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Annals of oncology, ISSN 0923-7534, 2014, Volume 25, Issue 3, pp. 552 - 563
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | ErbB Receptors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | ErbB Receptors - chemistry | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Biological Sciences | PNAS Plus
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 545, Issue 7653, pp. 224 - 228
Blood and lymphatic vasculatures are intimately involved in tissue oxygenation and fluid homeostasis maintenance. Assembly of these vascular networks involves... 
GENE-EXPRESSION DATA | MAINTENANCE | MULTIDISCIPLINARY SCIENCES | MOUSE | LYMPHANGIOGENESIS | ENDOTHELIAL-CELL METABOLISM | MECHANISMS | GROWTH-FACTOR | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Cell Proliferation | Lymphatic Vessels - cytology | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Proto-Oncogene Proteins c-myc - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - deficiency | Lymphatic Vessels - metabolism | Animals | Receptor, Fibroblast Growth Factor, Type 3 - deficiency | Endothelial Cells - cytology | Glycolysis | Female | Mice | Hexokinase - metabolism | Lymphangiogenesis | Neovascularization, Physiologic | Cell Movement | Fibroblast growth factors | Metabolism | Observations | Health aspects | Cell proliferation | Fibroblast growth factor | Leukocyte migration | c-Myc protein | Homeostasis | Biology | Myc protein | Kinases | Blood | Defects | Angiogenesis | Control | Cell growth | Metabolites | Rodents | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Growth factors | Medical research | Enzymes | Grants | Hexokinase | Endothelial cells | Endothelium | Signaling | Oxygenation | Cell migration | Fibroblast growth factor receptors
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 553, Issue 7689, pp. 461 - 466
The ageing suppressor alpha-klotho binds to the fibroblast growth factor receptor (FGFR). This commits FGFR to respond to FGF23, a key hormone in the... 
BETA-KLOTHO | TRANSCRIPTS ENCODING MEMBRANE | FIBROBLAST-GROWTH-FACTOR-1 FGF1 | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | METABOLIC-ACTIVITY | RECEPTOR | FIBROBLAST-GROWTH-FACTOR | C-TERMINAL TAIL | HEPARIN | Humans | Protein Multimerization | Glucuronidase - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Male | Multiprotein Complexes - genetics | Heparitin Sulfate - metabolism | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | Multiprotein Complexes - metabolism | Protein Domains | Female | Paracrine Communication | Signal Transduction | Solubility | Models, Molecular | Glucuronidase - chemistry | Binding Sites - genetics | Multiprotein Complexes - chemistry | Animals | Glucuronidase - genetics | Body Fluids - metabolism | Protein Binding | Ligands | Mice | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Mutation | Binding | Heparan sulfate | Fibroblast growth factor | Fibroblast growth factor 23 | Homeostasis | Paracrine signalling | Metabolism | Proteins | Vitamin D | Klotho protein | Fibroblasts | Aging | Tethers | Receptor mechanisms | Sulfate | Atomic structure | Dimerization | Growth factors | Crystal structure | Fibroblast growth factor receptors | X-ray crystallography | BASIC BIOLOGICAL SCIENCES | Ageing
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e14117
Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression... 
Fibroblast Growth Factor 7 - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Coculture Techniques | Humans | Lung Neoplasms - metabolism | Fibroblast Growth Factor 2 - pharmacology | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Fibroblasts - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Fibroblasts - drug effects | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Fibroblasts - cytology | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Tyrosine | Phenols | Fibroblast growth factors | RNA | Analysis | Luciferase | Fibroblast growth factor | Biotechnology | Transcription | Gene regulation | Lung cancer | Biology | Kinases | Cell adhesion & migration | Morphogenesis | Epidermal growth factor | Fibroblast growth factor receptor 7 | Gefitinib | Protein-tyrosine kinase | Fibroblast growth factor receptor 2 | Fibroblast growth factor 2 | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Non-small cell lung carcinoma | Gene expression | Src protein | Self sufficiency | Pulmonary hypertension | Studies | Signaling | Inhibitors | Monoclonal antibodies | Ligands | Mutation | Tumors | Fibroblast growth factor receptors
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2005, Volume 389, Issue 1, pp. 145 - 150
HS (heparan sulphate) proteoglycans bind secreted signalling proteins, including FGFs (fibroblast growth factors) through their HS side chains. Such chains... 
Fibroblast growth factor | Glycosaminoglycan | Co-receptor | Epitope | Heparan sulphate proteoglycan | SEQUENCE-ANALYSIS | co-receptor | PROTEOGLYCANS | COMPLEX | SPECIFICITY | FACTOR FGF | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURFACE | RECEPTOR | IDENTIFICATION | MOUSE DEVELOPMENT | fibroblast growth factor | heparan sulphate proteoglycan | epitope | glycosaminoglycan | Fibroblast Growth Factor 1 - metabolism | Fibroblast Growth Factors - genetics | Fibroblast Growth Factor 1 - genetics | Epitopes | Heparitin Sulfate - metabolism | Fibroblast Growth Factor 4 - chemistry | Fibroblast Growth Factor 7 - genetics | Fibroblast Growth Factor 8 - metabolism | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | Fibroblast Growth Factor 4 - genetics | Fibroblast Growth Factor 7 - metabolism | Heparitin Sulfate - chemistry | Fibroblast Growth Factor 1 - chemistry | Protein Binding | Fibroblast Growth Factor 7 - chemistry | Fibroblast Growth Factor 8 - genetics | Binding Sites | Fibroblast Growth Factor 4 - metabolism | Fibroblast Growth Factor 8 - chemistry | [1-3H]aManR, 2,5-anhydro-D-[1-3H]mannitol | GlcA, D-glucuronic acid | FGFR, FGF receptor | GAG, glycosaminoglycan | HS, heparan sulphate | PG, proteoglycan | FGF, fibroblast growth factor | IdoA, L-iduronic acid | GlcNAc, N-acetylglucosamine | GlcNS, N-sulphated glucosamine
Journal Article
Osteoarthritis and Cartilage, ISSN 1063-4584, 2015, Volume 23, Issue 3, pp. 443 - 453
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33870
Background: Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and... 
FIBROBLAST GROWTH FACTOR-19 | BETA-KLOTHO | PPAR-ALPHA | TRANSCRIPTS ENCODING MEMBRANE | MULTIDISCIPLINARY SCIENCES | INCREASES ENERGY-EXPENDITURE | ACTIVATED-RECEPTOR-GAMMA | BILE-ACID SYNTHESIS | HEPARAN-SULFATE | MOUSE KLOTHO GENE | INSULIN SENSITIVITY | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Diabetes Mellitus - genetics | Membrane Proteins - genetics | Humans | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Diabetes Mellitus - metabolism | Fibroblast Growth Factors - genetics | Multiprotein Complexes - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Obesity - genetics | Mice, Knockout | Obesity - metabolism | Fibroblast Growth Factors - metabolism | Multiprotein Complexes - metabolism | Animals | Cell Line, Tumor | Protein Binding | Membrane Proteins - metabolism | Mice | Adipose Tissue | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Type 2 diabetes | Physiological aspects | Obesity | Cellular signal transduction | Fibroblast growth factors | Liver | Adipose tissue | Body fat | Laboratories | Dietary minerals | Science | Homeostasis | Biology | Adipocytes | Metabolic syndrome | Angiogenesis | Signal transduction | Rodents | Animal tissues | Fibroblast growth factor receptor 4 | Fibroblasts | Physiology | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Binding | Heparan sulfate | Fibroblast growth factor 1 | Fasting | Diabetes mellitus | Melanoma | Gene expression | Metabolism | Ablation | Musculoskeletal system | Signaling | Proteomics | Stem cells | Affinity | Insulin resistance | Transduction | Diabetes | Kinetics | Nanotechnology | Cancer | Fibroblast growth factor receptors
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14379 - 14384
FGF19 is a hormone that regulates bile acid and glucose homeostasis. Progress has been made in identifying cofactors for receptor activation. However, several... 
Adipose tissues | Molecules | Receptors | Phosphorylation | Bile acids | Liver | Homeostasis | Fibroblast growth factors | Heparin | Adipocytes | Diabetes | FGF21 | BETA-KLOTHO | SIGNAL | HOMEOSTASIS | SPECIFICITY | liver | MULTIDISCIPLINARY SCIENCES | RECEPTOR | FIBROBLAST-GROWTH-FACTOR | SUPPRESSION | DETERMINES | diabetes | FGF23 | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Transcriptional Activation | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Obesity - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Tissue Distribution | Adipose Tissue - metabolism | Fibroblast Growth Factors - metabolism | Membrane Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Cell Line | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Glucose Tolerance Test | Membrane Proteins - genetics | Liver - metabolism | Mice, Inbred C57BL | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Obesity - metabolism | Animals | Fibroblast Growth Factors - pharmacokinetics | Glucose - pharmacokinetics | Glucose - metabolism | Protein Binding | Mice, Obese | Mice | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Glucose metabolism | Hormone receptors | Research | Chemical properties | Biological Sciences
Journal Article