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PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 11, pp. e14117 - e14117
Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression... 
Fibroblast Growth Factor 7 - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Coculture Techniques | Humans | Lung Neoplasms - metabolism | Fibroblast Growth Factor 2 - pharmacology | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Fibroblasts - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Fibroblasts - drug effects | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Fibroblasts - cytology | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Tyrosine | Phenols | Fibroblast growth factors | RNA | Analysis | Luciferase | Fibroblast growth factor | Biotechnology | Transcription | Gene regulation | Lung cancer | Biology | Kinases | Cell adhesion & migration | Morphogenesis | Epidermal growth factor | Fibroblast growth factor receptor 7 | Gefitinib | Protein-tyrosine kinase | Fibroblast growth factor receptor 2 | Fibroblast growth factor 2 | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Gene expression | Src protein | Self sufficiency | Pulmonary hypertension | Studies | Signaling | Inhibitors | Cell lines | Monoclonal antibodies | Ligands | Mutation | Tumors | Fibroblast growth factor receptors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Epidermal Growth Factor - genetics | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Receptor, Epidermal Growth Factor - metabolism | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Receptor, Epidermal Growth Factor - chemistry | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Amino acids | T cell receptors | Mutation | Kinases | Binding sites | Adenosine triphosphatase | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, pp. e33870 - e33870
Background: Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and... 
BETA-KLOTHO | PPAR-ALPHA | TRANSCRIPTS ENCODING MEMBRANE | METABOLIC REGULATOR | MULTIDISCIPLINARY SCIENCES | INCREASES ENERGY-EXPENDITURE | ACTIVATED-RECEPTOR-GAMMA | FIBROBLAST-GROWTH-FACTOR | BILE-ACID SYNTHESIS | MOUSE KLOTHO GENE | INSULIN SENSITIVITY | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Diabetes Mellitus - genetics | Membrane Proteins - genetics | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Diabetes Mellitus - metabolism | Fibroblast Growth Factors - genetics | Multiprotein Complexes - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Obesity - genetics | Mice, Knockout | Obesity - metabolism | Fibroblast Growth Factors - metabolism | Multiprotein Complexes - metabolism | Animals | Cell Line, Tumor | Protein Binding | Membrane Proteins - metabolism | Mice | Adipose Tissue | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Type 2 diabetes | Physiological aspects | Obesity | Cellular signal transduction | Fibroblast growth factors | Liver | Adipose tissue | Body fat | Laboratories | Dietary minerals | Science | Homeostasis | Biology | Adipocytes | Metabolic syndrome | Angiogenesis | Signal transduction | Rodents | Animal tissues | Fibroblast growth factor receptor 4 | Fibroblasts | Physiology | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Binding | Heparan sulfate | Fibroblast growth factor 1 | Fasting | Diabetes mellitus | Melanoma | Gene expression | Metabolism | Ablation | Musculoskeletal system | Signaling | Proteomics | Stem cells | Affinity | Insulin resistance | Transduction | Diabetes | Kinetics | Nanotechnology | Cancer | Fibroblast growth factor receptors | Index Medicus
Journal Article
The Journal of Pathology, ISSN 0022-3417, 09/2007, Volume 213, Issue 1, pp. 82 - 90
Fibroblast growth factor receptors (FGFRs) mediate the tumourigenic effects of FGFs in prostate cancer. These receptors are therefore potential therapeutic... 
prostate cancer | tissue microarray | laser capture microdissection | fibroblast growth factor receptors | Laser capture microdissection | Tissue microarray | Prostate cancer | Fibroblast growth factor receptors | FACTOR FAMILY | ISOFORMS | FGF | SPECIFICITY | RESTORATION | PATHOLOGY | TUMORIGENICITY | ARG ALLELE | EPITHELIAL-CELLS | GENES | PROGRESSION | Immunohistochemistry | Prostatic Neoplasms - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Cell Proliferation | Microdissection | Oligonucleotide Array Sequence Analysis | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Male | Gene Expression Profiling | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Case-Control Studies | Receptors, Fibroblast Growth Factor - analysis | Prostatic Neoplasms - genetics | RNA Interference | Receptor, Fibroblast Growth Factor, Type 2 - analysis | Receptors, Fibroblast Growth Factor - genetics | Transcription, Genetic | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Receptor, Fibroblast Growth Factor, Type 1 - analysis | Receptor, Fibroblast Growth Factor, Type 3 - genetics | RNA, Small Interfering - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - analysis | Microscopy, Confocal | Receptors, Fibroblast Growth Factor - metabolism | Cell Line, Tumor | Polymorphism, Single Nucleotide | Receptor, Fibroblast Growth Factor, Type 3 - analysis | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Protein Isoforms - genetics | Index Medicus
Journal Article
FEBS Journal, ISSN 1742-464X, 05/2016, Volume 283, Issue 9, pp. 1653 - 1668
Regeneration of skeletal muscles is required throughout life to ensure optimal performance. Therefore, a better understanding of the resident cells involved in... 
fibro/adipocytes | adipogenesis | FAP | FGF | fibroblast growth factor receptor | adipogenic differentiation | βKlotho | αKlotho | PiggyBac transposon | satellite cells | FAPs | FGF21 | PROGENITORS | CONNECTIVE-TISSUE FIBROBLASTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FIBROBLAST-GROWTH-FACTOR | MYOGENIC CELLS | GENE | METABOLIC-ACTIVITY | alpha Klotho | DIFFERENTIATION | beta Klotho | ADIPOSE-TISSUE | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Adipocytes - cytology | Male | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Adipogenesis - genetics | Fibroblasts - metabolism | Cell Line | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Satellite Cells, Skeletal Muscle - cytology | Gene Expression Regulation | Mice, Transgenic | Satellite Cells, Skeletal Muscle - metabolism | Lipid Droplets | Animals | Adipocytes - metabolism | Fibroblasts - cytology | Mice | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Index Medicus | Piggybac transposon | Fibro | Adipogenic differentiation | Satellite cells | adipocytes | Fibroblast growth factor receptors | Adipogenesis
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7653, pp. 224 - 241
Blood and lymphatic vasculatures are intimately involved in tissue oxygenation and fluid homeostasis maintenance. Assembly of these vascular networks involves... 
GENE-EXPRESSION DATA | MAINTENANCE | MULTIDISCIPLINARY SCIENCES | MOUSE | LYMPHANGIOGENESIS | ENDOTHELIAL-CELL METABOLISM | MECHANISMS | GROWTH-FACTOR | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Cell Proliferation | Lymphatic Vessels - cytology | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Proto-Oncogene Proteins c-myc - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - deficiency | Lymphatic Vessels - metabolism | Animals | Receptor, Fibroblast Growth Factor, Type 3 - deficiency | Endothelial Cells - cytology | Glycolysis | Female | Mice | Hexokinase - metabolism | Lymphangiogenesis | Neovascularization, Physiologic | Cell Movement | Fibroblast growth factors | Metabolism | Observations | Health aspects | Cell proliferation | Fibroblast growth factor | Leukocyte migration | c-Myc protein | Homeostasis | Biology | Myc protein | Kinases | Blood | Defects | Angiogenesis | Control | Cell growth | Metabolites | Rodents | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Growth factors | Medical research | Enzymes | Grants | Hexokinase | Endothelial cells | Endothelium | Signaling | Oxygenation | Cell migration | Fibroblast growth factor receptors | Index Medicus
Journal Article
2012, ISBN 9789814343718
This volume provides a comprehensive and multidisciplinary overview of fibrocytes, written by the main researchers in the field. It is aimed at a broad... 
Fibroblasts
Web Resource
Biochemical Journal, ISSN 0264-6021, 07/2005, Volume 389, Issue 1, pp. 145 - 150
HS (heparan sulphate) proteoglycans bind secreted signalling proteins, including FGFs (fibroblast growth factors) through their HS side chains. Such chains... 
Fibroblast growth factor | Glycosaminoglycan | Co-receptor | Epitope | Heparan sulphate proteoglycan | SEQUENCE-ANALYSIS | co-receptor | PROTEOGLYCANS | COMPLEX | SPECIFICITY | FACTOR FGF | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURFACE | RECEPTOR | IDENTIFICATION | MOUSE DEVELOPMENT | fibroblast growth factor | heparan sulphate proteoglycan | epitope | glycosaminoglycan | Fibroblast Growth Factor 1 - metabolism | Fibroblast Growth Factors - genetics | Fibroblast Growth Factor 1 - genetics | Epitopes | Heparitin Sulfate - metabolism | Fibroblast Growth Factor 4 - chemistry | Fibroblast Growth Factor 7 - genetics | Fibroblast Growth Factor 8 - metabolism | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | Fibroblast Growth Factor 4 - genetics | Fibroblast Growth Factor 7 - metabolism | Heparitin Sulfate - chemistry | Fibroblast Growth Factor 1 - chemistry | Protein Binding | Fibroblast Growth Factor 7 - chemistry | Fibroblast Growth Factor 8 - genetics | Binding Sites | Fibroblast Growth Factor 4 - metabolism | Fibroblast Growth Factor 8 - chemistry | Index Medicus | [1-3H]aManR, 2,5-anhydro-D-[1-3H]mannitol | GlcA, D-glucuronic acid | FGFR, FGF receptor | GAG, glycosaminoglycan | HS, heparan sulphate | PG, proteoglycan | FGF, fibroblast growth factor | IdoA, L-iduronic acid | GlcNAc, N-acetylglucosamine | GlcNS, N-sulphated glucosamine
Journal Article
Heart, ISSN 1355-6037, 05/2019, Volume 105, Issue Suppl 4, p. A6
IntroductionThe tyrosine kinase inhibitor sunitinib has dramatically improved cancer therapy in recent years however, this success has been marred by reports... 
Fibroblasts
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 12/2017, Volume 37, Issue 50, pp. 12094 - 12105
Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) are known for their potent effects on cell proliferation/differentiation and cortical patterning in... 
Dendritogenesis | Whisker barrel map | FGF | Neural activity | FGFR | Glutamatergic | dendritogenesis | whisker barrel map | MESSENGER-RNA EXPRESSION | glutamatergic | NEUROSCIENCES | CEREBRAL-CORTEX | MULTIPLE ROLES | neural activity | CORTICAL-NEURONS | SOMATOSENSORY CORTEX | IN-VIVO | FUNCTIONAL-ORGANIZATION | DENDRITE ORIENTATION | FIBROBLAST GROWTH-FACTORS | UP-REGULATION | Loss of Function Mutation | Fibroblast Growth Factors - genetics | Receptors, Fibroblast Growth Factor - deficiency | Male | Neurons - cytology | Recombinant Fusion Proteins - metabolism | Dendrites - physiology | Receptors, Fibroblast Growth Factor - genetics | Somatosensory Cortex - embryology | Female | Somatosensory Cortex - cytology | Neurogenesis - drug effects | Gain of Function Mutation | Kainic Acid - toxicity | Vibrissae - innervation | Fibroblast Growth Factors - physiology | Nerve Tissue Proteins - physiology | Somatosensory Cortex - drug effects | Cells, Cultured | Electroporation | Mice, Transgenic | Mice, Inbred ICR | Mice, Knockout | Pregnancy | Animals | Convulsants - toxicity | Mice | Receptors, Fibroblast Growth Factor - physiology | Cell proliferation | Pattern formation | Brain | Fibroblast growth factor | Physiological effects | Fibroblast growth factor receptor 9 | Circuits | Segments | Cortex (somatosensory) | Depolarization | Receptors | Etiology | Rodents | Sensory neurons | Fibroblasts | Polarity | Thalamus | Dendrites | Fibroblast growth factor receptor 7 | Fibroblast growth factor receptor 1 | Growth factors | Fibroblast growth factor 10 | Cortex (barrel) | Neurons | Cortex | Gene expression | Neurological diseases | Axons | Acids | Glutamatergic transmission | Kainic acid | Neurotransmission | Dendritic structure | Fibroblast growth factor receptors | Index Medicus | s
Journal Article
Cancer Science, ISSN 1347-9032, 10/2015, Volume 106, Issue 10, pp. 1278 - 1287
Cancer‐associated fibroblasts ( CAF s), as the activated fibroblasts in the tumor stroma, are important modifiers of tumour progression. In the present study,... 
Cancer‐associated fibroblasts | extracellular signal‐regulated kinase | fibroblast growth factor | colon cancer | metalloproteinase‐7 | Extracellular signal-regulated kinase | Cancer-associated fibroblasts | Fibroblast growth factor | Metalloproteinase-7 | Colon cancer | CELLS | extracellular signal-regulated kinase | ACTIVATION | PROLIFERATION | MESENCHYMAL TRANSITION | MICROENVIRONMENT | ONCOLOGY | COLORECTAL-CANCER | GROWTH | STROMAL FIBROBLASTS | RECURRENCE | EXPRESSION | metalloproteinase-7 | Human Umbilical Vein Endothelial Cells | Dextran Sulfate | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Colonic Neoplasms - genetics | Fibroblasts - secretion | Phosphorylation | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Azoxymethane | MAP Kinase Signaling System - genetics | Fibroblast Growth Factor 3 - pharmacology | Matrix Metalloproteinase 7 - metabolism | RNA Interference | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Fibroblast Growth Factor 3 - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Disease Models, Animal | Fibroblasts - metabolism | Colitis, Ulcerative - metabolism | HCT116 Cells | Fibroblast Growth Factor 1 - metabolism | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Colitis, Ulcerative - pathology | Pyrimidines - pharmacology | Disease Progression | HT29 Cells | Animals | Colonic Neoplasms - pathology | Cell Line, Tumor | Mice | RNA, Small Interfering | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Dextran | Prevention | Analysis | Development and progression | Fibroblast growth factors | Neovascularization | Sulfates | Mitogens | Protein kinases | Tumors | Cancer | Index Medicus | Original
Journal Article
Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6099, pp. 1231 - 1235
The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors... 
Exons | Neurons | Genes | REPORTS | Stem cells | Aneuploidy | Chromosomes | Cells | Tumors | Daughter cells | Cancer | ANEUPLOIDY | SELECTIVE INHIBITOR | POTENT | MULTIDISCIPLINARY SCIENCES | CANCER | RECEPTOR TYROSINE KINASE | DISCOVERY | CHROMOSOMAL INSTABILITY | FAMILY | Microtubule-Associated Proteins - chemistry | Neoplasm Transplantation | Translocation, Genetic | Oncogene Proteins, Fusion - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Mitosis | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - antagonists & inhibitors | Fetal Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Brain Neoplasms - metabolism | Oncogene Proteins, Fusion - chemistry | Spindle Apparatus - metabolism | Glioblastoma - genetics | Oncogene Fusion | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Nuclear Proteins - genetics | Chromosomal Instability | Pyrazoles - pharmacology | Protein Structure, Tertiary | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Enzyme Inhibitors - pharmacology | Brain Neoplasms - genetics | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | Nuclear Proteins - chemistry | Piperazines - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Cell Transformation, Neoplastic | Oncogene Proteins, Fusion - genetics | Fetal Proteins - genetics | Mice | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Fetal Proteins - chemistry | Physiological aspects | Development and progression | Fibroblast growth factors | Genetic aspects | Research | Health aspects | Glioblastoma multiforme | Proteins | Kinases | Brain cancer | Genomics | Pharmaceutical sciences | Index Medicus
Journal Article