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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 129, Issue 4, pp. 1031 - 1039.e1
Background Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH.... 
Allergy and Immunology | skin barrier | transepidermal water loss | confocal Raman spectroscopy | Flgft/Flgft (FlgdelAPfal) mice | Atopic dermatitis | IL-1 | IL-18 | FLG gene mutations | eczema | filaggrin | natural moisturizing factor | UNCONVENTIONAL PROTEIN SECRETION | INTERLEUKIN-1 RECEPTOR ANTAGONIST | TERM CULTURE | IMMUNOLOGY | PERMEABILITY BARRIER HOMEOSTASIS | HUMAN KERATINOCYTES | IN-VITRO | ALLERGY | Flg(ft)/Flg(ft)(Flg(delAPfal)) mice | EPIDERMIS | IL-1-BETA | Interleukin-1 - genetics | Interleukin-1 - metabolism | Dermatitis, Atopic - genetics | Cytokines - metabolism | Skin - metabolism | Humans | Mice, Inbred C57BL | Child, Preschool | Genotype | Infant | Male | Mice, Knockout | Animals | Adolescent | Alleles | Intermediate Filament Proteins - genetics | Female | Mice | Mutation | Child | Dermatitis, Atopic - metabolism | Intermediate Filament Proteins - metabolism | Hydrogen-Ion Concentration | Medical colleges | Cytokines | Proteases | Genes | Respiratory agents | Genetic aspects | Skin | Inflammation | Universities and colleges | Dermatitis | Proteins | Enzymes | Genotype & phenotype | Hypotheses | Families & family life | Values | Homeostasis | Animal models | Stratum corneum | Interleukin 1 receptor antagonist | Proteinase | Keratinocytes | mRNA | Filaggrin | Raman spectroscopy | pH effects | Tails | Interleukin 18 | Polymerase chain reaction | Water loss | Primers | Interleukin 1 | Interleukin 8 | FLG | SC, Stratum corneum | Flgft | Patient homozygous for null alleles (ie, 2 null alleles) | AD, Atopic dermatitis | FLG, Filaggrin gene | Homozygote wild-type (ie, 0 null alleles) | TEWL, Transepidermal water loss | Heterozygote null allele | Flgft (FlgdelAPfal) mice | IL-1RA, IL-1 receptor antagonist | wild-type (ie, 1 null allele) | NMF, Natural moisturizing factor | ADFLG, AD with FLG mutations | Atopic Dermatitis and Skin Disease | NESS, Nottingham Eczema Severity Score | ADNON-FLG, AD without FLG mutations
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 4, pp. 867 - 875.e1
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 2, pp. 482 - 491
Background Atopic dermatitis (AD) is an inflammatory skin condition that can occur in early life, predisposing to asthma development in a phenomenon known as... 
Allergy and Immunology | Allergy | mouse | mutation | type 2 innate lymphoid cells | innate immunity | flaky tail | atopy | eczema | atopic dermatitis | asthma | filaggrin | FILAGGRIN | BARRIER | SUSCEPTIBILITY LOCI | STRATUM-CORNEUM | IMMUNOLOGY | MURINE MODEL | filag-grin | DISEASE | SKIN | LYMPHOID-CELLS | T-CELLS | GENOME-WIDE ASSOCIATION | Adaptive Immunity | Lymphocytes - metabolism | Dermatitis, Atopic - genetics | Pneumonia - etiology | Skin - metabolism | Pneumonia - pathology | Mice, Transgenic | Dermatitis, Atopic - pathology | Immunity, Innate | Dermatitis, Atopic - complications | Lymphocytes - pathology | Phenotype | Animals | Lymphocytes - immunology | Intermediate Filament Proteins - deficiency | Dermatitis, Atopic - immunology | Intermediate Filament Proteins - genetics | Mice | Mutation | Skin - pathology | Disease Models, Animal | Skin - immunology | Skin | Hospitals | Research institutes | Atopic dermatitis | Analysis | Inflammation | Chlorophyll | Compliance | Laboratories | Patients | Proteins | Human subjects | Pathology | Lungs | Rodents | Suctioning | Software | NF-κB, Nuclear factor κB | AD, Atopic dermatitis | RL, Lung resistance | non-T cell | CFP, Cerulean fluorescent protein | FLG, Human filaggrin gene | Cdyn, Dynamic lung compliance | nILC2, Natural type 2 innate lymphoid cell | Flg, Murine filaggrin gene | dLN, Draining lymph node | AHR, Airway hyperresponsiveness | IL-7Rα, IL-7 receptor α | Atopic Dermatitis and Skin Disease | WT, Wild-type | eGFP, Enhanced green fluorescent protein | TSLP, Thymic stromal lymphopoietin | NBNT, Non-B | ILC2, Type 2 innate lymphoid cell | ROR, Retinoic acid–related orphan receptor | iILC2, Inflammatory type 2 innate lymphoid cells
Journal Article
Annals of Allergy, Asthma & Immunology, ISSN 1081-1206, 05/2019, Volume 122, Issue 5, pp. 449 - 455
To summarize studies investigating ethnical and racial differences in atopic dermatitis (AD) epidemiology, clinical features, and skin and blood phenotypes.... 
UNITED-STATES | RISK-FACTOR | ALLERGY | SPINK5 GENE POLYMORPHISMS | FILAGGRIN FLG MUTATIONS | NULL MUTATIONS | AFRICAN-AMERICAN CHILDREN | SERUM IGE LEVELS | ETHIOPIAN PATIENTS | IMMUNOLOGY | ASSOCIATION | SINGLE NUCLEOTIDE POLYMORPHISMS
Journal Article
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, ISSN 1081-1206, 11/2017, Volume 119, Issue 5, pp. 446 - 451
Background: Although mutations in the filaggrin (FLG) gene have been reported to predispose patients with atopic dermatitis (AD) skin infection susceptibility,... 
POPULATION | ICHTHYOSIS VULGARIS | ALLERGY | ECZEMA | GENE-ENCODING FILAGGRIN | MOLLUSCUM CONTAGIOSUM | OF-FUNCTION MUTATIONS | IMMUNOLOGY | FLG GENE | PREDISPOSE | ASSOCIATION | CHILDREN
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 1, pp. 166 - 172
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 1, pp. 164 - 170.e4
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 135, Issue 4, pp. 930 - 935.e1
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 127, Issue 3, pp. 661 - 667
Journal Article
Journal Article