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PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 11, p. e14117
Despite initial and sometimes dramatic responses of specific NSCLC tumors to EGFR TKIs, nearly all will develop resistance and relapse. Gene expression... 
Fibroblast Growth Factor 7 - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Coculture Techniques | Humans | Lung Neoplasms - metabolism | Fibroblast Growth Factor 2 - pharmacology | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Fibroblasts - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Drug Resistance, Neoplasm - genetics | Signal Transduction - drug effects | Fibroblasts - drug effects | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Fibroblasts - cytology | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Tyrosine | Phenols | Fibroblast growth factors | RNA | Analysis | Luciferase | Fibroblast growth factor | Biotechnology | Transcription | Gene regulation | Lung cancer | Biology | Kinases | Cell adhesion & migration | Morphogenesis | Epidermal growth factor | Fibroblast growth factor receptor 7 | Gefitinib | Protein-tyrosine kinase | Fibroblast growth factor receptor 2 | Fibroblast growth factor 2 | Epidermal growth factor receptors | Extracellular signal-regulated kinase | Non-small cell lung carcinoma | Gene expression | Src protein | Self sufficiency | Pulmonary hypertension | Studies | Signaling | Inhibitors | Monoclonal antibodies | Ligands | Mutation | Tumors | Fibroblast growth factor receptors
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 553, Issue 7689, pp. 461 - 466
The ageing suppressor alpha-klotho binds to the fibroblast growth factor receptor (FGFR). This commits FGFR to respond to FGF23, a key hormone in the... 
BETA-KLOTHO | TRANSCRIPTS ENCODING MEMBRANE | FIBROBLAST-GROWTH-FACTOR-1 FGF1 | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | METABOLIC-ACTIVITY | RECEPTOR | FIBROBLAST-GROWTH-FACTOR | C-TERMINAL TAIL | HEPARIN | Humans | Protein Multimerization | Glucuronidase - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Male | Multiprotein Complexes - genetics | Heparitin Sulfate - metabolism | Fibroblast Growth Factors - chemistry | Fibroblast Growth Factors - metabolism | Multiprotein Complexes - metabolism | Protein Domains | Female | Paracrine Communication | Signal Transduction | Solubility | Models, Molecular | Glucuronidase - chemistry | Binding Sites - genetics | Multiprotein Complexes - chemistry | Animals | Glucuronidase - genetics | Body Fluids - metabolism | Protein Binding | Ligands | Mice | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Mutation | Binding | Heparan sulfate | Fibroblast growth factor | Fibroblast growth factor 23 | Homeostasis | Paracrine signalling | Metabolism | Proteins | Vitamin D | Klotho protein | Fibroblasts | Aging | Tethers | Receptor mechanisms | Sulfate | Atomic structure | Dimerization | Growth factors | Crystal structure | Fibroblast growth factor receptors | X-ray crystallography | BASIC BIOLOGICAL SCIENCES | Ageing
Journal Article
Journal Article
Annals of oncology, ISSN 0923-7534, 2014, Volume 25, Issue 3, pp. 552 - 563
Journal Article
Cancer Science, ISSN 1347-9032, 10/2015, Volume 106, Issue 10, pp. 1278 - 1287
Cancer‐associated fibroblasts (CAFs), as the activated fibroblasts in the tumor stroma, are important modifiers of tumour progression. In the present study, we... 
Cancer‐associated fibroblasts | extracellular signal‐regulated kinase | fibroblast growth factor | colon cancer | metalloproteinase‐7 | Extracellular signal-regulated kinase | Cancer-associated fibroblasts | Fibroblast growth factor | Metalloproteinase-7 | Colon cancer | CELLS | extracellular signal-regulated kinase | ACTIVATION | PROLIFERATION | MESENCHYMAL TRANSITION | MICROENVIRONMENT | ONCOLOGY | COLORECTAL-CANCER | GROWTH | STROMAL FIBROBLASTS | RECURRENCE | EXPRESSION | metalloproteinase-7 | Human Umbilical Vein Endothelial Cells | Dextran Sulfate | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Colonic Neoplasms - genetics | Fibroblasts - secretion | Phosphorylation | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Azoxymethane | MAP Kinase Signaling System - genetics | Fibroblast Growth Factor 3 - pharmacology | Matrix Metalloproteinase 7 - metabolism | RNA Interference | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Fibroblast Growth Factor 3 - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Disease Models, Animal | Fibroblasts - metabolism | Colitis, Ulcerative - metabolism | HCT116 Cells | Fibroblast Growth Factor 1 - metabolism | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Colitis, Ulcerative - pathology | Pyrimidines - pharmacology | Disease Progression | HT29 Cells | Animals | Colonic Neoplasms - pathology | Cell Line, Tumor | Mice | RNA, Small Interfering | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Dextran | Prevention | Analysis | Development and progression | Fibroblast growth factors | Neovascularization | Sulfates | Mitogens | Protein kinases | Tumors | Cancer | Original
Journal Article
Methods (San Diego, Calif.), ISSN 1046-2023, 2017, Volume 115, pp. 80 - 90
[Display omitted] •TrackMate is a software tool for automated, and semi-automated particle tracking.•TrackMate’s major development focus is on usability and... 
Phototoxicity | Open-source software | Image analysis | Single-particle tracking | Microscopy | Clathin-mediated endocytosis | SYSTEM | CLATHRIN-MEDIATED ENDOCYTOSIS | TPLATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | TRANSPORT | DYNAMICS | ARABIDOPSIS | CELL | EMBRYOGENESIS | Image Processing, Computer-Assisted - statistics & numerical data | Plant Cells - metabolism | Adaptor Proteins, Vesicular Transport - genetics | Cell Tracking - methods | Embryo, Nonmammalian - metabolism | Arabidopsis - ultrastructure | Clathrin - genetics | Adaptor Proteins, Vesicular Transport - metabolism | Fibroblasts - ultrastructure | Cell Tracking - statistics & numerical data | Clathrin - metabolism | Arabidopsis - metabolism | Caenorhabditis elegans | Endocytosis | Algorithms | Animals | Light Signal Transduction | Single-Cell Analysis - statistics & numerical data | Single-Cell Analysis - methods | Embryo, Nonmammalian - ultrastructure | Plant Cells - ultrastructure | Gene Expression Regulation, Plant | Software | Fibroblasts - metabolism | Single-Cell Analysis/methods | Arabidopsis/metabolism | Embryo, Nonmammalian/ultrastructure | Cellular Biology | Life Sciences | Clathrin/genetics | Fibroblasts/metabolism | Cell Tracking/methods | Plant Cells/metabolism | Cell Tracking/statistics & numerical data | Arabidopsis/ultrastructure | Image Processing, Computer-Assisted/statistics & numerical data | Embryo, Nonmammalian/metabolism | Adaptor Proteins, Vesicular Transport/genetics | Clathrin/metabolism | Plant Cells/ultrastructure | Single-Cell Analysis/statistics & numerical data | Fibroblasts/ultrastructure | Adaptor Proteins, Vesicular Transport/metabolism
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 45, pp. E4869 - E4877
The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation.... 
Structure-based drug design | Drug discovery | Cancer drug resistance | Kinase inhibitor | structure-based drug design | WILD-TYPE | MULTIDISCIPLINARY SCIENCES | BCR-ABL | GROWTH-FACTOR RECEPTORS | DRUG-RESISTANCE | kinase inhibitor | LUNG-CANCER | GENE FUSIONS | cancer drug resistance | SELECTIVE INHIBITOR | drug discovery | THERAPEUTIC TARGET | FACTOR RECEPTOR 4 | REGULATES PROLIFERATION | Receptor, Fibroblast Growth Factor, Type 4 - chemistry | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - chemistry | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Humans | ErbB Receptors - genetics | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Mutation, Missense | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Protein Kinase Inhibitors - chemistry | Neoplasms - genetics | Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Binding Sites | ErbB Receptors - antagonists & inhibitors | ErbB Receptors - metabolism | Neoplasms - enzymology | Antineoplastic Agents - chemistry | Receptor, Fibroblast Growth Factor, Type 1 - antagonists & inhibitors | Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | ErbB Receptors - chemistry | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Receptor, Fibroblast Growth Factor, Type 1 - chemistry | Neoplasms - pathology | Receptor, Fibroblast Growth Factor, Type 4 - antagonists & inhibitors | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Biological Sciences | PNAS Plus
Journal Article
The FEBS journal, ISSN 1742-4658, 2016, Volume 283, Issue 9, pp. 1653 - 1668
Regeneration of skeletal muscles is required throughout life to ensure optimal performance. Therefore, a better understanding of the resident cells involved in... 
fibro/adipocytes | adipogenesis | fibroblast growth factor receptor | adipogenic differentiation | βKlotho | αKlotho | PiggyBac transposon | FAPs | FGF21 | satellite cells | PROGENITORS | FGF | CONNECTIVE-TISSUE FIBROBLASTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FIBROBLAST-GROWTH-FACTOR | MYOGENIC CELLS | GENE | METABOLIC-ACTIVITY | alpha Klotho | DIFFERENTIATION | beta Klotho | ADIPOSE-TISSUE | Receptor, Fibroblast Growth Factor, Type 4 - metabolism | Receptor, Fibroblast Growth Factor, Type 2 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Fibroblast Growth Factors - genetics | Adipocytes - cytology | Male | Muscle, Skeletal - metabolism | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Receptor, Fibroblast Growth Factor, Type 4 - genetics | Adipogenesis - genetics | Fibroblasts - metabolism | Cell Line | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Satellite Cells, Skeletal Muscle - cytology | Gene Expression Regulation | Mice, Transgenic | Satellite Cells, Skeletal Muscle - metabolism | Lipid Droplets | Animals | Adipocytes - metabolism | Fibroblasts - cytology | Mice | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Piggybac transposon | Fibro | Adipogenic differentiation | Satellite cells | adipocytes | Fibroblast growth factor receptors | Adipogenesis
Journal Article