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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical journal, ISSN 1470-8728, 2005, Volume 388, Issue 2, pp. 393 - 406
The Grb proteins (growth factor receptor-bound proteins) Grb7, Grb10 and Grb14 constitute a family of structurally related multidomain adapters with diverse cellular functions... 
Cell signalling | Type II diabetes | Tyrosine kinase | Cell growth | Adapter protein | adapter protein | SRC HOMOLOGY 2 | SILVER-RUSSELL-SYNDROME | GROWTH-FACTOR-RECEPTOR | FACTOR-I RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | tyrosine kinase | cell growth | ADAPTER PROTEIN GRB10 | SH2 DOMAIN | cell signalling | PLECKSTRIN HOMOLOGY | MATERNAL UNIPARENTAL DISOMY | FOCAL ADHESION KINASE | Protein Structure, Tertiary | Proteins - physiology | Genetic Predisposition to Disease | Insulin - physiology | Humans | Gene Expression Regulation | Structure-Activity Relationship | Amino Acid Motifs | Animals | GRB10 Adaptor Protein | Protein Isoforms | Protein Conformation | Proteins - chemistry | PI3K, phosphoinositide 3-kinase | SRS, Silver–Russell syndrome | MEK1, MAP kinase | BPS, between the PH and SH2 (domains) | Review | IGFR, IGF-I receptor | IRS, IR substrate | PDGF(-BB), platelet-derived growth factor(-BB) | UTR, untranslated region | RA, Ras-association | VEGF(R2), vascular endothelial growth factor (receptor 2) | Meg, maternally expressed gene | GIGYF protein, Grb10 interacting GYF protein | IUP, intrinsically unstructured protein | TZD, thiazolidinedione | ZIP, PKCζ-interacting protein | Erk, extracellular-signal-regulated kinase | IR, insulin receptor | Grb, growth factor receptor-bound protein | FGF(R), fibroblast growth factor receptor | GST, glutathione S-transferase | FAK, focal adhesion kinase | Shc, Src homology collagen | EGF(R), epidermal growth factor (receptor) | GM, Grbs and Mig | PDK-1, 3′-phosphoinositide-dependent kinase 1 | siRNA, small interfering RNA | PH, pleckstrin homology | PKCζ, protein kinase Cζ | APS, adapter protein with PH and SH2 domains | SH2, Src homology 2 | IGF-I, type I insulin-like growth factor | GK, Goto-Kakizaki | (m)UPD7, (maternal) uniparental disomy of chromosome 7 | MAPK, mitogen-activated protein kinase | Erk kinase | Nedd4, neuronal precursor cell-expressed developmentally down-regulated | PTP, protein tyrosine phosphatase
Journal Article
Progress in nucleic acid research and molecular biology, ISSN 0079-6603, 01/1993, Volume 44, Issue C, pp. 205 - 227
This chapter discusses: (1) the strategies used to identify Protein tyrosine kinase (PTK) substrates and (2) the recent progress made in identifying new and... 
product of the fps oncogene | product of the crk oncogene | steel factor receptor | pp60 | pp59 | complex | insulin-like growth factor | fluorescein isothiocyanate | inositol 1,4,5-trisphosphate | phosphatidylinositol 3-kinase | polyoma virus middle-t antigen-pp60 | cdc | phosphoprotein | product of the c-yes gene | Ins-R | colony-stimulating factor-1 receptor | MAPK | Mab | mt-c-SRC | diacylglyerol | RSV | fibroblast growth factor receptor | focal adhesion kinase | GAP | KIT | ROS | PDGF-R | CRK | EGF-R | GTPase-aetivating protein | IRS-1 | PLC | product of the ahl gene | PTK | YES | FPS | Rous sarcoma virus | ABL | cell cycle control | Ptdlns 4K | mitogen-activated protein kinase | FGF-R | FITC | PtdInsP 5K | TrpE | platelet-derived growth factor receptor | product of the raf gene | product of the Escherichia coli tryptophan E gene | enzyme that catalyzes the phosphorylation of the D-5 position of the inositol ring of phosphatidylinositol P | insulin receptor substrate | product of the ros oncogene | phospholipase C | epidermal growth factor receptor | IGF | DAG | FMS | CSF-l-R | product of the CSF-1 receptor gene | FAK | product of the c-fyn gene | enzyme that catalyzes phosphorylation of the D-4 position of the inositol ring of phosphatidylinositol | protein tyrosine kinase | PIP | RAF | phos-phatidylinositol 4,5-bisphosphate | product of the c-src gene; pp62 | insulin receptor | monoclonal antibody | SH2 | src homology 3 | src homology 2 | SH3 | Amino Acid Sequence | Phosphorylation | Animals | Proteins - metabolism | Protein-Tyrosine Kinases - metabolism | Molecular Sequence Data | Substrate Specificity | Cell Line, Transformed
Journal Article
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