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Acta pharmaceutica Sinica. B, ISSN 2211-3835, 03/2019, Volume 9, Issue 2, pp. 279 - 293
Over recent decades, many studies have reported that hypocrellin A (HA) can eliminate cancer cells with proper irradiation in several cancer cell lines.... 
iTRAQ | Reactive oxygen species | Photodynamic therapy | Hypocrellin A | LC–MS/MS | Proteomic | OXIDATIVE STRESS | MECHANISMS | DEATH | LC-MS/MS | NANOPARTICLES | IN-VITRO | THERAPY | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | Dox, doxorubicin | OCR, oxygen consumption rate | IAA, iodoacetamide | z-IETD-fmk, z-Ile-Glu-Asp-fluoromethylketone | FCCP, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone | PS, photosensitizer | ACN, acetonitrile | HRP, horseradish peroxidase | iTRAQ, isobaric tag for relative and absolute quantitation | DCFH-DA, 2′,7′-dichlorofuorescin diacetate | DMEM, Dulbecco׳s modified Eagle׳s medium | MPT, mitochondrial permeability transition | SCX, strong cation exchange | PDT, photodynamic therapy | ROS, reactive oxygen species | NAC, N-acetyl-l-cysteine | IKK, IκB kinase complex | MMP, mitochondrial membrane potential | CLSM, confocal laser scanning confocal microscopy | GO, gene ontology | PI, propidium iodide | HA, hypocrellin A | LC–MS | TCM, traditional Chinese medicinal | JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-benzimidazolcarbocyanine iodide | UA, urea | ECL, enhanced chemiluminescence | z-VAD-fmk, z-Val-Ala-Asp-fluoromethylketone | FDR, false discovery rate | TEM, transmission electron microscope | Original article | TFA, trifluoroacetic acid | z-LEHD-fmk, z-Leu-Glu(OMe)-His-Asp(OMe)-fluoromethylketone
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical journal, ISSN 0264-6021, 06/2012, Volume 444, Issue 3, pp. 515 - 527
IL (interleukin)-6, an established growth factor for multiple myeloma cells, induces myeloma therapy resistance, but the resistance mechanisms remain unclear.... 
Manganese superoxide dismutase (MnSOD) | Dexamethasone | Radiation therapy | Nuclear factor κB (NF-κB) | Multiple myeloma | Interleukin-6 | dexamethasone | nuclear factor kappa B (NF-kappa B) | multiple myeloma | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | manganese superoxide dismutase (MnSOD) | interleukin-6 | FACTOR-ALPHA | TUMOR-NECROSIS-FACTOR | REDOX REGULATION | radiation therapy | HYDROGEN-PEROXIDE | IONIZING-RADIATION | NF-KAPPA-B | INTRACELLULAR SUPEROXIDE | MARROW STROMAL CELLS | Cell Line | Multiple Myeloma - drug therapy | Multiple Myeloma - therapy | Reactive Oxygen Species - metabolism | Superoxide Dismutase - biosynthesis | Humans | Oxidative Stress - physiology | Up-Regulation - physiology | Interleukin-6 - physiology | Cell Line, Tumor | Multiple Myeloma - enzymology | Drug Resistance, Neoplasm - physiology | Dex, dexamethasone | TNF, tumour necrosis factor | E+, ethidium cation | KD, knockdown | H2DCF-DA, 2′,7′-dichlorodihydrofluorescein diacetate | CF, cleaved fragment | MM, multiple myeloma | NAC, N-acetylcysteine | BM, bone marrow | RLU, relative luciferase units | IR, ionizing radiation | DHE, dihydroethidium | JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide | MFI, mean fluorescence intensity | 2-OH-E+, 2-hydroxyethidium | GPx, glutathione peroxidase | ROS, reactive oxygen species | IκB, inhibitor of NF-κB | qPCR, quantitative PCR | ICCM, irradiated cell conditioned medium | NSF, normalized survival fraction | Z-VAD-FMK, benzyloxycarbonyl-Val-Ala-DL-Asp-fluoromethylketone | shRNA, small hairpin RNA | PI, propidium iodide | MnSOD, manganese superoxide dismutase | NBD, NEMO (NF-κB essential modulator)-binding domain | PEG–SOD, poly(ethylene glycol)-conjugated superoxide dismutase | SOD, superoxide dismutase | NF-κB, nuclear factor-κB | Z-LEHD-FMK, benzyloxycarbonyl-Leu-Glu-His-DL-Asp-fluoromethylketone | MOI, multiplicity of infection | IL, interleukin | MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide | nuclear factor κB (NF-κB) | PARP, poly(ADP-ribose) polymerase
Journal Article
Biochemical journal, ISSN 1470-8728, 2015, Volume 466, Issue 2, pp. 219 - 232
Clan CD forms a structural group of cysteine peptidases, containing seven individual families and two subfamilies of structurally related enzymes.... 
Caspase | Peptidase | Metacaspase | Clan CD | Crystallography | Protein structure | YEAST METACASPASE | PROTEASE DOMAIN | MALT1 PARACASPASE | CRYSTAL-STRUCTURE | PORPHYROMONAS-GINGIVALIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | VIRULENCE FACTOR | LEISHMANIA-MAJOR METACASPASE | caspase | protein structure | PROGRAMMED CELL-DEATH | crystallography | CLOSTRIDIUM-DIFFICILE TOXIN | clan CD | metacaspase | peptidase | TRYPANOSOMA-BRUCEI METACASPASE | Cysteine Endopeptidases - chemistry | Enzyme Precursors - chemistry | Humans | Models, Molecular | Isoenzymes - chemistry | Enzyme Precursors - metabolism | Animals | Cysteine Endopeptidases - metabolism | Isoenzymes - metabolism | Ligands | Protein Conformation | Enzyme Activation | Caspases - chemistry | Binding Sites | Dimerization | MARTX, multi-functional, autoprocessing repeat in toxin | CPD, cysteine peptidase domain | CSD, C-terminal subdomain | CARD, caspase recruitment domain | CHF, caspase | LSD1, lesion-simulating disease 1 | Z-VRPR-FMK, benzoxycarbonyl-Val-Arg-Pro-Arg-fluoromethylketone | LSAM, legumain stabilization and activity modulation | DED, death effector domain | Review | InsP6, myo-inositol hexakisphosphate | haemoglobinase fold | XIAP, X-linked inhibitor of apoptosis | DD, death domain | MALT1, mucosa-associated lymphoid tissue translocation protein 1 | AP, activation peptide | RMSD, root-mean-square deviation | SSE, secondary structural element
Journal Article
Biochemical journal, ISSN 0264-6021, 04/2012, Volume 443, Issue 1, pp. 287 - 295
The paracaspase domain of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a component of a gene translocation fused to the... 
CYLD | Positional-scanning substrate library | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) | Protease | Substrate specificity | Paracaspase | TRANSLOCATION | ACTIVATION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLEAVAGE | positional-scanning substrate library | protease | substrate specificity | CASPASES | LYMPHOMA | mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) | paracaspase | NF-KAPPA-B | ZYMOGEN | KEY | Protein Structure, Tertiary | Recombinant Fusion Proteins - biosynthesis | Amino Acid Sequence | Recombinant Fusion Proteins - isolation & purification | Neoplasm Proteins - biosynthesis | Escherichia coli | Humans | Substrate Specificity | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Caspases - isolation & purification | Citrates - chemistry | Chromatography, Affinity | Neoplasm Proteins - isolation & purification | Proteolysis | Enzyme Activators - chemistry | Caspases - biosynthesis | HEK293 Cells | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Enzyme Activation | Kinetics | Protein Stability | Caspases - chemistry | Oligopeptides - chemistry | PS-SCL, positional-scanning substrate combinatorial library | WT, wild-type | CARD, caspase recruitment domain | MALT1, mucosa-associated lymphoid tissue lymphoma translocation protein 1 | HEK, human embryonic kidney | AFC, 7-amino-4-trifluoromethylcoumarin | JNK, c-Jun N-terminal kinase | DTT, dithiothreitol | IAP, inhibitor of apoptosis protein | z, benzyloxycarbonyl | ACC, 7-amino-4-carbamoylmethylcoumarin | DD, death domain | CARMA1, CARD-containing MAGUK (membrane-associated guanylate kinase) 1 | TCA, trichloroacetic acid | Ac, acetyl | AMC, 7-amino-4-methylcoumarin | FMK, fluoromethylketone | IPTG, isopropyl β-D-thiogalactopyranoside | NF-κB, nuclear factor κB | FKBP, FK506-binding protein | BIR, baculovirus inhibitor of apoptosis protein repeat | Ni-NTA, Ni2+-nitrilotriacetate | NIK, NF-κB-inducing kinase | cIAP2, cellular inhibitor of apoptosis protein 2
Journal Article
Redox biology, ISSN 2213-2317, 2017, Volume 12, pp. 264 - 273
Journal Article
Biochemical journal, ISSN 1470-8728, 2005, Volume 389, Issue 2, pp. 527 - 539
Doxorubicin (DOX), a widely used antitumour drug, causes dose-dependent cardiotoxicity. Cardiac mitochondria represent a critical target organelle of toxicity... 
Oxidative stress | Calcium | Doxorubicin | Fas ligand (Fas L) | Apoptosis | NFAT | calcium | INDUCED APOPTOSIS | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC MYOCYTES | apoptosis | MEDIATED APOPTOSIS | INDUCED CARDIOMYOPATHY | PULSE-RADIOLYSIS | SUPEROXIDE GENERATION | ENDOTHELIAL-CELLS | IN-VIVO | HYDROGEN-PEROXIDE | doxorubicin | oxidative stress | Tumor Necrosis Factors - genetics | Transcription, Genetic - drug effects | Up-Regulation | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Apoptosis - drug effects | Calcium - metabolism | Male | Mitochondria, Heart - drug effects | Calcium - antagonists & inhibitors | Caspases - metabolism | Cell Nucleus - metabolism | Cell Line | Nerve Tissue Proteins - antagonists & inhibitors | Myocytes, Cardiac - cytology | NFATC Transcription Factors - metabolism | Hydrogen Peroxide - pharmacology | Rats | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Membrane Glycoproteins - genetics | Fas Ligand Protein | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Signal Transduction - drug effects | Myocytes, Cardiac - metabolism | Cell Nucleus - drug effects | NFATC Transcription Factors - antagonists & inhibitors | Doxorubicin - pharmacology | DPI, diphenyleneiodonium | CsA, cyclosporin A | carboxy-H2DCFDA, carboxy-2′,7′-dichlorodihydrofluorescein diacetate | RT-PCR, reverse transcriptase-PCR | C3i, caspase 3 inhibitor | Gpx-1, glutathione peroxidase 1 | HRP, horseradish peroxidase | NFAT-I, NFAT inhibitory peptide | c-FLIP, cellular FLICE-inhibitory protein | C8i, caspase 8 inhibitor | ROS, reactive oxygen species | DPBS, Dulbecco's phosphate-buffered saline | Z-DEVD (or -IETD)-FMK, benzyloxycarbonyl-Asp-Glu-Val-Asp (or Ile-Glu-Thr-Asp)-fluoromethylketone | GFP, green fluorescent protein | (carboxy-)DCF, (carboxy-)2′,7′-dichlorofluorescein | NF-κB, nuclear factor κB | FBS, fetal bovine serum | DOX, doxorubicin | MnSOD, manganese superoxide dismutase | CoQ, coenzyme Q10 | Mito-Q, a mitochondria-targeted antioxidant consisting of a mixture of mitoquinol and mitoquinone | Ac-DEVD (or -IETD, or -LEHD)-pNA, N-acetyl-Asp-Glu-Val-Asp (or Ile-Glu-Thr-Asp, or Leu-Glu-Thr-Asp) p-nitroanilide | ECL, enhanced chemiluminescence | Fas L, Fas ligand | BAPTA-AM, bis-(o-aminophenoxy)ethane-N,N,N′,N′-tetra-acetic acid tetrakis(acetoxymethyl ester) | NFAT, nuclear factor of activated T-lymphocytes
Journal Article
Biochemical journal, ISSN 0264-6021, 06/2012, Volume 444, Issue 3, pp. 591 - 599
Caspase 2 was initially identified as a neuronally expressed developmentally down-regulated gene (HUGO gene nomenclature CASP2) and has been shown to be... 
Sympathetic neuron | PIDDosome | Hippocampal neuron | Neuronal death | Penetratin1 small-interfering RNA (Pen1-siRNA) | Nerve growth factor deprivation | β-amyloid | Penetratin 1 small-interfering RNA (Pen1-siRNA) | PATHWAYS | APOPTOSIS | ACTIVATION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYMPATHETIC NEURONS | DOWN-REGULATION | hippocampal neuron | CELL-DEATH | DELIVERY | beta-amyloid | nerve growth factor deprivation | sympathetic neuron | neuronal death | PC12 CELLS | Animals, Newborn | CRADD Signaling Adaptor Protein - biosynthesis | Cells, Cultured | Nerve Growth Factor - pharmacology | Rats | Caspase 2 - metabolism | PC12 Cells | Rats, Sprague-Dawley | Mice, Knockout | Animals | Neurons - enzymology | Nerve Growth Factor - deficiency | Mice | Death Domain Receptor Signaling Adaptor Proteins - biosynthesis | Enzyme Activation - physiology | RIP1K, RIP kinase 1 | CED-3, cell-death determining 3 | NGF, nerve growth factor | biotin-VAD-FMK, biotin-Val-Ala-DL-Asp-fluoromethylketone | ERK, extracellular-signal-regulated kinase | DD, death domain | CARD, caspase-recruitment domain | TFD, trophic factor deprivation | CED-3 homologue 1] protein with a DD | RIP, receptor-interacting protein | AS, antisense | Pen1, Penetratin1 | Aβ, β-amyloid | HFIP, 1,1,1,3,3,3 hexafluoro-2-propanol | PIDD, p53-inducible protein with a death domain | siRNA, small interfering RNA | P1, postnatal day 1 | SCG, superior cervical ganglia | RAIDD, RIP (receptor-interacting protein)-associated ICH-1 [ICE (interleukin-1β-converting enzyme)
Journal Article
FEBS letters, ISSN 0014-5793, 02/2002, Volume 513, Issue 2-3, pp. 184 - 188
Journal Article