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American Journal of Sports Medicine, ISSN 0363-5465, 08/2016, Volume 44, Issue 8, pp. 1962 - 1971
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2006, Volume 119, Issue 7, pp. 1519 - 1529
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 03/2003, Volume 111, Issue 5, pp. 649 - 658
Preeclampsia, a syndrome affecting 5% of pregnancies, causes substantial maternal and fetal morbidity and mortality. The pathophysiology of preeclampsia... 
MEDICINE, RESEARCH & EXPERIMENTAL | PREGNANCIES | ANGIOGENESIS | VEGF | SERUM-LEVELS | NITRIC-OXIDE | FLT-1 | FACTOR RECEPTOR | BINDING | GROWTH-FACTOR CONCENTRATIONS
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 06/2016, Volume 22, Issue 12, pp. 2993 - 3004
Purpose: Obesity promotes pancreatic and breast cancer progression via mechanisms that are poorly understood. Although obesity is associated with increased... 
BREAST-CANCER | ACTIVATION | ADIPOSE-TISSUE DEVELOPMENT | METASTASIS | ANGIOGENESIS | ONCOLOGY | BONE-MARROW | BODY-MASS INDEX | FACTOR RECEPTOR-1 | FLT-1 | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2001, Volume 276, Issue 29, pp. 26969 - 26979
Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) achieves its multiple functions by activating two receptor tyrosine kinases, Flt-1... 
SIGNAL-TRANSDUCTION | ANGIOGENESIS | 3-KINASE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | KDR | EXTRACELLULAR-MATRIX | TUMOR-CELLS | FLT-1 | IDENTIFICATION | EXPRESSION
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2014, Volume 15, Issue 9, pp. 15456 - 15474
Journal Article
Cancer Cell, ISSN 1535-6108, 2004, Volume 6, Issue 5, pp. 485 - 495
We deleted the hypoxia-responsive transcription factor HIF-1α in endothelial cells (EC) to determine its role during neovascularization. We found that loss of... 
INDUCIBLE FACTOR-1-ALPHA | STEM-CELLS | ONCOLOGY | IN-VIVO | THERAPEUTIC IMPLICATIONS | MICE | PATHOLOGICAL ANGIOGENESIS | TUMOR ANGIOGENESIS | FLT-1 | TRANSCRIPTION FACTOR | GROWTH-FACTOR RECEPTOR-1 | CELL BIOLOGY
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2011, Volume 436, Issue 2, pp. 399 - 407
sFlt-1 (soluble Flt-1) potently inhibits angiogenesis by binding extracellularly to VEGF (vascular endothelial growth factor). In the present paper, we report... 
Angiogenesis | Vascular endothelial cell | Hypoxia | mRNA 3′-end processing | Soluble Flt-1 | Vascular endothelial growth factor (VEGF) | hypoxia | angiogenesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | mRNA 3 '-end processing | POLYADENYLATION | vascular endothelial growth factor (VEGF) | FACTOR CSTF-64 | RECEPTOR | PREECLAMPSIA | CLEAVAGE | POSSIBLE PARTICIPATION | soluble Flt-1 | ELEVATED LEVELS | GROWTH-FACTOR | PERICYTES | vascular endothelial cell | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Microcirculation - genetics | Alternative Splicing - genetics | Humans | RNA, Messenger - genetics | Cells, Cultured | Molecular Sequence Data | Vascular Endothelial Growth Factor Receptor-1 - biosynthesis | Down-Regulation - genetics | RNA, Messenger - biosynthesis | Base Sequence | RNA, Messenger - antagonists & inhibitors | RNA 3' End Processing - genetics | Cell Hypoxia - genetics | Endothelial Cells - physiology | Vascular Endothelial Growth Factor Receptor-1 - genetics | Index Medicus | hnRNP, heterogeneous nuclear ribonucleoprotein | RT, reverse transcription | sVEGFR, soluble VEGFR | PHD, prolyl hydroxylase | HEK-293TN cell, HEK (human embryonic kidney)-293 cell expressing the large T-antigen of SV40 (simian virus 40) and the neomycin-resistance gene | mFlt-1, membrane-bound Flt-1 | CstF, cleavage stimulation factor | FBS, fetal bovine serum | KDR, kinase insert domain-containing receptor | HUVEC, human umbilical vein EC | VEGF, vascular endothelial growth factor | MVEC, microvascular EC | EC, endothelial cell | HIF, hypoxia-inducible factor | sFlt-1, soluble Flt-1 | VEGFR, VEGF receptor | bFGF, basic fibroblast growth factor | DMOG, dimethyloxaloylglycine | Cst F64, 64-kDa subunit of CstF | CFIM25, 25-kDa subunit of the cleavage factor Im | ARE, A+U-rich element | HMVEC, human MVEC
Journal Article
Nature Communications, ISSN 2041-1723, 06/2017, Volume 8, Issue 1, pp. 15699 - 15699
Blood vessel expansion is driven by sprouting angiogenesis of endothelial cells, and is essential for development, wound healing and disease.... 
SIGNAL-TRANSDUCTION | PROTEIN STABILITY | PALMITOYLATION | TYROSINE KINASE | ACYL TRANSFERASES | CELL-MIGRATION | MULTIDISCIPLINARY SCIENCES | MOUSE | LYMPHANGIOGENESIS | FLT-1 VEGFR-1 | ENDOTHELIAL GROWTH-FACTOR | Index Medicus
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 08/2002, Volume 8, Issue 8, pp. 841 - 849
The mechanism by which angiogenic factors recruit bone marrow ( BM)-derived quiescent endothelial and hematopoietic stem cells ( HSCs) is not known. Here, we... 
PROGENITOR CELLS | FACTOR VEGF | MEDICINE, RESEARCH & EXPERIMENTAL | MOBILIZATION | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR RECEPTOR-1 | TUMOR ANGIOGENESIS | FLT-1 | CELL BIOLOGY | INHIBITION | ENDOTHELIAL-CELLS | MICE
Journal Article
BIOCHEMICAL PHARMACOLOGY, ISSN 0006-2952, 08/2013, Volume 86, Issue 3, pp. 392 - 400
Ginsenoside-Rg(1) (Rg(1)) has been identified as potent proangiogenic agent, which plays an important role in wound healing promotion or treatment of ischemic... 
PANAX-GINSENG | MECHANISM | HYPOXIA | FLT-1 | SIGNAL-TRANSDUCTION | Angiogenesis | Ginsenoside-Rg | GENOMICS | Microrna-15b | PATHWAY | VEGFR-2 | BIOLOGY | PHARMACOLOGY & PHARMACY | GINSENOSIDE RG1 | RECEPTORS | HUVECs
Journal Article
Gene Therapy, ISSN 0969-7128, 01/2009, Volume 16, Issue 1, pp. 10 - 16
Vascular endothelial growth factor (VEGF) is important in pathological neovascularization, which is a key component of diseases such as the wet form of... 
MEDICINE, RESEARCH & EXPERIMENTAL | VEGFR1 | ADENOASSOCIATED VIRAL VECTOR | IMMUNOGLOBULIN-LIKE DOMAIN | LIGAND-BINDING | VEGF | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACULAR DEGENERATION | THERAPEUTIC LEVELS | OCULAR NEOVASCULARIZATION | Fc fragment | FACTOR RECEPTOR FLT-1 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | retinal neovascularization | adeno-associated virus 2 | GENETICS & HEREDITY | GENE-TRANSFER | Flt-1 | ENDOTHELIAL GROWTH-FACTOR | Protein Structure, Tertiary | Dependovirus - genetics | Gene Expression | Retina - metabolism | Genetic Vectors - administration & dosage | Humans | Mice, Inbred C57BL | RNA, Messenger - analysis | Retinal Neovascularization - metabolism | Retinal Neovascularization - therapy | Vascular Endothelial Growth Factor A - metabolism | Recombinant Fusion Proteins - metabolism | Genetic Vectors - genetics | Animals | Genetic Engineering | Fluorescent Antibody Technique | Protein Binding | Recombinant Fusion Proteins - genetics | Mice | Transgenes | Immunoglobulin Fc Fragments - genetics | Transduction, Genetic - methods | Genetic Therapy - methods | Vascular Endothelial Growth Factor Receptor-1 - genetics | Usage | Care and treatment | Genetic vectors | Genetic aspects | Research | Retinal diseases | Vascular endothelial growth factor | Health aspects | Retina | Ophthalmology | Gene therapy | Molecular biology | Binding sites | Index Medicus
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 08/2003, Volume 198, Issue 3, pp. 483 - 489
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms... 
FACTOR VEGF | MEDICINE, RESEARCH & EXPERIMENTAL | angiogenesis | VEGF | CELL-ADHESION | immunity | IMMUNOLOGY | FLT-1 | retina | POTENCY | leukocyte | RETINOPATHY | ADHESION MOLECULE-1 ICAM-1 | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Neuroscience Letters, ISSN 0304-3940, 01/2019, Volume 692, pp. 70 - 76
Subcortical white matter infarction causes ischemic demyelination and loss of brain functions, as the result of disturbances of the blood flow. Although... 
Angiogenesis | Pericyte | Flt1 | Endothelial cell | VEGF | PDGF | White matter infarction | Flk1 | CELLS | BLOOD-VESSEL FORMATION | MODEL | FLT-1 | NEUROSCIENCES | STROKE | GROWTH | PERICYTES | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2006, Volume 443, Issue 7114, pp. 993 - 997
Journal Article