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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 4, pp. 867 - 875.e1
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 129, Issue 4, pp. 1031 - 1039.e1
Background Filaggrin (FLG) mutations result in reduced stratum corneum (SC) natural moisturizing factor (NMF) components and consequent increased SC pH.... 
Allergy and Immunology | skin barrier | transepidermal water loss | confocal Raman spectroscopy | Flgft/Flgft (FlgdelAPfal) mice | Atopic dermatitis | IL-1 | IL-18 | FLG gene mutations | eczema | filaggrin | natural moisturizing factor | UNCONVENTIONAL PROTEIN SECRETION | INTERLEUKIN-1 RECEPTOR ANTAGONIST | TERM CULTURE | IMMUNOLOGY | PERMEABILITY BARRIER HOMEOSTASIS | HUMAN KERATINOCYTES | IN-VITRO | ALLERGY | Flg(ft)/Flg(ft)(Flg(delAPfal)) mice | EPIDERMIS | IL-1-BETA | Interleukin-1 - genetics | Interleukin-1 - metabolism | Dermatitis, Atopic - genetics | Cytokines - metabolism | Skin - metabolism | Humans | Mice, Inbred C57BL | Child, Preschool | Genotype | Infant | Male | Mice, Knockout | Animals | Adolescent | Alleles | Intermediate Filament Proteins - genetics | Female | Mice | Mutation | Child | Dermatitis, Atopic - metabolism | Intermediate Filament Proteins - metabolism | Hydrogen-Ion Concentration | Medical colleges | Cytokines | Proteases | Genes | Respiratory agents | Genetic aspects | Skin | Inflammation | Universities and colleges | Dermatitis | Proteins | Enzymes | Genotype & phenotype | Hypotheses | Families & family life | Values | Homeostasis | Animal models | Stratum corneum | Interleukin 1 receptor antagonist | Proteinase | Keratinocytes | mRNA | Filaggrin | Raman spectroscopy | pH effects | Tails | Interleukin 18 | Polymerase chain reaction | Water loss | Primers | Interleukin 1 | Interleukin 8 | FLG | SC, Stratum corneum | Flgft | Patient homozygous for null alleles (ie, 2 null alleles) | AD, Atopic dermatitis | FLG, Filaggrin gene | Homozygote wild-type (ie, 0 null alleles) | TEWL, Transepidermal water loss | Heterozygote null allele | Flgft (FlgdelAPfal) mice | IL-1RA, IL-1 receptor antagonist | wild-type (ie, 1 null allele) | NMF, Natural moisturizing factor | ADFLG, AD with FLG mutations | Atopic Dermatitis and Skin Disease | NESS, Nottingham Eczema Severity Score | ADNON-FLG, AD without FLG mutations
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2017, Volume 140, Issue 5, pp. 1299 - 1309
Background Atopic eczema (AE) is characterized by skin barrier and immune dysfunction. Null mutations in filaggrin (FLG), a key epidermal barrier protein,... 
Allergy and Immunology | dermatitis | cyclophilin A | skin | proteomic | kallikrein-7 | filaggrin | Atopic eczema | BARRIER | STRATUM-CORNEUM | IMMUNOLOGY | GENE | ALLERGY | STAPHYLOCOCCUS-AUREUS | MUTATIONS | PROTEASE ACTIVITY | EXPRESSION | CYCLOPHILIN | CYCLOSPORINE | Cyclophilin A - metabolism | RNA, Small Interfering - genetics | Dermatitis, Atopic - genetics | Humans | Cells, Cultured | Gene Expression Regulation | Kallikreins - genetics | Transcriptome | Proteome | Inflammation - immunology | Cofilin 1 - genetics | Keratinocytes - pathology | Cofilin 1 - metabolism | Keratinocytes - metabolism | Proteolysis | Mass Spectrometry | Dermatitis, Atopic - immunology | Intermediate Filament Proteins - genetics | Chromatography, Liquid | Cytoskeleton - metabolism | Inflammation - genetics | Cyclophilin A - genetics | Kallikreins - metabolism | Loss of Function Mutation - genetics | Proteins | RNA | Eczema | Kallikrein | Skin | Liquid chromatography | Mass spectrometry | Transcription | Pathogenesis | Cytology | Filaggrin | Kinases | Dermatitis | Western blotting | Atopy | Protein folding | Consent | Cofilin | Skin diseases | Mass spectroscopy | Inflammation | Gene expression | Ribonucleic acid--RNA | Patients | Polymerase chain reaction | Studies | Biopsy | Cytoskeleton | Mutation | Immunofluorescence | Health risk assessment | Binding sites | LSE, Living skin equivalent | shFLG, Filaggrin knockdown short hairpin RNA | shNT, Nontargeting control short hairpin RNA | ANXA3, Annexin A3 | CFL1, Cofilin-1 | eIF, Eukaryotic initiation factor | IPA, Ingenuity Pathway Analysis | TXN, Thioredoxin | FLG, Filaggrin | KLK7, Kallikrein-7 | PPIA, Cyclophilin A | AE, Atopic eczema | RT-qPCR, Quantitative RT-PCR | mTOR, Mammalian target of rapamycin | VIM, Vimentin | CTSV, Cathepsin V
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2011, Volume 127, Issue 3, pp. 661 - 667
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 6, pp. 1573 - 1580.e2
Journal Article
Journal Article