
lysosomal storage disease (13) 13
feline model (12) 12
gene therapy (10) 10
mutation (10) 10
veterinary sciences (10) 10
disease models, animal (9) 9
feline (9) 9
genetics & heredity (9) 9
humans (9) 9
mice (9) 9
sandhoff disease (9) 9
tay-sachs-disease (9) 9
animal model (8) 8
gangliosidosis (8) 8
male (8) 8
medicine, research & experimental (8) 8
neurosciences (8) 8
female (7) 7
biotechnology & applied microbiology (6) 6
brain (6) 6
central-nervous-system (6) 6
disease (6) 6
g gangliosidosis (6) 6
gm2 gangliosidosis (6) 6
mouse models (6) 6
viruses (6) 6
cat diseases - genetics (5) 5
deficiency (5) 5
dogs (5) 5
gene-therapy (5) 5
genetic therapy (5) 5
hexosaminidase (5) 5
tay-sachs disease (5) 5
adeno-associated virus (4) 4
beta-galactosidase (4) 4
central nervous system (4) 4
dependovirus - genetics (4) 4
feline sandhoff disease (4) 4
gangliosidoses, gm2 - genetics (4) 4
genetic therapy - methods (4) 4
genomes (4) 4
golden retriever (4) 4
lysosomal storage (4) 4
proteins (4) 4
research (4) 4
sandhoff disease - genetics (4) 4
sandhoff-disease (4) 4
aav (3) 3
analysis (3) 3
animals, newborn (3) 3
article (3) 3
base sequence (3) 3
beta-hexosaminidase (3) 3
beta-n-acetylhexosaminidases - genetics (3) 3
biochemistry & molecular biology (3) 3
brain - pathology (3) 3
cat (3) 3
cat diseases - enzymology (3) 3
cerebrospinal-fluid (3) 3
dog diseases - genetics (3) 3
feline immunodeficiency virus (3) 3
g ganglioside - metabolism (3) 3
g-gangliosidosis (3) 3
gangliosides (3) 3
gangliosidoses, gm2 - metabolism (3) 3
gangliosidoses, gm2 - pathology (3) 3
genes (3) 3
genetic aspects (3) 3
genetic vectors - administration & dosage (3) 3
genetic vectors - genetics (3) 3
genetics (3) 3
gm2 ganglioside (3) 3
hexosaminidase b - genetics (3) 3
japanese domestic cats (3) 3
long-term expression (3) 3
lysosomal storage diseases (3) 3
medical research (3) 3
nervous system (3) 3
pathology (3) 3
pedigree (3) 3
research articles (3) 3
sandhoff disease - veterinary (3) 3
tay-sachs disease - genetics (3) 3
tay-sachs disease - therapy (3) 3
veterinary medicine (3) 3
zoology (3) 3
acid sphingomyelinase (2) 2
activator protein (2) 2
adenoassociated virus (2) 2
animal models (2) 2
antibody (2) 2
assays (2) 2
beta-galactosidase - genetics (2) 2
beta-hexosaminidase beta chain - genetics (2) 2
biomarkers (2) 2
blood-brain-barrier (2) 2
bone-marrow transplantation (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Current Gene Therapy, ISSN 1566-5232, 2018, Volume 18, Issue 2, pp. 68 - 89
Journal Article
Journal of Veterinary Internal Medicine, ISSN 0891-6640, 09/2010, Volume 24, Issue 5, pp. 1013 - 1019
Journal Article
Journal Article
Human Gene Therapy, ISSN 1043-0342, 03/2018, Volume 29, Issue 3, pp. 312 - 326
Journal Article
Journal Article
Journal of Veterinary Internal Medicine, ISSN 0891-6640, 01/2018, Volume 32, Issue 1, pp. 348 - 351
Journal Article
Human Gene Therapy, ISSN 1043-0342, 06/2017, Volume 28, Issue 6, pp. 51 - 522
GM2 gangliosidoses, including Tay–Sachs disease and Sandhoff disease, are lysosomal storage disorders caused by deficiencies in β-N-acetylhexosaminidase (Hex).... 
Research Articles | hexosaminidase | gene therapy | adeno-associated virus | Tay-Sachs disease | intracranial delivery | AAV | LONG-TERM | MOUSE-BRAIN | MEDICINE, RESEARCH & EXPERIMENTAL | SINGLE INJECTION | SANDHOFF-DISEASE | VECTOR | DELIVERY | FELINE MODEL | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | NERVOUS-SYSTEM DISEASE | GENE-THERAPY | REDUCES LYSOSOMAL STORAGE | Dependovirus - genetics | Neurons - pathology | Thalamus - metabolism | White Matter - metabolism | Injections, Intraventricular | Macaca fascicularis | Genetic Vectors - adverse effects | Male | Thalamus - pathology | Gangliosidoses, GM2 - pathology | Necrosis - pathology | Protein Subunits - metabolism | Apathy | Gray Matter - metabolism | Female | Neurons - metabolism | beta-N-Acetylhexosaminidases - genetics | Transgenes | Gangliosidoses, GM2 - genetics | Dyskinesias - genetics | Disease Models, Animal | Protein Subunits - genetics | Gangliosidoses, GM2 - therapy | Gene Expression | Dependovirus - metabolism | Genetic Vectors - chemistry | beta-N-Acetylhexosaminidases - metabolism | Dyskinesias - pathology | Genetic Vectors - metabolism | Necrosis - metabolism | Dyskinesias - etiology | Dyskinesias - metabolism | White Matter - pathology | Protein Subunits - adverse effects | Animals | Necrosis - etiology | Gray Matter - pathology | Necrosis - genetics | beta-N-Acetylhexosaminidases - adverse effects | Gangliosidoses, GM2 - metabolism | Genetic Therapy - methods | Neuroimaging | Brain | Hex protein | Central nervous system | Lysosomal storage diseases | Ventricles (cerebral) | Monkeys | Substantia grisea | Necrosis | Proteins | Infusion | Neurotoxicity | Histopathology | Coding | Ataxia | Thalamus | Safety | Lesions | Leukocytes (eosinophilic) | Abnormalities | Injection | Magnetic resonance imaging | Sheep | Ventricle | Index Medicus
Journal Article
VETERINARY PATHOLOGY, ISSN 0300-9858, 05/2015, Volume 52, Issue 3, pp. 543 - 552
Clinical, gross, histopathologic, electron microscopic findings and enzymatic analysis of 4 captive, juvenile springboks (Antidorcas marsupialis) showing both... 
springbok | storage disease | LYSOSOMAL STORAGE DISEASE | hexosaminidase | autosomal-recessive | PATHOLOGY | Antidorcas marsupialis | neurons | G(M2) GANGLIOSIDOSIS | SANDHOFF DISEASE | RENAL CYSTIC-DISEASE | FELINE MODEL | GM gangliosidosis | polycystic kidney disease | HEXB GENE | BETA-GALACTOSIDASE | VETERINARY SCIENCES | AUTOSOMAL-DOMINANT | TAY-SACHS-DISEASE | ALASKAN HUSKIES
Journal Article
Experimental Neurology, ISSN 0014-4886, 05/2004, Volume 187, Issue 1, pp. 30 - 37
In G gangliosidosis variant 0, a defect in the β-subunit of lysosomal β-N-acetylhexosaminidase (EC 3.2.1.52) causes abnormal accumulation of G ganglioside and... 
Animal model | Gangliosidosis | Quantitative RT-PCR | Antibody | Feline | GM2 ganglioside | Inversion | Mutation | Sandhoff disease | Hexosaminidase
Journal Article
EXPERIMENTAL NEUROLOGY, ISSN 0014-4886, 05/2004, Volume 187, Issue 1, pp. 30 - 37
In G(M2) gangliosidosis variant 0, a defect in the beta-subunit of lysosomal beta-N-acetylhexosaminidase (EC 3.2.1.52) causes abnormal accumulation of G(M2)... 
ALPHA-SUBUNITS | antibody | feline | gangliosidosis | hexosaminidase | FACTOR-VIII GENE | Sandhoff disease | SANDHOFF-DISEASE | NEUROSCIENCES | mutation | inversion | MESSENGER-RNA | HUMAN-FIBROBLASTS | GM2 ganglioside | GM1 GANGLIOSIDOSIS | quantitative RT-PCR | HEMOPHILIA-A | HUMAN BETA-HEXOSAMINIDASE | animal model | TAY-SACHS-DISEASE | MOLECULAR-BASIS
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 2009, Volume 209, Issue 1, pp. 139 - 142
Journal Article
Journal Article
Molecular Brain Research, ISSN 0169-328X, 2005, Volume 133, Issue 2, pp. 286 - 298
Brain inflammation in GM gangliosidosis has been recently realized as a key factor in disease development. The aim of this study was to investigate the effects... 
GM2 gangliosidosis | Lysosomal storage | Feline immunodeficiency virus | β-hexosaminidase | Gene therapy | LYSOSOMAL STORAGE DISEASE | BONE-MARROW-TRANSPLANTATION | feline immunodeficiency virus | LONG-TERM EXPRESSION | gene therapy | HUMAN TAY-SACHS | SANDHOFF-DISEASES | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | MOUSE MODELS | lysosomal storage | beta-hexosaminidase | CENTRAL-NERVOUS-SYSTEM | GENE-TRANSFER | RADIATION-INJURY | Central Nervous System - metabolism | beta-N-Acetylhexosaminidases - classification | Genetic Vectors - administration & dosage | Histocytochemistry - methods | Humans | Peripheral Nerves - virology | Glial Fibrillary Acidic Protein - metabolism | G(M2) Ganglioside - metabolism | Behavior, Animal | Hymecromone - analogs & derivatives | Indoles - metabolism | Central Nervous System - anatomy & histology | Reverse Transcriptase Polymerase Chain Reaction - methods | Histocompatibility Antigens Class II - metabolism | Lentivirus - genetics | Peripheral Nerves - metabolism | Hymecromone - pharmacology | Immunodeficiency Virus, Feline - physiology | beta-N-Acetylhexosaminidases - genetics | Transduction, Genetic - methods | Central Nervous System - virology | Fibroblasts - metabolism | Animals, Newborn | Fibroblasts - virology | Hexosaminidase B | Lentivirus Infections | Cell Line | Cricetinae | beta-N-Acetylhexosaminidases - biosynthesis | Rotation | Mice, Knockout | beta-N-Acetylhexosaminidases - deficiency | Gene Expression Regulation - drug effects | Animals | Cell Count - methods | Galactosides - metabolism | Mice | Index Medicus
Journal Article