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Biochemical Journal, ISSN 0264-6021, 09/2006, Volume 398, Issue 3, pp. 423 - 430
The Gpbar1 [G-protein-coupled BA (bile acid) receptor 1] is a recently identified cell-surface receptor that can bind and is activated by BAs, but its... 
Gene ablation | Bile acid | Cholesterol | Gall-bladder | G-protein-coupled bile acid receptor 1 (Gpbar1) | Gallstone | BETA-KLOTHO | PATHWAYS | HOMEOSTASIS | bile acid | NEGATIVE FEEDBACK-REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BILE-ACID SYNTHESIS | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | HEPATIC PHYSIOLOGY | gene ablation | gall-bladder | LIVER | cholesterol | gallstone | SHP | Dietary Fats - metabolism | Liver - pathology | Bile Acids and Salts - biosynthesis | Receptors, G-Protein-Coupled - metabolism | Gene Expression Regulation | Gallstones - chemistry | Gallbladder - pathology | Mice, Knockout | Animals | Gallstones - genetics | Cholesterol 7-alpha-Hydroxylase - metabolism | Gene Deletion | Cholesterol - analysis | Mice | Receptors, G-Protein-Coupled - genetics | RNA, Messenger | Gallstones - metabolism | CSI, cholesterol saturation index | Cyp27a1, sterol 27-hydroxylase | BA, bile acid | ES cell, embryonic stem cell | GPCR, G-protein-coupled receptor | SHP, small heterodimer partner | CA, cholic acid | LXR, liver X receptor α | PXR, pregnane X receptor | FXR, farnesoid X receptor | CDCA, chenodeoxycholic acid | FGFR4, FGF receptor 4 | FAM, 6-carboxyfluorescein | FGF, fibroblast growth factor | TEA, triethanolamine | D2, type 2 iodothyroninedeiodinase | CGD, cholesterol gallstone disease | TG, triacylglycerol | Cyp7a1, cholesterol 7α-hydroxylase | CBC, complete blood count | FTF, α-fetoprotein transcription factor | NSS, normal sheep serum | Gpbar1, G-protein-coupled BA receptor 1
Journal Article
Cellular Signalling, ISSN 0898-6568, 01/2018, Volume 42, pp. 144 - 154
Receptor tyrosine kinases (RTKs) form multiprotein complexes that initiate and propagate intracellular signals and determine the RTK-specific signalling... 
Fibroblast growth factor | receptor tyrosine kinase | interactome | signal transduction | FGFR3 | ACTIVATION | PROTEIN | FGF | PHOSPHORYLATION | CELL BIOLOGY | ARREST | CELL-MIGRATION | MOUSE MODEL | SKELETAL DYSPLASIA | S6 KINASE | C-SRC | NIH 3T3 Cells | Phosphorylation | Cyclin-Dependent Kinases - metabolism | Homeodomain Proteins - metabolism | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Gene Expression Profiling | Phosphoproteins - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | HEK293 Cells | Peptide Elongation Factor 1 - genetics | Proteomics - methods | Cyclin-Dependent Kinases - genetics | Protein-Serine-Threonine Kinases - metabolism | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - genetics | Endosomal Sorting Complexes Required for Transport - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Phosphoproteins - genetics | Homeodomain Proteins - genetics | Protein Interaction Mapping | Animals | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Mice | Adaptor Proteins, Signal Transducing - metabolism | Peptide Elongation Factor 1 - metabolism | Tyrosine | Phosphatases | Analysis | Phenols | Cellular signal transduction | Fibroblast growth factors | Cells
Journal Article
Science, ISSN 0036-8075, 5/1997, Volume 276, Issue 5314, pp. 955 - 960
A new class of protein tyrosine kinase inhibitors was identified that is based on an oxindole core (indolinones). Two compounds from this class inhibited the... 
Molecules | Receptors | Oxygen | Phosphorylation | Phenyls | NIH 3T3 cells | Hydrogen bonds | Atoms | Antibodies | Reports | Insulin | HUMAN ASTROCYTOMAS | INSULIN-RECEPTOR | POINT MUTATION | MULTIDISCIPLINARY SCIENCES | GENES | K RO MULTIDISCIPLINARY SCIENCES | BREAST-CARCINOMA CELLS | CROUZON-SYNDROME | FGF FAMILY | SIGNAL TRANSDUCTION | EXPRESSION | CANCER | Receptor, Fibroblast Growth Factor, Type 1 | Protein-Tyrosine Kinases - metabolism | Crystallography, X-Ray | Piperazines - metabolism | Piperazines - chemistry | Phosphotyrosine - metabolism | Adenosine Triphosphate - metabolism | Enzyme Inhibitors - chemistry | Protein-Tyrosine Kinases - chemistry | Amino Acid Sequence | Pyrroles - metabolism | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Receptors, Platelet-Derived Growth Factor - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Enzyme Inhibitors - pharmacology | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Models, Molecular | Receptors, Fibroblast Growth Factor - chemistry | Receptor, Insulin - antagonists & inhibitors | Piperazines - pharmacology | Receptor Protein-Tyrosine Kinases | Pyrroles - pharmacology | Animals | Hydrogen Bonding | Receptors, Platelet-Derived Growth Factor - metabolism | Receptors, Fibroblast Growth Factor - metabolism | Pyrroles - chemistry | Receptor, Insulin - metabolism | Mice | 3T3 Cells | Protein-Tyrosine Kinases - antagonists & inhibitors | Cell proliferation | Protein tyrosine kinase | Fibroblast growth factors | Research | Cellular control mechanisms | Proteins | Cellular biology
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2007, Volume 117, Issue 2, pp. 457 - 463
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 11/2018, Volume 293, Issue 44, pp. 17218 - 17228
Fibroblast growth factor receptor-1 (FGFR1) activity at the plasma membrane is tightly controlled by the availability of co-receptors and competing receptor... 
cytokine | fibroblast growth factor receptor (FGFR) | fluorescence resonance energy transfer (FRET) | inflammation | pancreas | fibroblast growth factor (FGF) | metabolism | islet | beta cell (B-cell) | diabetes | ACTIVATION | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | KLOTHO-BETA | MICROSCOPY | NONOBESE DIABETIC MICE | FRET | INSULITIS | PROTEINS | EXPRESSION | LIVING CELLS
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15378 - 15387
The Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in many physiological processes. Several studies indicate that AHR is... 
MESSENGER-RNA | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER | GENE-EXPRESSION | ALPHA | MICE | LIGAND | TARGET GENE | TRANSCRIPTION FACTOR | FGF21 | Humans | Fibroblast Growth Factors - genetics | Male | Fibroblast Growth Factors - biosynthesis | Hepatocytes - metabolism | Hepatocytes - cytology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Energy Metabolism - physiology | Nuclear Proteins - genetics | Response Elements - physiology | Cell Line | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptors, Aryl Hydrocarbon - genetics | Gene Expression Regulation - physiology | Nuclear Proteins - metabolism | PPAR alpha - genetics | Transcription Factors - genetics | Mice, Knockout | Transcription Factors - metabolism | Cyclic AMP Response Element-Binding Protein - genetics | Insulin-Like Growth Factor Binding Protein 1 - metabolism | Animals | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Signal Transduction - physiology | Mice | PPAR alpha - metabolism | Endoplasmic Reticulum Stress - physiology | Insulin-Like Growth Factor Binding Protein 1 - genetics | Index Medicus | Gene Regulation | peroxisome proliferator-activated receptor (PPAR) | aryl hydrocarbon receptor (AhR) (AHR) | carbohydrate response element-binding protein (ChREBP) | endoplasmic reticulum stress (ER stress) | fibroblast growth factor (FGF) | glucose metabolism | energy metabolism | cAMP-responsive element-binding protein hepatocyte-specific (CREBH)
Journal Article
by Liu, Z and Zhang, H and Ding, ST and Qi, SS and Liu, S and Sun, DQ and Dong, W and Yin, L and Li, MJ and Zhao, XB and Lu, JJ
ONCOLOGY REPORTS, ISSN 1021-335X, 07/2018, Volume 40, Issue 1, pp. 217 - 225
The epithelial-mesenchymal transition (EMT) is reported to have intimate crosstalk with androgen receptor (AR) signaling in prostate cancer (PCa) and is known... 
ANDROGEN RECEPTOR | ACTIVATION | FGF | CASTRATION RESISTANCE | ADENOCARCINOMA | CELL-PROLIFERATION | MECHANISMS | Klotho | EMT | AR | REGULATOR | prostate cancer | INVASION | ONCOLOGY | TRANSCRIPTION FACTOR | UP-REGULATION | Cell receptors | Care and treatment | Development and progression | Cellular signal transduction | Genetic aspects | Gene expression | Health aspects | Prostate cancer
Journal Article
Human Pathology, ISSN 0046-8177, 2013, Volume 44, Issue 12, pp. 2711 - 2718
Journal Article
FEBS Letters, ISSN 0014-5793, 07/2010, Volume 584, Issue 13, pp. 2845 - 2851
Farnesoid X receptor (FXR) is highly expressed in liver and intestine where it controls bile acid (BA), lipid and glucose homeostasis. Here we show that FXR is... 
Farnesoid X receptor | Type 2 diabetes | Islet | Lipotoxicity | islet amyloid polypeptide | FXR | guanidinium thiocyanate | LXR | peroxisome proliferator-activated receptor (α,δ,γ) | very low density lipoprotein-receptor | VLDL-R | PDX-1 | BSA | fibroblast growth factor | PPAR(α,δ,γ) | bile acids | SHP | liver X receptor | FGF | farnesoid X receptor | IPGTT | triglycerides | intraperitoneal glucose tolerance test | glucose-stimulated insulin secretion | SST | GSCN | GSIS | somatostatin | small heterodimer partner | IAPP | bovine serum albumin | pancreatic duodenal homeobox gene-1 | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SENSITIVITY | INDUCED INSULIN-RESISTANCE | CELL BIOLOGY | BIOPHYSICS | GENE | METABOLISM | GLUCOSE | FARNESOID-X-RECEPTOR | MICE | SECRETION | BILE-ACIDS | Islets of Langerhans - drug effects | Palmitic Acid - pharmacology | Humans | Mice, Inbred C57BL | Cells, Cultured | Rats | Male | Receptors, Cytoplasmic and Nuclear - physiology | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Blotting, Western | Obesity - metabolism | Isoxazoles - pharmacology | Insulin-Secreting Cells - metabolism | Animals | Islets of Langerhans - metabolism | Mice, Mutant Strains | Mice | In Vitro Techniques | Receptors, Cytoplasmic and Nuclear - metabolism | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2005, Volume 392, Issue 2, pp. 249 - 261
The MAPK (mitogen-activated protein kinase) pathway is one of the most important and intensively studied signalling pathways. It is at the heart of a... 
Receptor tyrosine kinase | Signalling network | Systems biology | Extracellular-signal-regulated kinase (ERK) | Computational modelling | Mitogen-activated protein kinase (MAPK) |