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11/2013
Survival rates for pediatric B-cell acute lymphoblastic leukemia (B-ALL) have improved dramatically, but outcomes for the 15% who relapse and for adults with... 
RANKL | Flt3 | 0992
Dissertation
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 01/2019, Volume 25, Issue 2, pp. 460 - 462
The presence of internal tandem duplications (ITD) in the FLT3 receptor tyrosine kinase gene have long been known to confer a poor prognosis in patients with... 
ONCOLOGY | FLT3 | MUTATIONS
Journal Article
Cancer, ISSN 0008-543X, 08/2017, Volume 123, Issue 15, pp. 2867 - 2874
Sorafenib has shown encouraging results in patients with Fms‐like tyrosine kinase 3 (FLT3)‐positive acute myeloid leukemia. When used as a maintenance agent... 
acute myeloid leukemia (AML) | allogeneic stem cell transplantation | Fms‐like tyrosine kinase 3 (FLT3) | sorafenib | maintenance | Fms-like tyrosine kinase 3 (FLT3) | AML | INTERNAL TANDEM DUPLICATION | CONTROLLED-TRIAL | FLT3 MUTATIONS | COMBINATION | YOUNGER | THERAPY | ONCOLOGY | OUTCOMES | PHASE-I | REMISSION | Niacinamide - analogs & derivatives | Humans | Middle Aged | Hematopoietic Stem Cell Transplantation | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Male | Treatment Outcome | Antineoplastic Agents - therapeutic use | Transplantation, Homologous | Feasibility Studies | Graft vs Host Disease | Young Adult | fms-Like Tyrosine Kinase 3 - genetics | Disease-Free Survival | Adolescent | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Maintenance Chemotherapy | Retrospective Studies | Chemotherapy, Adjuvant | Leukemia, Myeloid, Acute - genetics | Usage | Transplantation | Stem cells | Graft-versus-host reaction | Toxicity | Leukemia | Medical services | Clinical trials | Stem cell transplantation | Reduction | Quality | Remission | Protein-tyrosine kinase | Tyrosine | Myeloid leukemia | Feasibility studies | Maintenance | Disease control | Patients | Survival | Hemopoiesis | Flt3 protein | Feasibility | Mutation | Acute myeloid leukemia | Cancer | Index Medicus | Abridged Index Medicus | Life Sciences | Hematology | Human health and pathology
Journal Article
Cancer, ISSN 0008-543X, 07/2014, Volume 120, Issue 14, pp. 2142 - 2149
Secondary FLT3‐tyrosine kinase domain mutations can arise after treatment with FLT3 inhibitors in patients with FLT3‐internal tandem duplication–mutated acute... 
FLT3 inhibitors | FLT3‐ITD | FLT3‐TKD | acute myeloid leukemia | secondary FLT3 mutations | FLT3-TKD | FLT3-ITD | MOLECULAR-MECHANISM | INTERNAL TANDEM DUPLICATION | INTENSIVE CHEMOTHERAPY | ACUTE MYELOGENOUS LEUKEMIA | RISK MYELODYSPLASTIC SYNDROME | TYROSINE KINASES | OLDER PATIENTS | ONCOLOGY | LESTAURTINIB CEP701 | THERAPEUTIC TARGET | PROGNOSTIC-SIGNIFICANCE | Niacinamide - analogs & derivatives | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Humans | Middle Aged | Male | Antineoplastic Agents - therapeutic use | fms-Like Tyrosine Kinase 3 - genetics | DNA Mutational Analysis | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Antineoplastic Agents - pharmacology | Retrospective Studies | Medical Records | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Treatment Outcome | Leukemia, Myeloid, Acute - mortality | Protein Kinase Inhibitors - therapeutic use | Survival Analysis | Aged | Benzothiazoles - therapeutic use | Carbazoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Mutation | Leukemia, Myeloid, Acute - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | Care and treatment | Myelocytic leukemia | Gene mutations | Analysis | Protein tyrosine kinase | Nonlymphoid leukemia | Research | Index Medicus | Abridged Index Medicus
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 7/2017, Volume 23, Issue 14, pp. 3649 - 3656
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2015, Volume 5, Issue 6, pp. 668 - 679
Tyrosine kinase domain mutations are a common cause of acquired clinical resistance to tyrosine kinase inhibitors (TKIs) used to treat cancer, including the... 
Resistance | Gatekeeper Mutations | Quizartinib | FLT3
Journal Article
Clinical Lymphoma Myeloma and Leukemia, ISSN 2152-2650, 09/2017, Volume 17, pp. S124 - S126
Journal Article
European Journal of Haematology, ISSN 0902-4441, 04/2019, Volume 102, Issue 4, pp. 341 - 350
Objectives To assess real-world treatment patterns and healthcare resource utilization (HRU) among patients with FLT3-mutated (FLT3(mut)) and FLT3-wild-type... 
mutation | acute myeloid leukemia | FLT3 | healthcare resource utilization | treatment patterns | FLT3 mutation | SURVIVAL | AML | OLDER | FLT3 MUTATIONS | CHEMOTHERAPY | COSTS | INHIBITORS | OUTCOMES | HEMATOLOGY | Medical care | Utilization | Research | Oncology, Experimental | Cancer | Resource utilization | Cytarabine | Myeloid leukemia | Acute myeloid leukemia | Patients | Leukemia
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2015, Volume 16, Issue 12, pp. 4869 - 4872
AML | ITD | CSGE | FLT3
Journal Article
BLOOD, ISSN 0006-4971, 03/2017, Volume 129, Issue 9, pp. 1061 - 1062
In this issue of Blood, Knapper et al analyzed 2 consecutive randomized Medical Research Council (MRC) trials in newly diagnosed patients with mutant FMS-like... 
PLACEBO | FLT3 | SORAFENIB | HEMATOLOGY | CHEMOTHERAPY | YOUNGER
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 06/2008, Volume 9, Issue 6, pp. 676 - 683
Dendritic cell (DC) development begins in the bone marrow but is not completed until after immature progenitors reach their sites of residence in lymphoid... 
PROGENITORS | INHIBITION | IN-VIVO | BONE-MARROW | ONTOGENY | MONOCYTES | HEMATOPOIETIC PRECURSORS | MICE | DIFFERENTIATION | IMMUNOLOGY | FLT3 LIGAND
Journal Article
Biomarker Research, ISSN 2050-7771, 09/2019, Volume 7, Issue 1, pp. 1 - 6
FMS-like tyrosine kinase 3- internal tandem duplication (FLT3-ITD) remains as one of the most frequently mutated genes in acute myeloid leukemia (AML),... 
FLT3 | Tyrosine kinase inhibitor | Gilteritinib | FLT3 inhibitor
Journal Article
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 4/2016, Volume 22, Issue 8, pp. 1951 - 1957
Journal Article
Bioorganic & medicinal chemistry letters, 08/2019, pp. 126630 - 126630
FMS-like tyrosine kinase 3 (FLT3) was an important therapeutic target in acute myeloid leukemia (AML). We synthesized two series of... 
Index Medicus
Journal Article
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