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fibroblast-growth-factor-19 (74) 74
index medicus (74) 74
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Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2019, Volume 62, Issue 6, pp. 2905 - 2915
Hepatocellular carcinoma (HCC) is a lethal disease with limited therapeutic options and a particularly poor prognosis. Aberrant fibroblast growth factor 19... 
DOSE-ESCALATION | PONATINIB | CHEMISTRY, MEDICINAL | COVALENT INHIBITORS | FGF19 | JNJ-42756493 | PHASE-I | FIBROBLAST-GROWTH-FACTOR-19 | EXPRESSION | DISCOVERY | INSIGHTS
Journal Article
Cell Metabolism, ISSN 1550-4131, 08/2008, Volume 8, Issue 2, pp. 169 - 174
FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARα in rodents. However, the physiological role of FGF21 in... 
HUMDISEASE | BETA-KLOTHO | FGF19 | SUBFAMILY MEMBERS | FACTOR-21 | ENDOCRINOLOGY & METABOLISM | RECEPTOR | FIBROBLAST-GROWTH-FACTOR | BILE-ACID SYNTHESIS | DIURNAL-VARIATION | FIBROBLAST-GROWTH-FACTOR-19 | EXPRESSION | CELL BIOLOGY
Journal Article
American Journal of Gastroenterology, ISSN 0002-9270, 05/2018, Volume 113, Issue 5, pp. 725 - 734
Objective: NGM282 is an analog of fibroblast growth factor 19 (FGF19), a potent inhibitor of bile acid (BA) synthesis in animals and humans. In phase 2 trials... 
FIBROBLAST GROWTH FACTOR-19 | BIOMARKERS | DIARRHEA | TRANSPORTER | DEFECATION | DISORDERS | FEMALES | MICE | EXCRETION | GASTROENTEROLOGY & HEPATOLOGY | BILE-ACID MALABSORPTION | Constipation | Feces | Colon
Journal Article
Science, ISSN 0036-8075, 3/2011, Volume 331, Issue 6024, pp. 1621 - 1624
Journal Article
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue 6, pp. 1315 - 1328
Bariatric surgery has proven to be the most effective treatment for controlling hyperglycemia in severely obese patients with diabetes. We show that fibroblast... 
DIABETES REMISSION | BODY-WEIGHT | MEDICAL THERAPY | SERUM BILE-ACIDS | Y GASTRIC BYPASS | ENDOCRINOLOGY & METABOLISM | BARIATRIC SURGERY | FIBROBLAST-GROWTH-FACTOR | NONALCOHOLIC STEATOHEPATITIS | FIBROBLAST-GROWTH-FACTOR-19 | HORMONES
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2019, Volume 511, Issue 3, pp. 619 - 625
The abnormal expression of microRNAs (miRNAs) contributes to the development and progression of cancer. Recent studies have reported that miRNA-520e (miR-520e)... 
Glioma | Wnt | FGF19 | miR-520e | TUMOR PROGRESSION | FGF19 CONTRIBUTES | PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | PROMOTES PROGRESSION | HEPATOCELLULAR-CARCINOMA | GLIOBLASTOMA | BIOPHYSICS | MALIGNANT GLIOMAS | EXPRESSION | FIBROBLAST-GROWTH-FACTOR-19
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2018, Volume 475, Issue 18, pp. 2985 - 2996
Fibroblast growth factors (FGF) 19, 21 and 23 are characterized by being endocrinely secreted and require co-receptor a-klotho or beta-klotho (BKL) for binding... 
BETA-KLOTHO | BODY-WEIGHT | FGF21 ACTS | FIBROBLAST | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBFAMILY MEMBERS | MOUSE | FGF19 SUBFAMILY | EXPRESSION | FIBROBLAST-GROWTH-FACTOR-19 | GROWTH-FACTOR 21
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2005, Volume 115, Issue 6, pp. 1627 - 1635
Journal Article
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Current Opinion in Pharmacology, ISSN 1471-4892, 12/2018, Volume 43, pp. 93 - 98
Elevated bile acid (BA) concentrations in the liver is associated with severe disease, including cholestasis and hepatocellular carcinoma. The nuclear... 
SKELETAL-MUSCLE | HEPATOCELLULAR-CARCINOMA | GROWTH-FACTOR 19 | CHOLESTASIS | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | MICE | BILE-ACID RECEPTOR | EXPRESSION | FIBROBLAST-GROWTH-FACTOR-19 | BETA | Physiological aspects | Enzymes | Liver cancer | Fibroblast growth factors | Liver | Deoxycholic acid
Journal Article