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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2013, Volume 132, Issue 5, pp. 1121 - 1129
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 127, Issue 3, pp. 661 - 667
Journal Article
Contact Dermatitis, ISSN 0105-1873, 06/2019, Volume 80, Issue 6, pp. 359 - 364
Background: There are no Indian studies on the association between filaggrin gene (FLG) mutations and any dermatosis, including hand eczema. Objectives: To... 
filaggrin mutation | atopy | hand eczema | Indian patients | NULL MUTATIONS | SUSCEPTIBILITY | KOREAN PATIENTS | OF-FUNCTION MUTATIONS | CAUSE ICHTHYOSIS VULGARIS | HAPLOINSUFFICIENCY | DERMATOLOGY | ATOPIC-DERMATITIS | ALLERGY | FLG MUTATIONS | IRRITANT CONTACT-DERMATITIS | SEVERITY | Genetic research | Genetic aspects | Gene mutations | Genes | Eczema | Contact dermatitis | Filaggrin | Mutation | Hand | Dermatitis | Atopy
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 1, pp. 82 - 91
Background Atopic dermatitis (AD; eczema) is characterized by a widespread abnormality in cutaneous barrier function and propensity to inflammation. Filaggrin... 
Allergy and Immunology | single molecule | Atopic dermatitis | transcriptome | eczema | skin | tissue | filaggrin | direct RNA sequencing | gene expression | STRATUM-CORNEUM | BARRIER FUNCTION | RISK | DOWN-REGULATES FILAGGRIN | IMMUNOLOGY | CELL-DEATH | LIPID ORGANIZATION | ICHTHYOSIS VULGARIS | ALLERGY | GENE-EXPRESSION | MUTATIONS | Dermatitis, Atopic - genetics | Intermediate Filament Proteins - immunology | Skin - metabolism | Humans | Gene Expression Regulation | Male | Dermatitis, Atopic - pathology | Lipid Metabolism - immunology | Case-Control Studies | Extracellular Space - immunology | Young Adult | Adolescent | Dermatitis, Atopic - immunology | Intermediate Filament Proteins - genetics | Transcription, Genetic - immunology | Female | High-Throughput Nucleotide Sequencing | Child | Dermatitis, Atopic - metabolism | Skin - pathology | Skin - immunology | Pediatrics | Care and treatment | Skin | Analysis | Proteins | Genotype & phenotype | Biopsy | Quality control | Lipids | Genomes | Mutation | Stress response | Gene expression | Dermatitis | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus | Abridged Index Medicus | eQTL, Expression quantitative trait loci | AD, Atopic dermatitis | FLG, Filaggrin gene | CILP, Cartilage intermediate layer protein gene | DRS, Direct RNA sequencing | FDR, False discovery rate | GO, Gene ontology | STAT, Signal transducer and activator of transcription | Atopic Dermatitis and Skin Disease
Journal Article
Journal Article
by Li, M and Liu, Q and Liu, J and Cheng, R and Zhang, H and Xue, H and Bao, Y and Yao, Z
Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, 02/2013, Volume 27, Issue 2, pp. 169 - 174
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 08/2019, Volume 144, Issue 2, pp. 470 - 481
Atopic dermatitis (AD) is a common, complex, and highly heritable inflammatory skin disease. Genome-wide association studies offer opportunities to identify... 
genetics | proteomics | Atopic dermatitis | siRNA knockdown | genomics | organotypic | atopic eczema | filaggrin | EMSY | lipidomics | VARIANTS | ECZEMA | SUSCEPTIBILITY LOCI | LINKS | MECHANISMS | IMMUNOLOGY | RISK LOCI | ALLERGY | DIFFERENTIATION | MUTATIONS | GENOME-WIDE ASSOCIATION | Genetic research | Skin | Analysis | Genomics | Immunohistochemistry | Target recognition | Transcription | Genes | Gene regulation | Risk | Lipids | Genomes | Filaggrin | Leucine | Drug development | Kinases | Dermatitis | Proteins | Spectrometry | Epidermal growth factor | Interrogation | Chromosome 11 | Fibroblasts | Skin diseases | Chromosomes | Culture | Keratinocytes | Inflammation | siRNA | Electron microscopy | Loci | Investigations | Biopsy | Structure-function relationships | Index Medicus | Abridged Index Medicus | AD, Atopic dermatitis | NDF, Normal dermal fibroblasts | GO, Gene ontology | siRNA, Small interfering RNA | TEWL, Transepidermal water loss | EGF, Epidermal growth factor | FLG, Gene encoding filaggrin | LRRC32, Leucine-rich repeat-containing 32 gene, encoding the glycoprotein A repetitions predominant (GARP) protein | GWAS, Genome-wide association study | SNP, Single nucleotide polymorphism | qPCR, Quantitative PCR | NHK, Normal human keratinocytes | Hi-C, Genome-wide chromosome conformation capture and high-throughput sequencing to identify regions of DNA showing interaction in 3-dimensional space | DMEM, Dulbecco modified Eagle medium
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 129, Issue 4, pp. 1031 - 1039.e1
Background Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH.... 
Allergy and Immunology | skin barrier | transepidermal water loss | confocal Raman spectroscopy | Flgft/Flgft (FlgdelAPfal) mice | Atopic dermatitis | IL-1 | IL-18 | FLG gene mutations | eczema | filaggrin | natural moisturizing factor | pH | UNCONVENTIONAL PROTEIN SECRETION | INTERLEUKIN-1 RECEPTOR ANTAGONIST | TERM CULTURE | IMMUNOLOGY | PERMEABILITY BARRIER HOMEOSTASIS | HUMAN KERATINOCYTES | IN-VITRO | ALLERGY | Flg(ft)/Flg(ft)(Flg(delAPfal)) mice | EPIDERMIS | IL-1-BETA | Interleukin-1 - genetics | Interleukin-1 - metabolism | Dermatitis, Atopic - genetics | Cytokines - metabolism | Skin - metabolism | Humans | Mice, Inbred C57BL | Child, Preschool | Genotype | Infant | Male | Mice, Knockout | Animals | Adolescent | Alleles | Intermediate Filament Proteins - genetics | Female | Mice | Mutation | Child | Dermatitis, Atopic - metabolism | Intermediate Filament Proteins - metabolism | Hydrogen-Ion Concentration | Medical colleges | Cytokines | Proteases | Genes | Respiratory agents | Genetic aspects | Skin | Inflammation | Universities and colleges | Dermatitis | Proteins | Enzymes | Genotype & phenotype | Hypotheses | Families & family life | Values | Homeostasis | Animal models | Stratum corneum | Interleukin 1 receptor antagonist | Proteinase | Keratinocytes | mRNA | Filaggrin | Raman spectroscopy | pH effects | Tails | Interleukin 18 | Polymerase chain reaction | Water loss | Primers | Interleukin 1 | Interleukin 8 | Index Medicus | Abridged Index Medicus | FLG | SC, Stratum corneum | Flgft | Patient homozygous for null alleles (ie, 2 null alleles) | AD, Atopic dermatitis | FLG, Filaggrin gene | Homozygote wild-type (ie, 0 null alleles) | TEWL, Transepidermal water loss | Heterozygote null allele | Flgft (FlgdelAPfal) mice | IL-1RA, IL-1 receptor antagonist | wild-type (ie, 1 null allele) | NMF, Natural moisturizing factor | ADFLG, AD with FLG mutations | Atopic Dermatitis and Skin Disease | NESS, Nottingham Eczema Severity Score | ADNON-FLG, AD without FLG mutations
Journal Article