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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 35, pp. 15601 - 15606
Fragile X syndrome is caused by the absence of functional fragile X mental retardation protein (FMRP), an RNA binding protein. The molecular mechanism of... 
Dendritic spines | Receptors | Messenger RNA | Intellectual disability | Neurons | Protein synthesis | Imaging | Dendrites | Gene expression regulation | Fragile X syndrome | Local translation | Dendritic mRNA targeting | ACTIVATION | FMRP | MULTIDISCIPLINARY SCIENCES | fragile X syndrome | IDENTIFICATION | local translation | SYNAPTIC PLASTICITY | HIPPOCAMPAL-NEURONS | GRANULES | DENDRITIC SPINES | dendritic mRNA targeting | MYOSIN-VA | LONG-TERM DEPRESSION | MOUSE MODEL | Protein Biosynthesis | Neurons - cytology | Fragile X Mental Retardation Protein - metabolism | Green Fluorescent Proteins - genetics | Receptors, Metabotropic Glutamate - metabolism | RNA, Messenger - metabolism | Receptors, Metabotropic Glutamate - genetics | Time Factors | Receptor, Metabotropic Glutamate 5 | Neurons - metabolism | Neurons - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Dendrites - metabolism | Green Fluorescent Proteins - metabolism | RNA Transport | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | In Situ Hybridization, Fluorescence | Hippocampus - cytology | Mice, Knockout | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Protein Binding | Fragile X Mental Retardation Protein - genetics | Mice | Kinetics | Microscopy, Fluorescence | Protein biosynthesis | Genetic aspects | Chemical properties | Research | Binding proteins | Health aspects | Proteins | Ribonucleic acid--RNA | Intellectual disabilities | Rodents | Binding sites | Index Medicus | Translation | Data processing | mRNA | RNA-binding protein | Molecular modelling | RNA transport | fragile X mental retardation protein | Ca super(2+)/calmodulin-dependent protein kinase II | Protein transport | Glutamic acid receptors (metabotropic) | FMR1 protein | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2018, Volume 115, Issue 41, pp. E9707 - E9716
Fragile X syndrome (FXS) is the most frequent form of heritable intellectual disability and autism. Fragile X (Fmr1-KO) mice exhibit aberrant dendritic spine... 
Autism | Cognition | Fragile X syndrome | Autophagy | MTOR | MESSENGER-RNA TRANSLATION | autophagy | cognition | MULTIDISCIPLINARY SCIENCES | fragile X syndrome | BEHAVIORAL PHENOTYPES | HIPPOCAMPAL-NEURONS | autism | INDUCED NEURONAL DEATH | NEUROPSYCHIATRIC DISORDERS | LONG-TERM DEPRESSION | MOUSE MODEL | DISEASE | mTOR | MENTAL-RETARDATION PROTEIN | Fragile X Syndrome - genetics | Cytoskeletal Proteins - genetics | Disks Large Homolog 4 Protein - metabolism | Fragile X Syndrome - metabolism | Disks Large Homolog 4 Protein - genetics | Fragile X Syndrome - pathology | Fragile X Mental Retardation Protein - metabolism | Synapses - genetics | Synapses - pathology | Nerve Tissue Proteins - genetics | Mechanistic Target of Rapamycin Complex 1 - metabolism | Mice, Knockout | Nerve Tissue Proteins - metabolism | CA1 Region, Hippocampal - pathology | Mechanistic Target of Rapamycin Complex 1 - genetics | Animals | Synapses - metabolism | CA1 Region, Hippocampal - metabolism | Cytoskeletal Proteins - metabolism | Fragile X Mental Retardation Protein - genetics | Mice | Regulatory-Associated Protein of mTOR - genetics | Regulatory-Associated Protein of mTOR - metabolism | Autophagy (Cytology) | Care and treatment | Physiological aspects | Health aspects | Synapses | TOR protein | Spine | Cognitive ability | Activation | Mental retardation | Proteins | Dendritic spines | Cell growth | Fragile X mental retardation protein | Rodents | Plasticity | Plasticity (dendritic) | Translocation | Phenotypes | Neurons | Rapamycin | Studies | Plasticity (synaptic) | Cytoskeleton | Postsynaptic density | Postsynaptic density proteins | Dendritic structure | Hippocampus | Phagocytosis | Biochemical markers | FMR1 protein | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Cell, ISSN 0092-8674, 11/2001, Volume 107, Issue 4, pp. 489 - 499
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 10/2012, Volume 76, Issue 2, pp. 325 - 337
Fragile X syndrome (FXS) is the leading inherited cause of autism and intellectual disability. Aberrant synaptic translation has been implicated in the... 
MAMMALIAN TARGET | RAPAMYCIN SIGNALING PATHWAY | FMR1 KNOCKOUT MOUSE | MESSENGER-RNA | MEMORY | LONG-TERM DEPRESSION | PHOSPHOINOSITIDE 3-KINASE-AKT-MAMMALIAN TARGET | TRANSLATION | MENTAL-RETARDATION PROTEIN | NEUROSCIENCES | MTOR | Electric Stimulation | Fragile X Syndrome - pathology | Male | Fragile X Mental Retardation Protein - metabolism | Synapses - genetics | Recognition (Psychology) - physiology | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | Ribosomal Protein S6 Kinases, 70-kDa - deficiency | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Membrane Potentials - drug effects | Synapses - drug effects | Maze Learning - physiology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Dendritic Spines - physiology | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Behavior, Animal - physiology | Mice, Transgenic | Hippocampus - pathology | Mutation - genetics | Patch-Clamp Techniques | Phenotype | Analysis of Variance | Mice | Long-Term Synaptic Depression - genetics | Neurons - pathology | Membrane Potentials - genetics | Fragile X Syndrome - physiopathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Extracellular Signal-Regulated MAP Kinases - genetics | Exploratory Behavior - physiology | Neurons - classification | Female | Interpersonal Relations | Fragile X Syndrome - genetics | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Biophysics | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Motor Activity - genetics | Rotarod Performance Test | Animals | Fragile X Syndrome - prevention & control | Dendritic Spines - classification | Fragile X Mental Retardation Protein - genetics | In Vitro Techniques | Depression, Mental | Analysis | Genetic research | Protein biosynthesis | Genetic aspects | Fragile X syndrome | Genetic translation | Proteins | Phosphorylation | Brain research | Kinases | Protein synthesis | Rodents | Index Medicus | Animal models | Translation | Translation initiation | Pattern recognition | Mental retardation | Ribosomal protein S6 kinase | Autism | Dendritic spines | Molecular modelling | Social interactions | Etiology | p70 S6 kinase | Long-term depression | Elongation
Journal Article
Journal Article
STEM CELLS, ISSN 1066-5099, 02/2017, Volume 35, Issue 2, pp. 374 - 385
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and a leading cause of autism. FXS is due to the silencing of the Fragile... 
Therapeutic window | Autism | Intellectual disability | Fragile X syndrome | Embryonic stem cells | Neurogenesis | TRANSCRIPTION FACTORS | KNOCK-OUT MICE | FMR1 KNOCK | BRAIN-DEVELOPMENT | NEURONAL DIFFERENTIATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | DENDRITIC SPINES | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MOUSE MODEL | NEURAL PROGENITOR CELLS | ACTIN CYTOSKELETON | HEMATOLOGY | EXPRESSION | Gene Expression Regulation | Neurons - cytology | Fragile X Mental Retardation Protein - metabolism | Signal Transduction - genetics | Cell Shape - genetics | Mouse Embryonic Stem Cells - metabolism | Gene Knockdown Techniques | Mice, Knockout | Neurogenesis - genetics | Cell Differentiation - genetics | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Fragile X Mental Retardation Protein - genetics | Mice | Neurons - metabolism | Kinetics | RNA, Small Interfering - metabolism | Neurons | Analysis | Amyloid beta-protein | Mental illness | Mental retardation | Protein binding | Proteins | Intellectual disabilities | Stem cells | ASCL1 protein | Brain | Spine | Embryo cells | Stem cell transplantation | Dendritic spines | Alterations | Fragile X mental retardation protein | Tubulin | Allografts | Plasticity | Alzheimer's disease | Plasticity (dendritic) | Repressing | Translation | Pharmacology | Ribonucleic acid--RNA | Embryos | Amyloid precursor protein | Beta2 protein | Pathology | RNA-binding protein | Plasticity (synaptic) | Cyclin-dependent kinase inhibitor p27 | Differentiation | FMR1 protein | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, pp. e26120 - e26120
The formation and storage of memories in neuronal networks relies on new protein synthesis, which can occur locally at synapses using translational machinery... 
FXR1 | LOCALIZATION | ACTIVITY-DEPENDENT TRAFFICKING | FMRP | MAMMALIAN STRESS GRANULES | BINDING PROTEINS | BIOLOGY | NEURONS | TRANSLATION | MENTAL-RETARDATION PROTEIN | SYNAPTIC PLASTICITY | Disks Large Homolog 4 Protein | Humans | Ribosomes - metabolism | Male | Neurons - cytology | Dendritic Spines - metabolism | Fragile X Mental Retardation Protein - metabolism | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | HEK293 Cells | Female | Membrane Proteins - metabolism | Neurons - metabolism | Hippocampus - growth & development | Tissue Extracts | Green Fluorescent Proteins - metabolism | RNA Transport | Mice, Inbred C57BL | Hippocampus - cytology | Protein Transport | Hippocampus - metabolism | Animals | Guanylate Kinases - metabolism | Polyribosomes - metabolism | Mice | Ribosome Subunits - metabolism | Cluster Analysis | Brain | RNA | Neurons | Protein biosynthesis | Binding proteins | Genetic translation | Mental illness | Protein binding | Neurosciences | Intellectual disabilities | Memory | Central nervous system | Ribosomes | Homology | mRNA | Neurosurgery | Machinery | Mental retardation | Proteins | Dendritic spines | Dendrites | Localization | Polyclonal antibodies | Translation | Gene expression | Medicine | Autism | RNA-binding protein | Ribonucleic acids | Protein synthesis | Plasmids | Neural networks | Fragile X syndrome | Dendritic structure | Hippocampus | Synapses | FMR1 protein | Index Medicus
Journal Article
Genes, Brain and Behavior, ISSN 1601-1848, 07/2012, Volume 11, Issue 5, pp. 586 - 600
Fragile X syndrome (FXS), the most common inherited form of intellectual disability and prevailing known genetic basis of autism, is caused by an expansion in... 
tyrosine phosphatase | audiogenic seizures | social | fragile X syndrome | Anxiety | c‐Fos | STEP | behavior | Social | Tyrosine phosphatase | C-Fos | Audiogenic seizures | Behavior | Fragile X syndrome | HIPPOCAMPAL SLICES | c-Fos | FMR1 KO MICE | NEUROSCIENCES | AUDIOGENIC-SEIZURES | MESSENGER-RNAS | NEURONAL FUNCTION | LONG-TERM DEPRESSION | BEHAVIORAL SCIENCES | TYROSINE-PHOSPHATASE STEP | MENTAL-RETARDATION PROTEIN | RECEPTOR-DEPENDENT TRANSLATION | Motor Activity - physiology | Proto-Oncogene Proteins c-fos - metabolism | Behavior, Animal - physiology | Fragile X Mental Retardation Protein - metabolism | Receptors, Metabotropic Glutamate - metabolism | Social Dominance | Synaptosomes - metabolism | Mice, Knockout | Hippocampus - metabolism | Animals | Receptors, Metabotropic Glutamate - genetics | Protein Tyrosine Phosphatases, Non-Receptor - genetics | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Choice Behavior - physiology | Fragile X Mental Retardation Protein - genetics | Mice | Neurons - metabolism | Disease Models, Animal | Proteins | Anxieties | Manipulation | Index Medicus | alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors | Animal models | Translation | Synaptic strength | Transcription | Glutamic acid receptors (ionotropic) | Epilepsy | Periaqueductal gray area | Extracellular signal-regulated kinase | Exploration | N-Methyl-D-aspartic acid receptors | Auditory stimuli | Mental retardation | Autism | fragile X mental retardation protein | Glutamic acid receptors (metabotropic) | N-Methyl-D-aspartic acid | c-Fos protein | FMR1 protein | Fyn protein | Protein-tyrosine-phosphatase | Seizures | anxiety
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/2007, Volume 27, Issue 20, pp. 5338 - 5348
Journal Article