X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (250) 250
Publication (17) 17
Book Review (6) 6
Book Chapter (4) 4
Conference Proceeding (1) 1
Dissertation (1) 1
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
flupirtine (216) 216
animals (76) 76
pharmacology & pharmacy (72) 72
male (69) 69
humans (65) 65
index medicus (63) 63
rats (55) 55
aminopyridines - pharmacology (47) 47
female (43) 43
analgesics (42) 42
neurosciences (42) 42
rat (35) 35
pain (34) 34
adult (28) 28
aminopyridines - therapeutic use (27) 27
retigabine (27) 27
analgesics - pharmacology (26) 26
clinical neurology (25) 25
methyl-d-aspartate (25) 25
aged (24) 24
efficacy (24) 24
middle aged (24) 24
potassium channels (24) 24
rats, wistar (24) 24
dose-response relationship, drug (21) 21
neurons (20) 20
neuroprotective agents - pharmacology (20) 20
pharmacokinetics (20) 20
aminopyridines (18) 18
flupirtine maleate (18) 18
aminopyridines - administration & dosage (17) 17
aminopyridines - adverse effects (17) 17
apoptosis (17) 17
in-vitro (17) 17
anesthesiology (16) 16
channels (15) 15
kcnq (15) 15
analgesics - therapeutic use (14) 14
analysis (14) 14
double-blind method (14) 14
rats, sprague-dawley (14) 14
anticonvulsant retigabine (13) 13
care and treatment (13) 13
activation (12) 12
administration, oral (12) 12
analgesia (12) 12
analgesics - adverse effects (12) 12
chemistry, medicinal (12) 12
hepatotoxicity (12) 12
neurons - drug effects (12) 12
neuropathic pain (12) 12
pharmacology (12) 12
analgesic flupirtine (11) 11
analgesics - administration & dosage (11) 11
k+ channels (11) 11
mice (11) 11
neuroprotection (11) 11
aminopyridines - pharmacokinetics (10) 10
brain (10) 10
carbamates - pharmacology (10) 10
drugs (10) 10
epilepsy (10) 10
glutamate (10) 10
maleate (10) 10
morphine (10) 10
nmda receptor (10) 10
paracetamol (10) 10
tramadol (10) 10
biotransformation (9) 9
cells, cultured (9) 9
chemistry (9) 9
chemistry, analytical (9) 9
disease (9) 9
disease models, animal (9) 9
kv7 channels (9) 9
medicine, general & internal (9) 9
neuroprotective agents - therapeutic use (9) 9
oxidative stress (9) 9
phenylenediamines - pharmacology (9) 9
research (9) 9
toxicology (9) 9
analgesic (8) 8
bcl-2 (8) 8
biochemistry & molecular biology (8) 8
calcium - metabolism (8) 8
cell biology (8) 8
death (8) 8
expression (8) 8
health aspects (8) 8
metabolites (8) 8
neurology (8) 8
nmda (8) 8
pain - drug therapy (8) 8
pain measurement - drug effects (8) 8
psychiatry (8) 8
responses (8) 8
spasticity (8) 8
treatment outcome (8) 8
aged, 80 and over (7) 7
article (7) 7
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Neurochemistry, ISSN 0022-3042, 12/2000, Volume 75, Issue 6, pp. 2270 - 2276
The present study investigated the effects of flupirtine (Katadolon) on tumor necrosis factor (TNF)- alpha -mediated cell death and Bcl-2 expression in the... 
flupirtine
Journal Article
Journal of Substance Use, ISSN 1465-9891, 05/2016, Volume 21, Issue 3, pp. 335 - 336
This is the case of a 49-year-old woman, who was treated as an inpatient due to long-term flupirtine use and consecutive dependence to flupirtine. Earlier... 
withdrawal syndrome | flupirtine | craving | Benzodiazepines | flupirtine dependence
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 07/2012, Volume 166, Issue 5, pp. 1631 - 1642
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 07/2015, Volume 288, pp. 1 - 10
Chronic restraint stress (CRS) causes hippocampal neurodegeneration and hippocampus-dependent cognitive deficits. Flupirtine represents neuroprotective effects... 
Akt (protein kinase B) | Glycogen synthase kinase 3 beta | Chronic restraint stress | Flupirtine | Cognitive impairment | CHRONIC CEREBRAL HYPOPERFUSION | INDUCED NEURONAL APOPTOSIS | DEPRESSIVE-LIKE BEHAVIOR | MEMORY DEFICITS | NEUROSCIENCES | PROTECTS | PATHWAY | INDUCED IMPAIRMENTS | BEHAVIORAL SCIENCES | RAT HIPPOCAMPUS | ACTIVATOR FLUPIRTINE | BRAIN | Memory | Apoptosis
Journal Article
Journal of Neural Transmission, ISSN 0300-9564, 10/1999, Volume 106, Issue 9/10, pp. 857 - 867
The spectrum of action of flupirtine includes analgesia, muscle relaxation and neuroprotection. N-methyl-D-aspartate (NMDA) receptor antagonism has been... 
flupirtine
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 12/2018, Volume 28, Issue 23-24, pp. 3793 - 3797
Neuronal voltage-gated potassium channels, K(v)7s, are the molecular mediators of the M current and regulate membrane excitability in the central and... 
DRUG | CHEMISTRY, MEDICINAL | Epilepsy | KCNQ2 | KCNQ | Bladder | CHEMISTRY, ORGANIC | RETIGABINE | FLUPIRTINE | Opener
Journal Article
Journal of Hypertension, ISSN 0263-6352, 09/2010, Volume 28, Issue 9, pp. 1875 - 1882
Journal Article
Journal of Chromatography A, ISSN 0021-9673, 10/2019, Volume 1603, pp. 338 - 347
Supercritical fluid chromatography (SFC) holds the potential to become an orthogonal method to HPLC/UHPLC in xenobiotic metabolism studies, due to its... 
Validation | Halogen bonds | Green chemistry | Metabolism | Flupirtine | Supercritical fluid chromatography | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | MASS-SPECTROMETRY | SFC | PAIN | SEPARATION | SAMPLES | KETAMINE METABOLITES | DERIVATIVES
Journal Article
Current Medical Research and Opinion, ISSN 0300-7995, 08/2019, Volume 35, Issue 8, pp. 1397 - 1403
Objectives: This report characterizes flupirtine prescribing patterns before and after the implementation of risk minimization measures (RMM) in Germany as a... 
prescribing patterns | flupirtine | risk minimization measures | Drug utilization | MEDICINE, RESEARCH & EXPERIMENTAL | MEDICINE, GENERAL & INTERNAL | IMPACT | REGULATORY ACTION
Journal Article
Future Medicinal Chemistry, ISSN 1756-8919, 02/2019, Volume 11, Issue 4, pp. 337 - 355
The highly structurally similar drugs flupirtine and retigabine have been regarded as safe and effective for many years but lately they turned out to exert... 
drug-induced liver injury | flupirtine | ezogabine | DILI | retigabine | voltage-gated potassium channel
Journal Article
CHEMMEDCHEM, ISSN 1860-7179, 05/2019, Volume 14, Issue 9, pp. 952 - 964
The potassium channel openers flupirtine and retigabine have proven to be valuable analgesics or antiepileptics. Their recent withdrawal due to occasional... 
DISCOLORATION | SULFOXIMINES | CHEMISTRY, MEDICINAL | DISCOVERY | POTENT | K(V)7 | retigabine | flupirtine | KCNQ | PHARMACOLOGY & PHARMACY | SKIN | RECEPTORS | DERIVATIVES | sulfides
Journal Article
Liver International, ISSN 1478-3223, 02/2018, Volume 38, Issue 2, pp. 365 - 376
Background & Aims The analgesic flupirtine has been linked to cases of severe idiosyncratic drug‐induced liver injury (sFILI). We therefore examined whether... 
prednisolone | flupirtine‐induced liver injury | antidote | N‐acetylcysteine | flupirtine-induced liver injury | N-acetylcysteine | SAFETY | HEPATOTOXICITY | MODEL | GASTROENTEROLOGY & HEPATOLOGY | FAILURE | Glucocorticoids - administration & dosage | Liver - pathology | Liver Transplantation | Prednisolone - administration & dosage | Glutathione - metabolism | Humans | Middle Aged | Aminopyridines - adverse effects | Male | Antidotes - administration & dosage | Hepatocytes - metabolism | Recovery of Function | Liver - drug effects | Aged, 80 and over | Adult | Female | Retrospective Studies | Acetylcysteine - administration & dosage | Chemical and Drug Induced Liver Injury - blood | Drug Therapy, Combination | Hepatocytes - drug effects | Analgesics - adverse effects | Severity of Illness Index | Administration, Oral | Liver - metabolism | Cells, Cultured | Treatment Outcome | Biomarkers - blood | Disease Progression | Chemical and Drug Induced Liver Injury - diagnosis | Chemical and Drug Induced Liver Injury - drug therapy | Aged | Infusions, Intravenous | Medical research | Liver diseases | Corticosteroids | Analysis | Liver | Acetylcysteine | Medicine, Experimental | Transplantation of organs, tissues, etc | Biochemistry | Bilirubin | Prednisolone | Steroids | Drugs | Alanine | Glucocorticoids | Medical services | Cultures | Transplantation | Patients | Immunosuppressive agents | Infusion | Hepatocytes | Encephalopathy | Liabilities | Alanine transaminase | Aspartate aminotransferase | Hepatic encephalopathy | Glutathione | Liver transplantation | Index Medicus
Journal Article
American Journal of Animal and Veterinary Sciences, ISSN 1557-4555, 2015, Volume 10, Issue 2, pp. 91 - 100
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 01/2011, Volume 162, Issue 1, pp. 42 - 53
BACKGROUND AND PURPOSE KCNQ-encoded voltage-gated potassium channels (K(v)7) have recently been identified as important anti-constrictor elements in rodent... 
CELLS | vascular smooth muscle | ANTICONVULSANT RETIGABINE | MODULATORS | SENSITIVITY | K(V)7 CHANNELS | FLUPIRTINE | KV7 POTASSIUM CHANNELS | SMOOTH-MUSCLE | K(v)7 | KCNQ | RESISTANCE | TARGETS | PHARMACOLOGY & PHARMACY | human | arterial tone
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 2/2017, Volume 390, Issue 2, pp. 127 - 137
Voltage-gated type 7 K+ (KV7 or KCNQ) channels regulate the contractility of various smooth muscles. With this study, we aimed to assess the role of KV7... 
K V 7 channels | Neurosciences | Biomedicine | Retigabine | Flupirtine | Human detrusor | KCNQ channels | Pharmacology/Toxicology | XE-991 | 7 channels
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 8, pp. 12554 - 12555
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.