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The Journal of biological chemistry, ISSN 0021-9258, 09/2016, Volume 291, Issue 36, pp. 18632 - 18642
.... RPTECs express the NPT2A phosphate transporter, alpha Klotho, FGFR1, FGFR3, FGFR4, and the PTH receptor... 
RENAL PROXIMAL TUBULE | PROTEIN-KINASE-A | MDCK CELLS | ACTIVATION | PTH | FGF-RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | I COTRANSPORTERS | FACTOR RECEPTOR GENES | CALCIUM-TRANSPORT | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Receptor, Parathyroid Hormone, Type 1 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Phosphoproteins - genetics | Phosphoproteins - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 4 - biosynthesis | Parathyroid Hormone - genetics | Sodium-Hydrogen Exchangers - metabolism | Sodium-Phosphate Cotransporter Proteins, Type IIa - metabolism | Sodium-Phosphate Cotransporter Proteins, Type IIa - genetics | Fibroblast Growth Factors - metabolism | Phosphates - metabolism | Glucuronidase - biosynthesis | Glucuronidase - genetics | Parathyroid Hormone - metabolism | Receptor, Parathyroid Hormone, Type 1 - genetics | Signal Transduction - physiology | Sodium-Hydrogen Exchangers - genetics | Receptor, Fibroblast Growth Factor, Type 3 - biosynthesis | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Cell Line, Transformed | parathyroid hormone | NPT2A | klotho | PDZ Protein | fibroblast growth factor receptor (FGFR) | NHERF1 | alternative splicing | G protein-coupled receptor (GPCR) | transport | Cell Biology
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2011, Volume 30, Issue 4, pp. 783 - 795
.... During the EMT process, TGF‐β induced isoform switching of fibroblast growth factor (FGF) receptors, causing the cells to become sensitive to FGF‐2. Addition of FGF‐2 to TGF‐β... 
FGF‐2 | TGF‐β | δEF1 | FGF receptor | EMT | FGF-2 | TGF-β | CELLS | dEF1 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | IDENTIFICATION | SUPPRESSION | FIBROBLASTS | CELL BIOLOGY | PROSTATE ADENOCARCINOMA | COREPRESSORS | TGF-beta | TUMOR-GROWTH | PROGRESSION | Neoplasms - metabolism | Protein Binding - genetics | Myofibroblasts - physiology | Epithelial-Mesenchymal Transition - physiology | Homeodomain Proteins - metabolism | Humans | Actins - metabolism | Fibroblast Growth Factor 2 - pharmacology | Epithelial-Mesenchymal Transition - drug effects | Epithelial-Mesenchymal Transition - genetics | Actins - genetics | DNA-Binding Proteins - metabolism | Myofibroblasts - metabolism | Cell Differentiation - genetics | Protein Isoforms - metabolism | Neoplasms - genetics | Protein Binding - drug effects | Receptors, Fibroblast Growth Factor - genetics | Fibroblast Growth Factor 2 - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Cell Differentiation - physiology | Neoplasm Invasiveness | Alternative Splicing - genetics | Cells, Cultured | Transforming Growth Factor beta - physiology | Alcohol Oxidoreductases - metabolism | Signal Transduction - genetics | Myofibroblasts - drug effects | Protein Isoforms - physiology | Transcription Factors - metabolism | Transforming Growth Factor beta - pharmacology | Alternative Splicing - drug effects | Cell Differentiation - drug effects | Models, Biological | Receptors, Fibroblast Growth Factor - metabolism | Neoplasms - pathology | Protein Isoforms - genetics | Zinc Finger E-box-Binding Homeobox 1
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2009, Volume 52, Issue 3, pp. 455 - 462
A joint EASL/AASLD Monothematic Conference on ‘Nuclear Receptors and Liver Disease... 
Gastroenterology and Hepatology | Nuclear receptor | Fatty liver | Gene expression | Ligand | Cholestasis | Fibrosis | HNF | glucocorticoid receptor | GWAS | hepatitis B virus | AR (NR3C4) | MTP | nuclear (hormone) receptor | double knockout | pregnane X receptor | VDR (NR1I2) | PBC | androgen receptor | fibroblast growth factor | RARα (NR1B1) | primary biliary cirrhosis | HSC | vitamin D receptor | Abbreviations | HBV | hepatocellular carcinoma | hepatocyte nuclear factor | retinoid X receptor | GR (NR3C1) | PSC | hepatic stellate cells | peroxisomal proliferator-activated receptor gamma | LRH-1 (NR5A2) | FGF | bile acid | DKO | HCC | CAR (NR1I3) | non alcoholic fatty liver disease | SHP (NR0B2) | HCV | peroxisomal proliferator-activated receptor alpha | primary sclerosing cholangitis | NAFLD | white adipose tissue | fatty acid | PPARα (NR1C1) | WAT | hepatitis C virus | genome wide association study | farnesoid X receptor/bile acid receptor | liver receptor homolog-1 | microsomal transfer protein | estrogen receptor | RXRα (NR2B1) | intrahepatic cholestasis of pregnancy | retinoic acid receptor | PPARγ (NR1C3) | PXR (NR1I2) | ER (NR3A1) | constitutive androstane receptor | ICP | short heterodimer partner | FXR (NR1H4) | ADIPOSE-TISSUE EXPANDABILITY | SMALL HETERODIMER PARTNER | BILE-ACID | DETOXIFICATION | UNION-OF-PHARMACOLOGY | FARNESOID-X-RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | EXPRESSION | ASSOCIATION | INSIGHTS | Transcription Factors - physiology | Inactivation, Metabolic - physiology | Polymorphism, Genetic - physiology | Humans | Liver - physiology | Liver Diseases - therapy | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - genetics | Liver Diseases - physiopathology | Liver Regeneration - physiology | Lipid Metabolism - physiology | Inflammation - physiopathology
Journal Article
Cancer cell, ISSN 1535-6108, 2017, Volume 32, Issue 4, pp. 474 - 489.e6
Journal Article
Cell metabolism, ISSN 1550-4131, 2015, Volume 22, Issue 6, pp. 1020 - 1032
.... Previously, we demonstrated that circulating concentrations of fibroblast growth factor (FGF) 23 rise progressively in CKD and induce LVH through an unknown FGF receptor... 
KIDNEY-DISEASE | MORTALITY | KLOTHO | POINT MUTATION | SPECIFICITY | ENDOCRINOLOGY & METABOLISM | INHIBITOR | BLOCKADE | BINDING | EXPRESSION | FGF RECEPTOR | CELL BIOLOGY | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Humans | Glucuronidase - metabolism | Fibroblast Growth Factors - genetics | Male | Renal Insufficiency, Chronic - metabolism | Fibroblast Growth Factors - metabolism | Hypertrophy, Left Ventricular - pathology | HEK293 Cells | Receptor, Fibroblast Growth Factor, Type 4 - deficiency | Female | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Disease Models, Animal | Phospholipase C gamma - metabolism | Mutagenesis, Site-Directed | Myocytes, Cardiac - cytology | Signal Transduction | Hypertrophy, Left Ventricular - metabolism | Mice, Inbred C57BL | NFATC Transcription Factors - metabolism | Cells, Cultured | Rats | Rats, Sprague-Dawley | Gene Knock-In Techniques | Mice, Knockout | Renal Insufficiency, Chronic - pathology | Animals | Glucuronidase - genetics | Myocytes, Cardiac - metabolism | Mice | Calcineurin - metabolism | Hypertension | Medical colleges | Chronic kidney failure | Heart enlargement | Stem cells | Physiological aspects | Fibroblast growth factors | Phospholipases | Drug discovery | T cells | Health aspects | Heart | Resveratrol | Development and progression | Kidney diseases | Cells
Journal Article
Acta pharmaceutica Sinica. B, ISSN 2211-3835, 2015, Volume 5, Issue 2, pp. 93 - 98
...) are ligands of farnesoid X receptor(FXR), a nuclear receptor of ligand-activated transcription factor... 
Farnesoid X receptor | Liver-intestine croass talk | Fibroblast growth factor 15 | Bile acids | Liver regeneration | Transmembrane G protein coupled receptor 5 | RAT-LIVER | PARTIAL-HEPATECTOMY | PHOSPHORYLATION | PROLIFERATION | IDENTIFICATION | METABOLISM | DISEASE | PHARMACOLOGY & PHARMACY | MICE | GROWTH-FACTOR 15 | EXPRESSION | AMPK, AMP-activated protein kinase | Review | JNK, c-Jun N-terminal kinase | ABC, ATP-binding cassette | CTX, cerebrotendinous xanthomatosis | cAMP, cyclic adenosine monophosphate | FGF-15, fibroblast growth factor 15 | BA, bile acid | ERK1 | 2, extracellular signal-regulated kinase 1 | Fxr-KO, Fxr-knockout | NASH, nonalcoholic steatohepatitis | SHP, small heterodimer partner | CA, cholic acid | Rb, retinoblastoma | KC, Kupffer cells | EBPβ, CCAAT-enhancer binding protein β | HEX, hematopoietically expressed homeobox | Cyp27-KO, sterol 27-hydroxylase–knockout | DDAH-1, dimethylarginineaminohydrolase-1 | FXR, farnesoid X receptor | CDCA, chenodeoxycholic acid | FGFR4, FGF receptor 4 | WT, wild type | CYP8B1, sterol 12α-hydroxylase | STAT3, signal transducer and activator of transcription 3 | GPBAR1 or TGR5, G protein-coupled BA receptor 1 | CYP7A1, cholesterol 7alpha-hydroxylase | FOXM1b, forkhead boxm1b | MRP3, multidrug resistance associated protein 3 | PH, partial hepatectomy | THR, TH receptor | NF-κB, nuclear factor-κB | KO, knockout | hepFxr-KO, hepatocyte-specific Fxr knockout | TH, thyroid hormone | MAPK, mitogen-activated protein kinase
Journal Article
Acta pharmaceutica Sinica. B, ISSN 2211-3835, 2015, Volume 5, Issue 5, pp. 390 - 401
Since the discovery that non-small cell lung cancer(NSCLC) is driven by epidermal growth factor receptor(EGFR... 
Resistance | Mechanisms | TKIs | EGFR | TARGETED THERAPY | ACQUIRED-RESISTANCE | T790M MUTATION | GEFITINIB RESISTANCE | CELL LUNG-CANCER | EPITHELIAL-MESENCHYMAL TRANSITION | GROWTH-FACTOR RECEPTOR | ERLOTINIB RESISTANCE | PHARMACOLOGY & PHARMACY | INTEGRIN BETA1 | TUMOR-GROWTH | ALK, anaplastic lymphoma kinase | BH3, BCL2-homology domain 3 | PDGFRs, platelet-derived growth factor receptors | lymphoma-2 | PDGFs, platelet-derived growth factors | PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase,catalytic subunit alpha | VEGFR, vascular endothelial growth factor receptor | RAF, rapidly accelerated fibrosarcoma | FGFs, fibroblast growth factors | BCL-2, B-cell CLL | IGFBPs, IGF-binding proteins | ERK1 | BIM, BCL2-like 11 | ABCC10, ATP binding cassette, sub-family C, member 10 | ABCC1, ATP binding cassette, sub-family C, member 1 | VEGF, vascular endothelial growth factor | TKs, tyrosine kinases | HER, human epidermal receptor | MEK, mitogen-activated protein kinase | EGFR, epidermal growth factor receptor | BRAF, v-RAF murine sarcoma viral oncogene homolog B1 | AXL, Anexelekto | AKT, protein kinase B | IL, interleukin | TKIs, tyrosine kinase inhibitors | RAS, rat sarcoma | RTK, tyrosine kinase receptor | MAPK, mitogen-activated protein kinase | FGFRs, fibroblast growth factor receptors | SOCS3, suppressor of cytokine signaling 3 | EMT, epithelial mesenchymal transition | IGF, insulin growth factor | Review | 2, extracellular signal-regulated kinases | EML4, echinoderm microtubule-associated protein-like 4 | ABCG2, ATP binding cassette, sub-family G, member 2 | ABCB1, ATP binding cassette, sub-family B, member 1 | BCL2L11 | IL-6R, IL-6 receptor | IGF-1R, IGF-1 receptor | SF, scatter factor | PI3K, phosphatidylinositol-3-kinase | CML, chronic myelogenous leukemia | EGFR-TKIs, epidermal growth factor receptor tyrosine kinase inhibitors | JAK, janus kinase | NSCLC, non-small cell lung cancer | ABC, ATP binding cassette | GAS6, growth-arrest-specific protein 6 | STAT, signal transducers and activators of transcription | EGFRvIII, EGFR variant III | CRKL, Crk-like protein | HGF, hepatocyte growth factor | PTEN, phosphatase and tensin homolog
Journal Article
Journal Article
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 10/2011, Volume 54, Issue 20, pp. 7066 - 7083
Journal Article