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Journal of Biological Chemistry, ISSN 0021-9258, 04/2009, Volume 284, Issue 16, pp. 10774 - 10782
The innate immune system provides an initial defense system against microbial infections and contributes to the development of adaptive immune response. Type I... 
DOUBLE-STRANDED-RNA | SIGNALING PATHWAYS | IMMUNE-RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GENE-EXPRESSION | INNATE | TNF-ALPHA | HELICASE ANTIVIRAL PATHWAY | NF-KAPPA-B | ADAPTER PROTEIN | Fibroblasts - physiology | TNF Receptor-Associated Factor 2 - genetics | Immunity, Innate - physiology | p38 Mitogen-Activated Protein Kinases - metabolism | Interferons - genetics | DEAD-box RNA Helicases - metabolism | Virus Activation | Dendritic Cells - metabolism | Sendai virus - physiology | DEAD Box Protein 58 | MAP Kinase Kinase Kinases - genetics | Mice, Inbred C57BL | Cells, Cultured | TNF Receptor-Associated Factor 2 - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Mice, Knockout | DEAD-box RNA Helicases - genetics | Animals | Adaptor Proteins, Signal Transducing - genetics | Interferons - metabolism | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Dendritic Cells - cytology | Fibroblasts - cytology | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Mitogen-Activated Protein Kinases - metabolism | Pathogens | RNA viruses | Phosphorylation | Dendritic cells | TAK1 protein | MKK3 protein | Interleukin 12 | MAP kinase | a-Interferon | Infection | TRAF2 protein | Cell activation | Enzymatic activity | c-Jun amino-terminal kinase | Protein kinase | Fibroblasts | Replication | Interferon
Journal Article
Journal of Cell Science, ISSN 0021-9533, 02/2004, Volume 117, Issue 5, pp. 657 - 666
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12553 - 12558
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2014, Volume 461, Issue 3, pp. 531 - 537
IKK beta {I kappa B [inhibitor of NF-kappa B (nuclear factor kappa B)] kinase beta} is required to activate the transcription factor NF-kappa B, but how IKK... 
Inhibitor of nuclear factor κB kinase (IKK) | Linear ubiquitin chain assembly complex (LUBAC) | Nuclear factor κB(NF-κB) | Transforming growth factor β-activated kinase-1 (TAK1) | Interleukin-1 (IL-1) | nuclear factor kappa B (NF-kappa B) | linear ubiquitin chain assembly complex (LUBAC) | SIGNALING PATHWAYS | PROTEIN | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | interleukin-1 (IL-1) | KINASE COMPLEX | transforming growth factor beta-activated kinase-1 (TAK1) | UBIQUITIN CHAINS | INFLAMMATION | inhibitor of nuclear factor kappa B kinase (IKK) | POLYUBIQUITIN CHAINS | NF-KAPPA-B | NEMO | BINDING | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | I-kappa B Kinase - antagonists & inhibitors | HEK293 Cells | Protein Interaction Domains and Motifs | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Mutant Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cells, Cultured | Mutant Proteins - genetics | Recombinant Proteins - chemistry | Mice, Transgenic | Mutant Proteins - metabolism | MAP Kinase Kinase Kinases - metabolism | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Serine - metabolism | Gene Knock-In Techniques | Animals | Embryo, Mammalian - cytology | Mutant Proteins - chemistry | Mice | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Amino Acid Substitution | Index Medicus | NEMO, NF-κB essential modulator | TLR, Toll-like receptor | IKK, IκB kinase | TNF, tumour necrosis factor | transforming growth factor β-activated kinase-1 (TAK1) | HEK, human embryonic kidney | IL-1, interleukin-1 | JNK, c-Jun N-terminal kinase | PP1γ, protein phosphatase 1γ | TRAF, TNF receptor-associated factor | inhibitor of nuclear factor κB kinase (IKK) | LUBAC, linear ubiquitin chain assembly complex | HOIP, HOIL1 [haem-oxidized IRP2 (iron regulatory protein 2) ubiquitin ligase 1]-interacting protein | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | TAK1, transforming growth factor β-activated kinase-1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | M-CSF, macrophage colony-stimulating factor | MKK, MAPK kinase | Accelerated Publication | E, embryonic day | MEF, mouse embryonic fibroblast | HA, haemaglutinnin | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase
Journal Article
by Feng, Y and Ren, JF and Gui, Y and Wei, W and Shu, BY and Lu, QM and Xue, X and Sun, XL and He, WC and Yang, JW and Dai, CS
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 01/2018, Volume 29, Issue 1, pp. 182 - 193
The Wnt/beta-catenin pathway is crucial in normal development and throughout life, but aberrant activation of this pathway has been linked to kidney fibrosis,... 
RENAL FIBROSIS | FIBROBLAST ACTIVATION | REPAIR | DENDRITIC CELLS | DISEASE | INJURY | UROLOGY & NEPHROLOGY | GROWTH-FACTOR | BETA-CATENIN | WNT | POLARIZATION | β-catenin | macrophages | Wnt | kidney fibrosis | Basic Research
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