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index medicus (160) 160
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fetal-rat hepatocytes (74) 74
rats (73) 73
humans (66) 66
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biochemistry & molecular biology (51) 51
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liver - embryology (30) 30
tgf-beta (30) 30
liver - metabolism (29) 29
apoptosis (28) 28
hepatocytes (27) 27
endocrinology & metabolism (25) 25
messenger-rna (19) 19
physiology (19) 19
rats, sprague-dawley (19) 19
growth-factor-beta (18) 18
hepatocytes - cytology (18) 18
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rats, wistar (18) 18
rna, messenger - metabolism (18) 18
signal transduction (18) 18
liver - cytology (17) 17
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animals, newborn (15) 15
fetal-rat lung (15) 15
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fetus (14) 14
gene expression (14) 14
phosphorylation (14) 14
hepatocytes - drug effects (13) 13
immunohistochemistry (13) 13
oncology (13) 13
rna, messenger - genetics (13) 13
up-regulation (13) 13
base sequence (12) 12
hepatoma-cells (12) 12
liver - enzymology (12) 12
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respiratory system (12) 12
down-regulation (11) 11
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activation (10) 10
apoptosis - drug effects (10) 10
biophysics (10) 10
cell division (10) 10
developmental biology (10) 10
metabolism (10) 10
mice, knockout (10) 10
molecular sequence data (10) 10
reactive oxygen species - metabolism (10) 10
transforming growth factor beta - pharmacology (10) 10
abridged index medicus (9) 9
biology (9) 9
dexamethasone - pharmacology (9) 9
hepatocyte (9) 9
insulin (9) 9
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rats, inbred strains (9) 9
signal transduction - physiology (9) 9
survival signals (9) 9
apoptosis - physiology (8) 8
blotting, western (8) 8
carcinoma, hepatocellular - pathology (8) 8
cell line, tumor (8) 8
factor-i (8) 8
fetal rat hepatocytes (8) 8
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Journal Article
Journal Article
FEBS Journal, ISSN 1742-464X, 04/2016, Volume 283, Issue 7, pp. 1300 - 1310
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2008, Volume 49, Issue 6, pp. 965 - 976
Background/Aims The transforming growth factor-beta (TGF-β) induces apoptosis in hepatocytes through an oxidative stress process. Here, we have analyzed the... 
Gastroenterology and Hepatology | NOX4 | TGF-beta | Hepatocarcinogenesis | NADPH oxidase | Apoptosis | OXYGEN SPECIES PRODUCTION | SIGNALING PATHWAYS | OXIDATIVE STRESS | PRIMARY CULTURE | DOWN-REGULATION | HEPATOMA-CELLS | REACTIVE OXYGEN | FETAL-RAT HEPATOCYTES | TRANSFORMING-GROWTH-FACTOR | GASTROENTEROLOGY & HEPATOLOGY | DEPENDENT MECHANISM | Transcription, Genetic - drug effects | Rats, Wistar | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | NADPH Oxidases - metabolism | Hepatocytes - cytology | Up-Regulation - physiology | NADPH Oxidases - genetics | Liver Neoplasms - pathology | Genes, Reporter | Hepatocytes - drug effects | Rats | NADPH Oxidase 4 | Fetus - cytology | Gene Expression Regulation, Enzymologic | Up-Regulation - drug effects | Transforming Growth Factor beta - pharmacology | Transcription, Genetic - physiology | Animals | Signal Transduction - drug effects | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Signal Transduction - physiology | RNA, Small Interfering | Apoptosis - physiology | Hepatocytes - enzymology | Oxidases | Liver cancer | Growth factors | Analysis | Index Medicus | Cell and Molecular Biology | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell- och molekylärbiologi | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Experimental Cell Research, ISSN 0014-4827, 2006, Volume 312, Issue 15, pp. 2860 - 2871
Journal Article
ONCOGENE, ISSN 0950-9232, 06/2005, Volume 24, Issue 28, pp. 4580 - 4587
Transforming growth factor beta1 (TGF-beta 1) belongs to a family of polypeptide factors, whose cytostatic and apoptotic functions help restrain the growth of... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR SNAIL | apoptosis | NECROSIS-FACTOR-ALPHA | CELL-PROLIFERATION | TYROSINE KINASES | TUMOR-CELLS | Akt | MESENCHYMAL TRANSITION | EGFR | hepatocytes | CELL BIOLOGY | TGF-beta | c-Src | GROWTH-FACTOR-BETA | ONCOLOGY | GENETICS & HEREDITY | FETAL-RAT HEPATOCYTES | CONVERTING-ENZYME
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 19, pp. 15263 - 15274
Transforming growth factor-beta (TGF-beta) plays a dual role in hepatocytes, mediating both tumor suppressor and promoter effects. The suppressor effects of... 
SIGNAL-TRANSDUCTION | NADPH OXIDASE | OXIDATIVE STRESS | TGF-BETA | INDUCED-APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FETAL-RAT HEPATOCYTES | FACTOR-KAPPA-B | SMOOTH-MUSCLE-CELLS | FACTOR RECEPTOR | UP-REGULATION | Cell Cycle - genetics | Apoptosis - drug effects | Apoptosis - genetics | Smad3 Protein - metabolism | Hepatocytes - metabolism | Transcription Factor RelA - genetics | Smad3 Protein - genetics | Hepatocytes - cytology | Cell Nucleus - metabolism | RNA Interference | Smad2 Protein - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Phosphorylation - drug effects | NADH, NADPH Oxidoreductases - metabolism | Smad7 Protein - genetics | Hepatocytes - drug effects | Transforming Growth Factor beta1 - pharmacology | Smad7 Protein - metabolism | Animals, Newborn | NADH, NADPH Oxidoreductases - genetics | Cells, Cultured | Smad2 Protein - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - deficiency | Blotting, Western | NADPH Oxidase 1 | Mice, Knockout | Drug Resistance - genetics | Animals | Transcription Factor RelA - metabolism | Active Transport, Cell Nucleus - drug effects | Genistein - pharmacology | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Cell Nucleus - drug effects | Cell Line, Transformed | Index Medicus | Protein Phosphatase | NF-κB | PTP1B | Hepatocyte | Cell Biology | NADPH Oxidase | Transforming Growth Factor-β (TGF-β) | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2007, Volume 405, Issue 2, pp. 251 - 259
The TGF-beta (transforming growth factor-beta) induces survival signals in foetal rat hepatocytes through transactivation of EGFR (epidermal growth factor... 
Transforming growth factor (TGF) | NADPH oxidase (NOX) | Nuclear factor-κB (NF-κB) | Hepatocyte | Heparin-binding epidermal growth factor-like growth factor (HB-EGF) | Reactive oxygen species (ROS) | APOPTOSIS | OXIDATIVE STRESS | hepatocyte | TGF-BETA | FACTOR-ALPHA EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INVOLVEMENT | reactive oxygen species (ROS) | heparin-binding epidermal growth factor-like growth factor (HB-EGF) | transforming growth factor (TGF) | SIGNALING PATHWAY | nuclear factor-kappa B (NF-kappa B) | FETAL-RAT HEPATOCYTES | SURVIVAL SIGNALS | SMOOTH-MUSCLE-CELLS | EGF RECEPTOR | EGFR, EGF receptor | DPI, diphenyleneiodonium | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate | HB-EGF, heparin-binding EGF-like growth factor | JNK, c-Jun N-terminal kinase | NOX, NADPH oxidase | ERK, extracellular-signal-regulated kinase | XIAP, X-linked inhibitor of apoptosis | TGF, transforming growth factor | RT, reverse transcriptase | mTOR, mammalian target of rapamycin | ROS, reactive oxygen species | SBE, Smad-binding element | TβR-I, TGF-β receptor type I | TNFα, tumour necrosis factor α | DAPI, 4′,6-diamidino-2-phenylindole | nuclear factor-κB (NF-κB) | SOD, superoxide dismutase | EMSA, electrophoretic mobility-shift assay | NF-κB, nuclear factor-κB | DHE, dihydroethidine | MAPK, mitogen-activated protein kinase
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 05/2011, Volume 226, Issue 5, pp. 1214 - 1223
Transforming growth factor‐beta (TGF‐β) mediates several and sometime opposite effects in epithelial cells, inducing growth inhibition, and apoptosis but also... 
PROGENITOR CELLS | TRANSITION | HEPATOCELLULAR-CARCINOMA CELLS | APOPTOSIS | IN-VITRO | PHYSIOLOGY | FETAL-RAT HEPATOCYTES | SURVIVAL SIGNALS | UP-REGULATION | CONFERS RESISTANCE | EGF RECEPTOR | CELL BIOLOGY | Liver - pathology | Cell Proliferation | Cadherins - metabolism | Humans | Transforming Growth Factor beta1 - metabolism | Apoptosis - genetics | Hepatocytes - pathology | Cell Transdifferentiation - genetics | Hepatocytes - metabolism | Liver - embryology | Receptor, Epidermal Growth Factor - metabolism | Liver - drug effects | Cell Transdifferentiation - drug effects | Apoptosis Regulatory Proteins - genetics | Liver Neoplasms - pathology | Snail Family Transcription Factors | Hepatocytes - drug effects | Recombinant Proteins - metabolism | Mesenchymal Stromal Cells - drug effects | Neoplasm Invasiveness | Liver - metabolism | Cells, Cultured | Gene Expression Regulation | Mesenchymal Stromal Cells - metabolism | Signal Transduction - genetics | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Phenotype | Signal Transduction - drug effects | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Carcinoma, Hepatocellular - metabolism | Index Medicus | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article